The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria
Open accessAbstract
It is postulated that, in addition to cell density, other factors, such as the dimensions and diffusional characteristics of the environment, could influence quorum sensing (QS) and induction of genetic reprogramming. Modeling studies predict that QS may operate at the level of a single cell, but, due to experimental challenges, the potential benefits of QS by individual cells remain virtually unexplored. Here we report a physical system that mimics isolation of a bacterium, such as within an endosome or phagosome during infection, and maintains cell viability under conditions of complete chemical and physical isolation. For Staphylococcus aureus, we show quorum sensing and genetic re-programming to occur in a single isolated organism. Quorum sensing allows S. aureus to sense confinement and to activate virulence and metabolic pathways needed for survival. To demonstrate the benefit of confinement-induced quorum sensing to individuals, we showed quorum sensing bacteria to have significantly greater viability over non-QS bacteria.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
Cited by
Physicochemical regulation of biofilm formation
Renner, L. D., & Weibel, D. B. (2011) · MRS Bulletin · doi:10.1557/mrs.2011.65 · Cited by 616
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Intracellular staphylococcus aureus: Live-in and let die
Fraunholz, M., & Sinha, B. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00043 · Cited by 377
Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance
Zheng, M., Zhang, R., Tian, X., Zhou, X., Pan, X., & Wong, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00908 · Cited by 218
Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles
Surewaard, B. G. J., Nijland, R., Spaan, A. N., Kruijtzer, J. A. W., de Haas, C. J. C., & van Strijp, J. A. G. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002606 · Cited by 117
Metadata
- Authors
- Carnes, E. C., Lopez, D. M., Donegan, N. P., Cheung, A., Gresham, H., Timmins, G. S., & Brinker, C. J.
- Venue
- Nature Chemical Biology
- Published
- 2009-11-22
- Volume
- 6
- Issue
- 1
- Pages
- 41-45
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W1991505160
- Cited by
- 212
- References
- 1
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. https://app.cochat.ai/papers/10.1038/nchembio.264
- The paper
- Carnes, E. C., Lopez, D. M., Donegan, N. P., Cheung, A., Gresham, H., Timmins, G. S., & Brinker, C. J. (2010). Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. Nature Chemical Biology. https://doi.org/10.1038/nchembio.264
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
