Cited by 148DNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Reprogramming the assembly of unmodified DNA with a small molecule

Avakyan, Nicole, Greschner, Andrea A., Aldaye, Faisal, Serpell, Christopher J., Toader, Violeta, Petitjean, Anne, Sleiman, Hanadi F.·2016·Nature Chemistry

DOI 10.1038/nchem.2451

Open this paper in CoChat — free account

Abstract

The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA 'alphabet' by synthetic incorporation of new bases can introduce new functionalities and enable the formation of novel nucleic acid structures. However, reprogramming the self-assembly of existing nucleobases presents an alternative route to expand the structural space and functionality of nucleic acids. Here we report the discovery that a small molecule, cyanuric acid, with three thymine-like faces, reprogrammes the assembly of unmodified poly(adenine) (poly(A)) into stable, long and abundant fibres with a unique internal structure. Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies. Our studies are consistent with the association of adenine and cyanuric acid units into a hexameric rosette, which brings together poly(A) triplexes with a subsequent cooperative polymerization. Fundamentally, this study shows that small hydrogen-bonding molecules can be used to induce the assembly of nucleic acids in water, which leads to new structures from inexpensive and readily available materials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nchem.2451

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Supramolecular Polymerization
de Greef, T. F. A., Smulders, M. M. J., Wolffs, M., Schenning, A. P. H. J., Sijbesma, R. P., & Meijer, E. W. (2009) · Chemical Reviews · doi:10.1021/cr900181u · Cited by 2,495
Circular dichroism: Principles and applications
Jones, C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)90057-8 · Cited by 2,472
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian, S., Hurley, L. H., & Neidle, S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3428 · Cited by 1,720
Mixed-ligand complexes of ruthenium(II): factors governing binding to DNA
Pyle, A., Rehmann, J. P., Meshoyrer, R., Kumar, C. V., TURRO, N. J., & Barton, J. K. (1989) · Journal of the American Chemical Society · doi:10.1021/ja00190a046 · Cited by 1,463
Circular Dichroism: Principles and Applications
Berova, N. D., 中西, 香., & Woody, R. W. (1994) · Cited by 1,264
Noncovalent Synthesis: Using Physical-Organic Chemistry To Make Aggregates
Whitesides, G. M., Simanek, E. E., Mathias, J. P., Seto, C. T., Chin, D. N., Mammen, M., & Gordon, D. M. (1995) · Accounts of Chemical Research · doi:10.1021/ar00049a006 · Cited by 1,030
Assembling Materials with DNA as the Guide
Aldaye, F. A., Palmer, A. L., & Sleiman, H. F. (2008) · Science · doi:10.1126/science.1154533 · Cited by 989
Self-citation
Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone
Egholm, M., Buchardt, O., Nielsen, P. E., & Berg, R. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00031a062 · Cited by 739

Show all 58 references

Sorted by citations

DNA nanotechnology
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
Self-citation
Photoresponsive Supramolecular Polymers: From Light‐Controlled Small Molecules to Smart Materials
Xu, F., & Feringa, B. L. (2022) · Advanced Materials · doi:10.1002/adma.202204413 · Cited by 331
Single-stranded DNA and RNA origami
Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., et al. (2017) · Science · doi:10.1126/science.aao2648 · Cited by 300
Emerging Approaches to DNA Data Storage: Challenges and Prospects
Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235
DNA Nanostructures at the Interface with Biology
Bujold, K. E., Lacroix, A., & Sleiman, H. F. (2018) · Chem · doi:10.1016/j.chempr.2018.02.005 · Cited by 231
Self-citation
Bioinspired Adhesive Hydrogel Driven by Adenine and Thymine
