The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation
Open accessAbstract
Although transmission of the gene expression program from mother to daughter cells has been suggested to be mediated by gene bookmarking, the precise mechanism by which bookmarking mediates post-mitotic transcriptional re-activation has been unclear. Here, we used a real-time gene expression system to quantitatively demonstrate that transcriptional activation of the same genetic locus occurs with a significantly more rapid kinetics in post-mitotic cells versus interphase cells. RNA polymerase II large subunit (Pol II) and bromodomain protein 4 (BRD4) were recruited to the locus in a different sequential order on interphase initiation versus post-mitotic re-activation resulting from the recognition by BRD4 of increased levels of histone H4 Lys 5 acetylation (H4K5ac) on the previously activated locus. BRD4 accelerated the dynamics of messenger RNA synthesis by de-compacting chromatin and hence facilitating transcriptional re-activation. Using a real-time quantitative approach, we identified differences in the kinetics of transcriptional activation between interphase and post-mitotic cells that are mediated by a chromatin-based epigenetic mechanism.
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Metadata
- Authors
- Zhao, R., Nakamura, T., Fu, Y., Lazar, Z., & Spector, D. L.
- Venue
- Nature Cell Biology
- Published
- 2011-10-09
- Volume
- 13
- Issue
- 11
- Pages
- 1295-1304
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1980328649
- Cited by
- 253
- References
- 54
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, R., Nakamura, T., Fu, Y., Lazar, Z., & Spector, D. L. (2011). Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nature Cell Biology. https://doi.org/10.1038/ncb2341
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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