The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces
Open accessAbstract
Contact inhibition of locomotion (CIL) is the process through which cells move away from each other after cell-cell contact, and it contributes to malignant invasion and developmental migration. Various cell types exhibit CIL, whereas others remain in contact after collision and may form stable junctions. To investigate what determines this differential behavior, we study neural crest cells, a migratory stem cell population whose invasiveness has been likened to cancer metastasis. By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N-cadherin during EMT is essential for acquisition of CIL behavior. Loss of E-cadherin leads to repolarization of protrusions, via p120 and Rac1, resulting in a redistribution of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin junction. These data provide insight into the balance of physical forces that contributes to CIL in cells in vivo.
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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
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Contact inhibition of locomotion in vivo controls neural crest directional migration
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Self-citationSpatial organization of the extracellular matrix regulates cell–cell junction positioning
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P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases
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Self-citationLabernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3478 · Cited by 747
Tuning Collective Cell Migration by Cell–Cell Junction Regulation
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Self-citationEpithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
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Metadata
- Authors
- Scarpa, E., Szabó, A., Bibonne, A., Theveneau, E., Parsons, M., & Mayor, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 34
- Issue
- 4
- Pages
- 421-434
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1921522108
- Cited by
- 279
- References
- 49
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces. https://app.cochat.ai/papers/10.1016/j.devcel.2015.06.012
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- Scarpa, E., Szabó, A., Bibonne, A., Theveneau, E., Parsons, M., & Mayor, R. (2015). Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces. Developmental Cell. https://doi.org/10.1016/j.devcel.2015.06.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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