E2F8 is essential for polyploidization in mammalian cells

Pandit, Shusil K., Westendorp, Bart, Nantasanti, Sathidpak, van Liere, Elsbeth, Tooten, Peter C. J., Cornelissen, Peter W. A., Toussaint, Mathilda J. M., Lamers, Wouter H., de Bruin, Alain·2012·Nature Cell Biology
DOI 10.1038/ncb2585

Cited by (156)

Items 101–156 of 156

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  9. An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation
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  10. Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics
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  11. PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis
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  12. Inhibiting Cytokinesis in the Liver: A New Way to Reduce Tumor Development
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  14. Giant Island Mice Exhibit Widespread Gene Expression Changes in Key Metabolic Organs
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  15. ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation
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  16. Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
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  17. Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
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  18. An Atypical Oncogene Within the Atypical E2Fs.
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  19. More of a Good Thing or Less of a Bad Thing: Gene Copy Number Variation in Polyploid Cells of the Placenta
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  20. Changes in Hepatocyte Ploidy During Liver Regeneration
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  21. Arid1a deficiency promotes hepatocyte hyperpolyploidy and drives intrahepatic cholangiocarcinoma in mice
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  23. An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease
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  24. Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis
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  25. Polyploidy in Animal Development and Disease
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  26. E2F Transcription Factors in Cancer, More than the Cell Cycle
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  27. Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling
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  28. The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
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  29. Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling
    Sierra R. Wilson, Evan R. Delgado, Frances Alencastro, Rosa L. Loewenstein, Madeleine P. Leek, Leah R. Peters, Kerollos Kamel, Patrick D. Wilkinson, Siddhi Jain, Joseph D. Locker et al. · 2026 · Cell Death and Disease
  30. EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans
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  31. The polyploid state plays a tumor suppressive role in the liver
    Shu-Yuan Zhang, Ke-Jin Zhou, Xin-Yi Luo, Lin Li, Liem H. Nguyen, Yu Zhang, Branden D. Tarlow, D. Siegwart, Hao Zhu · 2017 · bioRxiv
  32. Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb
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  33. Translating whole‐genome doubling into precision medicine in cancer
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  34. A novel sorting method uncovers metabolic heterogeneity between mononucleated and binucleated tetraploid hepatocytes
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  35. Stereo-cell deciphers the spatial and functional heterogeneity of polyploid hepatocytes
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  36. A novel role for the E2F transcription factor and the ER stress sensor IRE1 in cytoplasmic DNA accumulation
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  37. Breaking the rules of cell biology: Lessons from the liver's exceptional regenerative capacity
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  38. E2F8-induced GRPEL2 promoted colorectal cancer progression via targeting TIGAR
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  39. Paracancerous binuclear hepatocytes assessed by computer program is a novel biomarker for short term recurrence of hepatocellular carcinoma after surgery
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  40. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
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  41. Targeted disruption of Pparγ1 promotes trophoblast endoreplication in the murine placenta
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  42. PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis
    Valentina C. Sladky, Katja Knapp, Tamas Szabo, L. Bongiovanni, H. van den Bos, D. Spierings, B. Westendorp, T. Stojaković, H. Scharnagl, G. Timelthaler et al. · 2020 · bioRxiv
  43. Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer
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  44. E2F-dependent genetic oscillators control endoreplication
    Minhee Kim, Nam-Sung Moon · 2019 · bioRxiv
  45. La polyploïdie hépatique
    Romain Donné, Maëva Saroul-Aïnama, Vanessa Maillet, Séverine Celton‐Morizur, Chantal Desdouets · 2019 · médecine/sciences
  46. Osteoclast Cytokinesis
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  47. Isolation of Mononucleated and Binucleated Hepatocytes by Flow Cytometry
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  48. miR‐204‐5p Promotes Hepatogenic Differentiation of Adipose‐Derived Stem Cells to Ameliorate Acute Liver Failure via the MDM2/E2F8/BMP4 Axis
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  49. Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice
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  50. Unusual modes of cell and nuclear divisions characterise Drosophila development
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  51. EFL-3/E2F7 modulates Wnt signalling through repressing the LIT-1 Nemo-like kinase during asymmetric epidermal cell division in Caenorhabditis elegans
    Mar Ferrando-Marco, M. Barkoulas · 2024 · bioRxiv
  52. Rôle de la MAP kinase p38α au cours d'une agression aiguë du foie
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  53. A Cell Cycle Switch Dictates Organ Repair and Tissue Growth Responses in The Drosophila Hindgut
    Erez Cohen, S. R. Allen, Jessica K. Sawyer, Donald T. Fox · 2018 · bioRxiv
  54. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
    A. de Bruin, B. Westendorp, L. Di Stefano, M. Milacić · 2017
  55. E2F transcription factor 1 overexpression as a poor prognostic factor in patients with nasopharyngeal carcinomas
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  56. Towards a better understanding of early drug-induced regulatory mechanisms of liver tumorigenesis
    R. Luisier · 2014