The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Synthetic beta cells for fusion-mediated dynamic insulin secretion
Open accessAbstract
Generating artificial pancreatic beta cells by using synthetic materials to mimic glucose-responsive insulin secretion in a robust manner holds promise for improving clinical outcomes in people with diabetes. Here, we describe the construction of artificial beta cells (AβCs) with a multicompartmental ‘vesicles-in-vesicle’ superstructure equipped with a glucose-metabolism system and membrane-fusion machinery. Through a sequential cascade of glucose uptake, enzymatic oxidation and proton efflux, the AβCs can effectively distinguish between high and normal glucose levels. Under hyperglycemic conditions, high glucose uptake and oxidation generate a low pH (<5.6), which then induces steric deshielding of peptides tethered to the insulin-loaded inner small liposomal vesicles. The peptides on the small vesicles then form coiled coils with the complementary peptides anchored on the inner surfaces of large vesicles, thus bringing the membranes of the inner and outer vesicles together and triggering their fusion and insulin ‘exocytosis’
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Cites
Hyperglycemic crises in adult patients with diabetes
Kitabchi, A. E., Umpierrez, G. E., Miles, J. M., & Fisher, J. N. (2009) · Diabetes Care · doi:10.2337/dc09-9032 · Cited by 2,062
Regulation of Insulin Secretion in Human Pancreatic Islets
Rorsman, P., & Braun, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183754 · Cited by 599
Wang, Z., & Thurmond, D. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.034355 · Cited by 386
Molecular basis of coiled-coil formation
Steinmetz, M. O., Jelesarov, I., Matousek, W. M., Honnappa, S., Jahnke, W., Missimer, J. H., Frank, S., Alexandrescu, A. T., & Kammerer, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700321104 · Cited by 136
Cited by
Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery
Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., Sun, W., Corder, R. D., Chen, Z., Khan, S. A., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08152 · Cited by 299
Self-citationEmerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Nair, G. G., Tzanakakis, E. S., & Hebrok, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0375-3 · Cited by 134
Autonomic integration in nested protocell communities
Yin, Z., Gao, N., Xu, C., Li, M., & Mann, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c02816 · Cited by 25
Functional prototissues using artificial cells as building blocks and their biomedical applications
Zhang, X., Li, C., Yang, B., Wang, W., Zhao, J., Zhao, W., Dong, M., & Han, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202405823 · Cited by 24
Self-citationRecent Progress in Glucose-Responsive Insulin
Liu, Y., Wang, S., Wang, Z., Yu, J., Wang, J., Buse, J. B., & Gu, Z. (2024) · Diabetes · doi:10.2337/dbi23-0028 · Cited by 19
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Metadata
- Authors
- Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., Lu, Y., Ligler, F. S., Buse, J. B., & Gu, Z.
- Venue
- Nature Chemical Biology
- Published
- 2017-10-30
- Volume
- 14
- Issue
- 1
- Pages
- 86-93
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2766858627
- Cited by
- 248
- References
- 4
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., Lu, Y., Ligler, F. S., Buse, J. B., & Gu, Z. (2018). Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nature Chemical Biology. https://doi.org/10.1038/nchembio.2511
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