Cited by 518Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Open access

Chau, You-Ying, Bandiera, Roberto, Serrels, Alan, Martínez-Estrada, Ofelia M., Qing, Wei, Lee, Martin, Slight, Joan, Thornburn, Anna, Berry, Rachel, McHaffie, Sophie, Stimson, Roland H., Walker, Brian R., Chapuli, Ramon Muñoz, Schedl, Andreas, Hastie, Nick·2014·Nature Cell Biology

DOI 10.1038/ncb2922PMC PMC4060514

Open this paper in CoChat — free account

Abstract

Fuelled by the obesity epidemic, there is considerable interest in the developmental origins of white adipose tissue (WAT) and the stem and progenitor cells from which it arises. Whereas increased visceral fat mass is associated with metabolic dysfunction, increased subcutaneous WAT is protective. There are six visceral fat depots: perirenal, gonadal, epicardial, retroperitoneal, omental and mesenteric, and it is a subject of much debate whether these have a common developmental origin and whether this differs from that for subcutaneous WAT. Here we show that all six visceral WAT depots receive a significant contribution from cells expressing Wt1 late in gestation. Conversely, no subcutaneous WAT or brown adipose tissue arises from Wt1-expressing cells. Postnatally, a subset of visceral WAT continues to arise from Wt1-expressing cells, consistent with the finding that Wt1 marks a proportion of cell populations enriched in WAT progenitors. We show that all visceral fat depots have a mesothelial layer like the visceral organs with which they are associated, and provide several lines of evidence that Wt1-expressing mesothelium can produce adipocytes. These results reveal a major ontogenetic difference between visceral and subcutaneous WAT, and pinpoint the lateral plate mesoderm as a major source of visceral WAT. They also support the notion that visceral WAT progenitors are heterogeneous, and suggest that mesothelium is a source of adipocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ncb2922

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
White Fat Progenitor Cells Reside in the Adipose Vasculature
Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D., & Graff, J. M. (2008) · Science · doi:10.1126/science.1156232 · Cited by 1,113
Pericardial Fat, Visceral Abdominal Fat, Cardiovascular Disease Risk Factors, and Vascular Calcification in a Community-Based Sample
Rosito, G. A., Massaro, J. M., Hoffmann, U., Ruberg, F. L., Mahabadi, A. A., Vasan, R. S., O’Donnell, C. J., & Fox, C. S. (2008) · Circulation · doi:10.1161/circulationaha.107.743062 · Cited by 1,021
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 980
Characterization of the adipocyte cellular lineage in vivo
Berry, R., & Rodeheffer, M. S. (2013) · Nature Cell Biology · doi:10.1038/ncb2696 · Cited by 566
Self-citation
The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)
Ding, J., Hsu, F., Harris, T. B., Liu, Y., Kritchevsky, S. B., Szklo, M., Ouyang, P., Espeland, M. A., Lohman, K. K., Criqui, M. H., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27358 · Cited by 476
The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 396
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
Martínez-Estrada, O. M., Lettice, L. A., Essafi, A., Guadix, J. A., Slight, J., Velecela, V., Hall, E. A., Reichmann, J., Devenney, P. S., Hohenstein, P., et al. (2009) · Nature Genetics · doi:10.1038/ng.494 · Cited by 369
Self-citation
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns
Tchkonia, T., Lenburg, M. E., Thomou, T., Giorgadze, N., Frampton, G. M., Pirtskhalava, T., Cartwright, A., Cartwright, M., Flanagan, J. N., Karagiannides, I., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00202.2006 · Cited by 365
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors
Sánchez-Gurmaches, J., Hung, C., Sparks, C. A., Tang, Y., Li, H., & Guertin, D. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.003 · Cited by 360

Flagged first, then by citations

Show all 29 references

Sorted by citations

Items 401–500 of 515

