Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Cited by (318)

Items 101–200 of 318

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4. Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
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5. TEAD4 as an Oncogene and a Mitochondrial Modulator
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7. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities
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8. Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression
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9. Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid
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10. Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer
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13. Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma
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15. Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
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19. Targeting YAP1 / TAZ in nonsmall‐cell lung carcinoma: From molecular mechanisms to precision medicine
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20. Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
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22. Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery
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23. Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy
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25. Auto-fatty acylation of transcription factor RFX3 regulates ciliogenesis
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26. Nuclear Import and Export of YAP and TAZ
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27. Diffuse Gastric Cancer: A Comprehensive Review of Molecular Features and Emerging Therapeutics
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28. Targeting the Hippo pathway in cancer: kidney toxicity as a class effect of TEAD inhibitors?
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29. Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
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30. Palmitoylation as a Signal for Delivery
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31. Regulation and functions of the Hippo pathway in stemness and differentiation
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32. Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity
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33. Targeting the Hippo/ YAP / TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
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34. The Hippo signaling pathway in gastric cancer
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35. Leveraging Hot Spots of TEAD–Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling
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36. A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors
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37. Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists
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38. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal
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40. Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders
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41. Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs
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42. Pharmacological regulators of Hippo pathway: Advances and challenges of drug development
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44. Discovery of Dioxo-Benzo[b]Thiophene Derivatives as Potent YAP-TEAD Interaction Inhibitors for Treating Breast Cancer
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45. Structural Insights into the Regulation of Hippo Signaling
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47. Discovering inhibitors of TEAD palmitate binding pocket through virtual screening and molecular dynamics simulation
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48. YAP1 is essential for malignant mesothelioma tumor maintenance
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50. Fluorescence polarization assay for the identification and evaluation of inhibitors at YAP–TEAD protein–protein interface 3
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51. Mechanosensitive Pathways Involved in Cardiovascular Development and Homeostasis in Zebrafish
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52. Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket
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53. Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex
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54. Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases
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55. The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
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56. Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer
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57. YAP/TAZ: An epitome of tumorigenesis
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58. Allosteric Modulation of the YAP/TAZ-TEAD Interaction by Palmitoylation and Small-Molecule Inhibitors
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59. NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop
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60. Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis
    Kristianne Michelle Oristian, Lisa E.S. Crose, Nina Kuprasertkul, Rex C. Bentley, Yi-Tzu Lin, Nerissa T. Williams, David G. Kirsch, Corinne Mary Linardic · 2018 · Cancer Research
61. Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges
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64. Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the α-Helix Pocket on TEAD
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66. Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response
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100. Activation of Hepatocyte Growth Factor/MET Signaling as a Mechanism of Acquired Resistance to a Novel YAP1/TEAD Small Molecule Inhibitor
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