The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
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Citations
Cites
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
Cited by
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Oxysterols are allosteric activators of the oncoprotein Smoothened
Nachtergaele, S., Mydock, L. K., Krishnan, K., Rammohan, J., Schlesinger, P. H., Covey, D. F., & Rohatgi, R. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.765 · Cited by 284
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
Milenkovic, L., Scott, M. P., & Rohatgi, R. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907126 · Cited by 263
Disruption at the PTCHD1 Locus on Xp22.11 in Autism Spectrum Disorder and Intellectual Disability
Noor, A., Whibley, A., Marshall, C. R., Gianakopoulos, P. J., Piton, A., Carson, A. R., Orlic-Milacic, M., Lionel, A. C., Sato, D., Pinto, D., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001267 · Cited by 193
Regeneration and Repair of the Exocrine Pancreas
Murtaugh, L. C., & Keefe, M. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071727 · Cited by 197
Structural Basis of Smoothened Activation in Hedgehog Signaling
Huang, P., Zheng, S., Wierbowski, B. M., Kim, Y., Nedelcu, D., Aravena, L., Liu, J., Kruse, A. C., & Salic, A. (2018) · Cell · doi:10.1016/j.cell.2018.04.029 · Cited by 176
Ruiz-Perez, V. L., Blair, H. J., Rodriguez-Andres, M. E., Blanco, M. J., Wilson, A., Liu, Y.-N., Miles, C., Peters, H., & Goodship, J. A. (2007) · Development · doi:10.1242/dev.007542 · Cited by 175
Hu, B.-Y., Du, Z.-W., Li, X.-J., Ayala, M., & Zhang, S.-C. (2009) · Development · doi:10.1242/dev.029447 · Cited by 169
Development-on-chip: in vitro neural tube patterning with a microfluidic device
Demers, C. J., Soundararajan, P., Chennampally, P., Cox, G. A., Briscoe, J., Collins, S. D., & Smith, R. L. (2016) · Development · doi:10.1242/dev.126847 · Cited by 149
Shifting paradigms in Hedgehog signaling
Wang, Y., McMahon, A. P., & Allen, B. L. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.005 · Cited by 124
Schou, K. B., Mogensen, J. B., Morthorst, S. K., Nielsen, B. S., Aleliunaite, A., Serra-Marques, A., Fürstenberg, N., Saunier, S., Bizet, A. A., Veland, I. R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14177 · Cited by 72
Titmarsh, D. M., Glass, N. R., Mills, R. J., Hidalgo, A., Wolvetang, E. J., Porrello, E. R., Hudson, J. E., & Cooper-White, J. J. (2016) · Scientific Reports · doi:10.1038/srep24637 · Cited by 59
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
Rosengren, T., Larsen, L. J., Pedersen, L. B., Christensen, S. T., & Møller, L. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2761-8 · Cited by 45
Metadata
- Authors
- Sinha, S., & Chen, J. K.
- Venue
- Nature Chemical Biology
- Published
- 2005-11-20
- Volume
- 2
- Issue
- 1
- Pages
- 29-30
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W1990567821
- Cited by
- 370
- References
- 2
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
