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Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures
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“This is in stark contrast to GCA, which undergoes the Strecker reaction in excellent yield to afford a stable aminonitrile product, Ser-CN (fig. S2) (23, 24).”
From Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water (2020) · cites this paper as [23]
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“Other difficulty that arise in this context is the possible intramolecular imidolactone formation (10) by larger cyanohydrins (from parent triose, tetrose and pentose sugars; e.g., 9), which conduces to their consumption and hydrolysis into the homologous carboxylic acids (12) (Scheme 7, inbox).97”
From The protometabolic nature of prebiotic chemistry (2023) · cites this paper as [97]
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“However, glycolaldehyde and glyceraldehyde can react with 2-aminothiazole to give the corresponding aminals, which selectively precipitate to give crystalline reservoirs of these key intermediates (Islam et al. 2017).”
From Protocells and RNA Self-Replication (2018) · cites this paper as Islam et al. 2017
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“This scenario relies on two main monomers, formaldehyde and HCN, to produce glyconitrile, plus the action of schreibersite ((Fe, Ni) 3P), hydrosulfide (HS−) as reducing agent, copper and ultraviolet light, to promote the homologation to higher cyanohydrins”
From The protometabolic nature of prebiotic chemistry (2023) · cites this paper as [97]
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Metadata
- Authors
- Islam, S., Bučar, D.-K., & Powner, M. W.
- Affiliations
- University College London (GB)
- Corresponding author
- Powner, Matthew W.
- Venue
- Nature Chemistry
- Published
- 2017-01-16
- Volume
- 9
- Issue
- 6
- Pages
- 584-589
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2578576796
- Cited by
- 115
- References
- 36
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 7 · 2023: 17 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 11 · 2017: 13
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemistry (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Leverhulme Trust
- Engineering and Physical Sciences Research Council (EP/K004980/1)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Physical Organic Chemistry and Reaction Kinetics
- Keywords
- prebiotic synthesis, proteinogenic amino acids, nucleotide synthesis, ribonucleotide synthesis, 2-aminothiazole, glycolaldehyde, glyceraldehyde, dihydroxyacetone, isomerization, sugar purification, amino acid selection, origin of life, origin of metabolism
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