Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

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Items 101–200 of 256

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2. The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment
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3. Allosteric regulation in metal–organic cages
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4. Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation
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5. PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas
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6. Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases
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7. PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization
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8. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function
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10. Shuttling and sorting lipid-modified cargo into the cilia
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11. Structure-based development of PDEδ inhibitors
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12. On the Wrong Track: Alterations of Ciliary Transport in Inherited Retinal Dystrophies
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13. Chemical Biology Tools for Regulating RAS Signaling Complexity in Space and Time
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14. Synthesis of Lipidated Proteins
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15. A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases
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16. Ras hitchhikes on PDE6δ
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17. ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane
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18. Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling
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19. Application of Reductive 13C-Methylation of Lysines to Enhance the Sensitivity of Conventional NMR Methods
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20. SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families
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21. RhoGDIα Acetylation at K127 and K141 Affects Binding toward Nonprenylated RhoA
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22. Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions
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23. The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space
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24. Compositional complexity of rods and rings
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25. An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth
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26. GTPases Rac1 and Ras Signaling from Endosomes
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27. Crosstalk of small GTPases at the Golgi apparatus
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28. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT
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29. Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment
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30. Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase
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31. Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins
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32. ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2
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33. DominantARL3-related retinitis pigmentosa
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34. RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner
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35. Small‐Molecule Inhibition of the UNC119–Cargo Interaction
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37. The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors
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38. Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics
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41. Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
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42. The N‐ and C‐terminal ends of RPGR can bind to PDE6δ
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43. Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3
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44. Chemical Synthesis and Biological Function of Lipidated Proteins
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45. Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies
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46. Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate
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47. Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors
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50. Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6
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51. ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses
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54. ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons
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57. Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation
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59. Balancing the Photoreceptor Proteome: Proteostasis Network Therapeutics for Inherited Retinal Disease
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60. FLIM-FRET Analysis of Ras Nanoclustering and Membrane-Anchorage
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61. Drug targeting opportunities en route to Ras nanoclusters
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62. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis
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63. Lipid Modifications in Cilia Biology
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65. Chaperone-mediated specificity in Ras and Rap signaling
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66. SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent
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67. Thermodynamic, Dynamic and Solvational Properties of PDEδ Binding to Farnesylated Cystein: A Model Study for Uncovering the Molecular Mechanism of PDEδ Interaction with Prenylated Proteins
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68. Maintaining protein composition in cilia
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69. The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms
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70. Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions
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71. Ciliary Proteins Repurposed by the Synaptic Ribbon: Trafficking Myristoylated Proteins at Rod Photoreceptor Synapses
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74. Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ
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82. A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2
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97. Small‐Molecule Inhibition of the UNC119–Cargo Interaction
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