The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Design and synthesis of digitally encoded polymers that can be decoded and erased
Open accessAbstract
Biopolymers such as DNA store information in their chains using controlled sequences of monomers. Here we describe a non-natural information-containing macromolecule that can store and retrieve digital information. Monodisperse sequence-encoded poly(alkoxyamine amide)s were synthesized using an iterative strategy employing two chemoselective steps: the reaction of a primary amine with an acid anhydride and the radical coupling of a carbon-centred radical with a nitroxide. A binary code was implemented in the polymer chains using three monomers: one nitroxide spacer and two interchangeable anhydrides defined as 0-bit and 1-bit. This methodology allows encryption of any desired sequence in the chains. Moreover, the formed sequences are easy to decode using tandem mass spectrometry. Indeed, these polymers follow predictable fragmentation pathways that can be easily deciphered. Moreover, poly(alkoxyamine amide)s are thermolabile. Thus, the digital information encrypted in the chains can be erased by heating the polymers in the solid state or in solution.
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Cites
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Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine
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Cited by
Iterative exponential growth of stereo- and sequence-controlled polymers
Barnes, J. C., Ehrlich, D. J. C., Gao, A. X., Leibfarth, F. A., Jiang, Y., Zhou, E., Jamison, T. F., & Johnson, J. A. (2015) · Nature Chemistry · doi:10.1038/nchem.2346 · Cited by 361
Encoding information into polymers
Rutten, M. G. T. A., Vaandrager, F. W., Elemans, J. A. A. W., & Nolte, R. J. M. (2018) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0051-5 · Cited by 216
Multifunctional sequence-defined macromolecules for chemical data storage.
Martens, S., Landuyt, A., Espeel, P., Devreese, B., Dawyndt, P., & Du Prez, F. (2018) · Nature Communications · doi:10.1038/s41467-018-06926-3 · Cited by 180
Aerolysin nanopores decode digital information stored in tailored macromolecular analytes
Cao, C., Krapp, L. F., Al Ouahabi, A., König, N. F., Cirauqui, N., Radenovic, A., Lutz, J.-F., & Peraro, M. D. (2020) · Science Advances · doi:10.1126/sciadv.abc2661 · Cited by 97
Self-citationData storage using peptide sequences
Ng, C. C. A., Tam, W. M., Yin, H., Wu, Q., So, P.-K., Wong, M. Y.-M., Lau, F. C. M., & Yao, Z.-P. (2021) · Nature Communications · doi:10.1038/s41467-021-24496-9 · Cited by 41
Metadata
- Authors
- Roy, R. K., Meszynska, A., Laure, C., Charles, L., Verchin, C., & Lutz, J.-F.
- Venue
- Nature Communications
- Published
- 2015-05-26
- Volume
- 6
- Issue
- 1
- Pages
- 7237-7237
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2261548822
- Cited by
- 308
- References
- 35
- FWCI
- 21.28
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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