The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chase-and-run between adjacent cell populations promotes directional collective migration
Open accessAbstract
Collective cell migration in morphogenesis and cancer progression often involves the coordination of multiple cell types. How reciprocal interactions between adjacent cell populations lead to new emergent behaviours remains unknown. Here we studied the interaction between neural crest (NC) cells, a highly migratory cell population, and placodal cells, an epithelial tissue that contributes to sensory organs. We found that NC cells chase placodal cells by chemotaxis, and placodal cells run when contacted by NC. Chemotaxis to Sdf1 underlies the chase, and repulsion involving PCP and N-cadherin signalling is responsible for the run. This chase-and-run requires the generation of asymmetric forces, which depend on local inhibition of focal adhesions. The cell interactions described here are essential for correct NC migration and for segregation of placodes in vivo and are likely to represent a general mechanism of coordinated migration.
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Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589
Neural Crest and the Origin of Vertebrates: A New Head
Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053
Cited by
Mechanobiology of collective cell behaviours
Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749
Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3478 · Cited by 747
Self-citationThe mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces
Mui, K. L., Chen, C. S., & Assoian, R. K. (2016) · Journal of Cell Science · doi:10.1242/jcs.183699 · Cited by 316
Scarpa, E., Szabó, A., Bibonne, A., Theveneau, E., Parsons, M., & Mayor, R. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.012 · Cited by 279
Self-citationPérez-González, C., Ceada, G., Greco, F., Matejčić, M., Gómez-González, M., Castro, N., Menendez, A., Kale, S., Krndija, D., Clark, A. G., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00699-6 · Cited by 225
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Metadata
- Authors
- Theveneau, E., Steventon, B., Scarpa, E., Garcia, S., Trepat, X., Streit, A., & Mayor, R.
- Venue
- Nature Cell Biology
- Published
- 2013-06-16
- Volume
- 15
- Issue
- 7
- Pages
- 763-772
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2168391253
- Cited by
- 320
- References
- 2
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Theveneau, E., Steventon, B., Scarpa, E., Garcia, S., Trepat, X., Streit, A., & Mayor, R. (2013). Chase-and-run between adjacent cell populations promotes directional collective migration. Nature Cell Biology. https://doi.org/10.1038/ncb2772
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