The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation
Open accessAbstract
Nucleic acids have attracted widespread attention due to the simplicity with which they can be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of DNA/RNA nanotechnology offer numerous opportunities for in-cell and in-vivo applications, and the technology holds great promise to advance the growing field of synthetic biology. Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss the key problems that must be solved to fully exploit the useful properties of nanostructures. Finally, we provide viewpoints on how to integrate the tools provided by DNA/RNA nanotechnology and related new technologies to construct nucleic acid nanostructure-based molecular circuitry for synthetic biology.
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,683
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.022 · Cited by 5,016
Molecular Computation of Solutions to Combinatorial Problems
Adleman, L. M. (1994) · Science · doi:10.1126/science.7973651 · Cited by 4,474
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
Gaj, T., Gersbach, C. A., & Barbas, C. F. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2013.04.004 · Cited by 3,820
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.044 · Cited by 3,696
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
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DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives
Li, H., Xie, Y., Chen, F., Bai, H., Xiu, L., Zhou, X., Guo, X., Hu, Q., & Yin, K. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00594h · Cited by 346
The biological applications of DNA nanomaterials: current challenges and future directions
Ma, W., Zhan, Y., Zhang, Y., Mao, C., Xie, X., & Lin, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00727-9 · Cited by 331
Solving mazes with single-molecule DNA navigators
Chao, J., Wang, J., Wang, F., Ouyang, X., Kopperger, E., Liu, H., Li, Q., Shi, J., Wang, L., Hu, J., et al. (2019) · Nature Materials · doi:10.1038/s41563-018-0205-3 · Cited by 258
Self-citationEncoding Carbon Nanotubes with Tubular Nucleic Acids for Information Storage
Zhang, Y., Li, F., Li, M., Mao, X., Jing, X., Liu, X., Li, Q., Li, J., Wang, L., Fan, C., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09116 · Cited by 49
Self-citation
Metadata
- Authors
- Li, J., Green, A. A., Yan, H., & Fan, C.
- Venue
- Nature Chemistry
- Published
- 2017-09-25
- Volume
- 9
- Issue
- 11
- Pages
- 1056-1067
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2760464869
- Cited by
- 353
- References
- 163
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
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