Endothelial Angpt2 Promotes Adipocyte Progenitor Cells Maturation to Increase Visceral Adipose Tissue Accumulation
Yi, X., Ling, J., Tang, Y., Cai, J., Zhu, S., & Zhu, L. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70012 · Cited by 3
An epigenome atlas of mouse adipocytes
Hinte, L. C., Ghosh, A., Castellano‐Castillo, D., Wolfrum, C., & von Meyenn, F. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102197 · Cited by 4
Cardiometabolic Syndrome
Kanodia, A. K., & Noland, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-30730-1_46 · Cited by 3
Robotic omentectomy in gynecologic oncology: surgical anatomy, indications, and a technical approach
Feuer, G. A., Briskin, C., & Lakhi, N. A. (2023) · Journal of Robotic Surgery · doi:10.1007/s11701-022-01519-1 · Cited by 3
Sex-Specific Effects of Long-Term Antipsychotic Drug Treatment on Adipocyte Tissue and the Crosstalk to Liver and Brain in Rats
Fehsel, K., & Bouvier, M.-L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042188 · Cited by 3
A Basic Study to Establish a Nutrition Education System for Welfare Facilities for the Elderly at Home Using Body Composition Analysis and Nutritional Management Cards
Lee, S. H., & Lee, S.-L. (2024) · The Korean Journal of Community Living Science · doi:10.7856/kjcls.2024.35.3.471 · Cited by 3
Epicardium-myocardium crosstalk orchestrates heart development
Nusrat, A., & Wu, M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1655878 · Cited by 3
Expression of Wilm’s Tumor Gene (WT1) in Endometrium with Potential Link to Gestational Vascular Transformation
Zhang, P. (2020) · Reproductive Medicine · doi:10.3390/reprodmed1010003 · Cited by 3
Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with severe obesity
Clément, A., Lacaille, M., Lounis, M. A., Biertho, L. D., Richard, D., Lemieux, I., Bergeron, J., Mounier, C., Joanisse, D. R., & Mauriège, P. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00855-4 · Cited by 3
Multiphoton Microscopy for Visualizing Lipids in Tissue
Lee, M. W., & Serrels, A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-4023-3_9 · Cited by 3
Self-citation
Comprendre le développement des muscles et des tissus adipeux : un préalable pour maîtriser les qualités des carcasses et des produits des animaux d’élevage
Bonnet, M., Louveau, I., Cassar‐Malek, I., Lefaucheur, L., & Rescan, P. (2020) · INRAE Productions Animales · doi:10.20870/productions-animales.2015.28.2.3021 · Cited by 3
Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.
Andrés‐Delgado, L., Galardi‐Castilla, M., Mercader, N., & Santamarı́a, L. (2020) · PubMed · doi:10.14670/hh-18-238 · Cited by 3
Epicardial Adipose Tissue in the Progression and Calcification of the Coronary Artery Disease
Luna‐Luna, M., Zentella‐Dehesa, A., & Pérez-Méndez, O. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_11 · Cited by 3
Effects of ACTH-Induced Long-Term Hypercortisolism on the Transcriptome of Canine Visceral Adipose Tissue
Pereira, M. T., Martin, I., Rehrauer, H., Kowalewski, M. P., Boretti, F. S., & Sieber‐Ruckstuhl, N. S. (2022) · Veterinary Sciences · doi:10.3390/vetsci9060250 · Cited by 3
Fat cell progenitors get singled out
Chau, Y.-Y., & Cawthorn, W. (2019) · Science · doi:10.1126/science.aax2967 · Cited by 3
Self-citation
Integration of single cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genesPreprint
Sukhatme, M. G., Kar, A., Arasu, U. T., Lee, S. H., Alvarez, M., Garske, K. M., Gelev, K. Z., Rajkumar, S., Das, S. S., Kamińska, D., et al. (2024) · medRxiv · doi:10.1101/2024.11.22.24317804 · Cited by 5
Single-cell chromatin accessibility and lipid profiling reveals SCD1-dependent metabolic shift in adipocytes induced by bariatric surgery
Harlan, B., Park, H. G., Spektor, R., Cummings, B. P., Brenna, J. T., & Soloway, P. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261783 · Cited by 2
The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches
Sexton, C. L., Meza‐Perez, S., Παπανικολάου, Κ., Kaminski, T. M., Nowacka-Chmielewska, M. M., Rodak, P., Lin, Y., Buford, T. W., Morris, P. E., Englund, D. A., et al. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00203.2025 · Cited by 2
