Sculpting Organs: Mechanical Regulation of Tissue Development
Abstract
The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mechanical properties in three-dimensional culture systems can have large effects on cell, organoid, tissue, and organ development.
“Finally, it has become increasingly clear that the mechanical properties in three-dimensional (3D) culture systems can have large effects on cell51, organoid52, tissue53, and organ development54,55.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [53]
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382 · see citing works
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138 · see citing works
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,628 · see citing works
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182 · see citing works
Self-citationTensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · see citing works
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289 · see citing works
Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S. A., Bershadsky, A. D., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,137 · see citing works
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057 · see citing works
Cells lying on a bed of microneedles: An approach to isolate mechanical force
Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0235407100 · Cited by 2,036 · see citing works
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 1,991 · see citing works
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Burridge, K., & Chrzanowska‐Wodnicka, M. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.463 · Cited by 1,943 · see citing works
Geometric cues for directing the differentiation of mesenchymal stem cells
Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841 · see citing works
Nonlinear elasticity in biological gels
Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,707 · see citing works
Maniotis, A. J., Chen, C. S., & Ingber, D. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.849 · Cited by 1,606 · see citing works
Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton
Ren, X. D., Kiosses, W. B., & Schwartz, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.578 · Cited by 1,573 · see citing works
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Grashoff, C., Hoffman, B. D., Brenner, M. D., Zhou, R., Parsons, M., Yang, M. T., McLean, M. A., Sligar, S. G., Chen, C. S., Ha, T., et al. (2010) · Nature · doi:10.1038/nature09198 · Cited by 1,549 · see citing works
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science · doi:10.1126/science.277.5324.333 · Cited by 1,543 · see citing works
How does the extracellular matrix direct gene expression?
Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522 · see citing works
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works
Physical forces during collective cell migration
Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E. J., Weitz, D. A., Butler, J. P., & Fredberg, J. J. (2009) · Nature Physics · doi:10.1038/nphys1269 · Cited by 1,198 · see citing works
Reconstruction of Tissues by Dissociated Cells
Steinberg, M. S. (1963) · Science · doi:10.1126/science.141.3579.401 · Cited by 1,122 · see citing works
Mechanical regulation of cell function with geometrically modulated elastomeric substrates
Fu, J., Wang, Y.-K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1487 · Cited by 1,073 · see citing works
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
Bertet, C., Sulak, L., & Lecuit, T. (2004) · Nature · doi:10.1038/nature02590 · Cited by 1,025 · see citing works
Deconstructing the Cadherin-Catenin-Actin Complex
Yamada, S., Pokutta, S., Drees, F., Weis, W. I., & Nelson, W. J. (2005) · Cell · doi:10.1016/j.cell.2005.09.020 · Cited by 1,022 · see citing works
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
Hove, J. R., Köster, R. W., Forouhar, A. S., Acevedo‐Bolton, G., Fraser, S. E., & Gharib, M. (2003) · Nature · doi:10.1038/nature01282 · Cited by 1,000 · see citing works
α-Catenin as a tension transducer that induces adherens junction development
Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A., & Shibata, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2055 · Cited by 972 · see citing works
Min, H.-S., Danilenko, D., Scully, S., Bolon, B., Ring, B., Tarpley, J., Derose, M., & Simonet, W. (1998) · Genes & Development · doi:10.1101/gad.12.20.3156 · Cited by 928 · see citing works
The differential adhesion hypothesis: a direct evaluation
Foty, R. A., & Steinberg, M. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.012 · Cited by 908 · see citing works
Collective cell guidance by cooperative intercellular forces
Tambe, D. T., Hardin, C., Angelini, T. E., Rajendran, K., Park, C. Y., Serra‐Picamal, X., Zhou, E. H., Zaman, M. H., Butler, J. P., Weitz, D. A., et al. (2011) · Nature Materials · doi:10.1038/nmat3025 · Cited by 888 · see citing works
Directed movements and selective adhesion of embryonic amphibian cells
Townes, P. L., & Holtfreter, J. (1955) · Journal of Experimental Zoology · doi:10.1002/jez.1401280105 · Cited by 872 · see citing works
Moerlooze, L. D., Spencer‐Dene, B., Revest, J., Hajihosseini, M. K., Rosewell, I. R., & Dickson, C. (2000) · Development · doi:10.1242/dev.127.3.483 · Cited by 863 · see citing works
Emergent patterns of growth controlled by multicellular form and mechanics
Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502575102 · Cited by 852 · see citing works
Self-citationMechanobiology and diseases of mechanotransduction
Ingber, D. E. (2003) · Annals of Medicine · doi:10.1080/07853890310016333 · Cited by 842 · see citing works
Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium
Prætorius, H. A., & Spring, K. R. (2001) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0075-4 · Cited by 828 · see citing works
Mechanisms of Mechanotransduction
Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.006 · Cited by 809 · see citing works
Tensile forces govern germ-layer organization in zebrafish
Krieg, M., Arboleda-Estudillo, Y., Puech, P., Käfer, J., Graner, F., Müller, D. J., & Heisenberg, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1705 · Cited by 804 · see citing works
Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration
Evans, E., & Yeung, A. (1989) · Biophysical Journal · doi:10.1016/s0006-3495(89)82660-8 · Cited by 801 · see citing works
The branching programme of mouse lung development
Metzger, R. J., Klein, O. D., Martin, G. R., & Krasnow, M. A. (2008) · Nature · doi:10.1038/nature07005 · Cited by 787 · see citing works
The extracellular matrix guides the orientation of the cell division axis
Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J., & Bornens, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1307 · Cited by 780 · see citing works
Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763 · see citing works
The PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 746 · see citing works
Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development
Costantini, F. D., & Kopan, R. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.04.008 · Cited by 741 · see citing works
LEUNG, T. K. C., Manser, E. J., Tan, L. H.-P., & Lim, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29051 · Cited by 720 · see citing works
Mechanical tugging force regulates the size of cell–cell junctions
Liu, Z., Tan, J. L., Cohen, D. M., Yang, M. T., Sniadecki, N. J., Ruiz, S. A., Nelson, C. M., & Chen, C. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914547107 · Cited by 704 · see citing works
Self-citationSingle stretch-activated ion channels in vascular endothelial cells as mechanotransducers?
Lansman, J. B., Hallam, T. J., & RINK, T. J. (1987) · Nature · doi:10.1038/325811a0 · Cited by 699 · see citing works
Integrins and Extracellular Matrix in Mechanotransduction
Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662 · see citing works
Lubarsky, B., & Krasnow, M. A. (2003) · Cell · doi:10.1016/s0092-8674(02)01283-7 · Cited by 660 · see citing works
le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D., & de Rooij, J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001149 · Cited by 652 · see citing works
Mechanical feedback as a possible regulator of tissue growth.
