A non-genetic route to aneuploidy in human cancers

Krajcovic, Matej, Johnson, Nicole B., Sun, Qiang, Normand, Guillaume, Hoover, Nicholas, Yao, Evelyn, Richardson, Andrea L., King, Randall W. +4 more·2011·Nature Cell Biology
DOI 10.1038/ncb2174

Cited by (189)

Items 101–189 of 189

  1. An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis
    Noelle A. Sterling, Jun Young Park, Raehee Park, Seo‐Hee Cho, Seonhee Kim · 2023 · Nature Communications
  2. Cell-in-cell phenomenon: A New Paradigm in Life Sciences.
    Xinqian Wang · 2015 · Current Molecular Medicine
  3. Homotypic cell-in-cell structures as an adverse prognostic predictor of hepatocellular carcinoma
    Ruizhi Wang, Yichao Zhu, Hao Zhong, Xinyue Gao, Qiang Sun, Meifang He · 2022 · Frontiers in Oncology
  4. Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis
    António J. M. Santos, Charlotte H. Durkin, Sophie Hélaine, Emmanuel Boucrot, David W. Holden · 2016 · Infection and Immunity
  5. Enhanced basal autophagy supports ameloblastoma-derived cell survival and reactivation
    Rachel C. Sharp, Olajumoke Ajibola Effiom, Anuradha Dhingra, Onatolu Odukoya, Adetokunbo Babajide Olawuyi, Godwin Toyin Arotiba, Kathleen Boesze‐Battaglia, Sunday O. Akintoye · 2018 · Archives of Oral Biology
  6. P53 clears aneuploid cells by entosis
    Dario Rizzotto, Andreas Villunger · 2020 · Cell Death and Differentiation
  7. Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase
    Joy Armistead, Julia Hatzold, Anna van Roye, Evelin Fahle, Matthias Hammerschmidt · 2019 · The Journal of Cell Biology
  8. Cell-in-cell: an emerging player in COVID-19 and immune disorders
    Qiang Sun, Wei Chen · 2022 · National Science Open
  9. Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma
    Sara Basbous, Lydia Dif, Camille Dantzer, Sylvaine Di-Tommaso, Jean‐William Dupuy, Paulette Bioulac‐Sage, Anne‐Aurélie Raymond, Chantal Desdouets, Frédéric Saltel, Violaine Moreau · 2024 · Cell Death and Disease
  10. Never in Neutral: A Systems Biology and Evolutionary Perspective on how Aneuploidy Contributes to Human Diseases
    Norman Pavelka, Giulia Irene Rancati · 2013 · Cytogenetic and Genome Research
  11. Stages of cell cannibalism–entosis–in normal human keratinocyte culture
    Anastasiia S. Garanina, L. A. Khashba, Г. Е. Онищенко · 2015 · Biochemistry (Moscow)
  12. Macro- and micro-nutrient–based multiplex stress conditions modulate in vitro tumorigenesis and aggressive behavior of breast cancer spheroids
    Sukanya Gayan, Abhishek Teli, Anish Nair, Geetanjali B. Tomar, Tuli Dey · 2021 · In vitro models
  13. Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
    Kohei Okuyama, Hiromasa Fukushima, Tomofumi Naruse, Souichi Yanamoto · 2023 · Frontiers in Oncology
  14. Multinucleation Is an Objective Feature Useful in the Diagnosis of Pleomorphic Lobular Carcinoma In Situ
    Luis Z. Blanco, Tiffany A. Thurow, Aparna Mahajan, Barbara Susnik, Irene Helenowski, Joan Sander Chmiel, Megan E. Sullivan · 2015 · American Journal of Clinical Pathology
  15. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51
    Zhengzhe An, Jae-Ran Yu, Woo‐Yoon Park · 2016 · Toxicology in Vitro
  16. Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells
    Hee Kyung Jin, Hye Eun Yoon, Jae‐Seon Lee, Jae-Kyung Kim, Sung Ho Myung, Yun‐Sil Lee · 2015 · Korean Journal of Physiology and Pharmacology
