Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581 · see citing works

Sphingosine-1-phosphate: an enigmatic signalling lipid

Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,080 · see citing works

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

MANDALA, S. M., Hajdu, R., Bergstrom, J. D., Quackenbush, E. J., Xie, J., Milligan, J. A., Thornton, R. A., Shei, G.-J., Card, D., Keohane, C.-A., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,691 · see citing works

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189 · see citing works

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,144 · see citing works

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Garcia, J. G. N., Liu, F., Verin, A. D., Birukova, A. A., Dechert, M. A., Gerthoffer, W. T., Bamberg, J. R., & English, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12450 · Cited by 886 · see citing works

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

Rosen, H., & Goetzl, E. (2005) · Nature reviews. Immunology · doi:10.1038/nri1650 · Cited by 740 · see citing works

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

Sanna, M., Liao, J., Jo, E., Alfonso, C., Ahn, M.-Y., Peterson, M. S., Webb, B., Lefebvre, S., Chun, J. J. M., Gray, N. S., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311743200 · Cited by 627 · see citing works

Vascular reactions to histamine, histamine‐liberator and leukotaxine in the skin of guinea‐pigs

Miles, A. A., & Miles, E. M. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004789 · Cited by 539 · see citing works

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

Miller, M. J., Wei, S. H., Cahalan, M. D., & Parker, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628040100 · Cited by 494 · see citing works

Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

Allende, M. L., Dreier, J. L., MANDALA, S. M., & Proia, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314291200 · Cited by 452 · see citing works

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

Sánchez, T., Estrada-Hernandez, T., Paik, J., Wu, M.-T., Venkataraman, K., Brinkmann, V., Claffey, K. P., & Hla, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306896200 · Cited by 374 · see citing works

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

Forrest, M. J., Sun, S.-Y., Hajdu, R., Bergstrom, J. D., Card, D., Doherty, G., Hale, J. J., Keohane, C. A., Meyers, C., Milligan, J. A., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062828 · Cited by 334 · see citing works

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

Lo, C. G., Xu, Y., Proia, R. L., & Cyster, J. G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041509 · Cited by 319 · see citing works

Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization

LaMontagne, K. R., Littlewood-Evans, A. J., Schnell, C., O’Reilly, T., Wyder, L., Sánchez, T., Probst, B., Butler, J., Wood, A. W., Liau, G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2001 · Cited by 295 · see citing works

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M., Wang, S., Jo, E., Wong, C., Parker, I., & Cahalan, M. D. (2005) · Nature Immunology · doi:10.1038/ni1269 · Cited by 277 · see citing works

First Human Trial of FTY720, a Novel Immunomodulator, in Stable Renal Transplant Patients

Budde, K., Schmouder, R., Brunkhorst, R. R., Nashan, B., Diaeresiscker, P. W. L., Mayer, T., Choudhury, S., Skerjanec, A., Kraus, G., & Neumayer, H. H. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1341073 · Cited by 270 · see citing works

Sphingosine 1-Phosphate Analogs as Receptor Antagonists

Davis, M. D., Clemens, J. J., Macdonald, T. L., & Lynch, K. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412356200 · Cited by 269 · see citing works

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

Jo, E., Sanna, M., Gonzalez‐Cabrera, P. J., Thangada, S., Tigyi, G., Osborne, D. A., Hla, T., Parrill, A. L., & Rosen, H. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.04.019 · Cited by 242 · see citing works

Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney

Awad, A. S., Ye, H., Huang, L., Li, L., Foss, F. W., Macdonald, T. L., Lynch, K. R., & Okusa, M. D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00311.2005 · Cited by 230 · see citing works

Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury

McVerry, B. J., Peng, X., Hassoun, P. M., Sammani, S., Simon, B. A., & Garcia, J. G. N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200405-684oc · Cited by 223 · see citing works

In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

McVerry, B. J., & Garcia, J. G. N. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.08.006 · Cited by 209 · see citing works

Endothelial cell barrier regulation by sphingosine 1‐phosphate

McVerry, B. J., & Garcia, J. G. N. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20088 · Cited by 195 · see citing works

Selective Chemical Functional Probes of Granzymes A and B Reveal Granzyme B Is a Major Effector of Natural Killer Cell-Mediated Lysis of Target Cells

