The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chromatin-level regulation of biosynthetic gene clusters
Open accessAbstract
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone 3 lysine 4 methylation, activated the expression of cryptic secondary metabolite (SM) clusters in A. nidulans. One novel cluster generated monodictyphenone, emodin and emodin derivatives while a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal SM clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.
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Cites
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., Berriman, M., Abe, K., Archer, D. B., Bermejo, C., et al. (2005) · Nature · doi:10.1038/nature04332 · Cited by 1,391
Self-citationLaeA, a Regulator of Secondary Metabolism in Aspergillus spp
Bok, J. W., & Keller, N. P. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.527-535.2004 · Cited by 902
Self-citationTranscriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Perrin, R. M., Fedorova, N. D., Bok, J. W., Cramer, R. A., Wortman, J. R., Kim, H. S., Nierman, W. C., & Keller, N. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030050 · Cited by 352
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Cited by
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
Rutledge, P. J., & Challis, G. L. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3496 · Cited by 986
Fungal secondary metabolites – Strategies to activate silent gene clusters
Brakhage, A. A., & Schroeckh, V. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.04.004 · Cited by 729
Amaike, S., & Keller, N. P. (2011) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-072910-095221 · Cited by 668
Self-citationNitrogen regulation of fungal secondary metabolism in fungi
Tudzynski, B. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00656 · Cited by 353
Nützmann, H.-W., Reyes-Dominguez, Y., Scherlach, K., Schroeckh, V., Horn, F., Gacek, A., Schümann, J., Hertweck, C., Strauss, J., & Brakhage, A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103523108 · Cited by 337
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Metadata
- Authors
- Bok, J. W., Chiang, Y.-M., Szewczyk, E., Reyes-Dominguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H.-C., Watanabe, K., Strauss, J., Oakley, B. R., Wang, C. C. C., & Keller, N. P.
- Venue
- Nature Chemical Biology
- Published
- 2009-05-17
- Volume
- 5
- Issue
- 7
- Pages
- 462-464
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2158612142
- Cited by
- 381
- References
- 3
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Bok, J. W., Chiang, Y.-M., Szewczyk, E., Reyes-Dominguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H.-C., Watanabe, K., Strauss, J., Oakley, B. R., Wang, C. C. C., & Keller, N. P. (2009). Chromatin-level regulation of biosynthetic gene clusters. Nature Chemical Biology. https://doi.org/10.1038/nchembio.177
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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