Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

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Items 201–292 of 292

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4. Identification of human lactate dehydrogenase A inhibitors with anti-osteosarcoma activity through cell-based phenotypic screening
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5. Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis Through Malic Enzyme 1 in Pancreatic Cancer Cells
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6. Characterization of CHK-336, A First-in-Class, Liver-Targeted, Small-Molecule Lactate Dehydrogenase Inhibitor for Hyperoxaluria Treatment
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14. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma
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15. Molecular dynamics simulation of lactate dehydrogenase adsorption onto pristine and carboxylic-functionalized graphene
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16. Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation
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17. Recent Progress in the Therapeutic Modulation of Lactate for Cancer Treatment
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22. Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies
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31. Identification of telmisartan’s potential as NADH competitive lactate dehydrogenase A inhibitor unlocks its possibility for drug repurposing in cancer therapy
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36. Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion
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38. Exploring the role of LDH in cancer cells through the use of small-molecule inhibitors.
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39. Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma
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40. Peptide-based drugs to inhibit LDH5, a potential target for cancer therapy
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41. Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
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42. Lactate dehydrogenase is associated with cholesterol/lipid metabolism, and fluvastatin plus dipyridamole suppresses canine hemangiosarcoma growth in patient-derived xenograft models
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43. Mitochondrial Regulation Assessment by 13C-NMR Isotopomer Analysis
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44. Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
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45. Targeting Lactate Dehydrogenase B-dependent Mitochondrial Metabolism Affects Tumor Initiating Cells and Inhibits Tumorigenesis of Non-small Cell Lung Cancer by Inducing MtDNA Damage
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48. Structure simplification of GNE-140 and discovery of a pyridone based analogue as a potential lead for hLDHA inhibitors
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63. Histone lactylation: a novel epigenetic bridge linking cellular metabolism to benign and malignant gynecological diseases
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79. BindingDB Entry 50010483: Identification of human lactate dehydrogenase A inhibitors with anti-osteosarcoma activity through cell-based phenotypic screening.
    BindingDB · 2021 · UC San Diego
80. BindingDB Entry 50009026: Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations.
    BindingDB · 2021 · UC San Diego
81. BindingDB Entry 50000457: Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
    BindingDB · 2019 · UC San Diego
82. BindingDB Entry 50016159: Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.
    BindingDB · 2023 · UC San Diego
83. BindingDB Entry 50014797: Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity.
    BindingDB · 2023 · UC San Diego
84. BindingDB Entry 50019168: Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.
    BindingDB · 2024 · UC San Diego
85. BindingDB Entry 50013770: Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
    BindingDB · 2022 · UC San Diego
86. BindingDB Entry 50011438: Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
    BindingDB · 2022 · UC San Diego
87. BindingDB Entry 50014135: Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
    BindingDB · 2022 · UC San Diego
88. BindingDB Entry 50012240: Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation.
    BindingDB · 2022 · UC San Diego
89. BindingDB Entry 50016866: Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
    BindingDB · 2023 · UC San Diego
90. BindingDB Entry 50022038: Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
    BindingDB · 2025 · UC San Diego
91. BindingDB Entry 50010002: Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
    BindingDB · 2021 · UC San Diego
92. BindingDB Entry 50010171: Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation.
    BindingDB · 2021 · UC San Diego