Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Ismail, Shehab A, Chen, Yong-Xiang, Rusinova, Alexandra, Chandra, Anchal, Bierbaum, Martin, Gremer, Lothar, Triola, Gemma, Waldmann, Herbert +2 more·2011·Nature Chemical Biology
DOI 10.1038/nchembio.686

Cited by (256)

Items 201–256 of 256

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  5. Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors
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  11. A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95
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  14. The small ARF-like 2 GTPase TITAN5 is linked with the dynamic regulation of IRON-REGULATED TRANSPORTER 1
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  18. Spatial regulation of ARL3 and GSF ‐mediated lipidated cargo trafficking in the primary cilium
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  25. Structure and Function of the mTOR Activator Rheb
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  26. Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells
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  27. Targeting PDE6D for inhibiting KRAS: A computational approach
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  28. Identification of bioactive compounds from Vaccinium vitis-idaea L. (Lingonberry) as inhibitors for treating KRAS-associated cancer: a computational approach
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  29. Development of a Genetically Encoded and Potent PDE6D Inhibitor
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  30. K-Ras controls asymmetric cell divisions from the primary cilium
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  31. The Spatial Organization of Ras Signaling
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  32. Stability of the Phosphotriester PDE6D Inhibitors
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  33. Ras Nanoclusters
    Yong Zhou, John F. Hancock · 2014 · Springer eBooks
  34. Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity
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  37. A new ferrocene derivative blocks KRAS localization and function by oxidative modification at His95
    Kristen M. Rehl, Jayaraman Selvakumar, Don Hoang, Kuppuswamy Arumugam, Alemayehu Abebe Gorfe, Kwang‐Jin Cho · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Inhibition of Oncogenic K‐Ras Signaling by Targeting K‐Ras–PDEδ Interaction
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  39. Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
    Jayson Bastien · 2012
  40. Complex Regulation of Protein Trafficking and Photoreceptor Cell Development by Small GTPases
    Zachary C. Wright · 2016
  41. Role of ciliary proteins ADP Ribosylation Factor Like GTPase 13B (ARL13B) and Bardet-Biedl Syndrome-8 (BBS8) in photoreceptor outer segment morphogenesis, maintenance, and viability
    Tanya L. Dilan · 2020
  42. Faculty Opinions recommendation of Coordination of Rheb lysosomal membrane interactions with mTORC1 activation.
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  43. Faculty Opinions recommendation of Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.
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  44. Characterization of the small Arabidopsis thaliana GTPase and ADP-ribosylation factor-like 2 protein TITAN 5
    Inga Mohr, Amin Mirzaiebadizi, Sibaji K. Sanyal, Pichaporn Chuenban, Mohammad Reza Ahmadian, Rumen Ivanov, Petra Bauer · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Targeting RAS and associated proteins
    Matthias Philipp Müller, Roger Sidney Goody, Daniel Rauh · 2025 · Elsevier eBooks
  46. Additional file 1 of Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development
    Laura Powell, Barroso-Gil, M., Gavin John Clowry, Laura Alice Devlin, Elisa Molinari, Ramsbottom, S. A., C. G. Miles, Sayer, J. A. · 2020 · Figshare
  47. Biochemical characterization of mTORC1 regulation by glutamine metabolism
    Clément Bodineau · 2020 · theses.fr (ABES)
  48. Posttranslational modifications of RAS: few pockets but many bumps
    Mercedes Fissore-O'Leary, Mark R. Philips · 2026 · Biological Chemistry
  49. The role of PDE6D in trafficking KRAS
    Luna Van Nimmen, Hanne Peeters, Shehab Ismail · 2026 · Biological Chemistry
  50. Regulation of de- and reciliation by KRAS during muscle cell differentiation
    Rohan Chippalkatti, Bianca Parisi, Elisabeth Schaffner‐Reckinger, Christina Laurini, Atanasio Gómez‐Mulas, Zoe Geimer, Daniel Abankwa · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  51. BindingDB Entry 50044523: Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site.
    BindingDB · 2015 · UC San Diego
  52. BindingDB Entry 50021942: An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth.
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  53. BindingDB Entry 50010796: Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.
    BindingDB · 2021 · UC San Diego
  54. BindingDB Entry 50000629: Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.
    BindingDB · 2019 · UC San Diego
  55. BindingDB Entry 50023610: Discovery of Potent PDEδ/NAMPT Dual Inhibitors: Preclinical Evaluation in KRAS Mutant Pancreatic Cancer Cells.
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  56. BindingDB Entry 50000422: Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.
    BindingDB · 2019 · UC San Diego