A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
Mohseni, Morvarid, Sun, Jianlong, Lau, Allison, Curtis, Stephen, Goldsmith, Jeffrey, Fox, Victor L., Wei, Chongjuan, Frazier, Marsha, Samson, Owen, Wong, Kwok-Kin, Kim, Carla, Camargo, Fernando D.·2014·Nature Cell Biology
DOI 10.1038/ncb2884
Cited by (290)
Items 201–290 of 290
- KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combinationRafael Rosell, Eloisa Jantus Lewintre, Peng Cao, Xueting Cai, B. Xing, Masaoki Ito, Jose Luis Gomez-Vazquez, Mireia Marco-Jordán, Silvia Calabuig Fariñas, Andrés Felipe Cardona et al. · 2024 · Cell Communication and Signaling
- Regulation of the Hippo signaling pathway by deubiquitinating enzymes in cancerAshley L. Mussell, Costa G. Frangou, Jianmin Zhang · 2019 · Genes & Diseases
- Targeting YAP/TAZ–TEAD and their protein-protein interaction for precision cancer therapyFangyuan Chen, Jinxuan Su, Yongqi Liu, Zhijing Zhang, Sijia Li, Yonggang Yuan, Jianqin Lai · 2025 · European Journal of Medicinal Chemistry
- Targeting YAP/TAZ in Combination with PD-L1 Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC)Kostas A. Papavassiliou, Georgios Marinos, Athanasios G. Papavassiliou · 2023 · Cells
- The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScribLorenzo Messa, Marta Celegato, Chiara Bertagnin, Beatrice Mercorelli, Gualtiero Alvisi, Lawrence Banks, Giorgio Palù, Arianna Loregian · 2021 · Cancers
- YAP and TAZ Regulate Cc2d1b and Purβ in Schwann CellsSophie Belin, Jacob Herron, Jordan J. S. VerPlank, Yungki Park, Laura M. Feltri, Yannick Poitelon · 2019 · Frontiers in Molecular Neuroscience
- Clinical potential of the Hippo-YAP pathway in bladder cancerXin Cheng, Kecheng Lou, Liang Ding, Xiaofeng Zou, Ruohui Huang, Gang Xu, Junrong Zou, Guoxi Zhang · 2022 · Frontiers in Oncology
- Low Expression of CAPON in Glioma Contributes to Cell Proliferation via the Akt Signaling PathwayShangfeng Gao, Jie Wang, Tong Zhang, Guangping Liu, Lei Jin, Daofei Ji, Peng Wang, Qingming Meng, Yufu Zhu, Rutong Yu · 2016 · International Journal of Molecular Sciences
- The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in DiseasesWenshuo Xie, Nianhong Xing, Jicheng Qu, Dongwu Liu, Qiuxiang Pang · 2023 · International Journal of Molecular Sciences
- MARK2 inhibits the growth of HeLa cells through AMPK and reverses epithelial-mesenchymal transitionGe Xu, Yinggang Ge, Xiaohong Tao, Qing Gao, Xiaoyan Liang · 2017 · Oncology Reports
- Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2Jiafu Ying, Yinghong Yang, Xuanpu Zhang, Ze Dong, Baoen Chen · 2024 · Proceedings of the National Academy of Sciences
- Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung developmentKatsumi Fumoto, Hisako Takigawa-Imamura, Kenta Sumiyama, Shige H. Yoshimura, Natsumi Maehara, Akira Kikuchi · 2019 · Journal of Cell Science
- Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancersHui Men Selina Chin, Karandeep Nandra, Joanna Clark, Viji M. Draviam · 2014 · Frontiers in Physiology
- EXPLICIT‐Kinase: A gene expression predictor for dissecting the functions of the Arabidopsis kinomeYuming Peng, Wanzhu Zuo, Hui Zhou, Fenfen Miao, Yu Zhang, Yue Qin, Yi Liu, Yu Long, Shisong Ma · 2022 · Journal of Integrative Plant Biology
- Phosphorylation analysis of the Hippo-YAP pathway using Phos-tagCho-Long Kim, Subin Lim, Kyeongseob Kim, Han-Sol Jeong, Jung‐Soon Mo · 2022 · Journal of Proteomics
- Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?Wun‐Jae Kim · 2015 · International Neurourology Journal