Mahrus, S., & Craik, C. S. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.03.006 · Cited by 156 · see citing works

A potential role for CD69 in thymocyte emigration

Feng, C., Woodside, K. J., Vance, B. A., El‐Khoury, D., Canelles, M., Lee, J., Gress, R., Fowlkes, B. J., Shores, E. W., & Love, P. E. (2002) · International Immunology · doi:10.1093/intimm/dxf020 · Cited by 145 · see citing works

Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate

Gräler, M. H., Shankar, G., & Goetzl, E. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4084 · Cited by 132 · see citing works

Regulation of immunity by lysosphingolipids and their G protein–coupled receptors

Goetzl, E. J., & Rosen, H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23704 · Cited by 122 · see citing works

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

Rosen, H., Alfonso, C., Surh, C. D., & McHeyzer‐Williams, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832725100 · Cited by 120 · see citing works

Regulation of immunity by lysosphingolipids and their G protein–coupled receptors

Goetzl, E. J., & Rosen, H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200423704 · Cited by 114 · see citing works

The Generation of Mature, Single-Positive Thymocytes In Vivo Is Dysregulated by CD69 Blockade or Overexpression

Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M. Y., Didierlaurent, A. M., Koseki, H., & Ziegler, S. F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.87 · Cited by 105 · see citing works

Pharmacodynamics of Single Doses of the Novel Immunosuppressant FTY720 in Stable Renal Transplant Patients

Budde, K., Schmouder, R., Nashan, B., Brunkhorst, R. R., Lücker, P. W., Mayer, T., Brookman, L. J., Nedelman, J. R., Skerjanec, A., Böhler, T., et al. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00130.x · Cited by 102 · see citing works

Egress: a receptor‐regulated step in lymphocyte trafficking

Rosen, H., Sanna, G., & Alfonso, C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00068.x · Cited by 101 · see citing works

Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes

Singer, I. I., Tian, M., Wickham, L. A., Lin, J. J., Matheravidathu, S. S., Forrest, M. J., MANDALA, S. M., & Quackenbush, E. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7151 · Cited by 90 · see citing works

Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma

Ho, J. W., Man, K., Sun, C. K.-W., Lee, T. K., Poon, R. T. P., & Fan, S. T. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0021 · Cited by 86 · see citing works

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Garcia, J. G. N., Liu, F., Verin, A. D., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112450 · Cited by 84 · see citing works

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

Hale, J. J., Neway, W. E., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G.-J., Chrebet, G. L., Bergstrom, J. D., et al. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.02.106 · Cited by 71 · see citing works

CD69 down‐modulation and inhibition of thymic egress by short‐ and long‐term selective chemical agonism of sphingosine 1‐phosphate receptors

Alfonso, C., McHeyzer‐Williams, M. G., & Rosen, H. (2005) · European Journal of Immunology · doi:10.1002/eji.200535127 · Cited by 59 · see citing works

Sphingosine 1-phosphate pathway therapeutics: a lipid ligand–receptor paradigm

Rosen, H., & Liao, J. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00085-1 · Cited by 57 · see citing works

Stat6 activation and Th2 cell proliferation driven by CD28 signals

Oki, S., Otsuki, N., Kohsaka, T., & Azuma, M. (2000) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(200005)30:5 · Cited by 25 · see citing works

Signals for lymphocyte egress

Ley, K. F., & Morris, M. (2005) · Nature Immunology · doi:10.1038/ni1205-1215 · Cited by 13 · see citing works

Lipid signalling in disease

Wymann, M. P., & Schneiter, R. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2335 · Cited by 1,285 · see citing works

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

Brinkmann, V., Billich, A., Baumruker, T., Heining, P., Schmouder, R., Francis, G., Aradhye, S., & Burtin, P. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3248 · Cited by 1,273 · see citing works

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 878 · see citing works

Sphingosine 1-phosphate and cancer

Pyne, N. J., & Pyne, S. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2875 · Cited by 856 · see citing works

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

Cyster, J. G., & Schwab, S. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075011 · Cited by 820 · see citing works

“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

Takabe, K., Paugh, S. W., Milstien, S., & Spiegel, S. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07113 · Cited by 719 · see citing works

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., & Rosen, H. (2011) · Cell · doi:10.1016/j.cell.2011.08.015 · Cited by 688 · see citing works

