Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

Sanna, M Germana, Wang, Sheng-Kai, Gonzalez-Cabrera, Pedro J, Don, Anthony, Marsolais, David, Matheu, Melanie P, Wei, Sindy H, Parker, Ian +5 more·2006·Nature Chemical Biology

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    Jen-Fu Lee, Sharon Gordon, Rosendo Estrada, Lichun Wang, Deanna L. Siow, Binks W. Wattenberg, David G. Lominadze, Menq-Jer Lee · 2008 · American Journal of Physiology-Heart and Circulatory Physiology
  3. Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
    Simona Federica Spampinato, Birgit Obermeier, Anne C Cotleur, Anna C. Love, Yukio Takeshita, Yasuteru Sano, Takashi Kanda, Richard M. Ransohoff · 2015 · PLoS ONE
  4. Sphingosine kinase 1 protects against renal ischemia–reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation
    Sang Won Park, Minjae Kim, Mihwa Kim, Vivette Denise D’Agati, H. Thomas Lee · 2011 · Kidney International
  5. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection
    Alexandre Pierre Benechet, Manisha Menon, Daqi Xu, Tasleem Samji, Leigh A. Maher, Thomas T. Murooka, Thorsten R. Mempel, Brian S. Sheridan, Francois Michel Lemoine, Kamal Mohan Khanna · 2016 · Proceedings of the National Academy of Sciences
  6. Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations
    Masahiro Murakami · 2011 · International Journal of Vascular Medicine
  7. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate
    Yugesh Kharel, Thomas P. Mathews, Amanda M. Gellett, Jose Luis Tomsig, Perry Kennedy, Morgan L. Moyer, Timothy L. Macdonald, Kevin R. Lynch · 2011 · Biochemical Journal
  8. Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement
    Geerte L. Van Sluis, Tatjana M.H. Niers, Charles T. Esmon, Wikky Tigchelaar, Dick J. Richel, Harry Roger Buller, Cornelis J.F. Van Noorden, C. Arnold Spek · 2009 · Blood
  9. Lysophospholipid receptors in vertebrate development, physiology, and pathology
    Athanasia Skoura, Timothy Hla · 2008 · Journal of Lipid Research
  10. Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain
    Daniela Salvemini, Timothy M. Doyle, Michaela Kress, G. D. Nicol · 2013 · Trends in Pharmacological Sciences
  11. S1PR1 as a Novel Promising Therapeutic Target in Cancer Therapy
    N. Rostami, A. Nikkhoo, Amir Ajoolabady, G. Azizi, M. Hojjat-Farsangi, G. Ghalamfarsa, B. Yousefi, M. Yousefi, Farhad Jadidi-Niaragh · 2019 · Molecular Diagnosis & Therapy
  12. Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease
    Sung-Yoon Jo, Amandeep Bajwa, Alaa S. Awad, Kevin R. Lynch, Mark Douglas Okusa · 2008 · Kidney International
  13. Lyase to live by: Sphingosine phosphate lyase as a therapeutic target
    Ashok Kumar, Julie Deane Saba · 2009 · Expert Opinion on Therapeutic Targets
  14. Pharmacological relevance and potential of sphingosine 1‐phosphate in the vascular system
    Mirjam Schuchardt, Markus Tölle, Jasmin Prüfer, Markus van der Giet · 2011 · British Journal of Pharmacology
  15. A sphingosine 1-phosphate receptor 2 selective allosteric agonist
    Hideo Satsu, Marie‐Therese Schaeffer, Miguel A. Guerrero, Adrian Saldana, Christina Eberhart, Peter Hodder, Charmagne S. Cayanan, Stephan C. Schürer, Barun Bhhatarai, Ed Roberts et al. · 2013 · Bioorganic & Medicinal Chemistry
  16. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation
    Sang Won Park, Mihwa Kim, Sean W. C. Chen, Kevin M Brown, Vivette Denise D’Agati, H. Thomas Lee · 2010 · Laboratory Investigation
  17. Successful Strategies to Determine High-Resolution Structures of GPCRs
    Jin Xiang, Eugene Chun, Chang Liu, Liang Jing, Zina Al-Sahouri, Lan Zhu, Wei Liu · 2016 · Trends in Pharmacological Sciences
  18. Modulating tone: the overture of S1P receptor immunotherapeutics
    Hugh Rosen, Pedro J. Gonzalez‐Cabrera, David Marsolais, Stuart M. Cahalan, Anthony Simon Don, Marta Sanna · 2008 · Immunological Reviews