Perirenal fat thickness may be a significant predictor of prognosis and postoperative renal function in renal cancer surgery patients
Tang, H., Xie, Y., Yang, L., Zhang, L., Fu, Q., Huang, Y., Huang, T., Wen, D., Ye, B., Yang, X., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-17865-7 · Cited by 2
Insights into current models for developing brown adipocytes from induced pluripotent stem cells
Butts, J. C., Martino, J., & Brown, A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823884-4.00004-3 · Cited by 2
The Effect of High-Intensity Interval Training on the Adiponectin and TNF-α Levels of Serum and Adipose Tissues in Rats Fed with a High-Fat Diet Plus Sucrose Solution
Delpisheh, A., & Safarzade, A. (2022) · Shiraz E-Medical Journal · doi:10.5812/semj-119373 · Cited by 2
Fat accumulation around and within the kidney
Lin, L., Dekkers, I. A., & Lamb, H. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822186-0.00028-6 · Cited by 2
Generation of a Wt1 conditional deletion, nuclear red fluorescent protein reporter allele in the mouse
Aloway, J. A., Ruteshouser, E. C., Huff, V., & Behringer, R. R. (2024) · Differentiation · doi:10.1016/j.diff.2024.100791 · Cited by 2
Effect of abnormal distribution of abdominal adiposity and skeletal muscle on the outcomes of endovascular treatment for emergent large vessel occlusion
Cui, C., Geng, Z., Chen, H., Lu, M., Wang, Y., Shen, D., Li, R., Xiao, L., & Liu, X. (2024) · Journal of NeuroInterventional Surgery · doi:10.1136/jnis-2024-022386 · Cited by 2
Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1
Tao, T., Xu, Y., Zhang, C., Zhang, X., Chen, J., & Liu, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159585 · Cited by 2
Anatomy and Physiology of Adipose Tissue
Huang, Y., Hu, Y., Chen, H., Cai, Z., & He, B. (2024) · Contemporary Endocrinology · doi:10.1007/978-3-031-72570-8_2 · Cited by 2
Is epicardial adipose tissue a key pathophysiologic target in heart failure with preserved ejection?
Martens, P., Nguyen, C. T., & Tang, W. H. W. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.07.003 · Cited by 2
A Subset of Malignant Mesothelioma Tumors Retain Osteogenic Potential
Lansley, S. M., Pedersen, B., Robinson, C., Searles, R. G., Sterrett, G. F., van Bruggen, I., Lake, R., Mutsaers, S. E., & Prêle, C. M. (2016) · Scientific Reports · doi:10.1038/srep36349 · Cited by 2
The Complexity of Adipose Tissue
Troike, K. M., Lee, K. Y., List, E. O., & Berryman, D. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_8 · Cited by 2
Genome profiling of mismatch repair genes in eight types of tumors
Wang, S., Guan, G., Zou, C., Guo, Q., Cheng, W., Shen, S., Fang, D., Wu, A., Li, G., & Zhu, C. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1922160 · Cited by 2
Development of an Optimized Clearing Protocol to Examine Adipocyte Subpopulations in White Adipose Tissue
Luong, Q. V., Israel, A., Sharma, R., Ussar, S., & Lee, K. Y. (2021) · Methods and Protocols · doi:10.3390/mps4020039 · Cited by 2
Preoperative analysis of factors associated with prolonged pneumoretroperitoneum time during retroperitoneal laparoscopic nephroureterectomy for upper tract urothelial carcinoma
Yanagi, M., Kiriyama, T., Akatsuka, J., Endo, Y., Takeda, H., Hamasaki, T., Nishimura, T., & Kondo, Y. (2024) · BMC Urology · doi:10.1186/s12894-024-01538-0 · Cited by 2
The genetic underpinnings of body fat distribution
Pulit, S. L., Laber, S., Glastonbury, C. A., & Lindgren, C. M. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2017.1390427 · Cited by 2
Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cellsPreprint
Andrés‐Delgado, L., Ernst, A., Galardi‐Castilla, M., Bazaga, D., Peralta, M., Münch, J., González‐Rosa, J. M., Tessadori, F., Bakkers, J., de la Pompa, J. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/332593 · Cited by 2
ADGRG6 promotes adipogenesis and is involved in sex-specific fat distributionPreprint
Nguyen, H. P., Ushiki, A., Sheng, R. R., Biellak, C., An, K., Choquet, H., Hoffman, T. J., Gray, R. S., & Ahituv, N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.24.497411 · Cited by 2
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 10
A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafish
Wafer, R., Tandon, P., & Minchin, J. E. N. (2025) · eLife · doi:10.7554/elife.107327 · Cited by 3
Impact of supplementation with native cerrado fruit oil on the composition of breast milk of lactating Wistar rats
BRAGA, V. T., de OLIVEIRA, M., Fernandes, D. S., Filiú, W. F. D. O., Cavalheiro, L. F., Nazário, C. E. D., Vargas, M. O. F., Asato, M. A., MENEZES, A. C. G., FRAZÍLIO, M. P. F. F., et al. (2024) · Food Science and Technology · doi:10.5327/fst.00143 · Cited by 1
Impact of β 3 ‐adrenergic receptor agonist on kidney cancer risk in patients with overactive bladder
Park, J. S., Choi, S. B., Kim, J., Jang, W. S., & Ham, W. S. (2025) · British Journal of Urology · doi:10.1111/bju.16771 · Cited by 1
Impact of β3-adrenergic receptor agonist on tumor progression and metastasis in renal cell carcinoma models
Park, J. S., Lee, M. E., Jung, M., Kim, J., Jang, W. S., & Ham, W. S. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03834-7 · Cited by 1
Self-citation
Heterogeneity of Obesity and Its Predictive Factors: A Narrative Review of Recent Human and Rodent Studies
Liu, P. F., Zhang, M., Li, A., Lv, T., Lu, J., Chen, W., Yin, K., & Zhang, G. (2025) · Obesity Reviews · doi:10.1111/obr.70024 · Cited by 2
Comparative Analysis of Adipose Tissue Depots in Immediate versus Delayed Breast Reconstruction
Pinho, C., Soares, B., Costa, B. N. L., Teixeira, D., Salazar, M. J., Neto, F. L. M., Almeida, H., Costa‐Ferreira, A., Rodrigues, A. R., & Gouveia, A. (2025) · Archives of Medical Research · doi:10.1016/j.arcmed.2025.103360 · Cited by 1
Single-cell RNA sequencing reveals depot-specific characteristics of adipose progenitor cells in ducks
Wang, Z., Yang, C., Liu, S., Jiang, Y., Bai, H., Chang, G., Chen, G., & Zhao, L. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107004 · Cited by 1
Lipedema as a disorder of adipose tissue heterogeneity: insights from single-cell and spatial transcriptomics
Reid, I., Ali, S. H., Shayan, R., & Karnezis, T. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1809914 · Cited by 1
THE ROLE OF PXR AND IKKβ SIGNALING IN CARDIOMETABOLIC DISEASE
Helsley, R. N. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.040 · Cited by 1
Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea
Lee, D.-W., Cho, M. S., Choe, E. Y., Park, S. W., Song, Y., Lee, S.-C., & Sung, J. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20170027 · Cited by 1
Anatomy and Pathology of the Peritoneum
Solaß, W., Staebler, A., Fend, F., & Bösmüller, H. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-62640-2_1 · Cited by 1
Obesity: A Multi Perspective of Physiology and Neurobiology Energy Regulation
Meiliana, A., Dewi, N. M., & Wijaya, A. (2024) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v16i1.2840 · Cited by 1
Repurposing the Incidental Detection of Internal Hemorrhoids as an Independent Predictor of Coronary Artery Disease Risk
Eroğlu, E., Türkmen, İ., Algül, Ş., Reddy, V., & Altınlı, E. (2023) · Journal of Disease Markers · doi:10.26420/jdismarkers.2023.1054 · Cited by 1
The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases
Prompetch, W., & Phuangphung, P. (2024) · Siriraj Medical Journal/San Sirirat · doi:10.33192/smj.v76i5.267374 · Cited by 1
mHealth-Based Diabetes Prevention Program for Chinese Mothers With Abdominal Obesity: Randomized Controlled Trial
Huang, Q., Zhong, Q., Zeng, Y., Li, Y., Wiley, J. A., Wang, M. P., Chen, J., & Guo, J. (2024) · JMIR mhealth and uhealth · doi:10.2196/47837 · Cited by 4
Isolation and Fluorescence-Activated Cell Sorting of Murine WT1-Expressing Adipocyte Precursor Cells
Cleal, L., & Chau, Y.-Y. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-4023-3_7 · Cited by 1
Self-citation
Lipid, water, and protein composition to facilitate kinetic modeling of the auditory pathway
