Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Cited by (292)

Items 101–200 of 292

1. Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis
   Qidi Chen, Min Xin, Lingjun Wang, Lin Li, Yingzhi Shen, Yan Geng, Haojie Jiang, Yang Wang, Lin Zhang, Yanyan Xu et al. · 2022 · Blood
2. Lactylation in cancer biology: Unlocking new avenues for research and therapy
   Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han · 2025 · 癌症：英文版
3. The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data
   Yanshan Ge, Zhengxi He, Yanqi Xiang, Dawei Wang, Yuping Yang, Jian Qiu, Yanhong Zhou · 2019 · Molecular Biology Reports
4. Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment?
   John M. Macharia, Zsolt Káposztás, Tímea Varjas, Ferenc Budán, Afshin Zand, Imre Bodnár, Bence László Raposa · 2023 · Biomedicine & Pharmacotherapy
5. Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention
   Mingyue Wang, Quanling Zhou, Tingping Cao, Fujun Li, Xiaohui Li, Mingyu Zhang, Ya Zhou · 2025 · Journal of Translational Medicine
6. MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer
   Alessio Cannistraci, Pauline Hascoët, Adnan Ali, Piyushkumar A. Mundra, Noel William Clarke, Valeria Pavet, Richard Marais · 2022 · Oncogene
7. Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies
   Shuying Xiao, Suhang Zhang, Kai Sun, Qibo Huang, Qilin Li, Chuanyu Hu · 2025 · Biomarker Research
8. Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
   Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael F. Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène et al. · 2019 · Oncogenesis
9. Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response
   Melissa Schwab, Katharina Thunborg, Omid Azimzadeh, Christine von Toerne, Caroline Werner, Maxim Alekseevich Shevtsov, Tommaso Di Genio, Maša Ždralević, Jacques Pouysségur, Kathrin Renner et al. · 2021 · Cancers
10. Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubín-de-Celis, Carsten Theiß, Veronika Matschke et al. · 2021 · iScience
11. Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity
    Ferran Nadal‐Bufí, Jody M. Mason, Lai Yue Chan, David J. Craik, Quentin Kaas, Sónia Troeira Henriques · 2021 · Journal of Medicinal Chemistry
12. The Development of Single-Cell Metabolism and Its Role in Studying Cancer Emergent Properties
    Dingju Wei, Meng Michelle Xu, Zhihua Wang, Jingjing Tong · 2022 · Frontiers in Oncology
13. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation
    Sichuan Xiang, Ding Huang, Qiaolin He, Jie Li, Kin Yip Tam, Shaolin Zhang, Yun He · 2020 · European Journal of Medicinal Chemistry
14. Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
    Laura Di Magno, Antonio Coluccia, Marianna Bufano, Silvia Ripa, Giuseppe La Regina, Marianna Nalli, Fiorella Di Pastena, Gianluca Canettieri, Romano Silvestri, Luigi Frati · 2022 · European Journal of Medicinal Chemistry
15. The potential role of reprogrammed glucose metabolism: an emerging actionable codependent target in thyroid cancer
    Saili Duan, Min Wu, Zhejia Zhang, Shi Chang · 2023 · Journal of Translational Medicine
16. Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting
    Bo‐Syong Pan, Che-Chia Hsu, Hsin‐En Wu, Yuan-Ru Chen, Xiaobo Zhou, Shu‐Chi Wang, Chia‐Yang Li, Hui-Kuan Lin · 2025 · Journal of Biomedical Science
17. Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria
    J. Ding, Rajesh Gumpena, Marc-Olivier Boily, Alexandre Caron, Oliver Chong, Jennifer H. Cox, Valérie Dumais, Samuel Gaudreault, Aaron H. Graff, Andrew King et al. · 2021 · ACS Medicinal Chemistry Letters
