A non-genetic route to aneuploidy in human cancers

A mechanism linking extra centrosomes to chromosomal instability

Ganem, N. J., Godinho, S. A., & Pellman, D. S. (2009) · Nature · doi:10.1038/nature08136 · Cited by 1,427 · see citing works

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

Fujiwara, T., Bandi, M., Nitta, M., Ivanova, E. V., Bronson, R. T., & Pellman, D. (2005) · Nature · doi:10.1038/nature04217 · Cited by 1,067 · see citing works

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859 · see citing works

A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

Overholtzer, M., Mailleux, A. A., Mouneimne, G., Normand, G., Schnitt, S. J., King, R. W., Cibas, E. S., & Brugge, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.040 · Cited by 748 · see citing works

Aneuploidy and cancer

Rajagopalan, H., & Christoph Lengauer, C. (2004) · Nature · doi:10.1038/nature03099 · Cited by 730 · see citing works

Tetraploidy, aneuploidy and cancer

Ganem, N. J., Storchova, Z., & Pellman, D. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.02.011 · Cited by 668 · see citing works

Does aneuploidy cause cancer?

Weaver, B. A. A., & Cleveland, D. W. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.002 · Cited by 560 · see citing works

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

Silkworth, W. T., Nardi, I. K., Scholl, L. M., & Cimini, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006564 · Cited by 445 · see citing works

Cytology: Diagnostic Principles and Clinical Correlates

Chen, L. (2010) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181cc7ca3 · Cited by 347 · see citing works

Origin of Malignant Tumors.

(1929) · Archives of Internal Medicine · doi:10.1001/archinte.1929.00140060125019 · Cited by 328 · see citing works

Investigating the hows and whys of DNA endoreduplication

Larkins, B. A., Dilkes, B. P., Dante, R. A., Coelho, C. M., Woo, Y., & Liu, Y. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.355.183 · Cited by 313 · see citing works

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

Davoli, T., Denchi, E. L., & de Lange, T. (2010) · Cell · doi:10.1016/j.cell.2010.01.031 · Cited by 298 · see citing works

Cell fusion: A hidden enemy?

Duelli, D. M., & Lazebnik, Y. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00114-4 · Cited by 291 · see citing works

Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells

Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3204 · Cited by 289 · see citing works

Experiments concerning the cleavage stimulus in sand dollar eggs

RAPPAPORT, R. (1961) · Journal of Experimental Zoology · doi:10.1002/jez.1401480107 · Cited by 277 · see citing works

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.Preprint

Minn, A. J., Boise, L., & Thompson, C. B. (1996) · Genes & Development · doi:10.1101/gad.10.20.2621 · Cited by 263 · see citing works

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation

Wang, X., Zhou, Y.-X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., & Deng, C.-X. (2006) · Oncogene · doi:10.1038/sj.onc.1209707 · Cited by 262 · see citing works

Terminal phase of cytokinesis in D-98S cells

Mullins, J., & Biesele, J. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.73.3.672 · Cited by 251 · see citing works

Cytology: Diagnostic Principles and Clinical Correlates

Cibas, E. S., & Ducatman, B. S. (1996) · Cited by 227 · see citing works

Cell cycle progression after cleavage failure

Uetake, Y., & Sluder, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403014 · Cited by 203 · see citing works

The cell biology of cell-in-cell structures

Overholtzer, M., & Brugge, J. S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2504 · Cited by 202 · see citing works

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

Mazzone, M., Selfors, L. M., Albeck, J. G., Overholtzer, M., Šale, S., Carroll, D. L., Pandya, D., Lu, Y., Mills, G. B., Aster, J. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000896107 · Cited by 163 · see citing works

Spontaneous Fusion In Vivo Between Normal Host and Tumor Cells: Possible Contribution to Tumor Progression and Metastasis Studied with a Lectin-Resistant Mutant Tumor