  19. The role of sphingosine-1-phosphate in endothelial barrier function
    Brent A. Wilkerson, Kelley M. Argraves · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  20. Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagonist
    Ran Zhu, Ashley Hall Snyder, Yugesh Kharel, Lisa M. Schaffter, Qin Sun, Perry Kennedy, Kevin R. Lynch, Timothy L. Macdonald · 2007 · Journal of Medicinal Chemistry
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  22. The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
    Gema Tarrasón, Mariona Aulí, Sanam Mustafa, Vladislav A. Dolgachev, Teresa Domènech, Neus Prats, María Domínguez, Rosa López, Núria Aguilar, Marta Calbet et al. · 2011 · International Immunopharmacology
  23. Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza
    David Marsolais, Bumsuk Hahm, Kurt H. Edelmann, Kevin B. Walsh, Miguel A. Guerrero, Yasuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B. A. Oldstone, Hugh Rosen · 2008 · Molecular Pharmacology
  24. Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems
    Luke M. Healy, Jack Perry Antel · 2015 · Current Drug Targets
  25. Alteration of sphingolipid metabolism as a putative mechanism underlying <scp>LPS</scp>‐induced <scp>BBB</scp> disruption
    Vutukuri, Rajkumar, Brunkhorst, Robert, Kestner, Roxane‐Isabelle, Hansen, Lena, Bouzas, Nerea Ferreiros, Pfeilschifter, Josef, Devraj, Kavi, Pfeilschifter, Waltraud · 2018 · Journal of Neurochemistry
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  27. Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1receptor modulator: Favorable impact of dose up-titration
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  28. Synthetic Analogs of FTY720 [2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] Differentially Regulate Pulmonary Vascular Permeability in Vivo and in Vitro
    S. M. Camp, Robert Bittman, Eddie T. Chiang, Liliana Moreno‐Vinasco, Tamara Mirzapoiazova, Saad Sammani, X. Lu, C.Y. Sun, Mark C. Harbeck, M. Roe et al. · 2009 · Journal of Pharmacology and Experimental Therapeutics
  29. Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca 2+ Sensitivity and Na + /H + Exchange and Mediates Protection by Ischemic Preconditioning
    Petra Keul, Marcel M. G. J. van Borren, Alexander Ghanem, Frank Ulrich Müller, Antonius Baartscheer, Arie O. Verkerk, Frank T. Stümpel, Jan Sebastian Schulte, Nazha Hamdani, Wolfgang Albrecht Linke et al. · 2016 · Journal of the American Heart Association
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  31. Fingolimod treatment in multiple sclerosis leads to increased macular volume
    Rachel C. Nolan, Jeffrey Marc Gelfand, Ari Green · 2012 · Neurology
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  33. Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
    Mandi M. Murph, Gordon Brent Mills · 2007 · Expert Reviews in Molecular Medicine
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  35. Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism
    Amanda Finley, Zhoumou Chen, Emanuela Esposito, Salvatore Cuzzocrea, Roger Allen Sabbadini, Daniela Salvemini · 2013 · PLoS ONE
  36. The Role of Sphingosine-1-Phosphate in Breast Cancer Tumor-Induced Lymphangiogenesis
    Tomoyoshi Aoyagi, Masayuki Nagahashi, Akimitsu Yamada, Kazuaki Takabe · 2012 · Lymphatic Research and Biology
  37. Sphingosine kinase 1 in viral infections
    Jillian M. Carr, Suresh Mahalingam, Claudine S. Bonder, Stuart Maxwell Pitson · 2012 · Reviews in Medical Virology
  38. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification
    John Ross Teijaro, Sean Studer, Nora B. Leaf, William Bill Kiosses, Nhan Nguyen, Kosuke Matsuki, Hideo Negishi, Tadatsugu Taniguchi, Michael B. A. Oldstone, Hugh Rosen · 2016 · Proceedings of the National Academy of Sciences
  39. Modulators of the Sphingosine 1-phosphate receptor 1
    Mariangela Urbano, Miguel A. Guerrero, Hugh Rosen, Edward Roberts · 2013 · Bioorganic & Medicinal Chemistry Letters