18. Metabolism heterogeneity in melanoma fuels deactivation of immunotherapy: Predict before protect
    Xinyue Zhang, Zongguang Tai, Fengze Miao, Hao Huang, Quangang Zhu, Leilei Bao, Zhongjian Chen · 2022 · Frontiers in Oncology
19. Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma
    John A. Smestad, Oksana Hamidi, Lin Wang, Molly Nelson Holte, Fatimah J. Al Khazal, Luke N. Erber, Yue Chen, Louis James Maher · 2017 · Oncotarget
20. Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis
    Maria V. Liberti, Annamarie E. Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R. Singleton, Zufeng Guo, Jun O. Liu, Kris C. Wood, Jason W. Locasale · 2019 · Journal of Biological Chemistry
21. Lactate metabolism reprogramming in PDAC: Potential for tumor therapy
    Fan Gao, Kang Sun, Sicheng Wang, Xiaozhen Zhang, Xueli Bai · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
22. Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas
    Masatomo Maeda, Myat Kyaw Ko, Mayuresh M. Mane, Ivan Cohen, Masahiro Shindo, Kiranmayi Vemuri, Inna S. Serganova, Ronald G. Blasberg · 2022 · Cancers
23. Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid
    Anderson R. Frank, Vicky Li, Spencer D. Shelton, Jiwoong Kim, Gordon M. Stott, Leonard Μ. Neckers, Yang Xie, Noelle Sevilir Williams, Prashant Mishra, David G. McFadden · 2023 · Cancer Discovery
24. Discovery of potent human lactate dehydrogenase A (LDHA) inhibitors with antiproliferative activity against lung cancer cells: virtual screening and biological evaluation
    Xiaomei Li, Wenhua Xiao, Huixia Zhao · 2017 · MedChemComm
25. Proteomics analysis of meclofenamic acid‐treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival
    Sevinç Yanar, Murat Kasap, Aylin Kanlı, Gürler Akpınar, Mehmet Sarıhan · 2022 · Journal of Biochemical and Molecular Toxicology
26. Therapeutic strategies targeting metabolic characteristics of cancer cells
    Rilan Bai, Ying Meng, Jiuwei Cui · 2023 · Critical Reviews in Oncology/Hematology
27. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH‐A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR
    Gopal Varma, Pankaj Seth, Patrícia Coutinho de Souza, Cody J. Callahan, Jocelin Pinto, Manushka V. Vaidya, Olmo Sonzogni, Vikas P. Sukhatme, Gerburg M. Wulf, Aaron K. Grant · 2021 · NMR in Biomedicine
28. Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis
    Rabdan M. Tikhov, Nikolai Yu. Kuznetsov · 2020 · Organic & Biomolecular Chemistry
29. Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure
    Sydney Stanley, Xin Wang, Qingyun Liu, Young‐Yon Kwon, Abigail M Frey, Nathan D. Hicks, Andrew Julian Vickers, Sheng Tony Hui, Sarah M. Fortune · 2024 · PLoS Pathogens
30. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer
    Horrick Sharma, Somrita Mondal, Uzziah S. Urquiza, Colter Esparza, Seth Bartlett, Landon Santa-Pinter, Hanna Hill, Madalyn White, Pragya Sharma, Lerin R. Luckett‐Chastain et al. · 2024 · European Journal of Medicinal Chemistry
31. Pyrazine Moiety: Recent Developments in Cancer Treatment
    Rakesh Sahu, Kamal Shah, Yash Gautam, Kaushilya Sahu · 2023 · Current Organic Chemistry
32. Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies
    Balaraman Kalyanaraman, Gang Cheng, Jacek Zielonka, Brian Bennett · 2018 · Cell Biochemistry and Biophysics
33. Modification in Structures of Active Compounds in Anticancer Mitochondria-Targeted Therapy
    Agnieszka Felczykowska, Anna Herman-Antosiewicz · 2025 · International Journal of Molecular Sciences
34. Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
