The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
Open accessAbstract
In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis. This suggested that the BM might be a metastasis 'restrictive soil' by encoding dormancy-inducing cues in DTCs. Here we show in a head and neck squamous cell carcinoma (HNSCC) model that strong and specific transforming growth factor-β2 (TGF-β2) signalling in the BM activates the MAPK p38α/β, inducing an (ERK/p38)(low) signalling ratio. This results in induction of DEC2/SHARP1 and p27, downregulation of cyclin-dependent kinase 4 (CDK4) and dormancy of malignant DTCs. TGF-β2-induced dormancy required TGF-β receptor-I (TGF-β-RI), TGF-β-RIII and SMAD1/5 activation to induce p27. In lungs, a metastasis 'permissive soil' with low TGF-β2 levels, DTC dormancy was short-lived and followed by metastatic growth. Importantly, systemic inhibition of TGF-β-RI or p38α/β activities awakened dormant DTCs, fuelling multi-organ metastasis. Our work reveals a 'seed and soil' mechanism where TGF-β2 and TGF-β-RIII signalling through p38α/β regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TGF-β2 was reported to contribute to metastatic tumor dormancy333–335”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [334]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Bao, B., Wang, Z. P., Ali, S. S., Kong, D., Banerjee, S., Ahmad, A., Li, Y., Azmi, A. S., Miele, L., & Sarkar, F. H. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23150 · Cited by 206
RetractedThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413
Models, mechanisms and clinical evidence for cancer dormancy
Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,756
Self-citationCytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Aslakson, C. J., & Miller, F. R. (1992) · PubMed · Cited by 1,234
Systemic Spread Is an Early Step in Breast Cancer
Hüsemann, Y., Geigl, J. B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T. N., Riethmüller, G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.003 · Cited by 1,220
The perivascular niche regulates breast tumour dormancy
Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 982
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 505
Zhang, W., Xu, S., Shi, L., Zhu, Z., & Xie, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238420 · Cited by 2
Choi, S., Whitman, M. A., Shimpi, A. A., Sempertegui, N. D., Chiou, A. E., Druso, J. E., Verma, A., Lux, S. C., Cheng, Z., Paszek, M. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.29.498001 · Cited by 2
From Worms to Tumors: Conserved Strategies of Cellular Arrest and Survival Governing Dormancy
Prahlad, V., & Gelman, I. H. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-2050 · Cited by 1
Chislock, E. M., Pan, T.-C., Pant, D. K., Chen, Y., Woodfield, G. W., Graves, J. M., Lawrence-Paul, M. R., Belka, G. K., Wang, J., Bayne, L. J., et al. (2025) · npj Breast Cancer · doi:10.1038/s41523-025-00853-5 · Cited by 2
Heras, U., Pardo-Sánchez, J. M., Fallert, L., de Aberasturi, D. J., Mitxelena‐Iribarren, O., & Cipitria, A. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070824-124153 · Cited by 1
An FAK Kinase/Scaffold Mode-Switch in Dormancy and Resistance
Sun, C., Qiuting, F., Zhao, Y., Dong, Q., & Bi, L. (2026) · Cancers · doi:10.3390/cancers18060995 · Cited by 1
Mucosal immunity in cancer metastasis: roles, mechanisms, and therapeutic implications
Miao, Y., Cui, D., Bi, Y., & Zhang, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1809558 · Cited by 2
Dynamic molecular networks unveil the mechanism behind hypoxia‐induced tumour cell dormancy
Wang, P., Li, H. X., Lan, Y., Zhang, H. G., Li, C. F., Zhang, X., & Wang, W. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70195 · Cited by 1
Vigneron, E., Vignau, J., Lowyck, O., den Bossche, V. V., Ambroise, J., Kieffer, Y., Mechta‐Grigoriou, F., Rizzi, I., Giolito, M. V., Desgres, M., et al. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03765-9 · Cited by 1
Kabak, E. C., Muraro, M. G., Bartoszek, E. M., Damle, A., Pouzet, F., Rouchon, A., García‐García, A., Foo, S. L., Bentires-Alj, M., & Martín, I. (2026) · Journal of Biological Engineering · doi:10.1186/s13036-026-00780-4 · Cited by 1
Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression
Linde, N., Sosa, M. S., & Aguirre‐Ghiso, J. A. (2014) · The EMBO Journal · doi:10.15252/embj.201489364 · Cited by 1
Self-citationEMT process in bone metastasis
Gao, D., Thompson, E. W., & Mittal, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00038-8 · Cited by 1
The Bone Marrow Microenvironment as a Regulator of Tumor Dormancy
Ono, M., & Ochiya, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803102-5.00016-1 · Cited by 1
Flavonoids Targeting Cancer Stem Cells: A Paradigm to Anticancer Efficacy
Siddiqui, N., Abidin, L., Nisar, N., Ahmad, I. S., & Siddiqui, A. N. (2021) · Springer eBooks · doi:10.1007/978-981-16-4935-6_7 · Cited by 1
Molecular Mechanisms of Metastasis to the Bone
Frieling, J. S., & Lynch, C. C. (2022) · Springer eBooks · doi:10.1007/978-3-030-93084-4_44 · Cited by 1
The Metabolism of Cancer Cells During Metastasis
Farshbafnadi, M., & Rezaei, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_60-1 · Cited by 1
Cancer stem cell–derived exosomes: what is known to date
Bhasin, N., Dabral, P., Selvendiran, K., & Anbalagan, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13212-4.00028-3 · Cited by 1
Breast Cancer Disseminated Tumor Cells: Do They Stay and Fight or Run and Hide?