Shraiman, B. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0404782102 · Cited by 636 · see citing works
Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis
Ewald, A. J., Brenot, A., Duong, M., Chan, B. S., & Werb, Z. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.003 · Cited by 620 · see citing works
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
Rauzi, M., Vérant, P., Lecuit, T., & Lenne, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1798 · Cited by 616 · see citing works
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 610 · see citing works
Self-citationZhong, C., Chrzanowska‐Wodnicka, M., Brown, J. A., Maddox, A. S., Belkin, A. M., & Burridge, K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.539 · Cited by 605 · see citing works
Rørth, P. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113231 · Cited by 600 · see citing works
Théry, M., Racine, V., Piel, M., Pépin, A., Dimitrov, A., Chen, Y., Sibarita, J., & Bornens, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609267103 · Cited by 593 · see citing works
Steinberg, M. S., & Takeichi, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.206 · Cited by 572 · see citing works
Patterned Gene Expression Directs Bipolar Planar Polarity in Drosophila
Zallen, J. A., & Wieschaus, E. F. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00060-7 · Cited by 556 · see citing works
Fibronectin requirement in branching morphogenesis
Sakai, T., Larsen, M., & Yamada, K. M. (2003) · Nature · doi:10.1038/nature01712 · Cited by 555 · see citing works
Integration of contractile forces during tissue invagination
Martin, A. C., Gelbart, M., Fernandez-Gonzalez, R., Kaschube, M., & Wieschaus, E. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910099 · Cited by 545 · see citing works
Defective planar cell polarity in polycystic kidney disease
Fischer, E. A., Legué, E., Doyen, A., Nato, F., Nicolas, J.-F., Torres, V. E., Yaniv, M., & Pontoglio, M. (2005) · Nature Genetics · doi:10.1038/ng1701 · Cited by 534 · see citing works
Mechanisms of convergence and extension by cell intercalation
Keller, R. E., Davidson, L. A., Edlund, A., Elul, T., Ezin, M., Shook, D. R., & Skoglund, P. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0626 · Cited by 521 · see citing works
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
Weaver, M., Dunn, N. R., & Hogan, B. L. M. (2000) · Development · doi:10.1242/dev.127.12.2695 · Cited by 507 · see citing works
Cell distribution of stress fibres in response to the geometry of the adhesive environment
Théry, M., Pépin, A., Dressaire, E., Chen, Y., & Bornens, M. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20126 · Cited by 452 · see citing works
Apical constriction: A cell shape change that can drive morphogenesis
Sawyer, J. M., Harrell, J. R., Shemer, G., Sullivan-Brown, J., Roh‐Johnson, M., & Goldstein, B. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.009 · Cited by 449 · see citing works
A two-tiered mechanism for stabilization and immobilization of E-cadherin
Cavey, M., Rauzi, M., Lenne, P., & Lecuit, T. (2008) · Nature · doi:10.1038/nature06953 · Cited by 438 · see citing works
The emergence of geometric order in proliferating metazoan epithelia
Gibson, M. C., Patel, A. B., Nagpal, R., & Perrimon, N. (2006) · Nature · doi:10.1038/nature05014 · Cited by 435 · see citing works
Warburton, D., El-Hashash, A. H. K., Carraro, G., Tiozzo, C., Sala, F., Rogers, O., Langhe, S. D., Kemp, P. J., Riccardi, D., Torday, J. S., et al. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)90003-3 · Cited by 431 · see citing works
Composition and Formation of Intercellular Junctions in Epithelial Cells
Knust, E., & Bossinger, O. (2002) · Science · doi:10.1126/science.1072161 · Cited by 422 · see citing works
Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures
Ruiz, S. A., & Chen, C. S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0432 · Cited by 415 · see citing works
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412 · see citing works
Levin, M. G., Thorlin, T., Robinson, K. R., Nogi, T., & Mercola, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00939-x · Cited by 397 · see citing works
Cell-Cell Mechanical Communication through Compliant Substrates
Reinhart‐King, C. A., Dembo, M., & Hammer, D. A. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.127662 · Cited by 391 · see citing works
Abe, K., & Takeichi, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710504105 · Cited by 378 · see citing works
Regulation of lung expansion and lung growth before birth
Harding, R., & Hooper, S. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.209 · Cited by 373 · see citing works
On the mechanism of wing size determination in fly development
Hufnagel, L., Teleman, A. A., Rouault, H., Cohen, S. M., & Shraiman, B. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607134104 · Cited by 372 · see citing works
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J. (2009) · Nature Genetics · doi:10.1038/ng.400 · Cited by 370 · see citing works
Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin
Gao, L., McBeath, R., & Chen, C. S. (2010) · Stem Cells · doi:10.1002/stem.308 · Cited by 369 · see citing works
Samakovlis, C., Hacohen, N., Manning, G., Sutherland, D. C., Guillemin, K. J., & Krasnow, M. A. (1996) · Development · doi:10.1242/dev.122.5.1395 · Cited by 368 · see citing works
Surface mechanics mediate pattern formation in the developing retina
Hayashi, T., & Carthew, R. W. (2004) · Nature · doi:10.1038/nature02952 · Cited by 366 · see citing works
Sakakura, T., Nishizuka, Y., & Dawe, C. J. (1976) · Science · doi:10.1126/science.827022 · Cited by 357 · see citing works
Drosophila oocyte localization is mediated by differential cadherin-based adhesion
Godt, D., & Tepaß, U. (1998) · Nature · doi:10.1038/26493 · Cited by 355 · see citing works
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration
Andrew, D. J., & Ewald, A. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.024 · Cited by 336 · see citing works
Kratochwil, K. (1969) · Developmental Biology · doi:10.1016/0012-1606(69)90004-9 · Cited by 332 · see citing works
The Orientation of Cell Divisions Determines the Shape of Drosophila Organs
Baena-López, L. A., Baonza, A., & Garcı́a-Bellido, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.062 · Cited by 332 · see citing works
Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1
Klebe, C., Bischoff, F. R., Ponstingl, H., & Wittinghofer, A. (1995) · Biochemistry · doi:10.1021/bi00002a031 · Cited by 323 · see citing works
Luschnig, S., Bätz, T., Armbruster, K., & Krasnow, M. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.11.072 · Cited by 318 · see citing works
Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development
Ciarloni, L., Mallepell, S., & Brisken, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611647104 · Cited by 316 · see citing works
Molecular Mechanisms Of Tubulogenesis
Hogan, B. L. M., & Kolodziej, P. A. (2002) · Nature Reviews Genetics · doi:10.1038/nrg840 · Cited by 315 · see citing works
FGF-10 Is a Chemotactic Factor for Distal Epithelial Buds during Lung Development
Park, W. Y., Miranda, B., Lebeche, D., Hashimoto, G., & Cardoso, W. V. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8994 · Cited by 312 · see citing works
Sternlicht, M. D., Sunnarborg, S. W., Kouros‐Mehr, H., Yu, Y., Lee, D. C., & Werb, Z. (2005) · Development · doi:10.1242/dev.01966 · Cited by 310 · see citing works
Wnt5a Participates in Distal Lung Morphogenesis
Li, C., Xiao, J., Hormi, K., Borok, Z., & Minoo, P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0729 · Cited by 310 · see citing works
Wiseman, B. S., Sternlicht, M. D., Lund, L. R., Alexander, C. M., Mott, J., Bissell, M. J., Soloway, P. D., Itohara, S., & Werb, Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302090 · Cited by 301 · see citing works
Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation
Blanchard, G. B., Kabla, A., Schultz, N., Butler, L., Sanson, B., Gorfinkiel, N., Mahadevan, L., & Adams, R. J. (2009) · Nature Methods · doi:10.1038/nmeth.1327 · Cited by 301 · see citing works
Brodland, G. W. (2002) · Journal of Biomechanical Engineering · doi:10.1115/1.1449491 · Cited by 296 · see citing works
Cell Migration Driven by Cooperative Substrate Deformation Patterns
Angelini, T. E., Hannezo, É., Trepat, X., Fredberg, J. J., & Weitz, D. A. (2010) · Physical Review Letters · doi:10.1103/physrevlett.104.168104 · Cited by 290 · see citing works
Korman, N. J., Eyre, R. W., Klaus-Kovtun, V., & Stanley, J. R. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909073211002 · Cited by 272 · see citing works
Organogenesis of the Caenorhabditis elegans Intestine
Leung, B., Hermann, G. J., & Priess, J. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9471 · Cited by 271 · see citing works
Wiesen, J. F., Young, P., Werb, Z., & Cunha, G. R. (1999) · Development · doi:10.1242/dev.126.2.335 · Cited by 265 · see citing works
Pierce, D. F., Johnson, M. D., Matsui, Y., Robinson, S. D., Gold, L. I., Purchio, A. F., Daniel, C. W., Hogan, B. L. M., & Moses, H. L. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2308 · Cited by 264 · see citing works
Genetic control of single lumen formation in the zebrafish gut
Bagnat, M., Cheung, I. D., Mostov, K. E., & Stainier, D. Y. R. (2007) · Nature Cell Biology · doi:10.1038/ncb1621 · Cited by 262 · see citing works
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis
Humphreys, R. C., Krajewska, M., Krnacik, S., Jæger, R., Weiher, H., Krajewski, S., Reed, J. C., & Rosen, J. M. (1996) · Development · doi:10.1242/dev.122.12.4013 · Cited by 260 · see citing works
An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos
Monier, B., Pélissier-Monier, A., Brand, A. H., & Sanson, B. (2009) · Nature Cell Biology · doi:10.1038/ncb2005 · Cited by 258 · see citing works
Moore, K. A., Polte, T., Huang, S., Shi, B., Alsberg, E., Sunday, M. E., & Ingber, D. E. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20237 · Cited by 258 · see citing works
Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate
Paszek, M. J., Boettiger, D. E., Weaver, V. M., & Hammer, D. A. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000604 · Cited by 257 · see citing works
Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling
Tamaríz, E., & Grinnell, F. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0291 · Cited by 253 · see citing works
Cell polarity triggered by cell-cell adhesion via E-cadherin
Desai, R. A., Gao, L., Raghavan, S., Liu, W. F., & Chen, C. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.028183 · Cited by 242 · see citing works
Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., San, I. V. L. C., Balda, M. S., & Matter, K. (2011) · Nature Cell Biology · doi:10.1038/ncb2156 · Cited by 238 · see citing works
Cell Mechanics Studied by a Reconstituted Model Tissue
Wakatsuki, T., Kolodney, M. S., Zahalak, G. I., & Elson, E. L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76481-2 · Cited by 236 · see citing works
Chi, X., Michos, O., Shakya, R., Riccio, P. N., Enomoto, H., Licht, J. D., Asai, N., Takahashi, M., Ohgami, N., Kato, M., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.013 · Cited by 234 · see citing works
Orchestrating size and shape during morphogenesis
Lecuit, T., & LeGoff, L. (2007) · Nature · doi:10.1038/nature06304 · Cited by 230 · see citing works
Lenzen, C. U., Cool, R. H., Prinz, H., Kuhlmann, J., & Wittinghofer, A. (1998) · Biochemistry · doi:10.1021/bi972621j · Cited by 227 · see citing works
Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch
Katsumi, A., Naoe, T., Matsushita, T., Kaibuchi, K., & Schwartz, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c400455200 · Cited by 225 · see citing works
Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis
Martín‐Belmonte, F., Yu, W., Rodriguez-Fraticelli, A., Ewald, A. J., Werb, Z., Alonso, M. A., & Mostov, K. E. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.076 · Cited by 224 · see citing works
Maternal β-catenin and E-cadherin in mouse development
de Vries, W. N., Evsikov, A. V., Haac, B. E., Fancher, K. S., Holbrook, A. E., Kemler, R., Solter, D., & Knowles, B. B. (2004) · Development · doi:10.1242/dev.01316 · Cited by 217 · see citing works
Harris, A. K. (1976) · Journal of Theoretical Biology · doi:10.1016/0022-5193(76)90019-9 · Cited by 215 · see citing works
Integrated morphodynamic signalling of the mammary gland
Gjorevski, N., & Nelson, C. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3168 · Cited by 215 · see citing works
Self-citationTissue geometry patterns epithelial–mesenchymal transition via intercellular mechanotransduction
Gomez, E. W., Chen, Q. K., Gjorevski, N., & Nelson, C. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22545 · Cited by 214 · see citing works
Self-citationEvidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
Mailleux, A., Tefft, D., Ndiaye‐Lobry, D., Itoh, N., Thiery, J. P., Warburton, D., & Bellusci, S. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00286-6 · Cited by 212 · see citing works
Cell and fibronectin dynamics during branching morphogenesis
Larsen, M., Wei, C., & Yamada, K. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03079 · Cited by 208 · see citing works
Zhou, J., Kim, H. Y., & Davidson, L. A. (2009) · Development · doi:10.1242/dev.026211 · Cited by 200 · see citing works
Developmental Regulation of Lung Liquid Transport
Olver, R. E., Walters, D. V., & Wilson, S. M. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.071702.145229 · Cited by 195 · see citing works
Embryonic origin and differentiation of the Drosophila heart
Rugendorff, A., Younossi‐Hartenstein, A., & Hartenstein, V. (1994) · Development Genes and Evolution · doi:10.1007/bf00360522 · Cited by 190 · see citing works
Collective Cell Migration Drives Morphogenesis of the Kidney Nephron
Vasilyev, A., Liu, Y., Mudumana, S. P., Mangos, S., Lam, P., Majumdar, Å., Zhao, J., Poon, K., Kondrychyn, I., Korzh, V. P., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.1000009 · Cited by 188 · see citing works
Renal branching morphogenesis: concepts, questions, and recent advances.
Costantini, F. (2006) · Differentiation; research in biological diversity · doi:10.1111/j.1432-0436.2006.00106.x · Cited by 187 · see citing works
Tsarouhas, V., Senti, K.-A., Jayaram, S. A., Tiklová, K., Hemphälä, J., Adler, J., & Samakovlis, C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.06.008 · Cited by 186 · see citing works
Warburton, D., Seth, R., Shum, L., Horcher, P. G., Hall, F. L., Werb, Z., & Slavkin, H. C. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90269-m · Cited by 186 · see citing works
González‐Reyes, A., & Johnston, D. S. (1998) · Development · doi:10.1242/dev.125.15.2837 · Cited by 186 · see citing works
Guillemin, K. J., Groppe, J. C., Duecker, K., Treisman, R., Hafen, E., Affolter, M., & Krasnow, M. A. (1996) · Development · doi:10.1242/dev.122.5.1353 · Cited by 185 · see citing works
Jaźwińska, A., Ribeiro, C., & Affolter, M. (2003) · Nature Cell Biology · doi:10.1038/ncb1049 · Cited by 183 · see citing works
Levin, M. G., & Mercola, M. A. (1999) · Development · doi:10.1242/dev.126.21.4703 · Cited by 180 · see citing works
Nelson, C. M., Pirone, D. M., Tan, J. L., & Chen, C. S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0745 · Cited by 180 · see citing works
Self-citationRoarty, K. P., & Serra, R. A. (2007) · Development · doi:10.1242/dev.008250 · Cited by 180 · see citing works
Tonning, A., Hemphälä, J., Tång, E., Nannmark, U., Samakovlis, C., & Uv, A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.012 · Cited by 179 · see citing works
Control of Mitotic Spindle Angle by the RAS-Regulated ERK1/2 Pathway Determines Lung Tube Shape
Tang, N., Marshall, W., McMahon, M., Metzger, R. J., & Martin, G. (2011) · Science · doi:10.1126/science.1204831 · Cited by 175 · see citing works
Wnt5a regulates Shh and Fgf10 signaling during lung development
Li, C., Hu, L., Xiao, J., Chen, H., Li, J. T., Bellusci, S., Langhe, S. D., & Minoo, P. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.035 · Cited by 174 · see citing works
Collagen involvement in branching morphogenesis of embryonic lung and salivary gland
Spooner, B. S., & Faubion, J. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90458-3 · Cited by 172 · see citing works
Ramasamy, S., Mailleux, A., Gupte, V. V., Mata, F., Sala, F., Veltmaat, J., del Moral, P., Langhe, S. D., Parsa, S., Kelly, L. K., et al. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.033 · Cited by 172 · see citing works
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
Taguchi, K., Ishiuchi, T., & Takeichi, M. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201104124 · Cited by 159 · see citing works
Schittny, J. C., Miserocchi, G., & Sparrow, M. P. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.1.3926 · Cited by 158 · see citing works
Uitto, J., & Christiano, A. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115938 · Cited by 156 · see citing works
Horowitz, A., & Simons, M. (2008) · Circulation Research · doi:10.1161/circresaha.108.181818 · Cited by 155 · see citing works
Basson, M. A., Watson-Johnson, J., Shakya, R., Akbulut, S., Hyink, D. P., Costantini, F. D., Wilson, P. D., Mason, I. J., & Licht, J. D. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.051 · Cited by 154 · see citing works
Effects of collagenase on developing epithelia in vitro: Lung, ureteric bud, and pancreas
Wessells, N. K., & Cohen, J. H. (1968) · Developmental Biology · doi:10.1016/0012-1606(68)90037-7 · Cited by 150 · see citing works
Helmke, B. P., & Davies, P. F. (2002) · Annals of Biomedical Engineering · doi:10.1114/1.1467926 · Cited by 149 · see citing works
Pattern and regulation of cell proliferation during murine ureteric bud development
Michael, L., & Davies, J. A. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00285.x · Cited by 146 · see citing works
Fujisawa, K., Fujita, A., Ishizaki, T., Saito, Y., & Narumiya, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23022 · Cited by 143 · see citing works
Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland
Nakanishi, Y., Sugiura, F., Kishi, J., & Hayakawa, T. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90122-3 · Cited by 142 · see citing works
Do different branching epithelia use a conserved developmental mechanism?