    Jan Dreute, Julia Stengel, Jonas Becher, David R. van den Borre, Maximilian Pfisterer, Marek Bartkuhn, Vanessa M. Beutgen, Benardina Ndreshkjana, Ulrich Gärtner, Johannes Graumann et al. · 2025 · Cell Death and Differentiation
35. Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
    Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong · 2025 · Advanced Science
36. Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy
    Eduardo Angulo-Elizari, Leire Gaviria-Soteras, Irati Zubiri, Sandra Ramos-Inza, Carmen Sanmartín, Daniel Plano · 2023 · Drugs and Drug Candidates
37. Perspective on the dynamics of cancer
    Youcef Derbal · 2017 · Theoretical Biology and Medical Modelling
38. Reclaiming Warburg: using developmental biology to gain insight into human metabolic diseases
    Daniela Drummond‐Barbosa, Jason M. Tennessen · 2020 · Development
39. Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
    Léopold Thabault, Maxime Liberelle, Katarina Koruza, Esra Yildiz, Nicolas Joudiou, Joris Messens, Lucie Brisson, Johan Wouters, Pierre Sonveaux, Raphaël Frédérick · 2021 · Journal of Biological Chemistry
40. Lactic Acidosis in Patients with Solid Cancer
    Petr Heneberg · 2022 · Antioxidants and Redox Signaling
41. α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting
    Yanwu Wang, Ning Shen, Gervase Spurlin, Sovannarith Korm, Sarah X.L. Huang, Nicole M. Anderson, Leah N. Huiting, Hudan Liu, Hui Feng · 2022 · Cancers
42. Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
    F. Borea, Marika A. Frańczak, M. Garcia, M. Perrino, Nadia Cordua, R. Smoleński, G. Peters, R. Dziadziuszko, A. Santoro, P. Zucali et al. · 2023 · International Journal of Molecular Sciences
43. The effect of lactate dehydrogenase inhibitors on proliferation, motility and invasion of breast cancer cells in vitro highlights a new role for lactate
    Maitham Abbas Khajah, Sarah Khushaish, Yunus A. Luqmani · 2023 · Molecular Medicine Reports
44. LDHA Suppression Altering Metabolism Inhibits Tumor Progress by an Organic Arsenical
    Yujiao Liu, Xiaoyang Fan, An-Dong Wang, Yin‐Zheng Xia, Wen-Rong Fu, Jun-Yi Liu, Feng‐Lei Jiang, Yi Liu · 2019 · International Journal of Molecular Sciences
45. The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy
    Xiaofeng Liu, Yongqiang Zheng, Zhengwei Li, Yiyang Ma, Ruomu Cao, Zhikai Zheng, Yuchen Tian, Lin Du, Jinshan Zhang, Changqing Zhang et al. · 2025 · Journal of Orthopaedic Translation
46. Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
    Ferran Nadal‐Bufí, Lai Yue Chan, Hadi H. Mohammad, Jody M. Mason, Carlos Salomón, Andrew Lai, Erik W. Thompson, David J. Craik, Quentin Kaas, Sónia Troeira Henriques · 2022 · Cellular and Molecular Life Sciences
47. LDHA‐mediated M2‐type macrophage polarization via tumor‐derived exosomal EPHA2 promotes renal cell carcinoma progression
    Xinxin Gan, Jiatao Hu, Qingyang Pang, Rui Yan, Yi Bao, Ying Liu, Jiaao Song, Zheng Wang, Wei‐Hao Sun, Fuzhao Huang et al. · 2024 · Molecular Carcinogenesis
48. Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP
    Hui Cong, Jian Ping Gao, Qing Wang, Min Du, Huimin Li, Qian Li, Jin Li, Yiyi Liang, Dan Zhao, Hancao Yang et al. · 2022 · Frontiers in Oncology
49. Predicting protein–ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A
    Iva Lukač, Hend E. Abdelhakim, Richard A. Ward, Stephen A. St-Gallay, Judith Clare Madden, Andrew G. Leach · 2019 · Chemical Science
50. Lactylation: a novel driver of drug resistance in the tumor microenvironment
    Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Lifeng Li · 2025 · Cancer Drug Resistance
51. Targeting inosine metabolism to enhance EGFR-targeted therapy in lung adenocarcinoma
