Single-stranded DNA and RNA origami
Open accessAbstract
Large origami from a single strand: Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures. Science , this issue p. eaao2648
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There is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains unexplored.
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
Three-dimensional nucleic acid nanostructures have successfully been produced inside cells.
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
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RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
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Rationally designed DNA-based nanocarriers
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Paranemic Crossover DNA: There and Back Again.
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Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering
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Self-citationRNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy
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Self-citationA DNA Origami‐Based Gene Editing System for Efficient Gene Therapy in Vivo
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“In 2017, researchers proposed a framework for assembling an individual DNA or RNA strand into a complex but unknotted single-stranded origami (ssOrigami) structure.(2) This ssOrigami does not involve auxiliary strands and can be assembled into diverse spatially compact structures.”
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“Strategies developed for fabricating DNA/ RNA nanoassembly mainly include DNA origami [296], single-stranded tile (SST) DNA nanostructures [297], and single-stranded (ss) DNA/RNA origami [298].”
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DNA Catalyzed Efficient Production of Single-Stranded DNA Nanostructures
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Programming molecular topologies from single-stranded nucleic acids
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Self-citationNanopore microscope identifies RNA isoforms with structural colours
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Comparing proteins and nucleic acids for next-generation biomolecular engineering
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Programming Structured DNA Assemblies to Probe Biophysical Processes
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“For single-stranded DNA/RNA origami (33), we would need to adapt the colour coding as we currently depict only one colour per single strand.”
MethodDNA‐Based Nanofabrication for Nanoelectronics
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Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification
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Synthesis of DNA Origami Scaffolds: Current and Emerging Strategies
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“[89] prepared self-complementary ssDNA scaffolds with sizes ranging from 966 to 10,682 nts for staple-free DNA origami assembly.”
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Artificial Bioaugmentation of Biomacromolecules and Living Organisms for Biomedical Applications
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“Besides small RNA nanoparticle s constructed by bottom-up assembly, large RNA nanoparticles are also available using RNA origami (up to 6000 nt) and RCT (100 – 2000 nm) method [102, 103].”
Method3D RNA-scaffolded wireframe origami
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Aptamer-Functionalized DNA Nanostructures for Biological Applications
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Self-citationProgramming Dynamic Assembly of Viral Proteins with DNA Origami
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Self-citationNucleic Acid‐based Enzyme Cascades—Current Trends and Future Perspectives
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Remote Photothermal Control of DNA Origami Assembly in Cellular Environments
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DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions
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“Recent progress has been made to scale up DNA assemblies in terms of size and quantity [30] and to fold nanostructures with single-stranded nucleic acids [31].”
BackgroundActive Nuclear Import of Mammalian Cell-Expressible DNA Origami
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“…Since programmable self-assembly with DNA or RNA origami enables the fabrication of complex three-dimensional objects from DNA or RNA in a user-defined manner, 5 − 8 these approaches could also enable delivering genetic instructions in more complex ways and with additional functionalities to cells.”
RNA origami: design, simulation and application
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“[50] method involved thermal annealing from 85°C over 18 hours in a high-Mg2+ buffer; however, it was later demonstrated that similar structures could be annealed from 65°C in 10 hours without Mg [51].”
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Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy
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Near-Atomic Fabrication with Nucleic Acids
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DNA Nanostructures in the Fight Against Infectious Diseases
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Self-citationLight‐Activated Assembly of DNA Origami into Dissipative Fibrils
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Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates
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DNA Origami Post‐Processing by CRISPR‐Cas12a
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“ssDNA origami was also created by self-folding of a ssDNA strand that contained a partial complement to the desired shape via parallel crossover cohesion [140].”
Self-citationgRNAde: Geometric Deep Learning for 3D RNA inverse designPreprint
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RNA Origami Functions as a Self-Adjuvanted Nanovaccine Platform for Cancer Immunotherapy
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Self-citationPRNCR1: a long non-coding RNA with a pivotal oncogenic role in cancer
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Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions
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- Authors
- Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., Yan, H., & Yin, P.
- Affiliations
- Harvard University (US)
- Arizona State University (US)
- University of Science and Technology of China (CN)
- Autodesk (United States) (US)
- Corresponding author
- Han, Dongran
- Qi, Xiaodong
- An, Byoungkwon
- Zhang, Fei
- Yan, Hao
- Yin, Peng
- ORCID
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6384012
- OpenAlex
- W2775235705
- Cited by
- 300
- References
- 67
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 31 · 2023: 30 · 2022: 41 · 2021: 39 · 2020: 48 · 2019: 24 · 2018: 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- National Science Foundation (award355762, 1360635, award355763, 1563799, award355764, 1334109)
- Office of Naval Research (award355757, N000141010827, award355758, N000141310593, award355759, N000141410610, award355761, N000141512689)
- China Scholarship Council (award355765, 201506340048)
- Army Research Office (award355760, W911NF1210238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Keywords
- DNA origami, RNA origami, single-stranded DNA, single-stranded RNA, nucleic acid nanostructures, self-assembly, in vitro replication, in vivo replication, bottom-up nanotechnology
- MeSH terms
- DNA Replication, DNA, Single-Stranded, Escherichia coli, Nucleotides, RNA, Nanotechnology, Nanostructures, RNA Folding
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