The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nrf2 regulates haematopoietic stem cell function
Open accessAbstract
Coordinating the balance between haematopoietic stem cell (HSC) quiescence and self-renewal is crucial for maintaining haematopoiesis lifelong. Equally important for haematopoietic function is modulating HSC localization within the bone marrow niches, as maintenance of HSC function is tightly controlled by a complex network of intrinsic molecular mechanisms and extrinsic signalling interactions with their surrounding microenvironment. In this study we demonstrate that nuclear factor erythroid 2-related factor 2 (Nfe2l2, or Nrf2), well established as a global regulator of the oxidative stress response, plays a regulatory role in several aspects of HSC homeostasis. Nrf2 deficiency results in an expansion of the haematopoietic stem and progenitor cell compartment due to cell-intrinsic hyperproliferation, which was accomplished at the expense of HSC quiescence and self-renewal. We further show that Nrf2 modulates both migration and retention of HSCs in their niche. Moreover, we identify a previously unrecognized link between Nrf2 and CXCR4, contributing, at least partially, to the maintenance of HSC function.
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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
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Cited by
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837
Stem cells and the impact of ROS signaling
Bigarella, C. L., Liang, R., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 632
Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis
Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252
Radiation‐induced tissue damage and response
McBride, W. H., & Schaue, D. (2020) · The Journal of Pathology · doi:10.1002/path.5389 · Cited by 155
Stem Cells, Redox Signaling, and Stem Cell Aging
Liang, R., & Ghaffari, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5300 · Cited by 106
Metadata
- Authors
- Tsai, J. J., Dudakov, J. A., Takahashi, K., Shieh, J.-H., Velardi, E., Holland, A. M., Singer, N. V., West, M. L., Smith, O. M., Young, L. F., Shono, Y., Ghosh, A., Hanash, A. M., Tran, H. T., Moore, M. A. S., & van den Brink, M. R. M.
- Venue
- Nature Cell Biology
- Published
- 2013-02-24
- Volume
- 15
- Issue
- 3
- Pages
- 309-316
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1996916774
- Cited by
- 202
- References
- 6
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsai, J. J., Dudakov, J. A., Takahashi, K., Shieh, J.-H., Velardi, E., Holland, A. M., Singer, N. V., West, M. L., Smith, O. M., Young, L. F., Shono, Y., Ghosh, A., Hanash, A. M., Tran, H. T., Moore, M. A. S., & van den Brink, M. R. M. (2013). Nrf2 regulates haematopoietic stem cell function. Nature Cell Biology. https://doi.org/10.1038/ncb2699
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