  17. Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types
    Eunhyong Chang, Joon‐Yong An · 2024 · BMB Reports
  18. Apoptosis and Autophagy
    Francesco Merolla · 2013 · Springer eBooks
  19. Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges
    Oskar A. Haas · 2021 · Frontiers in Cell and Developmental Biology
  20. Foci of entotic nuclei in different grades of noninherited renal cell cancers
    Yuke Kong, Yaojun Liang, Jianqin Wang · 2015 · IUBMB Life
  21. A bacterial encoded protein induces extreme multinucleation and cell-cell internalization in intestinal cells
    Paul Dean, Brendan Kenny · 2013 · Tissue Barriers
  22. Tetraploidy in normal tissues and diseases: mechanisms and consequences
    Micheline Kirsch‐Volders, Miroslav Mišík, Michael Felix Fenech · 2025 · Chromosoma
  23. Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models
    Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka et al. · 2025 · Scientific Reports
  24. Cell-in-Cell Structures in Gastrointestinal Tumors: Biological Relevance and Clinical Applications
    Дружкова Ирина Николаевна, Nadezhda I. Ignatova, Marina V. Shirmanova · 2023 · Journal of Personalized Medicine
  25. Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo
    Дружкова Ирина Николаевна, A. Potapov, Nadezhda I. Ignatova, Marina L. Bugrova, Ilia D Shchechkin, Maria M. Lukina, Liubov E. Shimolina, E. Kolesnikova, Marina V. Shirmanova, Загайнова Елена Вадимовна · 2024 · Scientific Reports
  26. Sarcomas as a mise en abyme of mesenchymal stem cells: Exploiting interrelationships for cell mediated anticancer therapy
    Jorge Sans Burns, Akmal Safwat, Giulia Grisendi, Moustapha S Kassem, Massimo Dominici · 2012 · Cancer Letters
  27. Cell-in-cell: A virgin land of cell biology
    Ying Wang, Xiaoning Wang · 2013 · OncoImmunology
  28. Modes of internalizations of human prostate carcinoma (DU145) cells in vitro and in murine xenotransplants
    Jacques Gilloteaux, Carston Ruffo, James M. Jamison, Jack L. Summers · 2016 · Ultrastructural Pathology
  29. [Retracted] Cell‐in‐Cell: From Cell Biology to Translational Medicine
    Qiao Chen, Xiaoning Wang, Meifang He · 2022 · BioMed Research International · Retracted
  30. Causes, consequences and clinical significance of aneuploidy across melanoma subtypes
    Eva R. Shteinman, James S. Wilmott, Inês Pires da Silva, Georgina Venetia Long, Richard A. Scolyer, Ismael A. Vergara · 2022 · Frontiers in Oncology
  31. Beyond typical histology of BAP1-inactivated melanocytoma
    Michele Donati, Dmitry V. Kazakov · 2024 · Pathology - Research and Practice
  32. Counteracting Genome Instability by p53-dependent Mintosis
    Jianqing Liang, Zubiao Niu, Xiaochen Yu, Bo Zhang, You Zheng, Manna Wang, Banzhan Ruan, Hongquan Qin, Xin Zhang, Songzhi Gu et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Etiology of polyploid giant cancer cells: a new frontier in cancer biology
    Mukesh Kumar Manickasamy, Babu Santha Aswani, Ruchira Banerjee, Mohamed Abd Elhamid Abbas, Mohammed S. Alqahtani, Gautam Sethi, Le Liu, Ajaikumar Bahulayan Kunnumakkara · 2026 · Cancer Cell International
  34. Le cannibalisme cellulaire par entose
    Arnaud Mailleux, Matej Krajcovic, Michael Overholtzer · 2011 · médecine/sciences
  35. Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