Crystal Structure of a Lipid G Protein–Coupled Receptor

Hanson, M. A., Roth, C., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G. J., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., et al. (2012) · Science · doi:10.1126/science.1215904 · Cited by 667 · see citing works

The alliance of sphingosine-1-phosphate and its receptors in immunity

Rivera, J., Proia, R. L., & Olivera, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2400 · Cited by 616 · see citing works

Finding a way out: lymphocyte egress from lymphoid organs

Schwab, S. R., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1545 · Cited by 607 · see citing works

The functional network of ion channels in T lymphocytes

Cahalan, M. D., & Chandy, K. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00816.x · Cited by 591 · see citing works

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer

Liang, J., Nagahashi, M., Kim, E. Y., Harikumar, K. B., Yamada, A., Huang, W.-C., Hait, N. C., Allegood, J. C., Price, M. M., Avni, D., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.013 · Cited by 563 · see citing works

The Concise Guide to PHARMACOLOGY 2013/14: G Protein‐Coupled Receptors

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12445 · Cited by 555 · see citing works

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology

Brinkmann, V. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.006 · Cited by 528 · see citing works

An update on the biology of sphingosine 1-phosphate receptors

Blaho, V. A., & Hla, T. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046300 · Cited by 516 · see citing works

Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454 · see citing works

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

Brinkmann, V. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00451.x · Cited by 438 · see citing works

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

Kunkel, G. T., Maceyka, M. W., Milstien, S., & Spiegel, S. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4099 · Cited by 437 · see citing works

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

Pham, T. H. M., Okada, T., Matloubian, M., Lo, C. G., & Cyster, J. G. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.017 · Cited by 427 · see citing works

Sphingosine 1-Phosphate Receptor Signaling

Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103733 · Cited by 404 · see citing works

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

zu Heringdorf, D. M., & Jakobs, K. H. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.026 · Cited by 390 · see citing works

A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System

Germain, R. N., Robey, E. A., & Cahalan, M. D. (2012) · Science · doi:10.1126/science.1221063 · Cited by 370 · see citing works

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

Müllershausen, F., Zécri, F. J., Cetin, C., Billich, A., Guerini, D., & Seuwen, K. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.173 · Cited by 370 · see citing works

Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice

Camerer, E., Regard, J. B., Cornelissen, I., Srinivasan, Y., Duong, D. N., Palmer, D., Pham, T. H. M., Wong, J. S., Pappu, R., & Coughlin, S. R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38575 · Cited by 367 · see citing works

Erythrocytes store and release sphingosine 1‐phosphate in blood

Hänel, P., Andréani, P., & Gräler, M. H. (2007) · The FASEB Journal · doi:10.1096/fj.06-7433com · Cited by 361 · see citing works

Extracellular and Intracellular Actions of Sphingosine-1-Phosphate

Strub, G. M., Maceyka, M. W., Hait, N. C., Milstien, S., & Spiegel, S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6741-1_10 · Cited by 356 · see citing works

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

Chun, J. J. M., Hla, T., Lynch, K. R., Spiegel, S., & Moolenaar, W. H. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003111 · Cited by 330 · see citing works

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Kihara, Y., Maceyka, M. W., Spiegel, S., & Chun, J. J. M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12678 · Cited by 325 · see citing works

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Gaengel, K., Niaudet, C., Hagikura, K., Laviña, B., Muhl, L., Hofmann, J. J., Ebarasi, L., Nyström, S., Rymo, S. F., Chen, L. L., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.005 · Cited by 317 · see citing works

Choreography of Cell Motility and Interaction Dynamics Imaged by Two-Photon Microscopy in Lymphoid Organs

Cahalan, M. D., & Parker, I. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090620 · Cited by 299 · see citing works

Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation

Wettschureck, N., Strilić, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 282 · see citing works

Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding

Zeng, Y., Adamson, R. H., CURRY, F. E., & Tarbell, J. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00687.2013 · Cited by 266 · see citing works

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

von Boehmer, H., & Daniel, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3683 · Cited by 221 · see citing works

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

Rosen, H., Stevens, R. C., Hanson, M. A., Roberts, E., & Oldstone, M. B. A. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062411-130916 · Cited by 221 · see citing works

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

Huwiler, A., & Zangemeister‐Wittke, U. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.001 · Cited by 223 · see citing works

