TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited

Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint

Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413

Models, mechanisms and clinical evidence for cancer dormancy

Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,756

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

Aslakson, C. J., & Miller, F. R. (1992) · PubMed · Cited by 1,234

Systemic Spread Is an Early Step in Breast Cancer

Hüsemann, Y., Geigl, J. B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T. N., Riethmüller, G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.003 · Cited by 1,220

The perivascular niche regulates breast tumour dormancy

Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 982

Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications

Dai, C. S., Mishra, A., Edd, J., Toner, M., Maheswaran, S., & Haber, D. A. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.07.008 · Cited by 104

The Role of the ECM in Lung Cancer Dormancy and Outgrowth

Parker, A. L., & Cox, T. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01766 · Cited by 95

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

Francescangeli, F., Contavalli, P., Angelis, M. L. D., Careccia, S., Signore, M., Haas, T. L., Salaris, F., Baiocchi, M., Boe, A., Giuliani, A., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1505-4 · Cited by 95

Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow

Decker, A. M., Jung, Y., Cackowski, F. C., Yumoto, K., Wang, J., & Taichman, R. S. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0132 · Cited by 86

Role of Microenvironment on the Fate of Disseminating Cancer Stem Cells

Ingangi, V., Minopoli, M., Ragone, C., Motti, M. L., & Carriero, M. V. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00082 · Cited by 88

Clinical Outcome With Correlation to Disseminated Tumor Cell (DTC) Status After DTC-Guided Secondary Adjuvant Treatment With Docetaxel in Early Breast Cancer

Naume, B., Synnestvedt, M., Falk, R. S., Wiedswang, G., Weyde, K., Risberg, T., Kersten, C., Mjaaland, I., Vindi, L., Sommer, H., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.9327 · Cited by 88

Hypoxia and Bone Metastatic Disease

Johnson, R. W., Sowder, M. E., & Giaccia, A. J. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0378-8 · Cited by 92

Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis

Aguirre‐Ghiso, J. A., & Sosa, M. S. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050446 · Cited by 84

TGF-β Family Signaling Pathways in Cellular Dormancy

Prunier, C., Baker, D. A., ten Dijke, P., & Ritsma, L. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.10.010 · Cited by 86

Mechanisms governing metastatic dormancy in breast cancer

Dittmer, J. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.006 · Cited by 83

Cell-intrinsic and microenvironmental determinants of metastatic colonization

Lambert, A. W., Zhang, Y., & Weinberg, R. A. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01409-8 · Cited by 87

Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis

Dalla, E., Papanicolaou, M., Park, M. D., Barth, N. D., Hou, R., Segura-Villalobos, D., Salazar, L. E. V., Sun, D., Forrest, A. R. R., Casanova-Acebes, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.016 · Cited by 92

Prostate cancer dormancy and recurrence

Cackowski, F. C., & Heath, E. I. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.037 · Cited by 82

Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy

Cackowski, F. C., Eber, M. R., Rhee, J., Decker, A. M., Yumoto, K., Berry, J. E., Lee, E., Shiozawa, Y., Jung, Y., Aguirre‐Ghiso, J. A., et al. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25768 · Cited by 78

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Wang, H., Pan, J., Barsky, L., Jacob, J. C., Zheng, Y., Gao, C., Wang, S., Zhu, W., Sun, H., Lu, L., et al. (2021) · Molecular Biomedicine · doi:10.1186/s43556-020-00022-z · Cited by 81

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

Seebacher, N. A., Krchniaková, M., Stacy, A. E., Skoda, J., & Jansson, P. J. (2021) · Antioxidants · doi:10.3390/antiox10111801 · Cited by 84

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Aouad, P., Zhang, Y., Martino, F. D., Stibolt, C., Ali, S., Ambrosini, G., Mani, S. A., Maggs, K., Quinn, H. M., Sflomos, G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32523-6 · Cited by 79

Cutting to the Chase: How Matrix Metalloproteinase-2 Activity Controls Breast-Cancer-to-Bone Metastasis

Tauro, M., & Lynch, C. C. (2018) · Cancers · doi:10.3390/cancers10060185 · Cited by 77

Bone as a Preferential Site for Metastasis

Sowder, M. E., & Johnson, R. W. (2018) · JBMR Plus · doi:10.1002/jbm4.10126 · Cited by 75

Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer

Papadaki, C., Stratigos, M., Markakis, G., Spiliotaki, M., Mastrostamatis, G., Nikolaou, C., Mavroudis, D., & Agelaki, S. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1001-3 · Cited by 77

Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy

Chen, J., Ding, Z., Li, S., Liu, S., Xiao, C., Li, Z., Zhang, B., Chen, X., & Yang, X. (2020) · Theranostics · doi:10.7150/thno.51383 · Cited by 77

Osteoclasts—Key Players in Skeletal Health and Disease

Novack, D. V., & Mbalaviele, G. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0011-2015 · Cited by 80

The CAM Model—Q&A with Experts

Fischer, D., Fluegen, G., Garcia, P., Ghaffari‐Tabrizi‐Wizsy, N., Gribaldo, L., Huang, R. Y., Rasche, V., Ribatti, D., Rousset, X., Pinto, M. T., et al. (2022) · Cancers · doi:10.3390/cancers15010191 · Cited by 82

The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer

Shiozawa, Y., Berry, J. E., Eber, M. R., Jung, Y., Yumoto, K., Cackowski, F. C., Yoon, H. J., Parsana, P., Mehra, R., Wang, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9251 · Cited by 73

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

Francescangeli, F., Angelis, M. L. D., Rossi, R., Cuccu, A., Giuliani, A., Maria, R. D., & Zeuner, A. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10092-4 · Cited by 80

Cellular Dormancy in Cancer: Mechanisms and Potential Targeting Strategies

Min, H.-Y., & Lee, H. (2023) · Cancer Research and Treatment · doi:10.4143/crt.2023.468 · Cited by 78

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

Tivari, S., Lü, H., Dasgupta, T., Lorenzo, M. S. D., & Wieder, R. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0259-5 · Cited by 73

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

Basnet, H., Tian, L. H., Ganesh, K., Huang, Y.-H., Macalinao, D. G., Brogi, E., Finley, L. W. S., & Massagué, J. (2019) · eLife · doi:10.7554/elife.43627 · Cited by 69

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

Dodagatta-Marri, E., Ma, H.-Y., Liang, B., Li, J., Meyer, D. S., Sun, K.-H., Ren, X., Zivak, B., Rosenblum, M. D., Headley, M. B., et al. (2020) · doi:10.1101/2020.05.14.084913 · Cited by 70

From latency to overt bone metastasis in breast cancer: potential for treatment and prevention

Salvador, F., Lope, A. L., & Gomis, R. R. (2019) · The Journal of Pathology · doi:10.1002/path.5292 · Cited by 73

Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells

Carpenter, R., Kwak, J., Peyton, S. R., & Lee, J. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0307-x · Cited by 69

Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs

Gui, J., Zahedi, F., Ortiz, A., Cho, C., Katlinski, K. V., Alicea-Torres, K. M., Li, J., Todd, L., Zhang, H., Beiting, D. P., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0064-0 · Cited by 70

Remodeling the ECM: Implications for Metastasis and Tumor Dormancy

Martino, J. S. D., Akhter, T., & Bravo‐Cordero, J. J. (2021) · Cancers · doi:10.3390/cancers13194916 · Cited by 70

Disseminated tumor cells and dormancy in prostate cancer metastasis

van der Toom, E. E., Verdone, J. E., & Pienta, K. J. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.002 · Cited by 68

Autophagy and Cancer Dormancy

Akkoç, Y., Peker, N., Akçay, A., & Gözüaçık, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.627023 · Cited by 71

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

Murali, B., Ren, Q., Luo, X., Faget, D. V., Wang, C., Johnson, R. M., Gruosso, T., Flanagan, K. C., Fu, Y., Leahy, K., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0234 · Cited by 67

Quiescent Cancer Cells—A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Lindell, E., Zhong, L., & Zhang, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043762 · Cited by 75

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Muranen, T. E., Selfors, L. M., Hwang, J., Gallegos, L. L., Coloff, J. L., Thoreen, C. C., Kang, S. A. W., Sabatini, D. M., Mills, G. B., & Brugge, J. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0155 · Cited by 66

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

Lee, H. R., Leslie, F., & Azarin, S. M. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0106-7 · Cited by 67

Systemic problems: a perspective on stem cell aging and rejuvenation.