    Xiaolong Huang, Jiaqi Liang, Yanjun Yi, Junkan Zhu, Han Lin, Shencheng Ren, Cheng Tao, Guoshu Bi, Guangyao Shan, Dejun Zeng et al. · 2025 · Cancer Letters
52. Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid
    ELIZABETH A. MAZZIO, Nzinga Mack, Ramesh Babu Badisa, Karam F. A. Soliman · 2021 · Biomolecules
53. Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase-A against Pancreatic Cancer
    Horrick Sharma, Pragya Sharma, Uzziah S. Urquiza, Lerin R. Luckett‐Chastain, Michael A. Ihnat · 2023 · Journal of Chemical Information and Modeling
54. Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization
    Yonghong Ding, Gabriele Stevanato, Frederike von Bonin, Dieter Kube, Stefan Glöggler · 2023 · Chemical Science
55. D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells
    Kathrin Hammon, Kathrin Renner, Michael Althammer, Florian Voll, Nathalie Babl, Sonja-Maria Decking, Peter J. Siska, Carina Matos, Zugey Elizabeth Cárdenas-Conejo, Karina Mendes et al. · 2024 · Haematologica
56. Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
    Fiona Grimm, Agustín Asuaje, Aakriti Jain, Mariana Silva dos Santos, Jens Kleinjung, Patrícia M. Nunes, Stefanie M. Gehrig, Louise Fets, Salihanur Darici, James I. MacRae et al. · 2024 · The EMBO Journal
57. An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors
    Haijun Gu, Yangrui Peng, Yihua Chen · 2020 · Current Topics in Medicinal Chemistry
58. Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms
    Ying Hao Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao et al. · 2025 · MedComm
59. Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target
    Weimei Xing, Xiaowei Li, Yuli Zhou, Mengsen Li, Mingyue Zhu · 2023 · Exploration of Medicine
60. Aberrant lactate dehydrogenase A signaling contributes metabolic signatures in pancreatic cancer
    Wenna Jiang, Lu Qiao, Duo Zuo, Di Qin, Jiawei Xiao, Haohua An, Yanhui Wang, Xinwei Zhang, Jin Hui Yu, Li Ren · 2021 · Annals of Translational Medicine
61. Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer
    Zhengwei Wu, Yi Fei Lee, Xun Hui Yeo, Ser Yue Loo, Wai Leong Tam · 2021 · Cancers
62. Metabolism in the tumor microenvironment: implications for pathogenesis and therapeutics
    Jonas Aakre Wik, Emma Riiser Berge, Kristine Stromsnes, Bjørn Steen Skålhegg · 2025 · Frontiers in Immunology
63. Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy
    Yongjian Guo, Chengju Luo, Yuening Sun, Wenjing Guo, Ruitian Zhang, Xin Zhang, Xue Ke, Libin Wei · 2023 · Biomedicine & Pharmacotherapy
64. Histone lactylation: a new target for overcoming immune evasion and therapy resistance
    Fatemeh Ghadyani, Pouyan Zandi, Soudeh Ghafouri‐Fard · 2025 · Medical Oncology
65. An antioxidant response element regulates the HIF1α axis in breast cancer cells
    Sarah E. Lacher, Cara Skon-Hegg, Brian L. Ruis, Jennifer Krznarich, Matthew G. Slattery · 2023 · Free Radical Biology and Medicine
66. Intracellular spatiotemporal metabolism in connection to target engagement
    Jingwei Zhang, Zhixia Qiu, Yongjie Jessica Zhang, Guangji Wang, Haiping Hao · 2023 · Advanced Drug Delivery Reviews
67. Metabolism and mRNA translation: a nexus of cancer plasticity
    Xinpu Tang, Kaixiu Li, Yuqing Wang, Stéphane Rocchi, Shensi Shen, Michaël Cerezo · 2024 · Trends in Cell Biology
68. Intranuclear TCA and mitochondrial overload: The nascent sprout of tumors metabolism
    Weixi Yuan, Guozhong Lu, Yin Zhao, Xianghuo He, Senyi Liao, Zhe Wang, Xiaoyong Lei, Zhizhong Xie, Xiaoyan Yang, Shengsong Tang et al. · 2025 · Cancer Letters
69. Metabolism, a Blossoming Target for Small-Molecule Anticancer Drugs
