Stem Cells, Redox Signaling, and Stem Cell Aging

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Reactive oxygen species in cell signaling

Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

Signal transduction by reactive oxygen species

Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,450 · see citing works

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Lagadinou, E. D., Sach, A., Callahan, K. P., Rossi, R. M., Neering, S. J., Minhajuddin, M., Ashton, J. M., Pei, S., Grose, V., O’Dwyer, K. M., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.013 · Cited by 1,410 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 4× · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

Lee, S.-R., Yang, K., Kwon, J., Lee, C., Jeong, W., & Rhee, S. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111899200 · Cited by 1,061 · see citing works

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

Meng, T.-C., Fukada, T., & Tonks, N. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00445-8 · Cited by 1,040 · see citing works

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032 · see citing works

FOXO3A genotype is strongly associated with human longevity

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983 · see citing works

Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

Castrillón, D. H., Miao, L., Kollipara, R., Horner, J. W., & DePinho, R. A. (2003) · Science · doi:10.1126/science.1086336 · Cited by 956 · see citing works

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891 · see citing works

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura‐Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.10.011 · Cited by 810 · see citing works

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature · doi:10.1038/nature01819 · Cited by 801 · see citing works

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

Le Belle, J. E., Orozco, N. M., Paucar, A. A., Saxe, J. P., Mottahedeh, J., Pyle, A. D., Wu, H., & Kornblum, H. I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.028 · Cited by 789 · see citing works

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Moreland, R. J., Iliopoulos, O., Lane, W. S., Kaelin, W. G., Elledge, S. J., Conaway, R. C., et al. (1999) · Science · doi:10.1126/science.284.5414.657 · Cited by 786 · see citing works

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works

Linking functional decline of telomeres, mitochondria and stem cells during ageing

Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759 · see citing works

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

Muñoz, J., Stange, D. E., Schepers, A. G., van de Wetering, M., Koo, B., Itzkovitz, S., Volckmann, R., Kung, K. S., Köster, J., Radulescu, S., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.166 · Cited by 758 · see citing works

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Owusu-Ansah, E., & Banerjee, U. (2009) · Nature · doi:10.1038/nature08313 · Cited by 742 · see citing works

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

Powell, A. E., Wang, Y., Li, Y., Poulin, E. J., Means, A. L., Washington, M. K., Higginbotham, J. N., Juchheim, A., Prasad, N., Levy, S. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.042 · Cited by 694 · see citing works

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682 · see citing works

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

Guzmán, M. L., Rossi, R. M., Karnischky, L., Li, X., Peterson, D. R., Howard, D. S., & Jordan, C. T. (2005) · Blood · doi:10.1182/blood-2004-10-4135 · Cited by 680 · see citing works

Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α

Yuan, Y., Hilliard, G., Ferguson, T., & Millhorn, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300463200 · Cited by 638 · see citing works

Redox regulation of PI 3‐kinase signalling via inactivation of PTEN

Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A., & Downes, C. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg513 · Cited by 614 · see citing works

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

Woo, H. A., Yim, S. H., Shin, D. H., Kang, D., Yu, D., & Rhee, S. G. (2010) · Cell · doi:10.1016/j.cell.2010.01.009 · Cited by 613 · see citing works

Mechanisms of Stem Cell Self-Renewal

He, S., Nakada, D., & Morrison, S. J. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113248 · Cited by 607 · see citing works

FoxO3 Regulates Neural Stem Cell Homeostasis

Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.014 · Cited by 586 · see citing works

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., & Hirao, A. (2010) · Nature · doi:10.1038/nature08734 · Cited by 583 · see citing works

Mitochondrial disease in superoxide dismutase 2 mutant mice

Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.846 · Cited by 581 · see citing works

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547 · see citing works

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524 · see citing works

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

Dykstra, B., Olthof, S., Schreuder, J., Ritsema, M., & de Haan, G. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111490 · Cited by 494 · cited 1× · see citing works

Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215

Barrett, W. C., DeGnore, J. P., König, S., Fales, H. M., Keng, Y., Zhang, Z., Yim, M. B., & Chock, P. B. (1999) · Biochemistry · doi:10.1021/bi990240v · Cited by 488 · see citing works

Bmi1 regulates mitochondrial function and the DNA damage response pathway

Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature · doi:10.1038/nature08040 · Cited by 474 · see citing works

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

Paik, J.-H., Ding, Z., Narurkar, R., Ramkissoon, S., Muller, F., Kamoun, W. S., Chae, S.-S., Zheng, H., Ying, H., Mahoney, J., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.013 · Cited by 459 · see citing works

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Gan, B., HU, J. L., Jiang, S., Liu, Y., Sahin, E., Li, Z., Fletcher-Sananikone, E., Colla, S., Wang, Y., Chin, L., et al. (2010) · Nature · doi:10.1038/nature09595 · Cited by 437 · see citing works

Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a

Lin, L., Hron, J. D., & Peng, S. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.016 · Cited by 420 · see citing works

An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells

Guzmán, M. L., Rossi, R. M., Neelakantan, S., Li, X., Corbett, C. A., Hassane, D. C., Becker, M. W., Bennett, J. M., Sullivan, E., Lachowicz, J. L., et al. (2007) · Blood · doi:10.1182/blood-2007-05-090621 · Cited by 404 · see citing works

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

Gurumurthy, S., Xie, S. Z.-J., Alagesan, B., Kim, J., Yusuf, R. Z., Sáez, B., Tzatsos, A., Ozsolak, F., Milos, P. M., Ferrari, F., et al. (2010) · Nature · doi:10.1038/nature09572 · Cited by 391 · see citing works

Oxidative Stress in the Regulation of Normal and Neoplastic Hematopoiesis

Ghaffari, S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2142 · Cited by 377 · see citing works