Conboy, I. M., Conboy, M. J., & Rebo, J. (2015) · Aging · doi:10.18632/aging.100819 · Cited by 58

The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation

Yadav, A. S., Pandey, P. R., Butti, R., Radharani, N. N. V., Roy, S., Bhalara, S. R., Gorain, M., Kundu, G. C., & Kumar, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00072 · Cited by 66

A cell cycle centric view of tumour dormancy

Weston, W. A., & Barr, A. R. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02401-z · Cited by 68

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

Dropmann, A., Dediulia, T., Breitkopf‐Heinlein, K., Korhonen, H., Janicot, M., Weber, S. N., Thomas, M., Piiper, A., Bertrán, E., Fabregat, I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6967 · Cited by 69

miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche

Li, B., Xia, Y., Lv, J., Wang, W., Xuan, Z., Chen, C., Jiang, T., Fang, L., Wang, L., Li, Z., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02011-0 · Cited by 63

Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis

Zhuang, X., Zhang, H., & Hu, G. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.005 · Cited by 61

Tumor Dormancy: Implications for Invasion and Metastasis

Gomatou, G., Syrigos, N. K., Vathiotis, I. A., & Kotteas, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094862 · Cited by 63

Circulating tumor cells in the early detection of human cancers

Feng, Z., Wu, J., Lu, Y., Chan, Y.-T., Zhang, C., Wang, D., Luo, D., Huang, Y., Feng, Y., & Wang, N. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71768 · Cited by 60

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy

Ruppender, N. S., Larson, S. R., Lakely, B., Kollath, L. A., Brown, L. G., Coleman, I. M., COLEMAN, R. T., Nguyen, H. M., Nelson, P. S., Corey, E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130565 · Cited by 59

Chemokine-Cytokine Networks in the Head and Neck Tumor Microenvironment

Nisar, S., Yousuf, P., Masoodi, T., Wani, N. A., Hashem, S., Singh, M. K., Sageena, G., Mishra, D., Kumar, R., Haris, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094584 · Cited by 63

A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors

Orienti, I., Francescangeli, F., Angelis, M. L. D., Fecchi, K., Bongiorno‐Borbone, L., Signore, M., Peschiaroli, A., Boe, A., Bruselles, A., Costantino, A., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1775-y · Cited by 58

microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings

Fang, C., Dai, C.-Y., Mei, Z., Jiang, M., Gu, D.-N., Huang, Q., & Tian, L. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0697-3 · Cited by 57

Ecology and evolution of dormant metastasis

Blasco, M. T., Espuny, I., & Gomis, R. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.03.002 · Cited by 56

Microenvironment in metastasis: roadblocks and supportive niches

Pein, M., & Óskarsson, T. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00145.2015 · Cited by 59

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

Sauer, S. J., Reed, D. R., Ihnat, M. A., Hurst, R. E., Warshawsky, D., & Barkan, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.659963 · Cited by 59

The role of tumor microenvironment and exosomes in dormancy and relapse

Attaran, S., & Bissell, M. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.09.008 · Cited by 57

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

Powell, E., Shao, J., Picon, H. M., Bristow, C. A., Ge, Z., Peoples, M. D., Robinson, F. S., Jeter-Jones, S. L., Schlosberg, C. E., Grzeskowiak, C. L., et al. (2018) · npj Breast Cancer · doi:10.1038/s41523-018-0062-x · Cited by 55

PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p

Jiang, J., Zheng, M., Zhang, M., Yang, X., Li, L., Wang, S.-S., Wu, J.-S., Yu, X.-H., Wu, J.-B., Pang, X., et al. (2019) · Neoplasia · doi:10.1016/j.neo.2018.12.001 · Cited by 54

The role of TGF-β2 in cartilage development and diseases

Duan, M., Wang, Q., Liu, Y., & Xie, J. (2021) · Bone and Joint Research · doi:10.1302/2046-3758.108.bjr-2021-0086 · Cited by 55

Gene expression predicts dormant metastatic breast cancer cell phenotype

Ren, Q., Khoo, W. H., Corr, A. P., Phan, T. G., Croucher, P. I., & Stewart, S. A. (2022) · Breast Cancer Research · doi:10.1186/s13058-022-01503-5 · Cited by 57

5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

Singh, D. K., Carcamo, S., Farias, E., Hasson, D., Zheng, W., Sun, D., Huang, X., Cheung, J. F., Nobre, A. R., Kale, N., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112560 · Cited by 54

A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response–Dependent Survival of Quiescent Cancer Cells

Calvo, V., Zheng, W., Adam‐Artigues, A., Staschke, K. A., Huang, X., Cheung, J. F., Nobre, A. R., Fujisawa, S., Liu, D., Fumagalli, M., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1427 · Cited by 54

Dark Side of Cytotoxic Therapy: Chemoradiation-Induced Cell Death and Tumor Repopulation

