The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320
Open accessAbstract
PTEN (Phosphatase and tensin homolog deleted on chromosome 10) expression in stromal fibroblasts suppresses epithelial mammary tumours, but the underlying molecular mechanisms remain unknown. Using proteomic and expression profiling, we show that Pten loss from mammary stromal fibroblasts activates an oncogenic secretome that orchestrates the transcriptional reprogramming of other cell types in the microenvironment. Downregulation of miR-320 and upregulation of one of its direct targets, ETS2 (v-ets erythroblastosis virus E26 oncogene homolog 2) are critical events in Pten-deleted stromal fibroblasts responsible for inducing this oncogenic secretome, which in turn promotes tumour angiogenesis and tumour-cell invasion. Expression of the Pten–miR-320–Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression.
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Self-citationDetection of microRNA Expression in Human Peripheral Blood Microvesicles
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
The functions and regulation of the PTEN tumour suppressor
Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926
Role of tumor microenvironment in tumorigenesis
Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., et al. (2017) · Journal of Cancer · doi:10.7150/jca.17648 · Cited by 1,404
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Lee, Y.-R., Chen, M., & Pandolfi, P. P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0015-0 · Cited by 917
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., & Zhou, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00641-0 · Cited by 773
Metadata
- Authors
- Bronisz, A., Godlewski, J., Wallace, J. A., Merchant, A. S., Nowicki, M. O., Mathsyaraja, H., Srinivasan, R., Trimboli, A. J., Martin, C. K., Li, F., Yu, L., Fernandez, S. A., Pécot, T., Rosol, T. J., Cory, S., Hallett, M., Park, M., Piper, M. G., Marsh, C. B., Yee, L. D., Jimenez, R. E., Nuovo, G., Lawler, S. E., Chiocca, E. A., Leone, G., & Ostrowski, M. C.
- Venue
- Nature Cell Biology
- Published
- 2011-12-18
- Volume
- 14
- Issue
- 2
- Pages
- 159-167
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2028718288
- Cited by
- 270
- References
- 49
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Bronisz, A., Godlewski, J., Wallace, J. A., Merchant, A. S., Nowicki, M. O., Mathsyaraja, H., Srinivasan, R., Trimboli, A. J., Martin, C. K., Li, F., Yu, L., Fernandez, S. A., Pécot, T., Rosol, T. J., Cory, S., Hallett, M., Park, M., Piper, M. G., Marsh, C. B., . . . Ostrowski, M. C. (2012). Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nature Cell Biology. https://doi.org/10.1038/ncb2396
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