The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids
Open accessAbstract
The translation of DNA sequences into corresponding biopolymers enables the production, function, and evolution of the macromolecules of life. In contrast, methods to generate sequence-defined synthetic polymers with similar levels of control have remained elusive. Here we report the development of a DNA-templated translation system that enables the enzyme-free translation of DNA templates into sequence-defined synthetic polymers that have no necessary structural relationship with nucleic acids. We demonstrate the efficiency, sequence-specificity, and generality of this translation system by oligomerizing building blocks including polyethylene glycol (PEG), α-(d)-peptides, and β-peptides in a DNA-programmed manner. Sequence-defined synthetic polymers with molecular weights of 26 kDa containing 16 consecutively coupled building blocks and 90 densely functionalized β-amino acid residues were translated from DNA templates using this strategy. We integrated the DNA-templated translation system developed here into a complete cycle of translation, coding sequence replication, template regeneration, and re-translation suitable for the iterated in vitro selection of functional sequence-defined synthetic polymers unrelated in structure to nucleic acids.
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Cites
Synthetic genetic polymers capable of heredity and evolution
Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S.-Y., McLaughlin, S. H., et al. (2012) · Science · doi:10.1126/science.1217622 · Cited by 730
Schrum, J. P., Ricardo, A., Krishnamurthy, M., Blain, J. C., & Szostak, J. W. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906557v · Cited by 103
Cited by
Lutz, J.-F., Ouchi, M., Liu, D. R., & Sawamoto, M. (2013) · Science · doi:10.1126/science.1238149 · Cited by 1,381
Self-citationTherapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation
Pelegri-O’Day, E. M., Lin, E.-W., & Maynard, H. D. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504390x · Cited by 622
Iterative exponential growth of stereo- and sequence-controlled polymers
Barnes, J. C., Ehrlich, D. J. C., Gao, A. X., Leibfarth, F. A., Jiang, Y., Zhou, E., Jamison, T. F., & Johnson, J. A. (2015) · Nature Chemistry · doi:10.1038/nchem.2346 · Cited by 361
Design and synthesis of digitally encoded polymers that can be decoded and erased
Roy, R. K., Meszynska, A., Laure, C., Charles, L., Verchin, C., & Lutz, J.-F. (2015) · Nature Communications · doi:10.1038/ncomms8237 · Cited by 308
Gutekunst, W. R., & Hawker, C. J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04940 · Cited by 283
Metadata
- Authors
- Niu, J., Hili, R., & Liu, D. R.
- Venue
- Nature Chemistry
- Published
- 2013-03-03
- Volume
- 5
- Issue
- 4
- Pages
- 282-292
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2142407424
- Cited by
- 213
- References
- 2
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- green
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