Liu, X., Zhang, Q., Gao, Z., Hou, R., & Gao, G. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b04832 · Cited by 214
Supramolecular peptide constructed by molecular Lego allowing programmable self-assembly for photodynamic therapy
Zhu, H., Wang, H., Shi, B., Shangguan, L., Tong, W., Yu, G., Mao, Z., & Huang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-10385-9 · Cited by 202
Bioinspired Adhesive Hydrogels Tackified by Nucleobases
Liu, X., Zhang, Q., & Gao, G. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703132 · Cited by 197
Reversible Assembly of Graphitic Carbon Nitride 3D Network for Highly Selective Dyes Absorption and Regeneration
Zhang, Y., Zhou, Z., Shen, Y., Zhou, Q. X., Wang, J., Liu, A., Liu, S., & Zhang, Y. (2016) · ACS Nano · doi:10.1021/acsnano.6b05488 · Cited by 194
Architectonics: Design of Molecular Architecture for Functional Applications
Avinash, M. B., & Govindaraju, T. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00434 · Cited by 129
A dissipative pathway for the structural evolution of DNA fibres
Rizzuto, F. J., Platnich, C. M., Luo, X., Shen, Y., Dore, M. D., Lachance-Brais, C., Guarné, A., Cosa, G., & Sleiman, H. F. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00751-w · Cited by 120
Self-citation
Tough Adhesion of Nucleobase‐Tackifed Gels in Diverse Solvents
Liu, X., Zhang, Q., Duan, L., & Gao, G. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900450 · Cited by 119
Hydrogen-bonded rosettes comprising π-conjugated systems as building blocks for functional one-dimensional assemblies
Adhikari, B., Xu, L. S., Yamauchi, M., Ouchi, H., Aratsu, K., & Yagai, S. (2017) · Chemical Communications · doi:10.1039/c7cc04172a · Cited by 108
A poly(thymine)–melamine duplex for the assembly of DNA nanomaterials
Li, Q., Zhao, J., Liu, L., Jonchhe, S., Rizzuto, F. J., Mandal, S., He, H., Wei, S., Sleiman, H. F., Mao, H., et al. (2020) · Nature Materials · doi:10.1038/s41563-020-0728-2 · Cited by 101
Self-citation
Hierarchical Hydrogen Bonds Endow Supramolecular Polymers with High Strength, Toughness, and Self‐Healing Properties
Wu, J., Zeng, F., Fan, Z., Xuan, S., Hua, Z., & Liu, G. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202410518 · Cited by 91
Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies
Ranallo, S., Sorrentino, D., & Ricci, F. (2019) · Nature Communications · doi:10.1038/s41467-019-13104-6 · Cited by 89
Self-Assembly of Metallacages into Multidimensional Suprastructures with Tunable Emissions
Sun, Y., Yao, Y. S., Wang, H., Fu, W., Chen, C., Saha, M. L., Zhang, M., Datta, S., Zhou, Z., Yu, H., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b05809 · Cited by 78
Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides
Kim, J., Ashwanikumar, N., Patel, S., & Sahay, G. (2019) · Theranostics · doi:10.7150/thno.33921 · Cited by 79
Freezing‐directed Stretching and Alignment of DNA Oligonucleotides
Liu, B., Wu, T., Huang, Z., Liu, Y., & Liu, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201814352 · Cited by 75
Bioinspired Supramolecular Hydrogel from Design to Applications
Gao, F., Yang, X., & Song, W. (2023) · Small Methods · doi:10.1002/smtd.202300753 · Cited by 67
Self-Assembled Nanomaterials for Enhanced Phototherapy of Cancer
Zhao, L., Xing, Y., Wang, R., Yu, F., & Yu, F. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00843 · Cited by 65
Reconfigurable A-motif, i-motif and triplex nucleic acids for smart pH-responsive DNA hydrogels
Hu, Y., & Ying, J. Y. (2022) · Materials Today · doi:10.1016/j.mattod.2022.12.003 · Cited by 63
Heating Drives DNA to Hydrophobic Regions While Freezing Drives DNA to Hydrophilic Regions of Graphene Oxide for Highly Robust Biosensors
Liu, B., Zhao, Y. R., Jia, Y., & Liu, J. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07028 · Cited by 59
Small Molecule‐Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids
Lachance‐Brais, C., Rammal, M., Asohan, J., Katolik, A., Luo, X., Saliba, D., Jonderian, A., Damha, M. J., Harrington, M. J., & Sleiman, H. F. (2023) · Advanced Science · doi:10.1002/advs.202205713 · Cited by 53
Self-citation
Flash Synthesis of DNA Hydrogel via Supramacromolecular Assembly of DNA Chains and Upconversion Nanoparticles for Cell Engineering
Tang, J., Ou, J., Zhu, C., Yao, C., & Yang, D. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107267 · Cited by 54
Supramolecular self-assembly of triazine-based small molecules: targeting the endoplasmic reticulum in cancer cells
Ghosh, C., Nandi, A., & Basu, S. (2019) · Nanoscale · doi:10.1039/c8nr08682f · Cited by 50
DNA‐Based Dissipative Assembly toward Nanoarchitectonics
Liu, Q., Li, H., Yu, B., Meng, Z., Zhang, X., Li, J., & Zheng, L. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202201196 · Cited by 50
Molecular and supramolecular chemistry of rosette nanotubes
Beingessner, R. L., Fan, Y., & Fenniri, H. (2016) · RSC Advances · doi:10.1039/c6ra16315g · Cited by 49
Cyanuric Acid‐Based Organocatalyst for Utilization of Carbon Dioxide at Atmospheric Pressure
Yu, B., Kim, D., Kim, S., & Hong, S. H. (2016) · ChemSusChem · doi:10.1002/cssc.201601684 · Cited by 47
Molecular self‐assembly using peptide nucleic acids
Berger, O., & Gazit, E. (2016) · Biopolymers · doi:10.1002/bip.22930 · Cited by 45
Assembly of Metallacages into Soft Suprastructures with Dimensions of up to Micrometers and the Formation of Composite Materials
Sun, Y., Zhang, F., Jiang, S., Wang, Z., Ni, R., Wang, H., Zhou, W., Li, X., & Stang, P. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11199 · Cited by 43
Hydrazide–Hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells
Patil, S., Pandey, S., Singh, A., Radhakrishna, M., & Basu, S. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201901074 · Cited by 43
Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Kumar, S., Pearse, A. J., Liu, Y., & Taylor, R. E. (2020) · Nature Communications · doi:10.1038/s41467-020-16759-8 · Cited by 41
Formation of supramolecular assemblies and liquid crystals by purine nucleobases and cyanuric acid in water: implications for the possible origins of RNA
Li, C., Cafferty, B. J., Karunakaran, S. C., Schuster, G. B., & Hud, N. V. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c6cp03047e · Cited by 38
Quantified structural speciation in self-sorted CoII6L 4 cage systems
Rizzuto, F. J., Kieffer, M., & Nitschke, J. R. (2018) · Chemical Science · doi:10.1039/c7sc04927g · Cited by 35
Mapping the energy landscapes of supramolecular assembly by thermal hysteresis
Harkness, R. W., V, Avakyan, N., Sleiman, H. F., & Mittermaier, A. (2018) · Nature Communications · doi:10.1038/s41467-018-05502-z · Cited by 35
Self-citation
Supramolecular Depolymerization in the Mixture of Two Poor Solvents: Mechanistic Insights and Modulation of Supramolecular Polymerization of Ionic π‐Systems
Kotha, S., Mabesoone, M. F. J., Srideep, D., Sahu, R., Reddy, S. K., & Rao, K. V. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202011977 · Cited by 34
Small Molecule Recognition Triggers Secondary and Tertiary Interactions in DNA Folding and Hammerhead Ribozyme Catalysis
Mao, J., DeSantis, C., & Bong, D. T.-Y. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05448 · Cited by 32
Molecular architectonics of DNA for functional nanoarchitectures
Ghosh, D., Datta, L. P., & Govindaraju, T. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.11 · Cited by 32
DNA-Guided Assemblies toward Nanoelectronic Applications
Vittala, S. K., & Han, D. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01178 · Cited by 32
Light‐Activated Assembly of DNA Origami into Dissipative Fibrils
Berg, W. R., Berengut, J. F., Bai, C., Wimberger, L., Lee, L. K., & Rizzuto, F. J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314458 · Cited by 31
