The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA-catalyzed sequence-specific hydrolysis of DNA
Open accessAbstract
Deoxyribozymes (DNA catalysts) have been reported for cleavage of RNA phosphodiester linkages, but cleaving peptide or DNA phosphodiester linkages is much more challenging. Using in vitro selection, here we identified deoxyribozymes that sequence-specifically hydrolyze DNA with multiple turnover and rate enhancement of 108 (possibly as high as 1014). The new DNA catalysts require both Mn2+ and Zn2+, which is intriguing because many natural DNA nucleases are bimetallic protein enzymes.
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Radzicka, A., & Wolfenden, R. (1996) · Journal of the American Chemical Society · doi:10.1021/ja954077c · Cited by 484
Cited by
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes
Silverman, S. K. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.04.010 · Cited by 364
Self-citationRecent progress in non-native nucleic acid modifications
McKenzie, L. K., El-Khoury, R., Thorpe, J. D., Damha, M. J., & Hollenstein, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01430c · Cited by 300
Metadata
- Authors
- Chandra, M., Sachdeva, A., & Silverman, S. K.
- Venue
- Nature Chemical Biology
- Published
- 2009-08-16
- Volume
- 5
- Issue
- 10
- Pages
- 718-720
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2059361662
- Cited by
- 194
- References
- 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
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