Functions of the Multifaceted Family of Sphingosine Kinases and Some Close Relatives

Spiegel, S., & Milstien, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600028200 · Cited by 219 · see citing works

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Mosnier, L. O., Sinha, R. K., Burnier, L., Bouwens, E. A. M., & Griffin, J. H. (2012) · Blood · doi:10.1182/blood-2012-08-452169 · Cited by 217 · see citing works

Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina

Skoura, A., Sánchez, T., Claffey, K. P., MANDALA, S. M., Proia, R. L., & Hla, T. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31123 · Cited by 216 · see citing works

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

Oo, M. L., Chang, S.-H., Thangada, S., Wu, M.-T., Rezaul, K., Blaho, V. A., Hwang, S., Han, D. K. M., & Hla, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45403 · Cited by 216 · see citing works

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

Camm, A. J., Hla, T., Bakshi, R., & Brinkmann, V. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.06.028 · Cited by 212 · see citing works

Fingolimod phosphate promotes the neuroprotective effects of microglia

Noda, H., Takeuchi, H., Mizuno, T., & Suzumura, A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.12.005 · Cited by 212 · see citing works

Fingolimod-associated macular edema

Jain, N., & Bhatti, M. T. (2012) · Neurology · doi:10.1212/wnl.0b013e318248deea · Cited by 201 · see citing works

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

Grigorova, I., Schwab, S. R., Phan, T. G., Pham, T. H. M., Okada, T., & Cyster, J. G. (2008) · Nature Immunology · doi:10.1038/ni.1682 · Cited by 187 · see citing works

The vascular S1P gradient—Cellular sources and biological significance

Hla, T. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.07.003 · Cited by 181 · see citing works

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

Chi, H. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.002 · Cited by 181 · see citing works

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

Wang, Y., Dix, M. M., Bianco, G., Remsberg, J. R., Lee, H.-Y., Kalocsay, M., Gygi, S. P., Forli, S., Vite, G., Lawrence, R. M., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0351-5 · Cited by 179 · see citing works

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

Zhang, G., Yang, L., Kim, G. S., Ryan, K. P., Lu, S., O’Donnell, R. K., Spokes, K., Shapiro, N. I., Aird, W. C., Kluk, M., et al. (2013) · Blood · doi:10.1182/blood-2012-11-467191 · Cited by 176 · see citing works

Sphingosine 1-phosphate in coagulation and inflammation

Obinata, H., & Hla, T. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0287-3 · Cited by 174 · see citing works

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

Zhang, L., Orban, M., Lorenz, M., Barocke, V., Braun, D., Urtz, N., Schulz, C., von Brühl, M.-L., Tirniceriu, A., Gaertner, F. C., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121090 · Cited by 171 · see citing works

Exit Strategies: S1P Signaling and T Cell Migration

Baeyens, A., Fang, V., Chen, C., & Schwab, S. R. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.005 · Cited by 167 · see citing works

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Schreiber, S. L., Kotz, J., Li, M., Aubé, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.023 · Cited by 168 · see citing works

The emerging role of FTY720 (Fingolimod) in cancer treatment

White, C., Alshaker, H. A., Cooper, C., Winkler, M. H., & Pchejetski, D. (2016) · Oncotarget · doi:10.18632/oncotarget.7145 · Cited by 168 · see citing works

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

Marsolais, D., & Rosen, H. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2356 · Cited by 168 · see citing works

Sphingolipids in the Lungs

Uhlig, S., & Gulbins, E. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-595so · Cited by 162 · see citing works

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

Janes, K., Little, J. W., Li, C., Bryant, L., Chen, C., Chen, Z., Kamocki, K., Doyle, T. M., Snider, A. J., Esposito, E., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.569574 · Cited by 156 · see citing works

Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

Vogel, P., Donoviel, M. S., Read, R. W., Hansen, G. M., Hazlewood, J., Anderson, S. J., Sun, W., Swaffield, J. C., & Oravecz, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004112 · Cited by 159 · see citing works

Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

Foss, F. W., Snyder, A. H., Davis, M. D., Rouse, M. D., Okusa, M. D., Lynch, K. R., & Macdonald, T. L. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.10.060 · Cited by 158 · see citing works

