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Reversing stratification during wound healing
Open accessAbstract
The involvement of proliferation and migration in epidermal healing has long been recognized, but three studies now reveal how a variety of individual cell behaviours achieve a collective epithelial response, and how diverse repair routes are taken by cells of different origins.
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Wound healing in the skin is largely driven by keratinocyte migration, and rapid reconstitution of the epidermal barrier is vital to stop invasion by pathogens.
“Wound healing in the skin is largely driven by keratinocyte migration28, where rapid reconstitution of the epidermal barrier is vital to stop invasion by pathogens.”
From Multimodal decoding of human liver regeneration (2024) · cites this paper as [28]
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Cites
Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis
Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419
A PATTERN OF EPIDERMAL CELL MIGRATION DURING WOUND HEALING
Krawczyk, W. S. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.2.247 · Cited by 418
Defining stem cell dynamics and migration during wound healing in mouse skin epidermis
Aragona, M., Dekoninck, S., Rulands, S., Lenglez, S., Mascré, G., Simons, B. D., & Blanpain, C. (2017) · Nature Communications · doi:10.1038/ncomms14684 · Cited by 389
Mechanisms Regulating Epithelial Stratification
Koster, M. I., & Roop, D. R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123357 · Cited by 324
A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium
Doupé, D. P., Alcolea, M. P., Roshan, A., Zhang, G., Klein, A. M., Simons, B. D., & Jones, P. H. (2012) · Science · doi:10.1126/science.1218835 · Cited by 309
Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice
Park, S., Gonzalez, D. G., Guirao, B., Boucher, J. D., Cockburn, K., Marsh, E. D., Mesa, K. R., Brown, S., Rompolas, P., Haberman, A. M., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3472 · Cited by 265
Safferling, K., Sütterlin, T., Westphal, K., Ernst, C., Breuhahn, K., James, M., Jäger, D., Halama, N., & Grabe, N. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212020 · Cited by 177
Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties
Donati, G., Rognoni, E., Hiratsuka, T., Liakath‐Ali, K., Hoste, E., Kar, G., Kayikci, M., Russell, R., Kretzschmar, K., Mulder, K. W., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3532 · Cited by 176
Roy, E., Neufeld, Z., Cerone, L., Wong, H. Y., Hodgson, S., Livet, J., & Khosrotehrani, K. (2016) · The EMBO Journal · doi:10.15252/embj.201693806 · Cited by 50
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Research works printed but not linked: 1
- Wilson, T. J. & Bergstralh, D. T. Bioessays http://doi.org/b6t8 (2017).
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Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies
Rousselle, P., Braye, F., & Dayan, G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.019 · Cited by 679
538 Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing
Liu, Z., Bian, X., Luo, L., Björklund, Å. K., Li, L., Zhang, L., Chen, Y., Guo, L., Gao, J., 曹春艳, et al. (2024) · Cell stem cell · doi:10.1016/j.jid.2024.10.551 · Cited by 265
Multimodal decoding of human liver regeneration
Matchett, K. P., Wilson-Kanamori, J. R., Portman, J. R., Kapourani, C. A., Fercoq, F., May, S., Zajdel, E., Beltran, M., Sutherland, E. F., Mackey, J. B. G., et al. (2024) · Nature · doi:10.1038/s41586-024-07376-2 · Cited by 140
“Generating Pearson correlations between patient age and the harmony components of the hepatocyte dataset demonstrated that age did not influence variability in the snRNA-seq data (Extended Data Fig.”
Wang, D., Li, D., Zhang, Y., Chen, J., Zhang, Y., Liao, C., Qin, S., Tian, Y., Zhang, Z., & Xu, F. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.017 · Cited by 94
Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review)
Song, J., Zhao, T., Wang, C., Sun, X., Sun, J., & Zhang, Z. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5567 · Cited by 100
Stem cells, niches and scaffolds: Applications to burns and wound care
Watt, S. M., & Pleat, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.012 · Cited by 63
Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine
Burclaff, J., & Mills, J. C. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035071 · Cited by 46
Du, H., Zhou, Y., Suo, Y., Xiao, L., Chai, B., Duan, R., Huang, X., & Li, Q. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.001 · Cited by 46
Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis
Wang, J., He, J., Zhu, M., Han, Y. Y., Yang, R., Liu, H., Xu, X., & Chen, X. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10295-8 · Cited by 22
Dynamic Culture Substrates That Mimic the Topography of the Epidermal–Dermal Junction
Helling, A. L., Viswanathan, P., Cheliotis, K. S., Mobasseri, S. A., Yang, Y., Haj, A. J. E., & Watt, F. M. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0125 · Cited by 13
Esculin promotes skin wound healing in mice and regulates the Wnt/β-catenin signaling pathway
Xu, M., Zhang, M., Wu, J., Wang, J., Wu, H., & Xu, X. (2025) · CytoJournal · doi:10.25259/cytojournal_184_2024 · Cited by 5
Spatiotemporal Single-Cell Roadmap of Human Skin Wound HealingPreprint
Liu, Z., Li, D., Bian, X., Luo, L., Björklund, Å. K., Li, L., Zhang, L., Chen, Y., Guo, L. M., Gao, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.30.609923 · Cited by 4
Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts
Wu, P., Zhang, C., Wu, C., Lang, J., & He, L. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70406 · Cited by 1
Metadata
- Authors
- Headon, D.
- Affiliations
- Roslin Institute (GB)
- Corresponding author
- Headon, Denis
- ORCID
- Headon, Denis
- Venue
- Nature Cell Biology
- Published
- 2017-05-31
- Volume
- 19
- Issue
- 6
- Pages
- 595-597
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2618210860
- Cited by
- 13
- References
- 9
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 1 · 2020: 1 · 2018: 4 · 2017: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- wound healing, epidermal regeneration, stratification, cell proliferation, cell migration, cell of origin, skin regeneration
- MeSH terms
- Animals, Cell Movement, Epidermis, Humans, Models, Biological, Wound Healing, Hair Follicle
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