Jiang, M., Gu, D.-N., Dai, J., Huang, Q., & Tian, L. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.01.018 · Cited by 54

Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis

Pan, X., Zhang, H., Xu, D., Chen, J., Chen, W., Gan, S., Qu, F., Chu, C., Cao, J., Fan, Y., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.46645 · Cited by 55

Cancer Cell Dormancy in MetastasisPreprint

Summers, M. A., McDonald, M. M., & Croucher, P. I. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037556 · Cited by 55

Matters of context guide future research in TGFβ superfamily signaling

Akhurst, R. J., & Padgett, R. W. (2015) · Science Signaling · doi:10.1126/scisignal.aad0416 · Cited by 52

In vitro Models of Breast Cancer Metastatic Dormancy

Montagner, M., & Sahai, E. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00037 · Cited by 50

Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis

Jiao, Y., Yu, Y., Zheng, M., Yan, M., Wang, J., Zhang, Y., & Zhang, S. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1567 · Cited by 51

Stromal contributions to the carcinogenic process

Spaw, M. C., Anant, S., & Thomas, S. M. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22583 · Cited by 54

Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

Montagner, M., & Dupont, S. (2020) · Cells · doi:10.3390/cells9010250 · Cited by 52

Cellular dormancy in minimal residual disease following targeted therapy

Ruth, J. R., Pant, D. K., Pan, T.-C., Seidel, H. E., Baksh, S. C., Keister, B. A., Singh, R., Sterner, C. J., Bakewell, S. J., Moody, S. E., et al. (2021) · Breast Cancer Research · doi:10.1186/s13058-021-01416-9 · Cited by 52

Mechanisms of colorectal liver metastasis development

Shasha, T., Gruijs, M., & van Egmond, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04630-6 · Cited by 51

Dormancy in Breast CancerPreprint

Dalla, E., Sreekumar, A., Aguirre‐Ghiso, J. A., & Chodosh, L. A. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041331 · Cited by 52

Concise Review: Breast Cancer Stem Cells: Regulatory Networks, Stem Cell Niches, and Disease Relevance

Guo, W. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0020 · Cited by 52

COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis

Zheng, Y., Comaills, V., Burr, R., Boulay, G., Miyamoto, D. T., Wittner, B. S., Emmons, E., Sil, S., Koulopoulos, M. W., Broderick, K. T., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819303116 · Cited by 49

Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer

Wang, H., Wang, S., Huang, M.-C., Liang, X., Tang, Y.-J., & Tang, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00498 · Cited by 55

Site‐specific metastasis: A cooperation between cancer cells and the metastatic microenvironment

Izraely, S., & Witz, I. P. (2020) · International Journal of Cancer · doi:10.1002/ijc.33247 · Cited by 52

The bone marrow niche in support of breast cancer dormancy

Walker, N. D., Patel, J. S., Munoz, J. L., Hu, M. D., Guiro, K., Sinha, G., & Rameshwar, P. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.033 · Cited by 47

Current and Emerging Therapies for Bone Metastatic Castration-Resistant Prostate Cancer

Frieling, J. S., Basanta, D., & Lynch, C. C. (2015) · Cancer Control · doi:10.1177/107327481502200114 · Cited by 47

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H., & Nakayama, K. I. (2019) · JCI Insight · doi:10.1172/jci.insight.125138 · Cited by 53

Metabolic Features of Tumor Dormancy: Possible Therapeutic Strategies

Pranzini, E., Raugei, G., & Taddei, M. L. (2022) · Cancers · doi:10.3390/cancers14030547 · Cited by 51

Breast Cancer Metastatic Dormancy and Relapse: An Enigma of Microenvironment(s)

Elkholi, I. E., Lalonde, A., Park, M., & Côté, J. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1902 · Cited by 48

Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth

Li, X., Kang, Y., Roife, D., Lee, Y., Pratt, M. F., Perez, M. V. R., Dai, B., Koay, E. J., & Fleming, J. B. (2017) · Oncogene · doi:10.1038/onc.2017.125 · Cited by 47

Tumor dormancy as an alternative step in the development of chemoresistance and metastasis - clinical implications

Rossari, F., Zucchinetti, C., Buda, G., & Orciuolo, E. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00467-7 · Cited by 46

The Hallmarks of Cancer as Ecologically Driven Phenotypes

Somarelli, J. A. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.661583 · Cited by 46