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

Dev, K. K., Müllershausen, F., Mattes, H., Kuhn, R. R., Bilbe, G., Hoyer, D., & Mir, A. K. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.08.005 · Cited by 155 · see citing works

Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial

Vaclavkova, A., Chimenti, S., Arenberger, P., Holló, P., Sator, P.-G., Burcklen, M., Stefani, M., & D’Ambrosio, D. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60803-5 · Cited by 154 · see citing works

Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury

Shea, B. S., Brooks, S. F., Fontaine, B. A., Chun, J. J. M., Luster, A. D., & Tager, A. M. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0345oc · Cited by 153 · see citing works

Tipping the gatekeeper: S1P regulation of endothelial barrier function

Rosen, H., Sanna, M., Cahalan, S. M., & Gonzalez‐Cabrera, P. J. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.007 · Cited by 152 · see citing works

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress

Nombela‐Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I. B., Wymann, M. P., Hirsch, E., Martínez‐A, C., Fukui, Y., von Andrian, U. H., & Stein, J. V. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061780 · Cited by 152 · see citing works

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

Feng, H., Stachura, D. L., White, R. M., Gutiérrez, A., Zhang, L., Sanda, T., Jette, C. A., Testa, J. R., Neuberg, D. S., Langenau, D. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.009 · Cited by 147 · see citing works

Insights into the pharmacological relevance of lysophospholipid receptors

Mutoh, T., Rivera, R. R., & Chun, J. J. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01622.x · Cited by 137 · see citing works

The structure and function of the S1P1 receptor

O'Sullivan, C., & Dev, K. K. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.05.002 · Cited by 136 · see citing works

Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways

Yoon, C. M., Hong, B. S., Moon, H. G., Lim, S., Suh, P., Kim, Y., Chae, C., & Gho, Y. S. (2008) · Blood · doi:10.1182/blood-2007-11-125203 · Cited by 134 · see citing works

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Chen, Z., Doyle, T. M., Luongo, L., Largent‐Milnes, T. M., Giancotti, L. A., Kolar, G. R., Squillace, S., Boccella, S., Walker, J. K., Pendleton, A. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820466116 · Cited by 127 · see citing works

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

Quancard, J., Bollbuck, B., Janser, P., Angst, D., Berst, F., Buehlmayer, P., Streiff, M. B., Beerli, C., Brinkmann, V., Guerini, D., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.016 · Cited by 128 · see citing works

Second generation S1P pathway modulators: Research strategies and clinical developments

Bigaud, M., Guerini, D., Billich, A., Bassilana, F., & Brinkmann, V. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.001 · Cited by 127 · see citing works

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

Gonzalez‐Cabrera, P. J., Jo, E., Sanna, M., Brown, S. J., Leaf, N. B., Marsolais, D., Schaeffer, M., Chapman, J. V., Cameron, M. D., Guerrero, M., et al. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049783 · Cited by 127 · see citing works

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

Ikeda, H., Watanabe, N., Ishii, I., Shimosawa, T., Kume, Y., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800496-jlr200 · Cited by 125 · see citing works

Finding a way out: S1P signaling and immune cell migration

Baeyens, A. A. L., & Schwab, S. R. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081519-083952 · Cited by 123 · see citing works

Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

Tran, J. Q., Hartung, J. P., Peach, R., Boehm, M. F., Rosen, H., Smith, H., Brooks, J. L., Timony, G. A., Olson, A. D., Gujrathi, S., et al. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.887 · Cited by 113 · see citing works

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors

Osinde, M., Müllershausen, F., & Dev, K. K. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.11.010 · Cited by 112 · see citing works

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

Oskeritzian, C. A., Price, M. M., Hait, N. C., Kapitonov, D., Falanga, Y. T., Morales, J. K., Ryan, J. J., Milstien, S., & Spiegel, S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091513 · Cited by 112 · see citing works

Vascular and immunobiology of the circulatory sphingosine 1-phosphate gradient

Yanagida, K., & Hla, T. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071635 · Cited by 109 · see citing works

GPCR crystal structures: Medicinal chemistry in the pocket

Shonberg, J., Kling, R. C., Gmeiner, P., & Löber, S. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.12.034 · Cited by 108 · see citing works

Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25

Gossens, K., Naus, S., Corbel, S. Y., Lin, S., Rossi, F. M. V., Kast, J., & Ziltener, H. J. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082502 · Cited by 108 · see citing works

