The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery
Open accessAbstract
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core–shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H 2 O 2 ) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel. Importantly, the H 2 O 2 -responsive microneedles are coated with a thin-layer embedding H 2 O 2 -scavenging enzyme, thus mimicking the complementary function of enzymes in peroxisomes to protect normal tissues from injury caused by oxidative stress. Utilizing a chemically induced type 1 diabetic mouse model, we demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility.
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Cites
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A detailed examination of boronic acid–diol complexation
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Self-citationDavis, S. P., Landis, B. J., Adams, Z. H., Allen, M. G., & Prausnitz, M. R. (2004) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2003.12.010 · Cited by 934
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Self-citationReactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges
Saravanakumar, G., Kim, J., & Kim, W. J. (2017) · Advanced Science · doi:10.1002/advs.201600124 · Cited by 675
Managing diabetes with nanomedicine: challenges and opportunities
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Injectable Nano-Network for Glucose-Mediated Insulin Delivery
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Current trends in polymer microneedle for transdermal drug delivery
Ahmed Saeed AL-Japairai, K., Mahmood, S., Hamed Almurisi, S., Reddy Venugopal, J., Rebhi Hilles, A., Azmana, M., & Raman, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119673 · Cited by 448
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Self-citationAdvances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Self-citationLi, X., Huang, X., Mo, J., Wang, H., Huang, Q., Yang, C., Zhang, T., Chen, H., Hang, T., Liu, F., et al. (2021) · Advanced Science · doi:10.1002/advs.202100827 · Cited by 250
Ruan, H., Hu, Q., Wen, D., Chen, Q., Chen, G., Lu, Y., Wang, J., Cheng, H., Lu, W., & Gu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201806957 · Cited by 220
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Metadata
- Authors
- Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., Sun, W., Corder, R. D., Chen, Z., Khan, S. A., Buse, J. B., & Gu, Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-19
- Volume
- 12
- Issue
- 3
- Pages
- 2466-2473
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2787410362
- Cited by
- 299
- References
- 46
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- green
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