The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zinc activates damage-sensing TRPA1 ion channels
Open accessAbstract
Zinc is an essential biological trace element. It is required for the structure or function of over 300 proteins, and is increasingly recognized for its role in cell signaling. However, high concentrations of zinc have cytotoxic effects, and overexposure to zinc can cause pain and inflammation through unknown mechanisms. Here we show that zinc excites nociceptive somatosensory neurons and causes nociception in mice through TRPA1, a cation channel previously shown to mediate the pungency of wasabi and cinnamon through cysteine-modification. Zinc activates TRPA1 through a novel mechanism that requires zinc influx through TRPA1 channels and subsequent activation via specific intracellular cysteine and histidine residues. TRPA1 is highly sensitive to intracellular zinc, as low nanomolar concentrations activate TRPA1 and modulate its sensitivity. These findings identify TRPA1 as a major target for the sensory effects of zinc, and support an emerging role for zinc as a signaling molecule that can modulate sensory transmission.
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Cites
Analysis of the structural consensus of the zinc coordination centers of metalloprotein structures
Patel, K., Kumar, A., & Durani, S. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.07.010 · Cited by 123
Cited by
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 606
The functions of TRPA1 and TRPV1: moving away from sensory nerves
Fernandes, E., Fernandes, M., & Keeble, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01851.x · Cited by 411
Jin, G., Qin, H., Cao, H., Qian, S., Zhao, Y., Peng, X., Zhang, X., Liu, X., & Chu, P. K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.074 · Cited by 406
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Qin, Y., Dittmer, P. J., Park, J. G., Jansen, K. B., & Palmer, A. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015686108 · Cited by 306
Metadata
- Authors
- Hu, H., Bandell, M., Petrus, M. J., Zhu, M. X., & Patapoutian, A.
- Venue
- Nature Chemical Biology
- Published
- 2009-02-08
- Volume
- 5
- Issue
- 3
- Pages
- 183-190
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2047426956
- Cited by
- 229
- References
- 1
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Hu, H., Bandell, M., Petrus, M. J., Zhu, M. X., & Patapoutian, A. (2009). Zinc activates damage-sensing TRPA1 ion channels. Nature Chemical Biology. https://doi.org/10.1038/nchembio.146
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