B-DNA model systems in non-terran bio-solvents: implications for structure, stability and replication
Hamlin, T. A., Poater, J., Guerra, C. F., & Bickelhaupt, F. M. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp01908d · Cited by 32
Small molecule-induced DNA hydrogel with encapsulation and release properties
He, M., Nandu, N., Uyar, T. B., Royzen, M., & Yigit, M. V. (2020) · Chemical Communications · doi:10.1039/d0cc03439h · Cited by 30
A Self-Immolative DNA Nanogel Vaccine toward Cancer Immunotherapy
Hu, Y., Gao, S., Lu, H., Tan, S., Chen, F., Ke, Y., & Ying, J. Y. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c02449 · Cited by 30
Sequence and Structure Dual-Dependent Interaction between Small Molecules and DNA for the Detection of Residual Silver Ions in As-Prepared Silver Nanomaterials
Wang, Z., Zhao, J., Li, Z., Bao, J., & Dai, Z. H. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b01238 · Cited by 29
Organic Semiconductor–DNA Hybrid Assemblies
Cui, C., Park, D. H., & Ahn, D. J. (2020) · Advanced Materials · doi:10.1002/adma.202002213 · Cited by 29
Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications
Yu, Y., Jin, B., Li, Y., & Deng, Z. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201900491 · Cited by 28
From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies
Surin, M., & Ulrich, S. (2020) · ChemistryOpen · doi:10.1002/open.202000013 · Cited by 29
Exceptional Nuclease Resistance of DNA and RNA with the Addition of Small-Molecule Nucleobase Mimics
Lachance‐Brais, C., Yao, C., Reyes-Valenzuela, A., Asohan, J., Guettler, E. M., & Sleiman, H. F. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c07023 · Cited by 25
Self-citation
Enzyme- and DNAzyme-Driven Transient Assembly of DNA-Based Phase-Separated Coacervate Microdroplets
Qin, Y., Sohn, Y. S., Nechushtai, R., Xia, F., Huang, F., & Willner, I. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c00637 · Cited by 26
Depsipeptide Nucleic Acids: Prebiotic Formation, Oligomerization, and Self-Assembly of a New Proto-Nucleic Acid Candidate
Fialho, D. M., Karunakaran, S. C., Greeson, K. W., Martínez, I., Schuster, G. B., Krishnamurthy, R., & Hud, N. V. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c02287 · Cited by 26
Tuning DNA Supramolecular Polymers by the Addition of Small, Functionalized Nucleobase Mimics
Lachance‐Brais, C., Hennecker, C. D., Alenaizan, A., Luo, X., Toader, V., Taing, M., Sherrill, C. D., Mittermaier, A., & Sleiman, H. F. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08972 · Cited by 26
Self-citation
Bifacial Nucleobases for Hexaplex Formation in Aqueous Solution
Kashida, H., Hattori, Y., Tazoe, K., Inoue, T., Nishikawa, K., Ishii, K., Uchiyama, S., Yamashita, H., Abe, M., Kamiya, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b02807 · Cited by 25
Differentiating the mechanism of self-assembly in supramolecular polymers through computation
Korlepara, D. B., Henderson, W. R., Castellano, R. K., & Balasubramanian, S. (2019) · Chemical Communications · doi:10.1039/c9cc01058k · Cited by 25
Noncovalent Helicene Structure between Nucleic Acids and Cyanuric Acid
Alenaizan, A., Fauché, K., Krishnamurthy, R., & Sherrill, C. D. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004390 · Cited by 25
Three-Dimensional Uracil Network with Sodium as a Linker
Giedraityte, Z., Lopez‐Acevedo, O., Espinosa-Leal, L., Pale, V., Sainio, J., Tripathi, T. S., & Karppinen, M. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.6b08986 · Cited by 24
The proto-Nucleic Acid Builder: a software tool for constructing nucleic acid analogs
Alenaizan, A., Barnett, J. L., Hud, N. V., Sherrill, C. D., & Petrov, A. S. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1159 · Cited by 22
The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