    Thomas J. Bartosh · 2016 · Molecular & Cellular Oncology
  36. Genome-based versus gene-based theory of cancer: Possibleimplications for clinical practice
    Nataša Todorović‐Raković · 2011 · Journal of Biosciences
  37. Entosis and Cell Cycle in Tumor Cell Culture
    Olga P. Kisurina-Evgenieva, L. A. Khashba, I. A. Mamichev, Margarita A. Savitskaya, Г. Е. Онищенко · 2019 · Cell and Tissue Biology
  38. Loss of Contact Inhibition of Locomotion in the Absence of JAM-A Promotes Entotic Cell Engulfments
    Mariel Flavia Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thüring, Marcus Alexander Schmidt, Volker Gerke, Klaus Ebnet · 2022 · iScience
  39. Cell-in-cell phenomena across the tree of life
    Stefania E. Kapsetaki, Luis Humberto Cisneros, Carlo C. Maley · 2024 · Scientific Reports
  40. Polyploid giant cancer cells: A novel target in future cancer therapy
    Guangli Wang, Hua Wang, Yuling Wang, Xi Li, Heng Luo · 2025 · European Journal of Cell Biology
  41. NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
    XU Xiao-yang, Yuliang Huang, Feng Yang, Xiaoxia Sun, Rijin Lin, Jiaxing Feng, Mingyang Yang, Jiaqi Shao, Xiaoqi Liu, Tianhua Zhou et al. · 2024 · Protein & Cell
  42. Transmission electron microscopic analysis of pancreatic ductal adenocarcinoma cell spheres formed in 3D cultures
    Yuuki Shichi, Masakazu Fujiwara, Fujiya Gomi, Keisuke Nonaka, Fumio Hasegawa, Seiichi Shinji, Hirofumi Rokutan, Tomio Arai, Kimimasa Takahashi, Toshiyuki Ishiwata · 2025 · Medical Molecular Morphology
  43. Entosis in Health and Disease
    Jyotirekha Das, Michael Overholtzer · 2025 · Advances in experimental medicine and biology
  44. Michael Overholtzer: Answering existential questions on entosis
    Caitlin E. Sedwick · 2011 · The Journal of Cell Biology
  45. In-cell infection: bringing uninvited guests
    Yongchan Lee, Michael Overholtzer · 2015 · Cell Research
  46. ARHGAP36 imposes a bifurcate activation of adherens junction and actomyosin to promote entosis
    Banzhan Ruan, Chenxi Wang, Xinyue Gao, Zhengrong Zhang, Zubiao Niu, Jianqing Liang, Bo Zhang, Linjing Liu, You Yi Zheng, Zhang Xin et al. · 2026 · Cell Death and Differentiation
  47. Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis
    Noelle A. Sterling, Seo‐Hee Cho, Seonhee Kim · 2024 · BioEssays
  48. WHICH WAY DO YOU PREFER TO DEATH ? Cell Death and Beyond
    2016 · OMICS International eBooks
  49. Phenotypic Characteristics of Dormant Human Non-Small Cell Lung Cancer Cells Surviving Multifraction X-Ray Irradiation
    Margarita V. Pustovalova, Elizaveta I. Yashkina, Lina Alhaddad, Andreyan Nikolaevich Osipov, Yongheng Chen, S. V. Leonov · 2022 · Bulletin of Experimental Biology and Medicine
  50. S1PR5 as a prognostic biomarker in colon cancer: insights into efferocytosis-related mechanisms and immune modulation
    Aijie Pei, Ling Lu, Xiaolin Wu · 2025 · Journal of Molecular Histology
  51. Unveiling the role of PGCCs in tumor recurrence and therapeutic resistance: Hidden architects of cancer’s comeback
    Mokhtar Rejili, Farid Hashemi · 2025 · Pathology - Research and Practice
  52. Establishment and characterization of a mutagenized cell line exhibiting the ‘cell‐in‐cell’ phenotype at a high frequency
    Tomoaki Kahyo, Haruhiko Sugimura · 2013 · Genes to Cells
  53. A bibliometric and visualization analysis of entosis research from 2007 to 2024