Cackowski, F. C., & Körkaya, H. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2408 · Cited by 1
EMT process in bone metastasis
Gao, D., Zhang, X. H.-F., Thompson, E. W., & Mittal, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00009-8 · Cited by 1
Cancer Biology and Implications for the Perioperative Period
Perry, N. J. S., Jhanji, S., & Poulogiannis, G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-69584-8.00003-7 · Cited by 1
Targeting Metastatic Disease: Challenges and New Opportunities
Hu, H., Hu, Z., & Zheng, H. (2022) · Springer eBooks · doi:10.1007/978-3-031-09518-4_4 · Cited by 1
Liu, Y., Liu, X., Liu, L., Wang, Y., Peng, L., Liu, J., Li, L., Zhang, L., Wang, G., Li, H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/728410 · Cited by 1
Elucidating the metastasis-specific tumor properties
Skvortsova, I. (2021) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2021.100002 · Cited by 1
Bakhshandeh, S., Heras, U., Taïeb, H. M., Varadarajan, A. R., Lissek, S. M., Hücker, S. M., Lu, X., Garske, D. S., Young, S. A. E., Abaurrea, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525382 · Cited by 1
Self-citationDalla, E., Papanicolaou, M., Park, M., Hou, R., Sun, D., Forrest, A. R. R., Barth, N. D., Casanova-Acebes, M., Entenberg, D. R., Mérad, M., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4453789 · Cited by 1
Self-citationRamponi, V., Richart, L., Kovatcheva, M., Attolini, C. S., Capellades, J., Lord, A. E., Yanes, Ó., Ficz, G., & Serrano, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.26.577389 · Cited by 1
Kadamb, R., Anton, M. L., Purwin, T. J., Seeneevassen, L., Chua, V. Y. L., Waltrich, F., Teh, J. L. F., Nieto, M. A., Sato, T., Terai, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.05.583565 · Cited by 1
Self-citationHochheuser, C., Boltjes, A., Keller, K. M., Tol, S., van de Mheen, M., Barros, C. P., van Gestel-Fadaie, Z., Kuilenburg, A. B. P., van Hooff, S. R., Voermans, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.13.612231 · Cited by 1
Choudhury, C., Singleton, M., Brauer, S., Friess, D., Hart, J. A., Skarne, N., Pullela, K., Mao, L., Day, B. W., & Harris, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.634421 · Cited by 1
Mechanisms of invasion and metastasis in colorectal cancer
García‐Albéniz, X. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Der metastatische Zyklus: metastatische Nischen und Tumorzell‐Dissemination
Géraud, C., Reiners-Koch, P.-S., Damm, F., Schledzewski, K., & Goerdt, S. (2014) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12451_suppl
Current insights into clinical dormancy and metastasis
Chakrabarti, A., & Anderson, R. L. (2014) · Cancer Forum
Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype
Flanagan, K. C. (2017) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k75x27b7
A possible IDO1- TSP1 role in breast cancer dormancy
Lopes-Bastos, B. (2017) · ORCA Online Research @Cardiff (Cardiff University)
[Mechanisms and implications of cancer cell dormancy in head and neck carcinoma].