Anderson, B. A., Fauché, K., Karunakaran, S. C., Yerabolu, J. R., Hud, N. V., & Krishnamurthy, R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004397 · Cited by 22
Freezing‐directed Stretching and Alignment of DNA Oligonucleotides
Liu, B., Wu, T., Huang, Z., Liu, Y., & Liu, J. (2018) · Angewandte Chemie · doi:10.1002/ange.201814352 · Cited by 22
Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics
Alexander, S., Moghadam, M. G., Rothenbroker, M., & Chou, L. Y. T. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114898 · Cited by 24
Duplex Stem Replacement with bPNA+ Triplex Hybrid Stems Enables Reporting on Tertiary Interactions of Internal RNA Domains
Miao, S., Liang, Y., Marathe, I. A., Mao, J., DeSantis, C., & Bong, D. T.-Y. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03435 · Cited by 20
Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout
Fortunati, S., Vasini, I., Giannetto, M., Mattarozzi, M., Porchetta, A., Bertucci, A., & Careri, M. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c05294 · Cited by 19
Fullerene Cluster Assisted Self‐Assembly of Short DNA Strands into Semiconducting Nanowires
Vittala, S. K., Saraswathi, S. K., & Joseph, J. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201703333 · Cited by 19
Exquisite regulation of supramolecular equilibrium polymers in water: chain stoppers control length, polydispersity and viscoelasticity
Karunakaran, S. C., Cafferty, B. J., Peláez-Fernández, M., Neselu, K., Schmidt‐Krey, I., Fernández‐Nieves, A., Schuster, G. B., & Hud, N. V. (2018) · Polymer Chemistry · doi:10.1039/c8py01146j · Cited by 19
Bringing Prebiotic Nucleosides and Nucleotides Down to Earth
Fiore, M., & Strazewski, P. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201606232 · Cited by 18
Oligo‐Adenine Derived Secondary Nucleic Acid Frameworks: From Structural Characteristics to Applications
Hu, Y., & Willner, I. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202412106 · Cited by 17
Molecular Architectonics‐guided Design of Biomaterials
Moorthy, H., Datta, L. P., & Govindaraju, T. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202001445 · Cited by 17
Supramolecular Depolymerization in the Mixture of Two Poor Solvents: Mechanistic Insights and Modulation of Supramolecular Polymerization of Ionic π‐Systems
Kotha, S., Mabesoone, M. F. J., Dasari, S., Sahu, R., Reddy, S. K., & Rao, K. V. (2020) · Angewandte Chemie · doi:10.1002/ange.202011977 · Cited by 18
A dynamic DNA nanostructure with switchable and size-selective molecular recognition properties
Kim, C., Jeong, E. H., Lee, H., & Park, S. (2019) · Nanoscale · doi:10.1039/c8nr09341e · Cited by 17
Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits
López‐Tena, M., Chen, S., & Winssinger, N. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00292 · Cited by 14
Unnatural bases for recognition of noncoding nucleic acid interfaces
Miao, S., Liang, Y., Rundell, S. R., Bhunia, D., Devari, S., Munyaradzi, O., & Bong, D. T.-Y. (2020) · Biopolymers · doi:10.1002/bip.23399 · Cited by 14
Bifacial PNAs Destabilize MALAT1 by 3′ A-Tail Displacement from the U-Rich Internal Loop
Miao, S., Bhunia, D., Devari, S., Liang, Y., Munyaradzi, O., Rundell, S. R., & Bong, D. T.-Y. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00575 · Cited by 15
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a
Tharu, R. J., Hanson, E., & Yigit, M. V. (2025) · ACS Chemical Biology · doi:10.1021/acschembio.5c00355 · Cited by 14
Assembly of Rolling Circle Amplification‐Produced Ultralong Single‐Stranded DNA to Construct Biofunctional DNA Materials
Tang, J., Liang, A., Yao, C., & Yang, D. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202202673 · Cited by 14
Nanosheets and 2D-nanonetworks by mutually assisted self-assembly of fullerene clusters and DNA three-way junctions