- New insights in Hippo signalling alteration in human papillomavirus-related cancersLeslie Olmedo‐Nieva, J. Omar Muñoz-Bello, Joaquín Manzo-Merino, Marcela Lizano · 2020 · Cellular Signalling
- Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinaseJohn R. Ferrarone, Jerin Thomas, Arun M. Unni, Yuxiang Zheng, Michal J. Nagiec, Eric E. Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano et al. · 2024 · Proceedings of the National Academy of Sciences
- Luciferase Reporter Assays to Determine YAP/TAZ Activity in Mammalian CellsSirio Dupont · 2018 · Methods in molecular biology
- Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1Yuhang Wang · 2024 · ImmunoHorizons
- Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescenceTakao Ito, Tatsushi Igaki · 2021 · Science Signaling
- PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposisJennifer L. Cotton, Kyvan Dang, Lu Hu, Yang Sun, Alka Singh, Mihir Rajurkar, Qi Li, Xu Wu, Junhao Mao · 2022 · Cell Reports
- Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanomaUsman Baqai, Alison Kurimchak, Isabella V. Trachtenberg, Timothy J. Purwin, Jelan I. Haj, Anna Han, Kristine Luo, Nikole Fandiño Pachon, Angela Jeon, Vivian Y.L. Chua et al. · 2023 · Journal of Biological Chemistry
- Non-hippo kinases: indispensable roles in YAP/TAZ signaling and implications in cancer therapyJun Zhu, Tiantian Wu, Qiong Lin · 2023 · Molecular Biology Reports
- New Horizons in Cancer Progression and Metastasis: Hippo Signaling PathwayMurali R. Kuracha, Uppala Radhakrishna, Sreenaga V. Kuracha, Navyasri Vegi, Jhyama Lhamo Gurung, Benita L. McVicker · 2024 · Biomedicines
- Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision MedicineToshinori Ando, Kento Okamoto, Tomoaki Shintani, Souichi Yanamoto, Mutsumi Miyauchi, Jorge Silvio Gutkind, Mikihito Kajiya · 2022 · Journal of Personalized Medicine
- RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1Thanh Nguyen, Adela Ralbovska, Jan‐Michael Kugler · 2020 · G3 Genes Genomes Genetics
- Polarity Determinants in Dendritic Spine Development and PlasticityHuaye Zhang · 2015 · Neural Plasticity
- TEAD transcription factor family emerges as a promising therapeutic target for oral squamous cell carcinomaShuang Wang, Dan Shao, Xiaoyan Gao, Peng Zhao, Fanzhi Kong, Jiawei Deng, Lianzhu Yang, Wei Shang, Yaping Sun, Zhiguang Fu · 2024 · Frontiers in Immunology
- Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer PathwaySusanna Plugge, H. Ma, Jelte van der Vaart, Joep Sprangers, Folkert H.M. Morsink, Despina Xanthakis, C. Jamieson, K B W Stroot, A. Keijzer, Thanasis Margaritis et al. · 2025 · Gastroenterology
- Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular CarcinomaChiara Andolfi, Claudio Tiribelli, Devis Pascut · 2022 · Frontiers in Bioscience-Landmark
- Structure of the complex of phosphorylated liver kinase B1 and 14-3-3ζYongjian Lu, Sheng Li Ding, Ruiqing Zhou, Jianyong Wu · 2017 · Acta Crystallographica Section F Structural Biology Communications
- Erratum: Corrigendum: A genetic screen identies an LKB1–MARK signalling axis controlling the Hippo–YAP pathwayMorvarid Mohseni, Jianlong Sun, Allison N. Lau, Stephen J. Curtis, Jeffrey D. Goldsmith, Victor L. Fox, Chongjuan Wei, Marsha L. Frazier, Owen J Samson, Kwok‐Kin Wong et al. · 2014 · Nature Cell Biology
- Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and MetastasisCamino Bermejo‐Rodríguez, Joaquín Araos Henríquez, Giuseppina Caligiuri, Sara Pinto Teles, Youngkyu Park, Anthony Evans, Lawrence N. Barrera, Albrecht Neeße, Robert Grützmann, Daniela Ellen Aust et al. · 2024 · Cancer Research
- KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activationShiny Shengzhen Guo, Zhiying Liu, Guan Wang, Zhiqi Sun, Kaikai Yu, James P. Fawcett, Reinhard Büttner, Bo Gao, Reinhard Faessler · 2024 · Nature Communications
- Methods to assess small molecule allosteric modulators of the STRAD pseudokinaseTingting Qing, Jin Liu, Fen Liu, Dom C. Mitchell, Richard T. Beresis, John Dozier Gordan · 2022 · Methods in enzymology on CD-ROM/Methods in enzymology
- Connections between cadherin-catenin proteins, spindle misorientation, and cancerMarta N. Shahbazi, Mirna Pérez‐Moreno · 2015 · Tissue Barriers
- Targeting the Hippo Pathway to Improve Response to ChemotherapyYulei Zhao, Xiaolong Yang · 2018 · Elsevier eBooks
- Breast cancer drug resistance: Decoding the roles of Hippo pathway crosstalkFariba Dehghanian, Laleh Ebrahimi Ghahnavieh, Amirhossein Naghsh Nilchi, Sheyda Khalilian, Rezvan Joonbakhsh · 2024 · Gene
- Molecular Bases for Combinatorial Treatment Strategies in Patients with KRAS Mutant Lung Adenocarcinoma and Squamous Cell Lung CarcinomaChiara Lazzari, Alberto Verlicchi, Αναστάσιος Γκουντάκος, Sara Pilotto, Mariacarmela Santarpía, Imane CHAIB-OUKADOUR, José Luis Ramírez, Santiago Viteri, Daniela Morales-Espinosa, Claudio Dazzi et al. · 2016 · Pulmonary Therapy
- MicroRNA-135b as therapeutic target in cancers2015 · RNA & DISEASE
- The role of Capon in multiple myelomaYaodong Shen, Haiyan Liu, Siyu Gu, Ziwei Wei, Hong Liu · 2017 · Tumor Biology
- Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRADLin Song, Dominique C. Mitchell, Jin Liu, Logan B. Leak, Rigney E. Turnham, LeeAnn Wang, Zheng Wang, Changliang He, Luo Ding, Marc Adler et al. · 2026 · Cell chemical biology
- [Role of Hippo Signaling Pathway in Lung Cancer].Yuechao Liu, Ying Xing, Li Cai · 2017 · Europe PMC (PubMed Central)
- The role of the neural NO synthase adapter protein in the pathogenesis of metabolic syndrome and type 2 diabetes mellitusLudmila A. Kuznetsova, Nataliia E. Basova · 2023 · Сибирский научный медицинский журнал
- Tumor suppressor genes and KRAS G12C inhibitor resistance in non-small cell lung cancerLinsha Zhu, Xiangbo Jia, Lei Xu, Li Chen, Xiangning Fu, Hua Yan, Bo Ai, Shu Peng · 2025 · iScience
- STK11 Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical AdenocarcinomaEmma Robinson, Elisabeth A. Murphy, Anaseidy Albanez, Sonam Tulsyan, Hong Lou, Yi Xie, Weiyin Zhou, Qian Yang, Tawnjerae R. Joe, Tongwu Zhang et al. · 2026 · Cancer Medicine
- Navigating the Maze of Kinases: CaMK-like Family Protein Kinases and Their Role in AtherosclerosisJules T. J. Teuwen, Emiel P. C. van der Vorst, Sanne Lidewij Maas · 2024 · International Journal of Molecular Sciences
- Section IV: Non–small cell lung cancer and malignant melanomaKevin E. Fisher, Rathi Narayana Pillai, Ragini Reiney Kudchadkar, Michael R. Rossi · 2014 · Current Problems in Cancer
- Integrative High-Throughput RNAi Screening Identifies BRSK1, STK32C and STK40 as Novel Activators of YAP/TAZMandeep K. Gill, Siyuan Song, Tania Y. Christova, Liliana Attisano · 2025 · International Journal of Molecular Sciences
- The role of LKB1 in prostate cancer: implications for tumor progression and therapyYuwei Liang, Hongliang Cao, Zhijun Tang, Shuxin Li, Gang Yang, Shuai Dong, Hao Du, Jinguo Wang · 2025 · Frontiers in Cell and Developmental Biology
- Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancerPeiqiang Yan, Weiwei Jiang, Xutong Xue, Tao Hou, Jingchao Wang, Daoyuan Huang, Li Chen, Hiroyuki Inuzuka, Xiaoming Dai, Wenyi Wei · 2026 · Cancer Letters
- LKB1: Controlling Quiescence and Genomic Integrity at HomeCarmen Berasain, Matias Antonio Avila · 2018 · Trends in Endocrinology and Metabolism
- Verteporfin mitigates sepsis-induced liver injury by blocking macrophage-derived inflammationYaopeng Yang, Anxiu Wang, Su Zhang, Guangming Peng, Wu Haiying · 2022 · Tropical Journal of Pharmaceutical Research
- Evaluation of Quantification and Normalization Strategies for Phosphoprotein Phosphatase Affinity Proteomics: Application to Breast Cancer SignalingBrooke L. Brauer, Kwame Wiredu, Scott A. Gerber, Arminja Nadine Kettenbach · 2022 · Journal of Proteome Research
- Differentiation and Development of the Bovine BlastocystVerónica M. Negrón‐Pérez · 2017 · PhDT
- Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesisChang-Soo Seong, Chunzi Huang, Austin C. Boese, Yuning Hou, Junghui Koo, Janna K. Mouw, Manali Rupji, Greg Joseph, H. Richard Johnston, Henry Claussen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cellsYebin Wang, Zhenxing Zhong, Yu Wang, Ying Zhu, Kun‐Liang Guan, Fa‐Xing Yu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Study of the Hippo/YAP1 signaling pathway in gastric carcinogenesis induced by Helicobacter pyloriSilvia Molina‐Castro · 2017 · theses.fr (ABES)
- Novel Posttranslational Modification in LKB1 Activation and FunctionSzu-Wei Lee · 2014 · Digital Commons-TMC (Texas Medical Center)
- Heat shock protein 27 inhibits the Hippo tumor suppressor pathway by facilitating MST1 proteasomal degradationSepideh Vahid · 2017 · cIRcle (University of British Columbia)
- WITHDRAWN: Regulation of Pyruvate Kinase M Switch towards PKM1 by LKB1-AMPK Axis Tolerates Hypoglycemic Stress in Cancer CellsGopinath Prakasam, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Ashu Bhan Tiku, Ramesh N K Bamezai · 2016 · Journal of Biological Chemistry · Retracted
- Characterization of ALDH1A1 as a novel tumorigenic target mediating TAZ-induced lung tumorigenesis and stem cell phenotypesJihang Yu · 2016 · QSpace (Queen's University Library)
- Identification and Characterization of Novel Upstream Regulators of the Hippo Signalling PathwayEmad Heidaryarash · 2018 · TSpace (University of Toronto)
- Hippo signaling pathway regulation of innate immune responseChengGang ZOU, Hui Han, YiCheng MA · 2019 · Scientia Sinica Vitae
- An integrative resource for investigating genetic model of drug response in cancerYi Guo, Xiang Chen · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- SPINT2 Suppresses Hippo Effector YAP and Limits Cellular Tolerance for AneuploidyHuadi Zhang · 2017 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A DissertationCheng Chang · 2015 · eScholarship@UMassChan
- YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney diseaseGiulia Ferri, Valentine Goffette, Esther Porée, Simone Braeg, Shana Carvalho, Marceau Quatredeniers, E. Wolfgang Kuehn, Sophie Saunier, Amandine Viau · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.Andrew C. Dudley · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- MAP/Microtubule Affinity-Regulating KinaseElizabeth I. Tang, C. Yan Cheng · 2016 · Springer eBooks
- MAP/Microtubule Affinity-Regulating KinaseElizabeth I. Tang, C. Yan Cheng · 2017 · Springer eBooks
- Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysisGuojiang Tan, Baiying Liu · 2023 · Scientific Reports
- Scribble Me This: The Basolateral Polarity Complex Regulates Hippo SignalingTobey Colston · 2023 · OSF Preprints (OSF Preprints)
- The Role of PDZ in Cerebral IschemiaYeting Chen, Yisi Shan, Wenping Cao, Ye Cao, Jianfeng Pu · 2024 · Modern Chemistry
- The ARK side of the cell: Kinases, metabolism, and therapeutic potential in malignanciesViviana Coliboro-Dannich, Alejandro Farías, Luis Espinoza-Francine, M Andrea Concha-Vega, Karen Almendras-Durán, Ana María Salazar, Roxana Pincheira, Ariel Fernando Castro · 2025 · Pharmacological Research
- Additional file 3 of Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathwaysHyuk Moon, Hyunjung Park, Min Jee Chae, Choi, Hye Jin, Kim, Do Young, Simon Weonsang Ro · 2022 · Figshare
- Additional file 1 of KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combinationRafael Rosell, Eloisa Jantus Lewintre, Cao, Peng, Cai, Xueting, B. Xing, Ito, Masaoki, Jose Luis Gomez-Vazquez, Mireia Marco-Jordán, Silvia Calabuig Fariñas, Cardona, Andrés Felipe et al. · 2024 · Figshare
- Additional file 1 of Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathwaysHyuk Moon, Hyunjung Park, Min Jee Chae, Choi, Hye Jin, Kim, Do Young, Simon Weonsang Ro · 2022 · Figshare
- Additional file 2 of Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathwaysHyuk Moon, Hyunjung Park, Min Jee Chae, Choi, Hye Jin, Kim, Do Young, Simon Weonsang Ro · 2022 · Figshare
- A novel effect of bevacizumab in reducing characteristic pigmentation in Peutz–Jeghers syndrome: a case report and literature reviewDi Wu, Xinyue Liu, Song Wang, Huanyu Zhang, Guofeng Qu, Lina Wang · 2026 · Frontiers in Oncology
- Oral Cancer and Lipids—Bridging the Gap between Health and Disease: A ReviewDinraj Kulkarni, Sachin Sarode, Sajda Khan Gajdhar, Dhananjay B Ghunawat, Apurva Naik, Gargi Sachin Sarode · 2026 · World Journal of Dentistry
- Caractérisation fonctionnelle du complexe LKB1/STRADß au cil primaire et les conséquences au cours de la tumorigenèsePauline Maurin · 2016 · theses.fr (ABES)
- The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disordersVera Lúcia Margarido Pinheiro · 2014 · theses.fr (ABES)
- The Noncanonical Role of Hippo Signaling in CancerXu Li, Jin Jiang · 2026 · Cold Spring Harbor Perspectives in Biology
- Régulation de la voie de signalisation Hippo/YAP/TAZ dans la carcinogenèse gastrique induite par Helicobacter pylori et les propriétés tumorigéniques et invasives des cellules souches cancéreusesCamille Tiffon · 2020 · theses.fr (ABES)
- Study of Hippo effectors, Yap1 et Wwrt1, during proepicardium formationLaia Ortiz López · 2021 · theses.fr (ABES)
- Hippo-YAP1 dysregulation as a central driver of therapeutic resistance in cancer: Mechanisms and targeting therapeutic strategiesJiahui Zhao, Wanjie Zheng, Yan Zhang, Jinhan He, Hongyu Shan, Baojie Wang, Li Guo, Tingming Liang · 2026 · Critical Reviews in Oncology/Hematology
- Greatwall kinase regulates acute myeloid leukaemia cell division through a non-canonical mechanismSandra M. Martín‐Guerrero, Tommy Shields, Pedro Casado, Róbert Zach, Vinothini Rajeeve, Nadia Afroz-Nishat, Irbaz I. Badshah, Megan Meredith, William R. Foster, Helfrid Hochegger et al. · 2026 · EMBO Reports
- BindingDB Entry 50015582: Development and Therapeutic Potential of NUAKs Inhibitors.BindingDB · 2023 · UC San Diego