Davies, J. A. (2002) · BioEssays · doi:10.1002/bies.10161 · Cited by 141 · see citing works
Self-Organization and Branching Morphogenesis of Primary Salivary Epithelial Cells
Wei, C., Larsen, M., Hoffman, M. P., & Yamada, K. M. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0123 · Cited by 139 · see citing works
Endogenous patterns of mechanical stress are required for branching morphogenesis
Gjorevski, N., & Nelson, C. M. (2010) · Integrative Biology · doi:10.1039/c0ib00040j · Cited by 137 · see citing works
Self-citationLiu, W. F., Nelson, C. M., Tan, J. L., & Chen, C. S. (2007) · Circulation Research · doi:10.1161/circresaha.107.158329 · Cited by 133 · see citing works
Self-citationModulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea
Shaye, D. D., Casanova, J., & Llimargas, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1756 · Cited by 124 · see citing works
The development in vitro of the submandibular and sublingual glands of Mus musculus.
Borghese, E. (1950) · PubMed · Cited by 122 · see citing works
mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins
Tefft, D., Lee, M., Smith, S. M., Crowe, D. L., Bellusci, S., & Warburton, D. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00372.2001 · Cited by 118 · see citing works
Force generated by actomyosin contraction builds bridges between adhesive contacts
Rossier, O., Gauthier, N. C., Biais, N., Vonnegut, W., Fardin, M.-A., Avigan, P., Heller, E., Mathur, A., Ghassemi, S., Koeckert, M. S., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.2 · Cited by 115 · see citing works
Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium
Matsuyama, M., Aizawa, S., & Shimono, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000427 · Cited by 108 · see citing works
Mechanics of head fold formation: investigating tissue-level forces during early development
Varner, V. D., Voronov, D. A., & Taber, L. A. (2010) · Development · doi:10.1242/dev.054387 · Cited by 98 · see citing works
Effect of tracheostomy on lung development in fetal lambs
Fewell, J. E., Hislop, A. A., Kitterman, J. A., & Johnson, P. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.4.1103 · Cited by 96 · see citing works
Zhang, H.-Z., Bennett, J. M., Smith, K. T., Sunil, N., & Haslam, S. Z. (2002) · Endocrinology · doi:10.1210/en.2002-220007 · Cited by 93 · see citing works
Unbekandt, M., del Moral, P.-M., Sala, F. G., Bellusci, S., Warburton, D., & Fleury, V. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.10.013 · Cited by 92 · see citing works
Myat, M. M., & Andrew, D. J. (2000) · Development · doi:10.1242/dev.127.4.679 · Cited by 91 · see citing works
Self-organization of engineered epithelial tubules by differential cellular motility
Mori, H., Gjorevski, N., Inman, J. L., Bissell, M. J., & Nelson, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901269106 · Cited by 88 · see citing works
Self-citationCalretinin neurons in human medial prefrontal cortex (areas 24a,b,c, 32?, and 25)
Gabbott, P. L. A., Jays, P. R. L., & Bacon, S. J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970519)381:4 · Cited by 81 · see citing works
COPI Vesicle Transport Is a Common Requirement for Tube Expansion in Drosophila
Jayaram, S. A., Senti, K.-A., Tiklová, K., Tsarouhas, V., Hemphälä, J., & Samakovlis, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001964 · Cited by 77 · see citing works
Polycystic kidney disease: Pathogenesis and potential therapies
Takiar, V., & Caplan, M. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.11.014 · Cited by 75 · see citing works
Iwaki, D. D., Johansen, K. A., Singer, J. B., & Lengyel, J. A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0483 · Cited by 70 · see citing works
Developing Rat Lung Has a Sided Pacemaker Region for Morphogenesis-Related Airway Peristalsis
Jesudason, E. C., Smith, N. P., Connell, M. G., Spiller, D. G., White, M., Fernig, D. G., & Losty, P. D. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0304oc · Cited by 68 · see citing works
Wurst is essential for airway clearance and respiratory-tube size control
Behr, M., Wingen, C., Wolf, C., Schuh, R., & Hoch, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1611 · Cited by 66 · see citing works
Vascular stenosis: biology and interventions
Roy‐Chaudhury, P., & Lee, T. C. (2007) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3282efa57f · Cited by 64 · see citing works
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells
Chanson, L., Brownfield, D., Garbe, J. C., Kuhn, I., Stampfer, M. R., Bissell, M. J., & LaBarge, M. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019556108 · Cited by 63 · see citing works
Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude
Li, B., Li, F., Puskar, K. M., & Wang, J. H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.04.033 · Cited by 62 · see citing works
Fetal lung growth after tracheal ligation is not solely a pressure phenomenon
Papadakis, K. A., Luks, F. I., Paepe, M. E. D., Piasecki, G. J., & Wesselhoeft, C. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90208-6 · Cited by 59 · see citing works
Moore, K. A., Huang, S., Kong, Y., Sunday, M. E., & Ingber, D. E. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6418 · Cited by 57 · see citing works
Kanwar, Y. S., Ota, K., Yang, Q., Wada, J., Kashihara, N., Tian, Y., & Wallner, E. I. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.6.f934 · Cited by 57 · see citing works
Jesudason, E. C., Smith, N. P., Connell, M. G., Spiller, D. G., White, M., Fernig, D. G., & Losty, P. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00498.2005 · Cited by 56 · see citing works
Role of fetal breathing movements in control of fetal lung distension
Miller, A. A., Hooper, S. B., & Harding, R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.6.2711 · Cited by 55 · see citing works
A mechanism for early branching in lung morphogenesis
Lubkin, S. R., & Murray, J. D. (1995) · Journal of Mathematical Biology · doi:10.1007/bf00180137 · Cited by 54 · see citing works
Upper airway dynamics during breathing and during apnoea in fetal lambs.
Fewell, J. E., & Johnson, P. A. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014729 · Cited by 51 · see citing works
Cellular and Matrix Contributions to Tissue Construct Stiffness Increase with Cellular Concentration
Marquez, J. P., Genin, G. M., Pryse, K. M., & Elson, E. L. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9160-2 · Cited by 49 · see citing works
The human lung: did evolution get it wrong?
West, J. B., Watson, R. R., & Fu, Z. (2006) · European Respiratory Journal · doi:10.1183/09031936.00133306 · Cited by 48 · see citing works
Kostetskii, I., Yuan, S.-Y., Kostetskaia, E., Linask, K. K., Blanchet, S., Seleiro, E. A. P., Michaille, J., Brickell, P. M., & Zile, M. H. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199810)213:2 · Cited by 45 · see citing works
Seshaiah, P., Miller, B. R., Myat, M. M., & Andrew, D. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0429 · Cited by 45 · see citing works
Pavlovich, A. L., Boghaert, E., & Nelson, C. M. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.03.017 · Cited by 26 · see citing works
Self-citationOntogenetic changes in the fractal geometry of the bronchial tree in Rattus norvegicus
Canals, M., OLIVARES, R., Sprohnle, F. L., & Novoa, F. F. (2000) · Biological Research · doi:10.4067/s0716-97602000000100010 · Cited by 22 · see citing works
Flagged first, then by citations
2 of the 189 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Spatiotemporal hydrogel biomaterials for regenerative medicine
Brown, T. E., & Anseth, K. S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00445a · Cited by 428 · see citing works
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409 · see citing works
In vivo quantification of spatially varying mechanical properties in developing tissues
Serwane, F., Mongera, A., Rowghanian, P., Kealhofer, D., Lucio, A. A., Hockenbery, Z. M., & Campàs, O. (2016) · Nature Methods · doi:10.1038/nmeth.4101 · Cited by 368 · see citing works
Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works
“The first human cell line – HeLa – was derived from the cervical adenoorgan microenvironment (Griffith and Swartz, 2006; Nelson and Gleghorn, 2011; Pexton et al., 2011).”
Human airway organoid engineering as a step toward lung regeneration and disease modeling
Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191 · see citing works
“Better understanding the morphogenetic function of YAP could facilitate advances in generating complex tissue engineered structures such as organoids, and given YAP's mechanoresponsive nature [53,56], our findings suggests that exogenous control of mechanical forces to better mimic the developmental environment may be…”
BackgroundMarx, U., Walles, H., Hoffmann, S., Lindner, G., Horland, R., Sonntag, F., Klotzbach, U., Sakharov, D. A., Tonevitsky, A., & Lauster, R. (2012) · Alternatives to Laboratory Animals · doi:10.1177/026119291204000504 · Cited by 174 · see citing works
Cellular and physical mechanisms of branching morphogenesis
Varner, V. D., & Nelson, C. M. (2014) · Development · doi:10.1242/dev.104794 · Cited by 169 · see citing works
Self-citationMechanical regulation of musculoskeletal system development
Felsenthal, N., & Zelzer, E. (2017) · Development · doi:10.1242/dev.151266 · Cited by 162 · see citing works
“, 2007), lung branching, alveolar cell differentiation and growth of the airway tree (Jesudason et al., 2006; Nelson and Gleghorn, 2012; Schittny et al., 2000), and pronephron morphogenesis in the developing kidney (Vasilyev et al.”
BackgroundA toolbox to explore the mechanics of living embryonic tissues
Campàs, O. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.03.011 · Cited by 143 · see citing works
Bioengineering approaches to guide stem cell-based organogenesis
Gjorevski, N., Ranga, A., & Lutolf, M. P. (2014) · Development · doi:10.1242/dev.101048 · Cited by 137 · see citing works
“The mechanical nature of morphogenesis and organogenesis is well-established (Nelson and Gleghorn, 2012).”
BackgroundLee, W., Kalashnikov, N., Mok, S., Halaoui, R., Kuzmin, E., Putnam, A. J., Takayama, S., Park, M., McCaffrey, L. M., Zhao, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07967-4 · Cited by 133 · see citing works
Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development
Nelson, C. M., Gleghorn, J. P., Pang, M.-F., Jaslove, J. M., Goodwin, K., Varner, V. D., Miller, E. E., Radisky, D. C., & Stone, H. A. (2017) · Development · doi:10.1242/dev.154823 · Cited by 131 · see citing works
“…but is also controlled by mechanical cues, consistent with an increasing appreciation for mechanical forces in the morphogenesis of a wide variety of tissues (Desprat et al., 2008; Hutson et al., 2003; Martin et al., 2009; Nelson and Gleghorn, 2012; Nerurkar et al., 2006; Varner et al., 2010).”
BackgroundSelf-citationGjorevski, N., Piotrowski-Daspit, A. S., Varner, V. D., & Nelson, C. M. (2015) · Scientific Reports · doi:10.1038/srep11458 · Cited by 130 · see citing works
Self-citationAn Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle
Gupta, V., Gemberling, M. P., Karra, R., Rosenfeld, G. E., Evans, T., & Poss, K. D. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.028 · Cited by 125 · see citing works
Kim, H. Y., Varner, V. D., & Nelson, C. M. (2013) · Development · doi:10.1242/dev.093682 · Cited by 121 · see citing works
“Recent studies, however, have suggested a possible regulatory role for mechanical forces and cytoskeletal contractility during branching (Michael et al., 2005; Moore et al., 2005; Nelson and Gleghorn, 2012).”
BackgroundSelf-citationSutton, A., Shirman, T., Timonen, J. V. I., England, G. T., Kim, P., Kolle, M., Ferrante, T. C., Zarzar, L. D., Strong, E. F., & Aizenberg, J. (2017) · Nature Communications · doi:10.1038/ncomms14700 · Cited by 121 · see citing works
Hirata, H., Tatsumi, H., Lim, C. T., & Sokabe, M. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00122.2013 · Cited by 106 · see citing works
Quantitative characterization of 3D bioprinted structural elements under cell generated forces
Morley, C. D., Ellison, S. T., Bhattacharjee, T., O’Bryan, C. S., Zhang, Y., Smith, K. F., Kabb, C. P., Sebastian, M., Moore, G. L., Schulze, K. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10919-1 · Cited by 104 · see citing works
Advancement of Sensor Integrated Organ-on-Chip Devices
Clarke, G. A., Hartse, B. X., Asli, A. E. N., Taghavimehr, M., Hashemi, N., Shirsavar, M. A., Montazami, R., Alimoradi, N., Nasirian, V., Ouedraogo, L. J. G., et al. (2021) · Sensors · doi:10.3390/s21041367 · Cited by 105 · see citing works
“The strain and stiffness measurements are of particular interest because mechanical stimulation has been shown to affect cell differentiation [58], branching tube formation [59], and implanted tissue compatibility [60].”
BackgroundKatira, P., Bonnecaze, R. T., & Zaman, M. H. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00145 · Cited by 102 · see citing works
“The underlying idea is that mechanical forces acting on cells can regulate signaling pathways responsible for cell death, division, differentiation, and migration (Assoian and Klein, 2008; Chen, 2008; Mammoto and Ingber, 2009; Nelson and Gleghorn, 2012; West-Foyle and Robinson, 2012).”
BackgroundThe Extracellular, Cellular, and Nuclear Stiffness, a Trinity in the Cancer Resistome—A Review
Deville, S. S., & Cordes, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01376 · Cited by 103 · see citing works
Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development
Träber, N., Uhlmann, K., Girardo, S., Kesavan, G., Wagner, K., Friedrichs, J., Goswami, R., Bai, K., Brand, M., Werner, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53425-6 · Cited by 95 · see citing works
Self-induced mechanical stress can trigger biofilm formation in uropathogenic Escherichia coli
Chu, E. K., Kilic, O., Cho, H., Groisman, A., & Levchenko, A. (2018) · Nature Communications · doi:10.1038/s41467-018-06552-z · Cited by 91 · see citing works
Spatial mapping of tissue properties in vivo reveals a 3D stiffness gradient in the mouse limb bud
Zhu, M. S., Tao, H., Samani, M., Luo, M., Wang, X., Hopyan, S., & Sun, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912656117 · Cited by 89 · see citing works
Mondrinos, M. J., Alisafaei, F., Yi, A. Y., Ahmadzadeh, H., Lee, I., Blundell, C., Seo, J., Osborn, M., Jeon, T., Kim, S. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe9446 · Cited by 86 · see citing works
An interplay of geometry and signaling enables robust lung branching morphogenesis
Menshykau, D., Blanc, P., Ünal, E., Sapin, V., & Iber, D. (2014) · Development · doi:10.1242/dev.116202 · Cited by 85 · see citing works
“The earliest models focused on physical forces (reviewed by Lubkin, 2008), and combinations of experimental and computational studies have since confirmed that mechanical stress and internal pressure influence branching morphogenesis (Gjorevski and Nelson, 2010, 2012; Kim et al., 2013; Nelson and Gleghorn, 2012; Unbek…”
BackgroundMongera, A., Pochitaloff, M., Gustafson, H. J., Stooke‐Vaughan, G. A., Rowghanian, P., Kim, S., & Campàs, O. (2022) · Nature Materials · doi:10.1038/s41563-022-01433-9 · Cited by 83 · see citing works
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self
Levin, M. G. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.04.007 · Cited by 82 · see citing works
Mapping cellular-scale internal mechanics in 3D tissues with thermally responsive hydrogel probes
Mok, S., Habyan, S. A., Ledoux, C., Lee, W., MacDonald, K. N., McCaffrey, L. M., & Moraes, C. (2020) · Nature Communications · doi:10.1038/s41467-020-18469-7 · Cited by 73 · see citing works
ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion
Frank, J. W., Seo, H., Burghardt, R. C., Bayless, K. J., & Johnson, G. A. (2017) · Reproduction · doi:10.1530/rep-17-0043 · Cited by 71 · see citing works
“Cells are variably exposed to mechanical forces, including tension, compression, shear and hydrostatic pressure, depending on their unique physiological environment (Nelson & Gleghorn 2012).”
BackgroundLüchtefeld, I., Pivkin, I. V., Gardini, L., Zare‐Eelanjegh, E., Gäbelein, C. G., Ihle, S. J., Reichmuth, A. M., Capitanio, M., Martinac, B., Zambelli, T., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02277-8 · Cited by 68 · see citing works
“More detailed information on the setup and calibration of the model is given in Supplementary Information 10.”
BackgroundInfluentialThe case for applying tissue engineering methodologies to instruct human organoid morphogenesis
Marti-Figueroa, C. R., & Ashton, R. S. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.03.023 · Cited by 64 · see citing works
“Technologies for dynamically regulating microenvironments will also be necessary to recapitulate the temporal dependence of cues during morphogenesis [44-47].”
Human immunity in vitro — Solving immunogenicity and more
Giese, C., & Marx, U. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.011 · Cited by 62 · see citing works
Bray, K., Gillette, M., Young, J., Loughran, E. A., Hwang, M., Sears, J. C., & Vargo-Gogola, T. C. (2013) · Breast Cancer Research · doi:10.1186/bcr3487 · Cited by 60 · see citing works
“Mammary gland branching morphogenesis also requires reiterative interactions between the epithelial and stromal compartments, and both secreted factors and mechanical signals between the two compartments contribute to branch formation and patterning [9-11].”
BackgroundHyaluronan modulates growth factor induced mammary gland branching in a size dependent manner
Tölg, C., Yuan, H., Flynn, S. M., Basu, K., Ma, J., Tse, K. C. K., Kowalska, B., Vulkanesku, D., Cowman, M. K., McCarthy, J. B., et al. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.02.003 · Cited by 59 · see citing works
Silver, B. B., & Nelson, C. M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00021 · Cited by 56 · see citing works
“Fluid flow is involved in shaping branched tissues in the developing embryo such as vasculature and airways (Nelson and Gleghorn, 2012).”
BackgroundSelf-citationInsights into regeneration tool box: An animal model approach
Mehta, A. S., & Singh, A. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.04.006 · Cited by 56 · see citing works
The Fog signaling pathway: Insights into signaling in morphogenesis
Manning, A. J., & Rogers, S. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.08.003 · Cited by 47 · see citing works
“Epithelial morphogenesis, the process through which simple sheets of cells are rearranged and change shape to form mature structures and organs, is an area of intense focus in the field of developmental biology (Nelson and Gleghorn, 2012; Spear and Erickson, 2012; Suzuki et al., 2012).”
BackgroundHydraRegeneration: Closing the Loop with Mechanical Processes in Morphogenesis
Braun, E., & Keren, K. (2018) · BioEssays · doi:10.1002/bies.201700204 · Cited by 50 · see citing works
In situ quantification of osmotic pressure within living embryonic tissues
Vian, A., Pochitaloff, M., Yen, S., Kim, S., Pollock, J. S., Liu, Y., Sletten, E. M., & Campàs, O. (2023) · Nature Communications · doi:10.1038/s41467-023-42024-9 · Cited by 52 · see citing works
Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues
Luciano, M., Versaevel, M., Vercruysse, E., Procès, A., Kalukula, Y., Remson, A., Deridoux, A., & Gabriele, S. (2022) · Biophysics Reviews · doi:10.1063/5.0074317 · Cited by 44 · see citing works
“13,14 Curved features, which are found in blood vessels, lung alveoli, intestinal villi, or lumens, spread over a large scale, from a few nanometers up to hundreds of micrometers in radii and are directly related to the physiological function of the tissue.”
BackgroundMechanotransduction drives morphogenesis to develop folding during placental development in pigs
Seo, H., Li, X., Wu, G., Bazer, F. W., Burghardt, R. C., Bayless, K. J., & Johnson, G. A. (2019) · Placenta · doi:10.1016/j.placenta.2019.12.011 · Cited by 46 · see citing works
Tissue mechanics regulates form, function, and dysfunction
Anlaş, A. A., & Nelson, C. M. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.05.012 · Cited by 44 · see citing works
Self-citationMorphomechanics: transforming tubes into organs
Taber, L. A. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.004 · Cited by 39 · see citing works
Jones, M. R., Chong, L., & Bellusci, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.620667 · Cited by 30 · see citing works
Visceral organ morphogenesis via calcium-patterned muscle constrictions
Mitchell, N., Cislo, D., Shankar, S., Lin, Y., Shraiman, B. I., & Streichan, S. J. (2022) · eLife · doi:10.7554/elife.77355 · Cited by 35 · see citing works
“Visceral organ morphogenesis proceeds by the assembly of layered cell sheets into tubes, which develop into complex shapes ( Nelson and Gleghorn, 2012 ).”
BackgroundDifferentiating zones at periodontal ligament–bone and periodontal ligament–cementum entheses
Lee, J., Pryce, B. A., Schweitzer, R., Ryder, M. I., & Ho, S. P. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12281 · Cited by 37 · see citing works
“Whether the source of mechanical strain is intrinsic (within tissues or cells) or extrinsic (from external environment on a load bearing organ), it plays a role in sculpting and maintaining the organ shape by coordinating the spatial arrangement matrix molecules, cells and controlling cell proliferation and directiona…”
BackgroundDemystification of animal symmetry: symmetry is a response to mechanical forces
Holló, G. (2017) · Biology Direct · doi:10.1186/s13062-017-0182-5 · Cited by 40 · see citing works
McDowell, G. S., Rajadurai, S., & Levin, M. G. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0409 · Cited by 36 · see citing works
“Mechanical forces are critical for the rotation and looping of internal organs ([195, 196], see reviews for the heart in chick [197, 198, 199, 200]).”
BackgroundWirshing, A. C. E., & Cram, E. J. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0029 · Cited by 32 · see citing works
“…including cell-cycle progression (Provenzano and Keely, 2011), cell migration (Li et al., 2005), tissue morphogenesis (Wozniak and Chen, 2009; Nelson and Gleghorn, 2012), wound closure (Brugues et al., 2014), and cell/tissue adaptation to physical stress (Davis et al., 2001; Burridge and…”
BackgroundProteolysis regulates cardiomyocyte maturation and tissue integration
Fukuda, R., Gunawan, F., Beisaw, A., Jiménez-Amilburu, V., Maischein, H., Sawa Kostin, D., Kawakami, K., & Stainier, D. Y. R. (2017) · Nature Communications · doi:10.1038/ncomms14495 · Cited by 34 · see citing works
Regulation of Actin Dynamics in the C. elegans Somatic Gonad
Kelley, C. A., & Cram, E. J. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7010006 · Cited by 30 · see citing works
The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation
Levin, M. G. (2020) · BioEssays · doi:10.1002/bies.201900146 · Cited by 34 · see citing works
Developmental biology-inspired tissue engineering by combining organoids and 3D bioprinting
Chakraborty, J., Chawla, S., & Ghosh, S. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102832 · Cited by 32 · see citing works
“This morphogenesis is instrumented by a synchronized transmission of genetic machinery involving chemical, electrical, and mechanical stimuli [5].”
BackgroundThe actin‐driven spatiotemporal organization of T‐cell signaling at the system scale
Roybal, K. T., Sinai, P., Verkade, P., Murphy, R. F., & Wülfing, C. (2013) · Immunological Reviews · doi:10.1111/imr.12103 · Cited by 30 · see citing works
“Similar actin sheets with embedded signaling complexes may play a comparably important role whenever dynamic cell contacts drive cell fate decisions, such as in development (87), stem differentiation (88), and cancer metastasis (89).”
BackgroundComputational models of airway branching morphogenesis
Varner, V. D., & Nelson, C. M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.003 · Cited by 28 · see citing works
“For decades, scientists have acknowledged a role for mechanical forces during lung development [36, 37].”
BackgroundSelf-citationSubstrate stiffness modulates the maturation of human pluripotent stem-cell-derived hepatocytes
Mittal, N., Tasnim, F., Yue, C., Qu, Y., Phan, D., Choudhury, Y., Tan, M.-H., & Yu, H. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00475 · Cited by 25 · see citing works
Heterotypic control of basement membrane dynamics during branching morphogenesis
Nelson, D. A., & Larsen, M. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.12.011 · Cited by 24 · see citing works
“…epithelial cell–cell adhesions creates critical cell subpopulations during morphogenesis Branching morphogenesis and the establishment of mature organ structure require complex spatio-temporal regulation of cell–cell adhesions (Hsu and Yamada, 2010; Nelson and Gleghorn, 2012; Walker et al., 2008).”
BackgroundToward the Directed Self-Assembly of Engineered Tissues
Varner, V. D., & Nelson, C. M. (2014) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-060713-040016 · Cited by 23 · see citing works
“Mechanical feedback has also been implicated during airway branching in the developing lung (121).”
BackgroundSelf-citationRoybal, K. T., Mace, E. M., Mantell, J., Verkade, P., Orange, J. S., & Wülfing, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133299 · Cited by 22 · see citing works
“Similar actin sheets with embedded signaling complexes linked to undulating cellular interfaces should play a comparably important role whenever dynamic cell contacts drive cell fate decisions, such as in development [36], stem differentiation [37], and cancer metastasis [38].”
BackgroundLinnemann, J. R., Meixner, L. K., Miura, H., & Scheel, C. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7021-6_9 · Cited by 21 · see citing works
Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung
Bokka, K. K., Jesudason, E. C., Lozoya, O. A., Guilak, F., Warburton, D., & Lubkin, S. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132015 · Cited by 21 · see citing works
Microscale Interrogation of 3D Tissue Mechanics
Zhang, J., Chada, N. C., & Reinhart‐King, C. A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00412 · Cited by 21 · see citing works
“In addition, these sensors primarily detect compressive stresses (Dolega et al., 2017), and may not genuinely reflect the active cell-generated stresses that are largely tensile (Legant et al., 2010; Gjorevski and Nelson, 2012).”
BackgroundMathematical Approaches of Branching Morphogenesis
Lang, C., Conrad, L., & Michos, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00673 · Cited by 20 · see citing works
“However, several studies exist confirming that mechanical stresses influence branching morphogenesis (Lubkin and Murray, 1995; Lubkin, 2008; Unbekandt et al., 2008; Wan et al., 2008; Gjorevski and Nelson, 2010, 2012; Nelson and Gleghorn, 2012; Kim et al., 2013; Varner and Nelson, 2014).”
BackgroundOn the coupling of mechanics with bioelectricity and its role in morphogenesis
Leronni, A., Bardella, L., Dorfmann, L., Pietak, A. M., & Levin, M. G. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0177 · Cited by 20 · see citing works
The RhoGEF Net1 Is Required for Normal Mammary Gland Development
Zuo, Y., Berdeaux, R., & Frost, J. A. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1128 · Cited by 18 · see citing works
“the epithelial cells and their surrounding stromal cells (4).”
BackgroundMechanical control of epithelial lumen formation
Rodriguez-Fraticelli, A., & Martín‐Belmonte, F. (2013) · Small GTPases · doi:10.4161/sgtp.24303 · Cited by 17 · see citing works
“However, only a few studies to date have performed a separate analysis of the individual properties of the ECM and their contribution to epithelial cell polarization.(5) Recent work using micropatterned devices, from our laboratory and others, has begun to shed light on the function of cell-to-matrix interactions.”
BackgroundFluid Mechanics as a Driver of Tissue-Scale Mechanical Signaling in Organogenesis
Gilbert, R. M., Morgan, J. T., Marcin, E. S., & Gleghorn, J. P. (2016) · Current Pathobiology Reports · doi:10.1007/s40139-016-0117-3 · Cited by 18 · see citing works
“Several cellular mechanosensors have been identified that transduce extracellular forces into intracellular molecular signaling cascades and gene transcription events [1].”
BackgroundSelf-citationQuantitative approaches to uncover physical mechanisms of tissue morphogenesis
Gleghorn, J. P., Manivannan, S., & Nelson, C. M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.04.006 · Cited by 17 · see citing works
“The evolving tissue architecture: a kinematic understanding The architecture of a tissue is linked to its function [1,2,3 ].”
Self-citationOlutoye, O. O., Short, W. D., Gilley, J., Hammond, J. D., Belfort, M. A., Lee, T. C., King, A., Espinoza, J., Joyeux, L., Lingappan, K., et al. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.925106 · Cited by 16 · see citing works
Self-citationLet's push things forward: disruptive technologies and the mechanics of tissue assembly
Varner, V. D., & Nelson, C. M. (2013) · Integrative Biology · doi:10.1039/c3ib40080h · Cited by 15 · see citing works
Self-citationThe development of body and organ shape
Cobham, A. E., & Mirth, C. K. (2020) · BMC Zoology · doi:10.1186/s40850-020-00063-5 · Cited by 15 · see citing works
The Mechanics of Building Functional OrgansPreprint
Andrews, T. G. R., & Priya, R. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041520 · Cited by 15 · see citing works
“…to the forces it experiences; from the behaviour of its constituent cells, neighbouring tissues, and the dynamic environment it is growing in (Nelson and Gleghorn 2012; Stooke-Vaughan and Campas 2018; Trepat and Sahai 2018; Hannezo and Heisenberg 2019; Hamant and Saunders 2020; Collinet and…”
Effects of Elasticity on Cell Proliferation in a Tissue-Engineering Scaffold Pore
Annunziata, C., Fattahpour, H., Fong, D., Hadjiargyrou, M., & Sanaei, P. (2023) · Bulletin of Mathematical Biology · doi:10.1007/s11538-023-01134-7 · Cited by 14 · see citing works
“Additionally, the engineered scaffoldmust offer a suitable microenvironment (i.e., ideal substrate and material properties), which will facilitate cell adhesion followed by robust proliferation (Nelson and Gleghorn 2012; Barthes et al. 2014; Engler et al. 2006; Lee-Thedieck and Spatz 2014).”
