Cited by 130Cellular Mechanics and InteractionsTissue Engineering and Regenerative MedicineCancer Cells and Metastasis

Sculpting Organs: Mechanical Regulation of Tissue Development

Nelson, Celeste M., Gleghorn, Jason P.·2012·Annual Review of Biomedical Engineering

Abstract

The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.

Integrity signals

Registry

Crossref · 10.1146/annurev-bioeng-071811-150043

Cites

187 of 187 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mechanical properties in three-dimensional culture systems can have large effects on cell, organoid, tissue, and organ development.

    “Finally, it has become increasingly clear that the mechanical properties in three-dimensional (3D) culture systems can have large effects on cell51, organoid52, tissue53, and organ development54,55.”

    From Towards organoid culture without Matrigel (2021) · cites this paper as [53]

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2 of the 189 references couldn’t be matched to a known paper.

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Authors
Nelson, C. M., & Gleghorn, J. P.
Affiliations
  • Princeton University (US)
  • Department of Chemical and Biological Engineering and
Venue
Annual Review of Biomedical Engineering
Published
2012-08-15
Volume
14
Issue
1
Pages
129-154
ISSN
  • 1523-9829 (ISSN-L)
  • 1545-4274
OpenAlex
W2170979166
Cited by
130
References
189
Citations by year
2026: 6 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 3
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Burroughs Wellcome Fund
  • Susan G. Komen
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R21HL110335, HL110335)
  • National Cancer Institute (CA128660, R21CA128660)
  • National Institute of General Medical Sciences (R01GM083997, GM083997)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
branching morphogenesis, organogenesis, cell contractility, mechanical regulation, mammary gland, lung development, epithelial sheets, microenvironment, tissue mechanics
MeSH terms
Animals, Biomedical Engineering, Humans, Lung, Mammary Glands, Animal, Models, Genetic, Morphogenesis, Time Factors, Signal Transduction, Gene Expression Regulation, Developmental, Tissue Engineering, Organogenesis, Mammary Glands, Human

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