Xiaolei, G., Xinhua, L., & Yaling, T. (2018) · PubMed Central · doi:10.7518/hxkq.2018.01.018
Stem cell niches in bone and their roles in cancer metastasis
Holen, I., & Quayle, L. A. (2020) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2020.09.002
Transforming growth factor-β and its signaling pathway in skeletal complications of malignancy
Juárez, P., Iduarte, B. I., & Fournier, P. G. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00071-2
Dormancy in cancer bone metastasis
Carrera, H. M. A., & Wang, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00064-5
Aulas, A., Liberatoscioli, M. L., Finetti, P., Cabaud, O., Birnbaum, D. J., Birnbaum, D., Bertucci, F., & Mamessier, É. (2021) · medRxiv · doi:10.1101/2021.10.13.21264887
Hypoxia and Metastatic Disease
Todd, V. M., & Johnson, R. W. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11243-7
Tumor Cell Dormancy: Threat or Opportunity in the Fight Against CancerPreprint
Seidi, K., Manjili, M. H., Jahanban‐Esfahlan, R., & Javaheri, T. (2018) · Preprints.org · doi:10.20944/preprints201810.0238.v1
(Sterling), J. A. R., Johnson, R. W., & Lynch, C. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00055-5
Recalde‐Percaz, L., Jáuregui, P., López‐Plana, A., Fernández‐Nogueira, P., Iniesta‐González, M., Manzano, S., Alonso, R., Noguera‐Castells, A., Moragas, N., Baquero, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1956933/v1
Self-citationA Bibliometric Analysis of Tumor Dormancy in the 21st Century (Preprint)Preprint
Zhang, Y., Yan, L., Li, F., Lv, J., Liu, J., Liu, X., Li, B., & Zhang, Y. (2023) · doi:10.2196/preprints.45498
Molecular Mechanisms Driving Bone Metastasis of Cancers
Qiu, F., Huang, J., Fu, X., & Liang, C. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_80-1
Rodrigo‐Faus, M., Vincelle-Nieto, Á., Vidal, N., Puente, J., Saiz‐Pardo, M., López-García, A., Mendiburu‐Eliçabe, M., Palao, N., Baquero, C., Cuesta, Á. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549704
Self-citationGutiérrez-Uzquiza, Á., Rodrigo‐Faus, M., Vincelle-Nieto, Á., Vidal, N., Puente, J., Saiz‐Pardo, M., López-García, A., Mendiburu‐Eliçabe, M., Palao, N., Baquero, C., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3316991/v1
Self-citationHarris, C. R., Wang, L., Dudgeon, C., Prela, O., Cazarin, J., Shih, C.-H., Davidson, C., Casabianca, A., De, S., Narrow, W. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.12.623005
Deterministic Role of FOXF2 in Organ-Specific Macrometastasis Transition
Bado, I. L. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4078
Shimizu, H., Wang, L., Tsuda, M., Maruyama, R., Saito, Y., Kumegawa, K., Takahashi, M., Horii, R., Suzuki, H., Watanabe, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.18.643632
The Metabolism of Cancer Cells During Metastasis
Farshbafnadi, M., & Rezaei, N. (2025) · Springer eBooks · doi:10.1007/978-3-032-00759-9_60
Takeda, K., Moriya, A., Nishimura, A., Okanoue, S., Kawai, Y., Seki, H., Nagahara, T., Jinno, H., Iwasaki, Y., & Ando, M. (2025) · Kanzo · doi:10.2957/kanzo.66.483
Additional file 10 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737017
Additional file 7 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737041
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116040
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116061
Additional file 1 of Gene expression predicts dormant metastatic breast cancer cell phenotype
Ren, Q., Khoo, W. H., Corr, A. P., Phan, T. G., Croucher, P. I., & Stewart, S. A. (2022) · Figshare · doi:10.6084/m9.figshare.19092447
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116049
Additional file 6 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737038
Additional file 1 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737023
Additional file 5 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737035
Additional file 8 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737044
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116058
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116028
Additional file 4 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737032
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116043
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116037
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116052
Additional file 3 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737029
Additional file 11 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737020
Additional file 9 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737047
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116046
Additional file 2 of Cellular dormancy in minimal residual disease following targeted therapy
Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14737026
Papadaki, C., Stratigos, M., Markakis, G., Spiliotaki, M., Mastrostamatis, G., Nikolaou, C., Mavroudis, D., & Agelaki, S. (2018) · Figshare · doi:10.6084/m9.figshare.6807719
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27116034