Controlled Elimination of Intracellular H ₂ O2: Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification

Rhee, S. G., Yang, K.-S., Kang, S. W., Woo, H. A., & Chang, T.-S. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.619 · Cited by 376 · see citing works

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

Han, M., Song, E.-K., Guo, Y., Ou, X., Mantel, C., & Broxmeyer, H. E. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.01.002 · Cited by 368 · see citing works

Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila

Hochmuth, C. E., Biteau, B., Bohmann, D., & Jasper, H. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.006 · Cited by 364 · see citing works

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

Barzilai, A. (2002) · DNA Repair · doi:10.1016/s1568-7864(01)00007-6 · Cited by 359 · see citing works

Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B

Barrett, W. C., DeGnore, J. P., Keng, Y., Zhang, Z., Yim, M. B., & Chock, P. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34543 · Cited by 355 · see citing works

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Yu, W., Liu, X., Shen, J., Jovanović, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E., & Qu, C. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.022 · Cited by 341 · see citing works

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

Zeng, Z., Sarbassov, D. D., Samudio, I. J., Yee, K. W. L., Munsell, M. F., Jackson, C. E., Giles, F. J., Sabatini, D. M., Andreeff, M., & Konopleva, M. Y. (2006) · Blood · doi:10.1182/blood-2006-06-030833 · Cited by 339 · see citing works

Generating specificity and diversity in the transcriptional response to hypoxia

Lendahl, U., Lee, K. L., Yang, H. H., & Poellinger, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2665 · Cited by 330 · see citing works

Mechanisms that Regulate Stem Cell Aging and Life Span

Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320 · see citing works

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

Marinković, D., Zhang, X., Yalcin, S., Luciano, J. P., Brugnara, C., Huber, T. L., & Ghaffari, S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31807 · Cited by 320 · see citing works

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315 · see citing works

Glutaredoxin Exerts an Antiapoptotic Effect by Regulating the Redox State of Akt*

Murata, H., Ihara, Y., Nakamura, H., Yodoi, J., Sumikawa, K., & Kondo, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310171200 · Cited by 304 · see citing works

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

Yahata, T., Takanashi, T., Muguruma, Y., Ibrahim, A. A., Matsuzawa, H., Uno, T., Sheng, Y., Onizuka, M., Ito, M., Kato, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-330050 · Cited by 298 · see citing works

E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination

Tanaka, H., Matsumura, I., Ezoe, S., Satoh, Y., Sakamaki, T., Albanese, C., Machii, T., Pestell, R. G., & Kanakura, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00522-1 · Cited by 289 · see citing works

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

Juntilla, M. M., Patil, V. D., Calamito, M., Joshi, R. P., Birnbaum, M. J., & Koretzky, G. A. (2010) · Blood · doi:10.1182/blood-2009-09-241000 · Cited by 284 · see citing works

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

Harrison, D. E., & Astle, C. M. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.6.1767 · Cited by 281 · see citing works

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

Sykes, S., Lane, S. W., Bullinger, L., Kalaitzidis, D., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.032 · Cited by 281 · see citing works

Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B

Meng, T., Buckley, D. A., Galić, S., Tiganis, T., & Tonks, N. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404606200 · Cited by 276 · see citing works

Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro

Hecht, D., & Zick, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91123-8 · Cited by 273 · see citing works

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Kharas, M. G., Okabe, R. O., Ganis, J. J., Gozo, M. C., Khandan, T., Paktinat, M., Gilliland, D. G., & Gritsman, K. (2009) · Blood · doi:10.1182/blood-2009-06-229443 · Cited by 272 · see citing works

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

Zhang, X., Yalcin, S., Lee, D., Yeh, T.-Y. J., Lee, S.-M., Su, J., Mungamuri, S. K., Rimmelé, P., Kennedy, M., Sellers, R. S., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2293 · Cited by 262 · see citing works

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

Shaw, M., Cohen, P., & Alessi, D. R. (1998) · Biochemical Journal · doi:10.1042/bj3360241 · Cited by 261 · see citing works

Hematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species

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Aging: A cell source limiting factor in tissue engineering

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Benefits of the Neurogenic Potential of Melatonin for Treating Neurological and Neuropsychiatric Disorders

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High-glutathione mesenchymal stem cells isolated using the FreSHtracer probe enhance cartilage regeneration in a rabbit chondral defect model

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Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche

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N-acetylcysteine protects against neurodevelopmental injuries induced by methylmercury exposure during pregnancy and lactation

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Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments

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Downregulation of Stemness Genes and Induction of Necrosis in Rat LA7 Cancer Stem Cells Induced Tumors Treated with Starved Fibroblasts Culture Supernatant

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In Search for Anti-Aging Strategy: Can We Rejuvenate Our Aging Stem Cells?

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Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged PatientsPreprint

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Ovarian Stem Cells and Progenitors and Their Regenerative Capabilities

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Periplakin Attenuates Liver Fibrosis via Reprogramming CD44Low Cells into CD44High Liver Progenitor Cells

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Reactive Oxygen Species Signaling from the Perspective of the Stem Cell

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Comparative Transcriptomics Identifies Potential Stemness-Related Markers for Mesenchymal Stromal/Stem CellsPreprint

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A REVIEW STUDY ON THE EFFECT OF FUNGI AND AFLATOXIN ON STEM CELLS

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Aktivitas Antioksidan Kulit Jeruk Pacitan (Citrus sinensis L.) Terhadap Kadar SGOT dan SGPT Rattus norvegicus Dengan Paparan Logam Berat Timbal (Pb)

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Superoxide dismutases maintain niche homeostasis in stem cell populations

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Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance

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