Grobe, N., Narayanan, L., Brown, D. N., Law, S. T., Sibomana, I., Shiyanov, P. A., Reo, N. V., Hack, C. E., Sterner, T. R., & Mattie, D. R. (2018) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2018.1508263 · Cited by 1
Adipose tissue development and metabolic regulation
Nguyen, H. P., Yi, D., & Sul, H. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00025-7 · Cited by 1
Tissu adipeux blanc
Rose, C., & Marcelin, G. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76753-1.00031-x · Cited by 2
Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult micePreprint
Wilm, T. P., Tanton, H., Mutter, F., Foisor, V., Middlehurst, B., Ward, K., Tarek, B., Hastie, N. D., & Wilm, B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.21.257154 · Cited by 1
Self-citation
Mesothelial Progenitors in Development, Lung Homeostasis, and Tissue Repair
Dixit, R., Ai, X., & Fine, A. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-16232-4_10
ANGIOGENESIS MODULATES OBESITY AND INSULIN SENSITIVITY
Honek, J. (2014) · Figshare
Role of sympathetic innervation in obesity
Pereira, M. M. R. D. A. A. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
In Vivo Assays for Assessing the Role of the Wilms’ Tumor Suppressor 1 (Wt1) in Angiogenesis
McGregor, R. J., Ogley, R. J., Hadoke, P., & Hastie, N. D. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-4023-3_8
Self-citation
Characterization of the critical biochemical and physiological role of 1-acylglycerol-3-phosphate-O-acyltransferase 4 (AGPAT4) in white adipose tissue
Mardian, E. B. (2016) · UWSpace (University of Waterloo)
Inflamação e alteração metabólica na caquexia: papel dos adipócitos, do fígado e da modulação oferecida pela microbiota intestinal.
das Neves, R. X. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-06092016-154205
Epicardial Progenitors in the Embryonic and Adult Heart
del Campo, C. V., Vieira, J. M., & Riley, P. R. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-56106-6_3
Anatomie und Pathologie des Peritoneums
Solaß, W., Staebler, A., & Fend, F. (2018) · Springer eBooks · doi:10.1007/978-3-662-54500-3_1
The multiple functions of the proepicardial/epicardial cell lineage in heart development
Dettman, R. W., Guadix, J. A., Cano, E., Carmona, R., & Muñoz‐Chápuli, R. (2018) · doi:10.1093/med/9780198757269.003.0020
Heterogeneity of White Adipose Tissue
Kwok, K. H. M., & Xu, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811297-7.00021-4 · Cited by 2
Epistatic Networks Associated with Parent-of-Origin Effects on Metabolic TraitsPreprint
Macias-Velasco, J. F., Pierre, C. L. S., Wayhart, J. P., Li, Y., Spears, L. D., Miranda, M. A., Funai, K., Cheverud, J. M., Semenkovich, C. F., & Lawson, H. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/579748 · Cited by 1
Is Epidural Fat Affected by Peripheric or Visceral Adipose Tissue? A Radiologic View
Aylanç, N., Reşorlu, M., & Adam, G. (2019) · Konuralp Tıp Dergisi · doi:10.18521/ktd.420560
Prevenção da obesidade e da resistência à insulina através do treinamento físico aeróbio: papel do sistema renina angiotensina no tecido adiposo branco
Américo, A. L. V. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2019.tde-04062019-121709
Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentumPreprint
Jackson-Jones, L. H., Smith, P., Pinto, M. M., Portman, J. R., Mylonas, K. J., Nixon, M., Henderson, B. E. P., Dobie, R., Henderson, N. C., Mole, D. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/774968
Single-Cell RNA Sequencing Identifies Functionally Distinct Fibro-inflammatory and Adipogenic Pdgfrβ Progenitor Subpopulations in Visceral Adipose TissuePreprint
Hepler, C., Shan, B., Zhang, Q., Henry, G. H., Shao, M., Vishvanath, L., Ghaben, A. L., Mobley, A. B., Strand, D. W., Hon, G. C., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3188404
Four Weeks Exercise in Vary Intensities Reduce More Inguinal Fat Than Perigonadal Fat in Mice
Lutfi, A. R., Liben, P., & Herawati, L. (2021) · Folia Medica Indonesiana · doi:10.20473/fmi.v57i2.18497 · Cited by 1