    Xinyu Yang, Jiatao Tu, Xinyi Zang, Xuan‐Yi Huang, Ye Tao · 2024 · Frontiers in Oncology
  54. ROCK signaling is involved in the entosis of both nonepithelial and epithelial tumors, whereas N‑cadherin is involved in the entosis of nonepithelial tumors
    Mizuha Oi, Raia Kushibiki, Yuki Kanehira, Yoshimi Nishijima, Sayaka Kobayashi, Masanao Saio · 2025 · Experimental and Therapeutic Medicine
  55. ЭНТОЗ И КЛЕТОЧНЫЙ ЦИКЛ В КУЛЬТУРЕ ОПУХОЛЕВЫХ КЛЕТОК, "Цитология"
    О.П. Кисурина-Евгеньева, L. A. Khashba, М.А. Савицкая, Г. Е. Онищенко · 2018 · Tsitologiya
  56. Cell-in-cell: an Emerging Player in COVID-19 and Immune Disorders
    Qiang Sun, Wei Chen · 2022 · National Science Open
  57. Nutritional stress alone can control in vitro tumor formation and its invasive nature
    Sukanya Gayan, Abhishek Teli, Anish Nair, Tuli Dey · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Aneuploidy
    Karen L. Swisshelm · 2013 · Elsevier eBooks
  59. Research Highlights
    2011 · Nature Medicine
  60. Mecanismos da toxidez de FGF2 em células malignas dependentes de Ras: bloqueio de divisão celular e estresse proteotóxico
    Matheus Henrique Dias · 2012
  61. Chaos from within
    Darren J. Burgess · 2011 · Nature reviews. Cancer
  62. Integrins in Tumorigenesis and Cancer Cell Invasion
    Gunilla Högnäs · 2013 · UTUPub (University of Turku)
  63. Necrobiology of Liver Cancer: Other Forms of Cell Death Related or not Related to Apoptosis
    Arthur Zimmermann · 2016 · Springer eBooks
  64. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast
    Tomasz Jodlowski, K.H. Ramesh · 2019 · Springer eBooks
  65. Risk assessment models of integrative medicine indicators for malignant transformation of chronic atrophic gastritis: A registry study protocol
    Yue Liu, Wanjuan Wang, Yuan Li, Fusheng Liu, Li Zhang, Tao Tang, Mingxuan Zang, Yin Zhang, Xia Ding · 2019 · Journal of Traditional Chinese Medical Sciences
  66. Urindiagnostik – die neue Liquid Biopsy
    Elmar Stickeler · 2021 · Der Gynäkologe
  67. Entosis
    Jamuna A. Bai, Ravishankar Rai V · 2018
  68. Necrobiology of Liver Cancer: Other Forms of Cell Death Related or Not Related to Apoptosis
    Arthur Zimmermann · 2016 · Springer eBooks
  69. Loss of Contact Inhibition of Locomotion in the Absence of JAM-A Promotes Entotic Cell Engulfments
    Mariel Flavia Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Alexander M. Schmidt, Gerke Voker, Klaus Ebnet · 2022 · SSRN Electronic Journal
  70. NudCL2 is essential for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
    XU Xiao-yang, Yuliang Huang, Feng Yang, Xiaoxia Sun, Rijin Lin, Jiaxing Feng, Mingyang Yang, Jiaqi Shao, Tianhua Zhou, Yuehong Yang · 2022 · Research Square
  71. NudCL2 is essential for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
    XU Xiao-yang, Yuliang Huang, Feng Yang, Xiaoxia Sun, Rijin Lin, Jiaxing Feng, Mingyang Yang, Jiaqi Shao, Tianhua Zhou, Yuehong Yang · 2023 · Research Square
  72. Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma
    Sara Basbous, Lydia Dif, Camille Dantzer, Sylvaine Di-Tommaso, Jean‐William Dupuy, Paulette Bioulac‐Sage, Anne‐Aurélie Raymond, Chantal Desdouets, Frédéric Saltel, Violaine Moreau · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Titanium-Dioxide Nanoparticles Suppress Entosis in MCF-7 Human Breast Adenocarcinoma Culture
