Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Miyake, Yasuyuki, Keusch, Jeremy J, Wang, Longlong, Saito, Makoto, Hess, Daniel, Wang, Xiaoning, Melancon, Bruce J, Helquist, Paul, Gut, Heinz, Matthias, Patrick·2016·Nature Chemical Biology
DOI 10.1038/nchembio.2140

Cited by (355)

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  8. BindingDB Entry 50008290: Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
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  12. BindingDB Entry 50014198: Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
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  13. BindingDB Entry 50010450: Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.
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  14. BindingDB Entry 50006699: Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.
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  15. BindingDB Entry 50013991: Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
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  16. BindingDB Entry 50007224: Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.
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  17. BindingDB Entry 50023657: Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
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  18. BindingDB Entry 50001427: Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.
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  19. BindingDB Entry 50021347: Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine.
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  20. BindingDB Entry 50014711: Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease.
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  22. BindingDB Entry 50008152: Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
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  23. BindingDB Entry 50003278: Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.
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  24. BindingDB Entry 50002245: Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
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  25. BindingDB Entry 50018173: Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
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  26. BindingDB Entry 50007194: Highly fluorescent and HDAC6 selective scriptaid analogues.
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  27. BindingDB Entry 50010801: Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6.
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  28. BindingDB Entry 50020470: Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
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  29. BindingDB Entry 50009704: HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.
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  30. BindingDB Entry 50012424: Structure-activity relationship and mechanistic studies for a series of cinnamyl hydroxamate histone deacetylase inhibitors.
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  31. BindingDB Entry 50001936: Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.
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  32. BindingDB Entry 50018218: Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
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  33. BindingDB Entry 50000191: Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
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  34. BindingDB Entry 50007910: Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
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  35. BindingDB Entry 50015587: A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity.
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  36. BindingDB Entry 50008856: Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
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  37. BindingDB Entry 50009674: Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
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  38. BindingDB Entry 50016863: Histone deacetylase 6 inhibitors with blood-brain barrier penetration as a potential strategy for CNS-Disorders therapy.
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  39. BindingDB Entry 50023583: Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases.
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  40. BindingDB Entry 50049021: Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.
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  41. BindingDB Entry 50010615: Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.
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  42. BindingDB Entry 50002898: The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.
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  43. BindingDB Entry 50006856: Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.
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  44. BindingDB Entry 50022753: Discovery of Janus Kinase and Histone Deacetylase Dual Inhibitors as a New Strategy to Treat Psoriasis.
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  46. BindingDB Entry 50015193: Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.
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  47. BindingDB Entry 50009095: Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.
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  49. BindingDB Entry 50002433: Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
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  53. BindingDB Entry 50007091: Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.
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  54. BindingDB Entry 50000333: Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
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  55. BindingDB Entry 50013572: Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction.
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