Vittala, S. K., Saraswathi, S. K., Ramesan, A. B., & Joseph, J. (2019) · Nanoscale Advances · doi:10.1039/c9na00485h · Cited by 14
Chain Entropy Beats Hydrogen Bonds to Unfold and Thread Dialcohol Phosphates inside Cyanostar Macrocycles To Form [3]Pseudorotaxanes
Fadler, R. E., Ouahabi, A. A., Qiao, B., Carta, V., König, N. F., Gao, X., Zhao, W., Zhang, Y., Lutz, J., & Flood, A. H. (2021) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c02887 · Cited by 14
Electrostatically Directed Long‐Range Self‐Assembly of Nucleotides with Cationic Nanoparticles To Form Multifunctional Bioplasmonic Networks
Roy, S., Adury, V. S. S., Rao, A., Roy, S., Mukherjee, A., & Pillai, P. P. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202203924 · Cited by 13
Prebiotic synthesis of noncanonical nucleobases under plausible alkaline hydrothermal conditions
Pérez-Fernández, C., Vega, J., Rayo-Pizarroso, P., Mateo‐Martí, E., & Ruiz‐Bermejo, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-19474-0 · Cited by 14
Self-assembled methodologies for the construction of DNA nanostructures and biological applications
Ye, R., Wang, Y., Liu, Y., Cai, P., & Song, J. (2024) · Biomaterials Science · doi:10.1039/d4bm00584h · Cited by 13
Probing the self-assembly process of amphiphilic tetrahedral DNA frameworks
Liang, C., Chen, J., Li, M., Ge, Z., Fan, C., & Shen, J. (2022) · Chemical Communications · doi:10.1039/d2cc03451d · Cited by 13
Probing Conformational Polymorphism of DNA Assemblies with Nanopores
Sheng, Y., Zhou, K., Liu, Q., Liu, L., & Wu, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05650 · Cited by 13
Oligo-Adenine and Cyanuric Acid Supramolecular DNA-Based Hydrogels Exhibiting Acid-Resistance and Physiological pH-Responsiveness
Hu, Y., Liu, J., Ke, Y., Wang, B., Lim, J. Y. C., Dong, Z., Long, Y., & Willner, I. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c03834 · Cited by 12
Recent advances in the construction strategy, functional properties, and biosensing application of self-assembled triangular unit-based DNA nanostructures
Duan, M., Chang, Y., Chen, X., Wang, Z., Wu, S., & Duan, N. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108436 · Cited by 12
Biomimetic Hydrogen‐Bonded Base Pairing of Nucleoside Triphosphates in Water by a Tetraphenylethene‐Based Octaimidazolium Cage
Li, Y., Cheng, L., Wang, P., Kang, X., Li, Q., & Cao, L. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505732 · Cited by 12
AMP Aptamer Programs DNA Tile Cohesion without Canonical Base Pairing
Zhang, Z., Jin, J., Paluzzi, V. E., Jin, Z., Wen, Y., Huang, C. Z., Li, C. M., Mao, C., & Zuo, H. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c06260 · Cited by 11
Melamine driven supramolecular self‐assembly of nucleobase derivatives in water
Xiao, Y., Zhang, J., & Lang, M. (2018) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28954 · Cited by 11
Insights into the self-assembly steps of cyanuric acid toward rosette motifs: a DFT study
Petelski, A. N., Peruchena, N. M., Pamies, S. C., & Sosa, G. L. (2017) · Journal of Molecular Modeling · doi:10.1007/s00894-017-3428-3 · Cited by 10
Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination
Wang, C., Di, Z., Fan, Z., & Li, L. (2019) · Chemical Research in Chinese Universities · doi:10.1007/s40242-019-0028-z · Cited by 10
Spatiotemporal dynamic and catalytically mediated reconfiguration of compartmentalized cyanuric acid/polyadenine DNA microdroplet condensates
Xu, S., Ouyang, Y., Qin, Y., Chen, D., Duan, Z., Song, D., Harries, D., Xia, F., Willner, I., & Huang, F. (2025) · Nature Communications · doi:10.1038/s41467-025-58650-4 · Cited by 9
Revealing the Hydrogen Bonding Interaction of DNA with Unnatural Bases via Plasmonic Antenna Enhanced Infrared Spectroscopy
Li, J. P., Li, J., Yan, Z., Ding, X., & Xia, X. (2021) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.1c02901 · Cited by 9
The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B
McCormack, K. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.889 · Cited by 9
Introducing Bacteria and Synthetic Biomolecules along Engineered DNA Fibers
Burns, J. R. (2021) · Small · doi:10.1002/smll.202100136 · Cited by 9
A Dual‐Action Nucleoside‐Based Supramolecular Hydrogel Combats Periodontitis by Disrupting the Bacteria‐Osteoclast Cascade
Wang, Q., Zhao, Y., Han, L., Li, C., Wang, Z., Zhang, X., Liu, T., Wang, K., Han, X., Xie, L., et al. (2025) · Advanced Materials · doi:10.1002/adma.202516181 · Cited by 8
Thymine-Induced Dynamic Switching of Self-Assembled Nanofibers in Diaminotriazine-Functionalized Tetraphenylethylene Derivatives: Implications for One-Dimensional Molecular Devices
Saraswathi, S. K., & Joseph, J. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c00310 · Cited by 8
Target-switched triplex nanotweezer and synergic fluorophore translocation for highly selective melamine assay
Mao, T., Gao, L., Tong, X., Zhou, Y., Li, Q., Fei, Y., Yu, Y., Ye, T., Zhou, X., & Shao, Y. (2018) · Microchimica Acta · doi:10.1007/s00604-018-3134-6 · Cited by 8
Supramolecular assembly-enabled homochiral polymerization of short (dA) n oligonucleotides
Mangalath, S., Karunakaran, S. C., Newnam, G. P., Schuster, G. B., & Hud, N. V. (2021) · Chemical Communications · doi:10.1039/d1cc05420a · Cited by 8
Poly(propylene fumarate)-Based Adhesives with a Transformable Adhesion Force for Suture-Free Fixation of Soft Tissue Wounds
Guan, X., Wei, T., Cai, J., Sun, J., Yu, S., & Guo, D. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.1c01733 · Cited by 8
Structural and Thermodynamic Control of Supramolecular Polymers and DNA Assemblies with Cyanuric Acid: Influence of Substituents and Intermolecular Interactions
Schuster, G. B., Hud, N. V., & Alenaizan, A. (2022) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c05934 · Cited by 8
Dynamic behavior of the single-strand DNA molecules from the hydrophilic to hydrophobic regions on graphene oxide surface driven by heating
Wu, M., Huang, Y., Yang, L., Song, Y., & Lei, X. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp00911d · Cited by 8
SERS Investigation on Oligopeptides Used as Biomimetic Coatings for Medical Devices
Foggia, M. D., Tugnoli, V., Ottani, S., Dettin, M., Zamuner, A., Sánchez‐Cortés, S., Cesini, D., & Torreggiani, A. (2021) · Biomolecules · doi:10.3390/biom11070959 · Cited by 8

Authors: Avakyan, N., Greschner, A. A., Aldaye, F., Serpell, C. J., Toader, V., Petitjean, A., & Sleiman, H. F.
Affiliations: McGill University (CA)
Institut National de la Recherche Scientifique (CA)
University of Kent (GB)
Queen's University (CA)
Corresponding author: Sleiman, Hanadi F.
ORCID: Avakyan, Nicole
Greschner, Andrea A.
Serpell, Christopher J.
Toader, Violeta
Petitjean, Anne
Sleiman, Hanadi F.
Venue: Nature Chemistry
Publisher: Springer Science and Business Media LLC
Published: 2016-02-22
Volume: 8
Issue: 4
Pages: 368-376
ISSN: 1755-4330 (ISSN-L)
1755-4349
DOI: 10.1038/nchem.2451
OpenAlex: W2283133204
Cited by: 148
References: 58
Citations by year: 2026: 10 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 21 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 15 · 2017: 10 · 2016: 11
FWCI: 8.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Chemistry (publishedVersion)
PubMed (publishedVersion)
Kent Academic Repository (University of Kent) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
Keywords: cyanuric acid, nucleic acid self-assembly, triplex DNA, peptide nucleic acid, nucleic acid nanostructures
MeSH terms: Circular Dichroism, DNA, Hydrogen Bonding, Poly A, Triazines, Peptide Nucleic Acids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reprogramming the assembly of unmodified DNA with a small molecule

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks