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A nucleator arms race: cellular control of actin assembly
Open accessAbstract
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting factors and formins were the only molecules known to directly nucleate actin filament formation de novo. However, the past several years have seen a surge in the discovery of mammalian proteins with roles in actin nucleation and dynamics. Newly recognized nucleation-promoting factors, such as WASP and SCAR homologue (WASH), WASP homologue associated with actin, membranes and microtubules (WHAMM), and junction-mediating regulatory protein (JMY), stimulate ARP2/3 activity at distinct cellular locations. Formin nucleators with additional biochemical and cellular activities have also been uncovered. Finally, the Spire, cordon-bleu and leiomodin nucleators have revealed new ways of overcoming the kinetic barriers to actin polymerization.
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Cites
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
Merrifield, C. J., Perrais, D., & Zenisek, D. (2005) · Cell · doi:10.1016/j.cell.2005.03.015 · Cited by 476 · cited 1×
“Dominant-negative and RNA interference studies have revealed a role for cortactin in membrane fission during endocytosis and trans -Golgi expor”
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Cited by
Dominguez, R., & Holmes, K. C. (2011) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-042910-155359 · Cited by 1,211
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Iskratsch, T., Wolfenson, H., & Sheetz, M. P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3903 · Cited by 798
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New insights into the regulation and cellular functions of the ARP2/3 complex
Rotty, J. D., Wu, C., & Bear, J. E. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3492 · Cited by 516
The WAVE regulatory complex links diverse receptors to the actin cytoskeleton
Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S., & Rosen, M. K. (2014) · Cell · doi:10.1016/j.cell.2013.11.048 · Cited by 323
Metadata
- Authors
- Campellone, K. G., & Welch, M. D.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-03-18
- Volume
- 11
- Issue
- 4
- Pages
- 237-251
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1991549216
- Cited by
- 928
- References
- 2
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
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