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial

DeMichele, A. M., Clark, A. S., Shea, E. K., Bayne, L. J., Sterner, C. J., Rohn, K., Dwyer, S., Pan, T.-C., Nivar, I., Chen, Y., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03877-3 · Cited by 45

Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis

Graham, N., & Qian, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041121 · Cited by 45

Circulating tumor cells and their advances to promote cancer metastasis and relapse, with focus on glioblastoma multiforme

Chistiakov, D. A., & Chekhonin, V. P. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.07.007 · Cited by 44

Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

Cheung, A. H. K., Hui, C. H., Wong, K. Y., Liu, X., Chen, B., Kang, W., & To, K. F. (2022) · International Journal of Cancer · doi:10.1002/ijc.34288 · Cited by 47

Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer

Choi, S., Whitman, M. A., Shimpi, A. A., Sempertegui, N. D., Chiou, A. E., Druso, J. E., Verma, A., Lux, S. C., Cheng, Z., Paszek, M. J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01077-3 · Cited by 47

Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy

Nobutani, K., Shimono, Y., Mizutani, K., Ueda, Y., Suzuki, T., Kitayama, M., Minami, A., Momose, K., Miyawaki, K., Akashi, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130032 · Cited by 43

Tumor cell dormancy as an adaptive cell stress response mechanism

Ramírez, L. V., & Hunter, K. W. (2017) · F1000Research · doi:10.12688/f1000research.12174.1 · Cited by 43

ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis

Michael, I. P., Saghafinia, S., Tichet, M., Zangger, N., Marinoni, I., Perren, A., & Hanahan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.015 · Cited by 42

Regulation of Metastatic Tumor Dormancy and Emerging Opportunities for Therapeutic Intervention

Tamamouna, V., Pavlou, E., Neophytou, C. M., Papageorgis, P., & Costeas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213931 · Cited by 46

How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy

Nasr, M., & Lynch, C. C. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10124-z · Cited by 44

Disseminated tumour cells in bone marrow are the source of cancer relapse after therapy

Sai, B., & Xiang, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13867 · Cited by 44

Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis

Cook, L. M., Frieling, J. S., Nerlakanti, N., McGuire, J., Stewart, P. A., Burger, K. L., Cleveland, J. L., & Lynch, C. C. (2019) · Oncogene · doi:10.1038/s41388-019-0913-4 · Cited by 40

HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer

Clements, M. E., Holtslander, L., Edwards, C. M., Todd, V. M., Dooyema, S. D. R., Bullock, K. K., Bergdorf, K. N., Zahnow, C. A., Connolly, R. M., & Johnson, R. W. (2021) · Oncogene · doi:10.1038/s41388-021-01931-1 · Cited by 42

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

Tang, Y., Lei, Z.-G., Wang, S., Liang, X., & Ren, X. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s95633 · Cited by 41

Disseminated cancer cells in breast cancer: Mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities

Ramamoorthi, G., Kodumudi, K. N., Gallen, C., Zachariah, N. N., Basu, A. B., Albert, G. K., Beyer, A., Snyder, C., Wiener, D. A., Costa, R. L. B., et al. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.004 · Cited by 42

Abstract 5234: Microenvironmental signals dictate disseminated tumor cells (DTCs) fate through regulation of TGFβII and p38α

Bragado, P., Estrada, Y. D., Sosa, M. S., Schewe, D. M., Capobianco, C. S., Moore, K. A., Fariña, H. G., & Aguirre‐Ghiso, J. A. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-5234 · Cited by 3

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

Recalde‐Percaz, L., la Guia-Lopez, I. D., Linzoain-Agos, P., Noguera‐Castells, A., Rodrigo‐Faus, M., Jauregui, P., López‐Plana, A., Fernández‐Nogueira, P., Iniesta‐González, M., Cueto‐Remacha, M., et al. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101220 · Cited by 7

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumour cells dormancy escape and promotes metastasis outgrowthPreprint

Recalde‐Percaz, L., Jáuregui, P., López‐Plana, A., Fernández‐Nogueira, P., Iniesta‐González, M., Manzano, S., Alonso, R., Noguera‐Castells, A., Moragas, N., Baquero, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1956933/v1

Control of disseminated breast cancer cell dormancy in the bone marrow by TGFβ2 and BMP4 signaling

Risson, E. (2022) · theses.fr (ABES) · doi:10.70675/3371f566z1bcdz4181z87bfza563bd174f81

The role of the microenvironment-dormant prostate disseminated tumor cells in the bone marrow

Lam, H., Vessella, R. L., & Morrissey, C. M. (2014) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2014.02.002 · Cited by 27