Cited by 901Mass Spectrometry Techniques and ApplicationsProtein Structure and DynamicsMolecular Spectroscopy and Structure

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The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

Lanucara, Francesco, Holman, Stephen W., Gray, Christopher J., Eyers, Claire E.·2014·Nature Chemistry

DOI 10.1038/nchem.1889

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Abstract

Mass spectrometry is a vital tool for molecular characterization, and the allied technique of ion mobility is enhancing many areas of (bio)chemical analysis. Strong synergy arises between these two techniques because of their ability to ascertain complementary information about gas-phase ions. Ion mobility separates ions (from small molecules up to megadalton protein complexes) based on their differential mobility through a buffer gas. Ion mobility-mass spectrometry (IM-MS) can thus act as a tool to separate complex mixtures, to resolve ions that may be indistinguishable by mass spectrometry alone, or to determine structural information (for example rotationally averaged cross-sectional area), complementary to more traditional structural approaches. Finally, IM-MS can be used to gain insights into the conformational dynamics of a system, offering a unique means of characterizing flexibility and folding mechanisms. This Review critically describes how IM-MS has been used to enhance various areas of chemical and biophysical analysis.

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Authors: Lanucara, F., Holman, S. W., Gray, C. J., & Eyers, C. E.
Affiliations: University of Liverpool (GB)
University of Manchester (GB)
Corresponding author: Eyers, Claire E.
ORCID: Holman, Stephen W.
Gray, Christopher J.
Eyers, Claire E.
Venue: Nature Chemistry
Publisher: Springer Science and Business Media LLC
Published: 2014-03-21
Volume: 6
Issue: 4
Pages: 281-294
ISSN: 1755-4330 (ISSN-L)
1755-4349
DOI: 10.1038/nchem.1889
OpenAlex: W1992505804
Cited by: 901
References: 163
Citations by year: 2026: 28 · 2025: 58 · 2024: 50 · 2023: 60 · 2022: 67 · 2021: 79 · 2020: 92 · 2019: 92 · 2018: 100 · 2017: 108 · 2016: 85 · 2015: 56 · 2014: 24
FWCI: 8.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Chemistry (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: European Commission
Biotechnology and Biological Sciences Research Council (BB/H007113/1, BB/F00561X/1, BB/G009058/1)
Topics: Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Physical Sciences › Chemistry › Spectroscopy › Molecular Spectroscopy and Structure
Keywords: ion mobility mass spectrometry, structural characterization, conformational dynamics, cross-sectional area, complex mixtures, protein flexibility, protein folding mechanism, molecular characterization
MeSH terms: Biophysics, Ions, Molecular Conformation, Mass Spectrometry

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The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

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