    Michela Puxeddu, Romano Silvestri, Giuseppe La Regina · 2025 · Molecules
70. Transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor–resistant pancreatic ductal adenocarcinoma
    Parmanand Malvi, Vipin Rawat, Romi Gupta, Narendra Wajapeyee · 2022 · Frontiers in Oncology
71. The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment
    Julie Contenti, Yongjian Guo, A. Mazzu, Marie Irondelle, Matthieu Rouleau, Chiara Lago, Gloria Leva, Luca Tiberi, Issam Ben‐Sahra, Frédéric Bost et al. · 2023 · Cell Death and Disease
72. Chlamydia trachomatis development requires both host glycolysis and oxidative phosphorylation but has only minor effects on these pathways
    Maimouna D. N’Gadjaga, Stéphanie Perrinet, Michael G. Connor, Giulia Bertolin, Gaël A. Millot, Agathe Subtil · 2022 · Journal of Biological Chemistry
73. A patent review of lactate dehydrogenase inhibitors (2014–present)
    Giulia Bononi, Valeria Di Bussolo, Tiziano Tuccinardi, Filippo Minutolo, Carlotta Granchi · 2024 · Expert Opinion on Therapeutic Patents
74. Flipping the Target: Evaluating Natural LDHA Inhibitors for Selective LDHB Modulation
    Amanda El Khoury, Christos P. Papaneophytou · 2025 · Molecules
75. A Medicinal Chemistry Perspective on Lactate Dehydrogenase: Current Status and Future Directions
    Wanyi Pan, Chengpeng Tao, Yi Wu, Feng Jiang · 2025 · Journal of Medicinal Chemistry
76. Lactate and lactylation in tumor immunity
    Song Liu, Lingjuan Sun, Song Chen, Peixiang Lan · 2025 · Frontiers of Medicine
77. Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment
    Jiarui Ma, Vipul Bhardwaj, Peter Edward Lobie, Vijay Pandey · 2026 · Molecular Cancer
78. EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
    Aishwarya Krishnan, Aishwarya I. Bhasker, Mithalesh Kumar Singh, Carlos Iván Rodríguez, Edgardo Castro‐Pérez, Sarah Altameemi, Marcos Lares, Hamidullah Khan, Mary Ann Ndiaye, Nihal Ahmad et al. · 2022 · Molecular Cancer Research
79. High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells
    Veronica Valvo, Elena Parietti, Kyle Deans, Sebastian W. Ahn, Noel R. Park, Benjamin Ferland, Devon Thompson, Christine A. Dominas, Sharath K. Bhagavatula, Shawn M. Davidson et al. · 2022 · Frontiers in Cell and Developmental Biology
80. Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay
    Yuanyuan Shu, Jianda Yue, Yaqi Li, Yekui Yin, Jiaxu Wang, Tingting Li, Xiao He, Songping Liang, Gaihua Zhang, Zhonghua Liu et al. · 2024 · Journal of Computer-Aided Molecular Design
81. Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection
    Mark S. Gibson, Cláudia Noronha-Estima, Margarida Gama‐Carvalho · 2022 · Genes
82. The Emerging Role of Lactate and Lactylation Modifications in the Pathophysiology of Atherosclerotic Cardiovascular Diseases
    Xianqiong Lu, Qiyuan Luo, Danfeng Yu, Yan He, Jiyu Chen · 2025 · Cardiovascular Drugs and Therapy
83. Lactate and lactylation in intervertebral disc degeneration
    Yadong Liu, Jihao Yang, Zihui Wang, Jing Hui Fu, Hongpeng Liu, Zekun Lu, Jinwei Dong, Zhong Li, Qiuyue Mao, Chunlan Li et al. · 2025 · Frontiers in Molecular Biosciences
84. Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors
    Giulio Poli, Carlotta Granchi, Mohamed Aissaoui, Filippo Minutolo, Tiziano Tuccinardi · 2017 · Molecules
85. Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1
    Biljana Blagojevic, Fadi Almouhanna, Gernot Poschet, Stefan Wölfl · 2022 · Cells
86. Catalytic immunotherapy via ultrasmall Ir supported metal clusters on defect-engineered nanoplatforms for tumor metabolic disruption and enhanced immunogenic cell death
    Liang Zhuang, Qinzong Gao, Lishi Chen, Xinyu Xiong, Yu Wei, Shan He, Dawei Li, Shanyue Guan, Hui Chen · 2025 · Nano Today
87. Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors
    Horrick Sharma, Ty Elliott, Amery Good, Pragya Sharma, Somrita Mondal, Lerin R. Luckett‐Chastain, Michael A. Ihnat · 2025 · European Journal of Medicinal Chemistry
88. A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity
    Xingxiu Pan, Subrata Munan, Austin L. Zuckerman, Andrew Pon, Niklas B. Thompson, Rasangi M. Perera, Nirajan Shrestha, Sara Nunes Violante, Justin R. Cross, Russell P. Goodman et al. · 2026 · Nature Metabolism
89. Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications
    Yue Yang, Ying He, Ziyi Zhang, Y L Zhang, Rui Gao, Ke Du, Yan Wu, Ji Wu, Minjie Wei, Mingyan Liu · 2026 · Signal Transduction and Targeted Therapy
90. Single-Cell Transcriptome Reveals the Metabolic and Clinical Features of a Highly Malignant Cell Subpopulation in Pancreatic Ductal Adenocarcinoma
    Yangyang Fang, Shunjie Pei, Kaizhao Huang, Feng Xu, Guangxin Xiang, Linhua Lan, Xiaoqun Zheng · 2022 · Frontiers in Cell and Developmental Biology
91. Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability
    Alexander G. Dalecki, Braxton D. Greer, Alexandra Emilie Duverger, Elan L. Strange, Eric Carlin, Frederic Wagner, Bi Shi, Kelsey Elizabeth Lowman, Mildred D. Perez, Christopher Tidwell et al. · 2022 · Journal of Virology
92. Chemoproteomics Maps Glycolytic Targetome in Cancer Cells
    Yang Tian, Ning Wan, Ming Ding, Chang Shao, Nian Wang, Qiuyu Bao, Wenjie Lu, Hai Hu, Huiyong Sun, Chenxi Yang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
93. Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets
    Xiuping Wang, Cheng Liu, Yue Chen, Yuqing Fang, J N Li, Yu Liu, Yu Pan, Suya Bao, Xiwen Wang, Yi Liu et al. · 2026 · Molecular Biomedicine
94. ATF4‐amino acid circuits: a recipe for resistance in melanoma
    Mario R. Fernandez, John L. Cleveland · 2018 · The EMBO Journal
95. Tumor Metabolism: Focused on Tumor Glycolysis, Progress, and Prospects in Cancer Therapy
    Atul Kumar, Mamta Singh, Dolly Sharma, Vinit Kumar, Reshma Rani · 2021 · Burger's Medicinal Chemistry and Drug Discovery
96. A Natural LDHA Allosteric Inhibitor Geraniin Suppresses Triple‐Negative Breast Cancer Cell Growth
    Yan Ping Yu, Xianlong Ye, Tao Hou, Han Zhou, Longying Liu, Wenjie Yuan, Jixia Wang, Xinmiao Liang · 2025 · Phytotherapy Research
97. Biomimetic nanoparticles targeting metabolic reprogramming of tumor and immune cells to enhance colon cancer therapy
    Shaomin Wang, Xuerui Li, Ze Sheng Xu, Kaixuan Zhang, Chunzhi Huang, Yuxia Luan, Wenxiu He, Yue Jiang · 2025 · Chemical Engineering Journal
98. Machine-Learning-Driven Discovery of N-Phenylbenzenesulfonamides as a Novel Chemotype for Lactate Dehydrogenase A Inhibition with Anti-Pancreatic Cancer Activity
    Qijie Gong, Ying Dong, Jiaqi Liang, Jian Zhou, Guowei Zhang, Le Yang, Tiande Bing, Fidiniaina Rina Juliana, Ziyuan Zhu, Yue Wu et al. · 2025 · Journal of Medicinal Chemistry
99. Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias
    María Dolores Moya-Garzón, José Antonio Gómez-Vidal, Alfonso Alejo‐Armijo, Joaquı́n Altarejos, Juan Roberto Rodriguez Madoz, Miguel X. Fernandes, EDUARDO C. SALIDO, Sofı́a Salido, Mónica Díaz‐Gavilán · 2021 · Journal of Personalized Medicine
100. Computational Modeling to Identify Drugs Targeting Metastatic Castration-Resistant Prostate Cancer Characterized by Heightened Glycolysis
     Mei‐Chi Su, Adam M. Lee, Weijie Zhang, Danielle Maeser, Robert F. Gruener, Yibin Deng, R. Stephanie Huang · 2024 · Pharmaceuticals