    Olga P. Kisurina-Evgenieva, Margarita A. Savitskaya, D. S. Smeshnova, Г. Е. Онищенко · 2023 · Cell and Tissue Biology
  74. Additional file 2 of Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer
    Jianlu Song, Rexiati Ruze, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Chengcheng Wang, Qiang Xu, Yupei Zhao · 2022 · Figshare
  75. Titanium Dioxide Nanoparticles Inhibits Entosis in the Human Breast Adenocarcinoma Cell Line
    Olga P. Kisurina-Evgenieva, Margarita A. Savitskaya, D. S. Smeshnova, Г. Е. Онищенко · 2023 · Tsitologiya
  76. Poliploidia jako rezultat terapii przeciwnowotworowych i przyczyna braku ich skuteczności
    Kinga Kołacz-Milewska, Karolina Gronkowska, Magdalena Strachowska, Agnieszka Robaszkiewicz · 2024 · Postępy Biochemii
  77. A distinctive PI(4,5)P 2 compartment forms during entosis and related engulfment processes
    Joanne Durgan, Katherine Sloan, Marie‐Charlotte Domart, Lucy Collinson, Oliver Florey · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  78. M phase–specific generation of supernumerary centrioles in cancer cells
    Byungho Shin, Myungse Kim, Yejoo Lee, Kunsoo Rhee · 2025 · Molecular Biology of the Cell
  79. Mutant p53 induces SH3BGRL expression to promote cell engulfment
    Lobsang Dolma, Mary I. Patterson, Antonia Banyard, Callum Hall, Steven Bell, Wolfgang Breitwieser, Sudhakar Sahoo, John Weightman, Maria Pazos Gil, Garry Ashton et al. · 2025 · Cell Death Discovery
  80. Construction and validation of a cell-in-cell related prognostic signature for hepatocellular carcinoma
    Hao Zhong, Dong Wang, Yisheng Chen, Danhong Zhan, Chenxi Wang, Rongqi Lin, Wen Li, Qiang Sun, Ruizhi Wang, Meifang He · 2025 · Discover Oncology
  81. Correlation of Cell‐in‐Cell Structure With Prognosis in Solid Tumors—A Meta‐Analysis
    Haoyi Zi, Yinhai Dai, Mengxuan Li, Yidi Wang, Mao Wang, Shuai Wang, Yujie Bai, Jianing Sun, Cong Fan, Jiajun Ding et al. · 2025 · BioMed Research International
  82. Additional file 1 of Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer
    Jianlu Song, Rexiati Ruze, Chen, Yuan, Xu, Ruiyuan, Xinpeng Yin, Chengcheng Wang, Xu, Qiang, Zhao, Yupei · 2022 · Figshare
  83. Characterization of the Signaling Pathways Involved in Cellular Cannibalism Elicited by Ionizing Radiation
    Dorine de Jong · 2018 · theses.fr (ABES)
  84. Study of HOXB8-mediated tumor suppression in a chicken embryo model : towards novel therapeutic targets for ERK-dependent cancers
    Axelle Wilmerding · 2021
  85. Fascin-1 as a druggable target in Hepatoblastoma
    Lydia Dif · 2024 · theses.fr (ABES)
  86. An entosis-anchored hybrid prognostic signature identifies immunotherapy-resistant subgroups in head and neck squamous cell carcinoma
    Pan Xie, Ying Zhang, Zhichao Xiao, Mengting Tan, Zhikui Luo, Fusen Peng · 2026 · Discover Oncology
  87. Breast cancer–osteoclast interactions generate hybrid-like cells via non-canonical fusion and cell-in-cell processes
    King Hoo Lim, Damrongrat Siriwanna, Xining Li, Eunice Dotse, Meijun Wang, Choa Mun, Yusong Li, Xin Wang, Kwan Ting Chow · 2026 · Research Square
  88. Metabolic hallmarks of regulated cell death
    Rui Kang, Xin Chen, Guido Kroemer, Daolin Tang · 2026 · Cell Research
  89. Vergleich der Strahlenwirkung auf Tumorzellkulturen und Tumorstammzellkulturen aus unterschiedlichen Glioblastomen
    Manuela Oettler · 2014