Body Composition and Diabetes
Yoo, H. J. (2021) · Journal of Korean Diabetes · doi:10.4093/jkd.2021.22.4.238
IRX1 Promotes Loss of Subcutaneous Adipose Tissue by Inhibiting Adipocyte Differentiation in Cachectic Patients with Gastric CancerPreprint
Han, J. S., Ding, Z., Zhuang, Q., Shen, L., Yang, F., Sah, S., & Wu, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1344846/v1
Health Risks of Obesity
(2015) · Chettinad Health City Medical Journal · doi:10.36503/chcmj4(1)-09
Expression Of Visceral Adipose Tissue Extracellular Matrix Related Genes Correlates With Insulin Resistance And Predicts Metabolic Improvement Following Bariatric SurgeryPreprint
Quiles, M., Beisani, M., Bello, J. V. M., Arbos, M. A., Balibrea, J. M., & Gil-Barrionuevo, E. (2023) · Research Square · doi:10.21203/rs.3.rs-3064271/v1
Different Lipidomic Signatures between proximal and distal adipose tissue in diabetic nephropathyPreprint
Huang, Y., Zheng, X., Yang, M., Jin, L., Zhang, R., Wu, Y., Li, F., Yang, B., & Liu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4018109/v1
The Relationship of Peri and Para-Renal Fat Tissue with Subclinical Atherosclerosis and Myocardial Functions in Newly Diagnosed Type 2 Diabetic PatientsPreprint
İşel, I., Karagülle, M., & Karabağ, T. (2024) · Research Square · doi:10.21203/rs.3.rs-4813103/v1
Effect of smoking behaviour and related blood DNA methylation on visceral adipose tissues
Song, Z., Chen, Y., Xuan, C., Ni, T., Xu, Y., Lu, X., Chen, F., & Chen, Y.-D. I. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16054
The influence of preoperative fat distribution on post‐bariatric surgery body mass index and body weight loss
Lu, S., Wang, Y., Zhang, T., Zhang, X., Liu, S., Miao, X., Zhao, G., Wang, Y., & Chen, H. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16172
A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafishPreprint
Wafer, R., Tandon, P., & Minchin, J. E. N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.20.649706
The relationship between renal cell carcinoma pathological types and perirenal fat area
Leng, X., Zhou, C., Wu, J., Zheng, H., Wang, J., Li, Q., Huang, Y., & Liu, J. (2025) · BMC Cancer · doi:10.1186/s12885-025-14164-2
In vivo CRISPR screening identifies regulators of hyperplastic and hypertrophic adipose remodelling in zebrafishPreprint
Wafer, R., Tandon, P., & Minchin, J. E. N. (2025) · eLife · doi:10.7554/elife.107327.1
Integrative analysis of gene expression and histone modifications for DES, DSP, GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health
Saeed, S., Hoffmann, A., Svensson, S. I. A., Visnovska, T., Hagemann, T., Ghosh, A., Wolfrum, C., Çayır, A., Mala, T., Kristinsson, J. A., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01391-3
Additional file 1 of ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease
Мирошникова, В. В., Panteleeva, A., Pobozheva, I. A., Razgildina, N. D., Polyakova, E. A., Markov, A. V., Belyaeva, O. D., Беркович, О. А., Baranova, E. I., Nazarenko, M. S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17088391
Additional file 5 of ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease
Мирошникова, В. В., Panteleeva, A., Pobozheva, I. A., Razgildina, N. D., Polyakova, E. A., Markov, A. V., Belyaeva, O. D., Беркович, О. А., Baranova, E. I., Nazarenko, M. S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17088403
Additional file 2 of Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
Han, J., Ding, Z., 庄秋林, Shen, L., Yang, F., Sah, S., & Wu, G. (2022) · Figshare · doi:10.6084/m9.figshare.21443683
Additional file 3 of ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease
Мирошникова, В. В., Panteleeva, A., Pobozheva, I. A., Razgildina, N. D., Polyakova, E. A., Markov, A. V., Belyaeva, O. D., Беркович, О. А., Baranova, E. I., Nazarenko, M. S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17088397
Additional file 1 of Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
Han, J., Ding, Z., 庄秋林, Shen, L., Yang, F., Sah, S., & Wu, G. (2022) · Figshare · doi:10.6084/m9.figshare.21443680