Molecular Mechanisms Driving Bone Metastasis of Cancers
Qiu, F., Huang, J., Fu, X., & Liang, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-00759-9_80
TGFβ signaling systems are prone to inhibition and ligand competition by coreceptorPreprint
Fares, W. A., & Janes, K. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.01.708909
Guo, S., Hu, H., Wen, H., Zhang, J., Song, Y., Wang, K., Huang, D., & Shan, Y. (2026) · Bulletin of Mathematical Biology · doi:10.1007/s11538-026-01631-5
Lighting up Invasion with Optogenetics : RalB Mobilizes the WRC Complex Downstream Ras
Zago, G. (2018) · theses.fr (ABES) · doi:10.70675/5530038ez9f6bz4870zb51ezdb058f3e56c0
Etude de la dissémination du cancer colorectal
Belthier, G. (2020) · theses.fr (ABES) · doi:10.70675/041d8f10zf4bcz416bz92b5zc99057a94d09
Santamaria, K. (2020) · theses.fr (ABES) · doi:10.70675/0550da9bz6935z43d6z9117z2f2fdffb714c
Long-term regulation of colorectal cancer cells under mechanical stress
Mouelhi, M. (2023) · theses.fr (ABES) · doi:10.70675/c4c32dd5zfd5ez4187za887z25dd0c7e3452
Intrinsic and extrinsic regulators of cancer dormancy and awakening
Zhang, J., Khalil, M. I., Mishra, R. K., Li, H., Perelli, L., & Weinberg, R. A. (2026) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2026.03.007
Extracellular Matrix–Tumor Crosstalk and Its Influence on Tumor Dormancy
Gawarguru, R., Shinde, S., & Dey, T. (2026) · Biology of extracellular matrix · doi:10.1007/978-3-032-22618-1_1
Lee, Y., 장병석, & Jung, H. (2026) · iScience · doi:10.1016/j.isci.2026.116048
Tsuji, T., & Ghajar, C. M. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01977-x
Insights Into the Molecular Mechanisms and Use of Cancer Dormancy and Reawakening
Al-Janabi, I. I. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v11i1.2941
Immunity and Beyond: Emerging Roles of Monocytes and Macrophages in Cancer
Tomás, A., & Pojo, M. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_7
Hu, Y. R., Li, S., Zhu, M., Gong, C., & Fang, Z. (2026) · Molecular Carcinogenesis · doi:10.1002/mc.70147
Genetic and epigenetic modifiers of metastasis: Context matters
Welch, D. R., Swancutt, K. L., Walsh, R. M., & Fisette, G. (2026) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583526100201
Yuan, Z., Zhang, H., Xing, J., Cao, X., Liu, G., Tan, T., Zhao, C., & Yang, C. (2026) · Journal of bone oncology · doi:10.1016/j.jbo.2026.100793
Li, X., 楊其泰, Zhai, J., Zhang, X., Dong, F., & Ema, H. (2026) · Blood Science · doi:10.1097/bs9.0000000000000307
Tumor-Driven Inflammation Promotes Tumor Growth: A Focus on Anti-Inflammatory Cancer Treatments
Seledtsov, V. I. (2026) · Diseases · doi:10.3390/diseases14080294
Atoom, A. M., Rizaev, J., Polatova, D., Patel, P. N., Jamuna, K. V., Maharana, L., Bainsal, N., & Singhal, D. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101403
Li, J., Zhu, J., Yang, M., Liu, Y., Li, X., Li, Z., & Zeng, B. (2026) · Gene · doi:10.1016/j.gene.2026.150394
Li, Y., Zhan, W., Min, M., Zhang, K., Liu, Y., Chen, H., & Yan, X. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1979062
Beyond target presence: A cross-cancer contextual framework for siRNA therapeutics in solid tumors
Zhao, N., Zhang, Y., Qian, C., 张华巍, & Wang, L. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189732
Wound healing and recurrence in head and neck cancer: a narrative review
Harris, M. K., Cai, W. L., Kim, J., Helou, V., Smith, J. D., & Spector, M. E. (2026) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2026.1002405
Metadata
- Authors
- Bragado, P., Estrada, Y., Parikh, F., Krause, S., Capobianco, C., Farina, H. G., Schewe, D. M., & Aguirre-Ghiso, J. A.
- Affiliations
- Tisch Cancer Institute (US)
- University Hospital Schleswig-Holstein (DE)
- National University of Quilmes (AR)
- Venue
- Nature Cell Biology
- Published
- 2013-10-27
- Volume
- 15
- Issue
- 11
- Pages
- 1351-1361
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4006312
- OpenAlex
- W2163472474
- Cited by
- 503
- References
- 55
- Citations by year
- 2026: 36 · 2025: 30 · 2024: 50 · 2023: 44 · 2022: 44 · 2021: 75 · 2020: 43 · 2019: 35 · 2018: 39 · 2017: 35 · 2016: 31 · 2015: 23 · 2014: 18
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- New York State Stem Cell Science
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Deutsche Krebshilfe
- National Cancer Institute (CA109182, U54CA163131, CA163131, R01CA109182)
- National Institute of Environmental Health Sciences (R21ES017146, ES017146)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- disseminated tumor cells, TGF-beta2, p38 MAPK, head and neck squamous cell carcinoma, tumor dormancy, bone marrow microenvironment, lung metastasis, seed and soil hypothesis, Smad1/5, p27, CDK4
- MeSH terms
- Animals, Enzyme Activation, Mice, Nude, Neoplasms, Experimental, Proteoglycans, Signal Transduction, Receptors, Transforming Growth Factor beta, Cell Lineage, p38 Mitogen-Activated Protein Kinases, Mice, Transforming Growth Factor beta2, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review