The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A mass spectrometry–guided genome mining approach for natural product peptidogenomics
Open accessAbstract
Peptide natural products exhibit broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes. To harvest this large and diverse resource of bioactive molecules, we introduce Natural Product Peptidogenomics (NPP), a new mass spectrometry-guided genome mining method that connects the chemotypes of peptide natural products to their biosynthetic gene clusters by iteratively matching de novo MSn structures to genomics-based structures following current biosynthetic logic. In this study we demonstrate that NPP enabled the rapid characterization of >10 chemically diverse ribosomal and nonribosomal peptide natural products of novel composition from streptomycete bacteria as a proof of concept to begin automating the genome mining process. We show the identification of lantipeptides, lasso peptides, linardins, formylated peptides and lipopeptides, many of which from well-characterized model streptomycetes, highlighting the power of NPP in the discovery of new peptide natural products from even intensely studied organisms.
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Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380
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Role of the normal gut microbiota
Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Self-citationNakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095
Self-citationmetaFlye: scalable long-read metagenome assembly using repeat graphs
Kolmogorov, M., Bickhart, D. M., Behsaz, B., Gurevich, A., Rayko, M., Shin, S. B., Kuhn, K., Yuan, J., Polevikov, E., Smith, T. P. L., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-00971-x · Cited by 1,077
Minimum Information about a Biosynthetic Gene cluster
Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., de Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1890 · Cited by 873
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Metadata
- Authors
- Kersten, R. D., Yang, Y.-L., Xu, Y., Cimermancic, P., Nam, S.-J., Fenical, W., Fischbach, M. A., Moore, B. S., & Dorrestein, P. C.
- Venue
- Nature Chemical Biology
- Published
- 2011-10-09
- Volume
- 7
- Issue
- 11
- Pages
- 794-802
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2052591459
- Cited by
- 359
- References
- 1
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Kersten, R. D., Yang, Y.-L., Xu, Y., Cimermancic, P., Nam, S.-J., Fenical, W., Fischbach, M. A., Moore, B. S., & Dorrestein, P. C. (2011). A mass spectrometry–guided genome mining approach for natural product peptidogenomics. Nature Chemical Biology. https://doi.org/10.1038/nchembio.684
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