Additional file 4 of ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease
Мирошникова, В. В., Panteleeva, A., Pobozheva, I. A., Razgildina, N. D., Polyakova, E. A., Markov, A. V., Belyaeva, O. D., Беркович, О. А., Baranova, E. I., Nazarenko, M. S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17088400
Analyzing the transcriptomic diversity in isolated mature adipocytes from the major fat depots in rainbow trout (Oncorhynchus mykiss)
Rosell-Moll, E., Capilla, E., Navarro, I., & de la serrana, D. G. (2026) · BMC Genomics · doi:10.1186/s12864-026-12571-8
Perirenal adipose tissue imaging characteristics as predictors of systemic inflammatory response syndrome following percutaneous nephrolithotomy
Liu, M., Li, G., Yu, J., Wu, Q. Y., & Hao, Z. (2026) · World Journal of Urology · doi:10.1007/s00345-026-06215-5
Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity
Li, Y., Tao, M., Ibáñez, C. F., & Xie, M. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003700
Surface protein profiling reveals depot-specific features of subcutaneous and visceral adipose progenitor cells
Hachiya, K., Yamasaki, N., Fukai, H., Uchida, Y., Nozaki, Y., Mizunoe, Y., & Higami, Y. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102750
A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafishPreprint
Wafer, R., Tandon, P., & Minchin, J. E. N. (2026) · eLife · doi:10.7554/elife.107327.2
Vital functions of WT1 during renal progenitor life
Motamedi, F. J. (2015) · theses.fr (ABES) · doi:10.70675/9b62ba64zdf74z4b3bzbb3fz122536d2a8f6
Rôle de la Thrombospondine-1 dans le remodelage vasculaire
Grenier, C. (2016) · theses.fr (ABES) · doi:10.70675/32ae12b8z1945z4c94z8696z4bfe4e8cc8ee
Function of the transcription factor Osr1 in the connective tissue-mediated control of muscle formation
Vallecillo-García, P. (2015) · doi:10.70675/2816fdc8z934dz4a66zaaacz53d1e7cbba48
Dépôts de graisse ectopique : étude de leur développement et de leur modulation
Abdesselam, I. (2016) · theses.fr (ABES) · doi:10.70675/1f016024z175cz4b35z8034za3b418cfe9c3
Rôle de la mPGES-1 dans le développement de l'inflammation chronique de bas seuil et de l'obésité
Clément, P. (2018) · theses.fr (ABES) · doi:10.70675/03fb1889z1609z4461z931dze2b1aebfa2b6

Authors: Chau, Y.-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., Stimson, R. H., Walker, B. R., Chapuli, R. M., Schedl, A., & Hastie, N.
Affiliations: Western General Hospital (GB)
Inserm (FR)
Universitat de Barcelona (ES)
The Queen's Medical Research Institute (GB)
Corresponding author: Chau, You-Ying
Hastie, Nick
ORCID: Chau, You-Ying
Serrels, Alan
Martínez-Estrada, Ofelia M.
Qing, Wei
Lee, Martin
McHaffie, Sophie
Stimson, Roland H.
Walker, Brian R.
Schedl, Andreas
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-03-09
Volume: 16
Issue: 4
Pages: 367-375
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2922
PMC: PMC4060514
OpenAlex: W2081513869
Cited by: 518
References: 29
Citations by year: 2026: 17 · 2025: 27 · 2024: 45 · 2023: 28 · 2022: 49 · 2021: 57 · 2020: 50 · 2019: 53 · 2018: 50 · 2017: 36 · 2016: 50 · 2015: 41 · 2014: 14
FWCI: 30.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
HAL (submittedVersion)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
Newcastle University ePrints (Newcastle Univesity)
Funders: Universidad de Málaga
Wellcome Trust (091374/Z/10/Z)
British Heart Foundation (RG/11/4/28734)
Agence Nationale de la Recherche
Directorate for Biological Sciences
Medical Research Council (MR/K010271/1)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: visceral adipose tissue, subcutaneous adipose tissue, mesothelium, WT1, adipocyte origin, adipose tissue development, lateral plate mesoderm, brown adipose tissue, adipose tissue heterogeneity, obesity
MeSH terms: Animals, Adipose Tissue, Brown, Mesoderm, Tamoxifen, Adipocytes, Antineoplastic Agents, Hormonal, Cell Lineage, WT1 Proteins, Green Fluorescent Proteins, Mice, Adipose Tissue, White, Gene Knock-In Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks