The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Actin cortex architecture regulates cell surface tension
Open accessAbstract
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell-cycle progression. We then show that the actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis. This suggests that the mitotic cortex is poised close to a tension maximum. Finally, using a computational model, we identify a physical mechanism by which maximum tension is achieved at intermediate actin filament lengths. Our results indicate that actin network architecture, alongside myosin activity, is key to cell surface tension regulation.
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Li, J., Yin, W., Jing, Y., Kang, D., Yang, L., Cheng, J., Yu, Z., Peng, Z., Li, X., Wen, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03096 · Cited by 70
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Metadata
- Authors
- Chugh, P., Clark, A. G., Smith, M. B., Cassani, D. A. D., Dierkes, K., Ragab, A., Roux, P. P., Charras, G., Salbreux, G., & Paluch, E. K.
- Venue
- Nature Cell Biology
- Published
- 2017-05-22
- Volume
- 19
- Issue
- 6
- Pages
- 689-697
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2620431387
- Cited by
- 473
- References
- 55
- FWCI
- 20.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chugh, P., Clark, A. G., Smith, M. B., Cassani, D. A. D., Dierkes, K., Ragab, A., Roux, P. P., Charras, G., Salbreux, G., & Paluch, E. K. (2017). Actin cortex architecture regulates cell surface tension. Nature Cell Biology. https://doi.org/10.1038/ncb3525
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