  40. Therapeutic Potential of Targeting SK1 in Human Cancers
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  41. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity
    Taimur A. Abbasi, Joe G. N. Garcia · 2013 · Handbook of experimental pharmacology
  42. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice
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  43. Guanine Nucleotide-Binding Proteins of the G12 Family Shape Immune Functions by Controlling CD4+ T Cell Adhesiveness and Motility
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  44. Ligand-Binding Pocket Shape Differences between Sphingosine 1-Phosphate (S1P) Receptors S1P1 and S1P3 Determine Efficiency of Chemical Probe Identification by Ultrahigh-Throughput Screening
    Stephan C. Schürer, Steven J Brown, Pedro J. Gonzalez‐Cabrera, Marie‐Therese Schaeffer, Jacqueline V. Chapman, Euijung Jo, Peter S. Chase, Timothy Spicer, Peter Hodder, Hugh Rosen · 2008 · ACS Chemical Biology
  45. Sphingolipids in Lung Growth and Repair
    Jeroen Tibboel, Irwin K. M. Reiss, Johan C. de Jongste, Martin Post · 2014 · CHEST Journal
  46. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction
    Marta Sanna, Kevin P. Vincent, Emanuela Repetto, Nhan Nguyen, Steven J Brown, Lusine Abgaryan, Sean Riley, Nora B. Leaf, Stuart M. Cahalan, William Bill Kiosses et al. · 2015 · Molecular Pharmacology
  47. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance
    Shanmugam Panneer Selvam, Besim Öğretmen · 2013 · Handbook of experimental pharmacology
  48. Building a Pharmacological Lexicon: Small Molecule Discovery in Academia
    John Stephen Lazo, Linda S. Brady, Raymond J Dingledine · 2007 · Molecular Pharmacology
  49. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3
    Chao Li, Jun-nan Li, Joanne S. Kays, Miguel A. Guerrero, G. D. Nicol · 2015 · Journal of Neuroinflammation
  50. A role for LFA‐1 in delaying T‐lymphocyte egress from lymph nodes
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  51. Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)
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  52. LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells
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  53. Sphingosine-1-Phosphate Signaling in Endothelial Disorders
    Teresa Sánchez · 2016 · Current Atherosclerosis Reports
  54. The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk
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  56. Sphingolipid Regulation of Tissue Fibrosis
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  57. Bioluminescence imaging of G protein-coupled receptor activation in living mice
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  58. Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate
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  59. Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
    Anthony Simon Don, Xin Ying Lim, Timothy A. Couttas · 2014 · Biomolecules
  60. FTY720 (fingolimod) for relapsing multiple sclerosis
    A. Horga, X. Montalban · 2008 · Expert Review of Neurotherapeutics
  61. Targeting Sphingosine 1-phosphate (S1P) Levels and S1P Receptor Functions for Therapeutic Immune Interventions
    Markus H. Gräler · 2010 · Cellular Physiology and Biochemistry
  62. Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
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  63. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules
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  64. Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors
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  65. Sphingosine-1-Phosphate Receptors: Zooming in on Ligand-Induced Intracellular Trafficking and Its Functional Implications
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  67. Sphingosine kinase 1 as an anticancer therapeutic target
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