Kerbel, R. S., Lagarde, A., Dennis, J. W., & Donaghue, T. P. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.4.523 · Cited by 150 · see citing works

Cannibalism: A way to feed on metastatic tumors

Fais, S. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.09.014 · Cited by 146 · see citing works

Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer

Nadler, Y., Camp, R. L., Schwartz, C., Rimm, D. L., Kluger, H. M., & Kluger, Y. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5268 · Cited by 143 · see citing works

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

Wong, C., & Stearns, T. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-6 · Cited by 136 · see citing works

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

Vinciguerra, P., Godinho, S. A., Parmar, K., Pellman, D. S., & D’Andrea, A. D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43391 · Cited by 115 · see citing works

p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

Casenghi, M., Mangiacasale, R., Tuynder, M., Caillet-Fauquet, P., Elhajouji, A., Lavia, P., Mousset, S., Kirsch‐Volders, M., & Cundari, E. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4554 · Cited by 104 · see citing works

When 2+2=5: The origins and fates of aneuploid and tetraploid cells

King, R. W. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.007 · Cited by 98 · see citing works

A primate virus generates transformed human cells by fusion

Duelli, D. M., Hearn, S., Myers, M. P., & Lazebnik, Y. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507069 · Cited by 96 · see citing works

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

Guerrero, A. A., Gamero, M. C., Trachana, V., Fütterer, A., Pacios-Bras, C., Díaz-Concha, N. P., Cigudosa, J. C., Martínez‐A, C., & van Wely, K. H. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912143106 · Cited by 91 · see citing works

Cell cannibalism in ductal carcinoma of breast

Abodief, W. T., Dey, P., & Al‐Hattab, O. (2006) · Cytopathology · doi:10.1111/j.1365-2303.2006.00326.x · Cited by 86 · see citing works

DNA Ploidy Status and Prognosis in Colorectal Cancer: A Meta-Analysis of Published Data

Araújo, S. E. A., Bernardo, W. M., Habr‐Gama, A., Kiss, D. R., & Cecconello, I. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-007-9013-6 · Cited by 73 · see citing works

Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis

Jensen, C. G., Jensen, L. C. W., Rieder, C. L., Cole, R. W., & Ault, J. G. (1996) · Carcinogenesis · doi:10.1093/carcin/17.9.2013 · Cited by 68 · see citing works

Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation

Suehiro, Y., Okada, T., Okada, T., Anno, K., Okayama, N., Ueno, K., Hiura, M., Nakamura, M., Kondo, T., Oga, A., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4609 · Cited by 65 · see citing works

Ten‐year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma

Susini, T., Amunni, G., Molino, C., Carriero, C., Rapi, S., Branconi, F., Marchionni, M., Taddei, G., & Scarselli, G. (2007) · Cancer · doi:10.1002/cncr.22465 · Cited by 64 · see citing works

Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines

Tsuiki, H., Nitta, M., Tada, M., Inagaki, M., Ushio, Y., & Saya, H. (2001) · Oncogene · doi:10.1038/sj.onc.1204126 · Cited by 53 · see citing works

Abnormal Cytokinesis after X-Irradiation in Tumor Cells that Override the G2 DNA Damage Checkpoint

Huang, H., Fletcher, L., Beeharry, N., Daniel, R., Kao, G. D., Yen, T. J., & Muschel, R. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0479 · Cited by 43 · see citing works

Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization

Talos, F., & Moll, U. M. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6199-0_5 · Cited by 26 · see citing works

Prognostic Biomarkers in Renal Cell Carcinoma: Relevance of DNA Ploidy in Predicting Disease-Related Survival

Pinto, A. E., Monteiro, P., Silva, G. L., Ayres, J. V., & Soares, J. (2005) · The International Journal of Biological Markers · doi:10.1177/172460080502000408 · Cited by 16 · see citing works

DNA Flow Cytometry but Not Telomerase Activity as Predictor of Disease-Free Survival in pT1–2/N0/G2 Breast Cancer

Pinto, A. E., André, S., Pereira, T., Silva, G. L., & Soares, J. (2006) · Pathobiology · doi:10.1159/000094490 · Cited by 11 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

The molecular machinery of regulated cell death

Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,595 · see citing works

Cell Death SignalingPreprint

Green, D. R., & Llambi, F. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006080 · Cited by 1,117 · see citing works

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M., & Overholtzer, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2363 · Cited by 459 · see citing works

Genetic heterogeneity and cancer drug resistance

Turner, N. C., & Reis-Filho, J. S. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70335-7 · Cited by 451 · see citing works

Overcoming anoikis – pathways to anchorage-independent growth in cancer

Guadamillas, M. C., Cerezo, A., & del Pozo, M. Á. (2011) · Journal of Cell Science · doi:10.1242/jcs.072165 · Cited by 425 · see citing works

Determinants and clinical implications of chromosomal instability in cancer

Sansregret, L., Vanhaesebroeck, B., & Swanton, C. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.198 · Cited by 396 · see citing works

The impact of mitotic errors on cell proliferation and tumorigenesisPreprint

Levine, M. S., & Holland, A. J. (2018) · Genes & Development · doi:10.1101/gad.314351.118 · Cited by 268 · see citing works

Cytokinesis defects and cancer

Lens, S. M. A., & Medema, R. H. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0084-6 · Cited by 266 · see citing works

Competition between human cells by entosis

Sun, Q., Luo, T., Ren, Y., Florey, O., Shirasawa, S., Sasazuki, T., Robinson, D. N., & Overholtzer, M. (2014) · Cell Research · doi:10.1038/cr.2014.138 · Cited by 233 · see citing works

Entosis Is Induced by Glucose Starvation

Hamann, J. C., Surcel, A., Chen, R., Teragawa, C., Albeck, J. G., Robinson, D. N., & Overholtzer, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.037 · Cited by 203 · see citing works

New Insights into the Troubles of Aneuploidy

Siegel, J. J., & Amon, A. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155807 · Cited by 204 · see citing works

Cell-in-cell phenomena in cancer

Fais, S., & Overholtzer, M. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0073-9 · Cited by 190 · see citing works

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

Harrison, B. D., Hashemi, J., Bibi, M., Pulver, R., Bavli, D., Nahmias, Y., Wellington, M., Sapiro, G., & Berman, J. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001815 · Cited by 174 · see citing works

Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)

Bartosh, T. J., Ullah, M., Zeitouni, S., Beaver, J., & Prockop, D. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612290113 · Cited by 164 · see citing works

Entosis Allows Timely Elimination of the Luminal Epithelial Barrier for Embryo Implantation

Li, Y., Sun, X., & Dey, S. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.035 · Cited by 155 · see citing works

Induction of entosis by epithelial cadherin expression

Sun, Q., Cibas, E. S., Huang, H., Hodgson, L., & Overholtzer, M. (2014) · Cell Research · doi:10.1038/cr.2014.137 · Cited by 148 · see citing works

mTOR regulates phagosome and entotic vacuole fission

Krajcovic, M., Krishna, S., Akkari, L., Joyce, J. A., & Overholtzer, M. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0408 · Cited by 149 · see citing works

Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease

Gudipaty, S. A., Conner, C. M., Rosenblatt, J., & Montell, D. J. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060748 · Cited by 145 · see citing works

Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death

Wen, S., Niu, Y., Lee, S. O., & Chang, C. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.07.008 · Cited by 131 · see citing works

Cytokinesis, ploidy and aneuploidy

Lacroix, B., & Maddox, A. (2012) · Journal of Pathology · doi:10.1002/path.3013 · Cited by 144 · see citing works

Mechanisms and consequences of entosis

Krishna, S., & Overholtzer, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2207-0 · Cited by 118 · see citing works

Mitosis can drive cell cannibalism through entosis

Durgan, J., Tseng, Y.-Y., Hamann, J. C., Domart, M.-C., Collinson, L., Hall, A., Overholtzer, M., & Florey, O. (2017) · eLife · doi:10.7554/elife.27134 · Cited by 117 · see citing works

Mitochondria Related Cell Death Modalities and Disease

Tian, C., Liu, Y., Li, Z., Zhu, P., & Zhao, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.832356 · Cited by 113 · see citing works

Genomic instability in mutant p53 cancer cells upon entotic engulfment

Mackay, H. L., Moore, D. A., Hall, C., Birkbak, N. J., Jamal‐Hanjani, M., Karim, S. A., Phatak, V. M., Piñon, L., Morton, J. P., Swanton, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05368-1 · Cited by 107 · see citing works

High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer

Choi, J.-W., Kim, Y., Lee, J.-H., & Kim, Y. (2013) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-013-1473-6 · Cited by 104 · see citing works

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism

Krajcovic, M., & Overholtzer, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3127 · Cited by 102 · see citing works

Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer

Chen, Y., González, M. E., Burman, B., Zhao, X., Anwar, T., Tran, M., Medhora, N., Hiziroglu, A. B., Lee, W., Cheng, Y.-H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.084 · Cited by 96 · see citing works

Polyploidy formation in cancer cells: How a Trojan horse is born

Waś, H., Borkowska, A., Olszewska, A., Klemba, A., Marciniak, M., Synowiec, A., & Kiéda, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.003 · Cited by 98 · see citing works

Genetic instability: tipping the balance

Janssen, A., & Medema, R. H. (2012) · Oncogene · doi:10.1038/onc.2012.576 · Cited by 97 · see citing works

Chromatin features and the epigenetic regulation of pluripotency states in ESCs

Tee, W., & Reinberg, D. (2014) · Development · doi:10.1242/dev.096982 · Cited by 94 · see citing works

Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

Parekh, A., Das, S., Parida, S., Das, C. K., Dutta, D., Mallick, S. K., Wu, P.-H., Kumar, B. N. P., Bharti, R., Dey, G., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0272-6 · Cited by 94 · see citing works

Cancer cell cannibalism: Multiple triggers emerge for entosis

Durgan, J., & Florey, O. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.03.004 · Cited by 83 · see citing works

Mitosis can drive cell cannibalism through entosis.

Durgan, J., Tseng, Y., Hamann, J. C., Domart, M., Collinson, L., Hall, A., Overholtzer, M., & Florey, O. (2017) · Figshare · doi:10.17863/cam.41122 · Cited by 81 · see citing works

Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells

Rappa, G., Green, T. M., Karbanová, J., Corbeil, D., & Lorico, A. (2015) · Oncotarget · doi:10.18632/oncotarget.3419 · Cited by 78 · see citing works

Centrosome dysfunction: a link between senescence and tumor immunity

Wu, Q., Li, B., Liu, L., Sun, S., & Sun, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00214-7 · Cited by 76 · see citing works

Extracellular Matrix Regulation of Metabolism and Implications for TumorigenesisPreprint

Grassian, A. R., Coloff, J. L., & Brugge, J. S. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010967 · Cited by 75 · see citing works

Entosis: From Cell Biology to Clinical Cancer Pathology

Młynarczuk-Biały, I., Dziuba, I., Sarnecka, A. K., Płatos, E., Kowalczyk, M., Pels, K. K., Wilczynski, G. M., Wójcik, C., & Biały, Ł. P. (2020) · Cancers · doi:10.3390/cancers12092481 · Cited by 74 · see citing works

Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer

van Jaarsveld, R. H., & Kops, G. J. P. L. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.003 · Cited by 69 · see citing works

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma

Hayashi, A., Yavas, A., McIntyre, C. A., Ho, Y.-J., Erakky, A., Wong, W., Varghese, A. M., Melchor, J. P., Overholtzer, M., O'Reilly, E. M., et al. (2020) · Modern Pathology · doi:10.1038/s41379-020-0549-5 · Cited by 68 · see citing works

Cell death pathologies: targeting death pathways and the immune system for cancer therapy

Pentimalli, F., Grelli, S., Daniele, N. D., Melino, G., & Amelio, I. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0052-x · Cited by 67 · see citing works

At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity

Rizzotto, D., Englmaier, L., & Villunger, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910883 · Cited by 66 · see citing works

Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells

Wang, S., Mf, H., Yh, C., My, W., Xm, Y., Bai, J., Hy, Z., Wang, Y.-Y., Zhao, H., Mei, Q., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.352 · Cited by 66 · see citing works

G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

Purvanov, V., Holst, M., Khan, J., Baarlink, C., & Grosse, R. (2014) · eLife · doi:10.7554/elife.02786 · Cited by 67 · see citing works

Comprehensive understanding of anchorage-independent survival and its implication in cancer metastasis

Deng, Z., Wang, H., Liu, J., Deng, Y., & Zhang, N. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03890-7 · Cited by 65 · see citing works

Involvement of the Actin Machinery in Programmed Cell Death

Ren, W., Zhao, W., Cao, L., & Huang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634849 · Cited by 64 · see citing works

Entosis: The emerging face of non-cell-autonomous type IV programmed death

Martins, I., Raza, S. Q., Voisin, L., Dakhli, H., Law, F., de Jong, D., Allouch, A., Thoreau, M., Brenner, C., Deutsch, É., et al. (2017) · Biomedical Journal · doi:10.1016/j.bj.2017.05.001 · Cited by 64 · see citing works

p53-dependent elimination of aneuploid mitotic offspring by entosis

Liang, J., Niu, Z., Zhang, B., Yu, X., Zheng, Y., Wang, C., Ren, H., Wang, M., Ruan, B., Qin, H., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00645-3 · Cited by 66 · see citing works

Regulation of myosin activation during cell–cell contact formation by Par3-Lgl antagonism: entosis without matrix detachment

Wan, Q., Liu, J., Zheng, Z., Zhu, H., Chu, X., Dong, Z., Huang, S., & Du, Q. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0940 · Cited by 58 · see citing works

Aurora A orchestrates entosis by regulating a dynamic MCAK–TIP150 interaction

Xia, P., Zhou, J., Song, X., Wu, B., Liu, X., Li, D., Zhang, S., Wang, Z., Yu, H., Ward, T. L., et al. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju016 · Cited by 57 · see citing works

Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation

Liu, P., Wang, L., & Yu, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1410637 · Cited by 56 · see citing works

Biological relevance of cell-in-cell in cancers

Mackay, H. L., & Muller, P. A. J. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180618 · Cited by 56 · see citing works

Cell-in-Cell Phenomenon and Its Relationship With Tumor Microenvironment and Tumor Progression: A Review

Wang, X., Li, Y., Li, J., Li, L., Zhu, H., Chen, H., Kong, R., Wang, G., Wang, Y., Hu, J., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00311 · Cited by 53 · see citing works

How Mitotic Errors Contribute to Karyotypic Diversity in Cancer

Nicholson, J. M., & Cimini, D. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-387688-1.00003-x · Cited by 53 · see citing works

Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45 triple staining

Huang, H., Chen, A., Wang, T., Wang, M., Ning, X., He, M., Hu, Y., Yuan, L., Li, S., Wang, Q., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4275 · Cited by 52 · see citing works

Immortalization and malignant transformation of Eukaryotic cells

Stepanenko, A. A., & KAVSAN, V. M. (2012) · Cytology and Genetics · doi:10.3103/s0095452712020041 · Cited by 50 · see citing works

The unfolded protein response links tumor aneuploidy to local immune dysregulation

Su, X., Dosset, M., Almanza, G., Searles, S. C., Sahani, P., Waller, T. C., Jepsen, K., Carter, H. K., & Zanetti, M. (2021) · EMBO Reports · doi:10.15252/embr.202152509 · Cited by 51 · see citing works

Entosis, a key player in cancer cell competition

Kroemer, G., & Perfettini, J. (2014) · Cell Research · doi:10.1038/cr.2014.133 · Cited by 49 · see citing works

The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells

Zanetti, M., Rodvold, J., & Mahadevan, N. (2016) · Oncogene · doi:10.1038/onc.2015.108 · Cited by 41 · see citing works

Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

Florey, O., Kim, S., & Overholtzer, M. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666151026100042 · Cited by 45 · see citing works

Ploidy variation in multinucleate cells changes under stress

Anderson, C. A., Roberts, S. E., Zhang, H., Kelly, C. M., Kendall, A., Lee, C., Gerstenberger, J. P., Koenig, A. B., Kabeche, R., & Gladfelter, A. S. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-09-1375 · Cited by 46 · see citing works

Classification of Cell-in-Cell Structures: Different Phenomena with Similar Appearance

Borensztejn, K., Tyrna, P., Gaweł, A. M., Dziuba, I., Wójcik, C., Biały, Ł. P., & Młynarczuk-Biały, I. (2021) · Cells · doi:10.3390/cells10102569 · Cited by 47 · see citing works

Cell-cell fusion as a mechanism of DNA exchange in cancer

Searles, S. C., Santosa, E. K., & Bui, J. D. (2017) · Oncotarget · doi:10.18632/oncotarget.23715 · Cited by 46 · see citing works

Progress of Research in Cell‐in‐Cell Phenomena

Yang, Y., & Li, J. (2012) · The Anatomical Record · doi:10.1002/ar.21537 · Cited by 44 · see citing works

The impact of non-genetic heterogeneity on cancer cell death

Inde, Z., & Dixon, S. J. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1412395 · Cited by 40 · see citing works

In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures

Ni, C., Chen, Y., Zeng, M., Pei, R., Du, Y., Tang, L., Wang, M., Hu, Y., Zhu, H., He, M., et al. (2015) · Cell Research · doi:10.1038/cr.2015.50 · Cited by 42 · see citing works

MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion

Hinojosa, L. S., Holst, M., Baarlink, C., & Grosse, R. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702010 · Cited by 41 · see citing works

Prevalence of Heterotypic Tumor/Immune Cell-In-Cell Structure In Vitro and In Vivo Leading to Formation of Aneuploidy

Chen, Y., Wang, S., He, M., Wang, Y., Zhao, H., Zhu, H.-Y., Yu, X.-M., Ma, J., Che, X.-J., Wang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059418 · Cited by 40 · see citing works

Cell Death by Entosis: Triggers, Molecular Mechanisms and Clinical Significance

Kianfar, M., Balcerak, A., Chmielarczyk, M., Tarnowski, L. J., & Grzybowska, E. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094985 · Cited by 39 · see citing works

Consecutive entosis stages in human substrate-dependent cultured cells

Garanina, A. S., Kisurina-Evgenieva, O. P., Erokhina, M. V., Смирнова, Е. А., Factor, V. M., & Онищенко, Г. Е. (2017) · Scientific Reports · doi:10.1038/s41598-017-12867-6 · Cited by 37 · see citing works

Modeling cell-in-cell structure into its biological significance

He, M.-F., Wang, S., Wang, Y., & Wang, X.-N. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.147 · Cited by 37 · see citing works

TRAIL signaling promotes entosis in colorectal cancer

Bozkurt, E., Düßmann, H., Salvucci, M., Cavanagh, B., Schaeybroeck, S. V., Longley, D. B., Martin, S. J., & Prehn, J. H. M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202010030 · Cited by 38 · see citing works

Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

Kim, S. E., & Overholtzer, M. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.004 · Cited by 35 · see citing works

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

van de Ven, R. A. H., de Groot, J. S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O. M., Ali, H. R., Caldas, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13874 · Cited by 35 · see citing works

High Frequency of Cell-in-Cell Formation in Heterogeneous Human Breast Cancer Tissue in a Patient With Poor Prognosis: A Case Report and Literature Review

Ruan, B., Niu, Z., Jiang, X., Li, Z. Y., Tai, Y., Huang, H., & Sun, Q. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01444 · Cited by 36 · see citing works

Entosis: aneuploidy by invasion

Janssen, A., & Medema, R. H. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-199 · Cited by 34 · see citing works

Mechanisms and significance of entosis for tumour growth and progression

Gaptulbarova, K. A., Tsydenova, I. A., Dolgasheva, D. S., Kravtsova, E. A., Ibragimova, M. K., Vtorushin, S. V., & Литвяков, Н. В. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01877-9 · Cited by 35 · see citing works

Entosis: the core mechanism and crosstalk with other cell death programs

Kim, S.-H., Lee, D., Kim, S. E., & Overholtzer, M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01227-w · Cited by 35 · see citing works

Cell-in-Cell Structures in the Liver: A Tale of Four E’s

Davies, S. P., Terry, L. V., Wilkinson, A. L., & Stamataki, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00650 · Cited by 33 · see citing works

Androgen receptor enhances entosis, a non‐apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells

Wen, S., Shang, Z., Zhu, S., Chang, C., & Niu, Y. (2013) · The Prostate · doi:10.1002/pros.22676 · Cited by 32 · see citing works

Cell-in-cell structure mediates in-cell killing suppressed by CD44

Su, Y. P., Huang, H., Luo, T., Zheng, Y. Y., Fan, J., Ren, H., Tang, M., Niu, Z., Wang, C., Wang, Y., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00387-1 · Cited by 32 · see citing works

p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells

Yi, Q., Zhao, X., Huang, Y., Ma, T., Zhang, Y., Hou, H., Cooke, H. J., Yang, D.-Q., Wu, M., & Shi, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027304 · Cited by 31 · see citing works

Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating

Balvan, J., Gumulec, J., Raudenská, M., Křížová, A., Štěpka, P., Babula, P., Kizek, R., Adam, V., & Masařík, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145016 · Cited by 30 · see citing works

Cell-in-cell structures are involved in the competition between cells in human tumors

Sun, Q., Huang, H., & Overholtzer, M. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2014.1002707 · Cited by 30 · see citing works

Induction of entosis in prostate cancer cells by nintedanib and its therapeutic implications

Liu, J., Wang, L., Zhang, Y., Li, S., Sun, F., Wang, G., Yang, T., Dong, W., Guo, L., & Xiao, H. (2019) · Oncology Letters · doi:10.3892/ol.2019.9951 · Cited by 27 · see citing works

The Unfolded Protein Response at the Tumor-Immune Interface

Zanetti, M., Su, X., Dosset, M., & Carter, H. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.823157 · Cited by 25 · see citing works

Tumour Stem Cells in Breast Cancer

Ibragimova, M. K., Tsyganov, M. M., & Литвяков, Н. В. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095058 · Cited by 24 · see citing works

Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer

Song, J., Ruze, R., Chen, Y., Xu, R., Yin, X., Wang, C., Xu, Q., & Zhao, Y. (2022) · BMC Cancer · doi:10.1186/s12885-022-09983-6 · Cited by 24 · see citing works

Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis

Choudhary, A., Lera, R. F., Martowicz, M. L., Oxendine, K., Laffin, J. J. S., Weaver, B. A. A., & Burkard, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308203110 · Cited by 24 · see citing works

Cell-in-cell promotes lung cancer malignancy by enhancing glucose metabolism through mitochondria transfer

Wang, S., Liu, B., Huang, J., He, H., Li, L., & Tao, A. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113665 · Cited by 20 · see citing works

Cell-In-Cell Structures in Early Breast Cancer Are Prognostically Valuable

Bauer, M. F., Hildebrand, L. S., Rosahl, M.-C., Erber, R., Schnellhardt, S., Büttner-Herold, M. J., Putz, F., Ott, O. J., Hack, C. C., Fietkau, R., et al. (2022) · Cells · doi:10.3390/cells12010081 · Cited by 20 · see citing works

The romantic history of signaling pathway discovery in cell death: an updated review

Wang, L., Liu, X., Li, Q.-Q., Zhu, Y., Ren, H.-L., Song, J., Zeng, J., Mei, J., Tian, H., Rong, D., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04873-2 · Cited by 20 · see citing works

Exploratory Factor Analysis for Validating Traditional Chinese Syndrome Patterns of Chronic Atrophic Gastritis

Zhang, Y., Zhou, A. X., Liu, Y., Zhao, Y., Zhang, L., Sun, L., Du, S., Yang, Q., Song, X., Liang, C., et al. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/6872890 · Cited by 19 · see citing works

Fluorescence-Activated Cell Sorting Analysis of Heterotypic Cell-in-Cell Structures

He, M., Huang, H., Wang, M., Chen, A., Ning, X., Yu, K., Li, Q., Li, W., Ma, L., Chen, Z., et al. (2015) · Scientific Reports · doi:10.1038/srep09588 · Cited by 18 · see citing works

The relationship between diet, plasma glucose, and cancer prevalence across vertebrates

Kapsetaki, S. E., Basile, A. J., Compton, Z. T., Rupp, S. M., Duke, E. G., Boddy, A. M., Harrison, T. M., Sweazea, K. L., & Maley, C. C. (2025) · Nature Communications · doi:10.1038/s41467-025-57344-1 · Cited by 17 · see citing works

Multinucleation regulated by the Akt/PTEN signaling pathway is a survival strategy for HepG2 cells

Mukherjee, A., Misra, S., Howlett, N. G., & Karmakar, P. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.06.009 · Cited by 17 · see citing works

Mechanisms of oncogenic cell competition–Paths of victory

Gutiérrez-Martínez, A., Sew, W. Q. G., Molano-Fernández, M., Carretero, M., & Herranz, H. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.015 · Cited by 17 · see citing works

Orai1 is an Entotic Ca 2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development

Lee, A. R., & Park, C. Y. (2023) · Advanced Science · doi:10.1002/advs.202205913 · Cited by 14 · see citing works

Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule

Ahmed, N., Yang, P., Huang, Y., Chen, H., Liu, T., Wang, L., Nabi, F., Liu, Y., & Chen, Q. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00361 · Cited by 15 · see citing works

Intracellular Mechanical Drugs Induce Cell‐Cycle Altering and Cell Death

Arjona, M. I., Duch, M., Hernández‐Pinto, A. M., Vázquez, P., Agusil, J. P., Gómez, R., Redondo‐Horcajo, M., Amirthalingam, E., Pérez‐García, L., Suárez, T., et al. (2022) · Advanced Materials · doi:10.1002/adma.202109581 · Cited by 15 · see citing works

Entosis: aneuploidy by invasion

Janssen, A., & Medema, R. H. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-199 · Cited by 34 · see citing works

Cytokinesis defects and cancer

Lens, S. M. A., & Medema, R. H. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0084-6 · Cited by 266 · see citing works

Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis

Choudhary, A., Lera, R. F., Martowicz, M. L., Oxendine, K., Laffin, J. J. S., Weaver, B. A. A., & Burkard, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308203110 · Cited by 24 · see citing works

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism

Krajcovic, M., & Overholtzer, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3127 · Cited by 102 · see citing works

When 2+2=5: The origins and fates of aneuploid and tetraploid cells

King, R. W. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.007 · Cited by 98 · see citing works