The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
Open accessAbstract
Signalling by the GTPase RhoA, a key regulator of epithelial cell behaviour, can stimulate opposing processes: RhoA can promote junction formation and apical constriction, and reduce adhesion and cell spreading. Molecular mechanisms are thus required that ensure spatially restricted and process-specific RhoA activation. For many fundamental processes, including assembly of the epithelial junctional complex, such mechanisms are still unknown. Here we show that p114RhoGEF is a junction-associated protein that drives RhoA signalling at the junctional complex and regulates tight-junction assembly and epithelial morphogenesis. p114RhoGEF is required for RhoA activation at cell–cell junctions, and its depletion stimulates non-junctional Rho signalling and induction of myosin phosphorylation along the basal domain. Depletion of GEF-H1, a RhoA activator inhibited by junctional recruitment, does not reduce junction-associated RhoA activation. p114RhoGEF associates with a complex containing myosin II, Rock II and the junctional adaptor cingulin, indicating that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis.
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Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669
Aijaz, S., D’Atri, F., Citi, S., Balda, M. S., & Matter, K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.003 · Cited by 226
Self-citationBirkenfeld, J., Nalbant, P., Yoon, S.-H., & Bokoch, G. M. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.02.006 · Cited by 190
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Self-citationThe role of molecular remodeling in differential regulation of tight junction permeability
Turner, J. R., Buschmann, M. M., Romero-Calvo, I., Sailer, A., & Shen, L. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.09.022 · Cited by 200
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Metadata
- Authors
- Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., Leefa Chong San, I. V., Balda, M. S., & Matter, K.
- Venue
- Nature Cell Biology
- Published
- 2011-01-23
- Volume
- 13
- Issue
- 2
- Pages
- 159-166
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2016979375
- Cited by
- 241
- References
- 3
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., Leefa Chong San, I. V., Balda, M. S., & Matter, K. (2011). Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nature Cell Biology. https://doi.org/10.1038/ncb2156
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