BackgroundPiotrowski-Daspit, A. S., Simi, A. K., Pang, M.-F., Tien, J., & Nelson, C. M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6475-8_12 · Cited by 14 · see citing works
Self-citationAndrews, T. G. R., Cornwall-Scoones, J., Ramel, M., Gupta, K., Briscoe, J., & Priya, R. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.07.011 · Cited by 15 · see citing works
Gilbert, R. M., & Gleghorn, J. P. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00349.2022 · Cited by 13 · see citing works
Self-citationLi, J., Zhang, W., Liu, A., Lu, Y., Yu, L., Liu, X., Sun, L., Zhao, B., Tong, X., Liu, T., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401564 · Cited by 12 · see citing works
Donzanti, M. J., Ferrick, B. J., Mhatre, O., Chernokal, B., Renteria, D. C., & Gleghorn, J. P. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01247 · Cited by 12 · see citing works
Self-citationNegative Transpulmonary Pressure Disrupts Airway Morphogenesis by Suppressing Fgf10
Stanton, A. E., Goodwin, K., Sundarakrishnan, A., Jaslove, J. M., Gleghorn, J. P., Pavlovich, A. L., & Nelson, C. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725785 · Cited by 12 · see citing works
“In addition to these biochemical signals, the embryonic lung is exposed to a variety of mechanical forces (Nelson and Gleghorn, 2012; Hogan, 2018).”
BackgroundSelf-citationAhmed, D. W., Eiken, M. K., DePalma, S. J., Helms, A. S., Zemans, R. L., Spence, J. R., Baker, B. M., & Loebel, C. (2023) · iScience · doi:10.1016/j.isci.2023.108472 · Cited by 10 · see citing works
Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium
Peak, K. E., Mohr-Allen, S. R., Gleghorn, J. P., & Varner, V. D. (2022) · Biology Open · doi:10.1242/bio.059436 · Cited by 11 · see citing works
Self-citationChernokal, B., Ferrick, B. J., & Gleghorn, J. P. (2024) · Lab on a Chip · doi:10.1039/d4lc00579a · Cited by 10 · see citing works
Self-citationManipulating the Patterns of Mechanical Forces That Shape Multicellular Tissues
Herrera-Perez, R. M., & Kasza, K. E. (2019) · Physiology · doi:10.1152/physiol.00018.2019 · Cited by 10 · see citing works
Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges
Jiao, C., Karakaya, O. F., Dadgar, N., Wehrle, C. J., Massoud, Z., Hong, H., Fairchild, R. L., Leipzig, N. D., Aucejo, F., Ma, W. W., et al. (2026) · MedComm · doi:10.1002/mco2.70571 · Cited by 8 · see citing works
A Systems Approach to Biomechanics, Mechanobiology, and Biotransport
Peirce, S. M., Sander, E. A., Fisher, M. B., Deymier, A. C., LaDisa, J. F., O’Connell, G. D., Corr, D. T., Han, B., Singh, A. K., Wilson, S. E., et al. (2024) · Journal of Biomechanical Engineering · doi:10.1115/1.4064547 · Cited by 6 · see citing works
Fiaz, A. W., Léon‐Kloosterziel, K. M., LEEUWEN, J. L. V., & Kranenbarg, S. (2014) · Journal of Applied Ichthyology · doi:10.1111/jai.12510 · Cited by 6 · see citing works
Nelson, C. M. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.09.014 · Cited by 6 · see citing works
“The past 10 years have thus seen a resurgent interest in the ideas of Thompson, Wilhelm His, and other early developmental biologists and renewed efforts to investigate the mechanical mechanisms that underlie tissue morphogenesis (Nelson and Gleghorn, 2012).”
BackgroundSelf-citationMechanobiology throughout development
Gleghorn, J. P., & Killian, M. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812952-4.00003-9 · Cited by 6 · see citing works
Self-citationNimiritsky, P., Novoseletskaya, E. S., Eremichev, R. Y., Alexandrushkina, N. A., Karagyaur, M. N., Vetrovoy, O. V., Basalova, N. A., Khrustaleva, A. M., Tyakht, A., Efimenko, A. Y., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9091192 · Cited by 6 · see citing works
“As mentioned before, Rho GTPase pathway via ROCK-1/2 activity governs rearrangement of actin cytoskeleton during mesenchymal condensation preceding organogenesis in vivo [96].”
BackgroundGonyea, C. R., Shen, Y., Nelson, K. M., Bird, R. N., Gilbert, R. M., Olutoye, O. O., Keswani, S. G., & Gleghorn, J. P. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00233.2024 · Cited by 5 · see citing works
Self-citationSymmetry breaking during morphogenesis in the embryo and in engineered tissues
Nelson, C. M. (2012) · AIChE Journal · doi:10.1002/aic.13941 · Cited by 5 · see citing works
Self-citationMiyake, Y., Tse, W. H., Wang, J. Q., Leon, N. D., Mourin, M., Patel, D., Aptekmann, A. O., Yamataka, A., & Keijzer, R. (2022) · Pediatric Surgery International · doi:10.1007/s00383-022-05340-7 · Cited by 5 · see citing works
“Fetal lung fluid and fetal breathing movements cause bio-mechanical forces on the fetal lung, which play an important role in fetal lung development [12].”
Early Development of the Mammalian Lung-Branching Morphogenesis
Stewart, K. M., & Morrisey, E. E. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781139680349.003 · Cited by 5 · see citing works
Mechanics of the cellular microenvironment as perceived by cells in vivoPreprint
Mongera, A., Pochitaloff, M., Gustafson, H. J., Stooke‐Vaughan, G. A., Rowghanian, P., & Campàs, O. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.04.425259 · Cited by 5 · see citing works
Peak, K. E., Rajaguru, P., Khan, A. R., Gleghorn, J. P., Obaid, G., Ferruzzi, J., & Varner, V. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.22.609268 · Cited by 5 · see citing works
Self-citationForce-Bioreactor for Assessing Pharmacological Therapies for Mechanobiological Targets
Scholp, A. J., Jensen, J., Chinnathambi, S., Atluri, K., Mendenhall, A., Fowler, T. P., Salem, A. K., Martin, J. A., & Sander, E. A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.907611 · Cited by 4 · see citing works
Mechanical Cues Regulate Cargo Sorting and Export at the Golgi
Serafino, G., Forciniti, S., Scarpa, E., Ranieri, A., Santorelli, L., Blasi, G. D., Costantini, S., Lee, E. J., Galeone, A., Calcagni', A., et al. (2025) · bioRxiv · doi:10.1002/advs.202506241 · Cited by 4 · see citing works
Developmental Biology-Based 3D Bioprinting: An Off-the-Shelf Strategy to Induce Tissue Regeneration
Chakraborty, J., & Ghosh, S. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00213 · Cited by 4 · see citing works
Purkayastha, P., Pendyala, K., Saxena, A. S., Hakimjavadi, H., Chamala, S., Dixit, P. D., Baer, C. F., & Lele, T. P. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab102 · Cited by 3 · see citing works
“This differential proliferation results in elongated and laterally branched structures (Gjorevski and Nelson 2011; Nelson and Gleghorn 2012).”
Background
- Authors
- Nelson, C. M., & Gleghorn, J. P.
- Affiliations
- Princeton University (US)
- Department of Chemical and Biological Engineering and
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2012-08-15
- Volume
- 14
- Issue
- 1
- Pages
- 129-154
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2170979166
- Cited by
- 130
- References
- 189
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 3
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Susan G. Komen
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R21HL110335, HL110335)
- National Cancer Institute (CA128660, R21CA128660)
- National Institute of General Medical Sciences (R01GM083997, GM083997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- branching morphogenesis, organogenesis, cell contractility, mechanical regulation, mammary gland, lung development, epithelial sheets, microenvironment, tissue mechanics
- MeSH terms
- Animals, Biomedical Engineering, Humans, Lung, Mammary Glands, Animal, Models, Genetic, Morphogenesis, Time Factors, Signal Transduction, Gene Expression Regulation, Developmental, Tissue Engineering, Organogenesis, Mammary Glands, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review