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

Cai, Y., Bolte, C., Le, T. T., Goda, C., Xu, Y. J., Kalin, T. V., & Kalinichenko, V. V. (2016) · Science Signaling · doi:10.1126/scisignal.aad1899 · Cited by 107 · see citing works

FTY720 Story. Its Discovery and the following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology

Adachi, K., & Chiba, K. (2007) · Perspectives in Medicinal Chemistry · doi:10.1177/1177391x0700100002 · Cited by 107 · see citing works

Endothelial Functions of Sphingosine-1-phosphate

Lucke, S., & Levkau, B. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000315109 · Cited by 104 · see citing works

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Brinkman, C. C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav1263 · Cited by 99 · see citing works

B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids by a Mechanism Independent of Sphingosine-1-Phosphate-Mediated Chemotaxis

Sinha, R. K., Park, C., Hwang, I., Davis, M. D., & Kehrl, J. H. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.018 · Cited by 100 · see citing works

Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Reduce Radiation-Induced Lung Injury

Wang, H., Yang, Y., Zhao, L., Xiao, F., Zhang, Q., Wen, M., Wu, C.-T., RuiYun, P. E. N. G., & Wang, L. (2013) · Human Gene Therapy · doi:10.1089/hum.2012.177 · Cited by 97 · see citing works

Concise Review: Therapeutic Potential of the Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Radiation-Induced Lung Injury: Progress and Hypotheses

Xu, S., Liu, C., & Ji, H. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0038 · Cited by 97 · see citing works

Vascular permeability in the fibrotic lung

Probst, C. K., Montesi, S. B., Medoff, B. D., Shea, B. S., & Knipe, R. S. (2020) · European Respiratory Journal · doi:10.1183/13993003.00100-2019 · Cited by 95 · see citing works

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

Baumruker, T., Billich, A., & Brinkmann, V. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.3.283 · Cited by 94 · see citing works

The role of sphingolipids in respiratory disease

Yang, Y., & Uhlig, S. (2011) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465811406772 · Cited by 93 · see citing works

Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis

Shea, B. S., & Tager, A. M. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-005aw · Cited by 92 · see citing works

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

Burnier, L., & Mosnier, L. O. (2013) · Blood · doi:10.1182/blood-2013-03-488957 · Cited by 91 · see citing works

Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis

Oskeritzian, C. A., Milstien, S., & Spiegel, S. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.05.011 · Cited by 90 · see citing works

G PROTEIN‐COUPLED RECEPTORS

Alexander, S., Mathie, A. A., & Peters, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01649_3.x · Cited by 88 · see citing works

Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage

Sun, N., Shen, Y., Han, W., Shi, K., Wood, K., Fu, Y., Hao, J., Liu, Q., Sheth, K. N., Huang, D., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.012236 · Cited by 86 · see citing works

Topical Application of Sphingosine-1-Phosphate and FTY720 Attenuate Allergic Contact Dermatitis Reaction through Inhibition of Dendritic Cell Migration

Reines, I., Kietzmann, M., Mischke, R. H., Tschernig, T., Lüth, A., Kleuser, B., & Bäumer, W. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.454 · Cited by 86 · see citing works

Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer

Wang, Q., Alshaker, H. A., Böhler, T., Srivats, S., Chao, Y., Cooper, C., & Pchejetski, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-06142-x · Cited by 90 · see citing works

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

Kihara, A., & Igarashi, Y. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.05.003 · Cited by 85 · see citing works

Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics

Gonzalez‐Cabrera, P. J., Hla, T., & Rosen, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610581200 · Cited by 84 · see citing works

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

Schwalm, S. A., Pfeilschifter, J. M., & Huwiler, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.022 · Cited by 84 · see citing works

Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice

Cahalan, S. M., Gonzalez‐Cabrera, P. J., Sarkisyan, G., Nguyen, N., Schaeffer, M., Huang, L., Yeager, A. R., Clemons, B., Scott, F. L., & Rosen, H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.547 · Cited by 82 · see citing works

Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF , sphingosine kinase, and CCL 2 signaling pathway

Wacker, B. K., Perfater, J. L., & Gidday, J. M. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12047 · Cited by 81 · see citing works

Modulating molecular gateways

Owens, J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2126 · Cited by 1 · see citing works

Signaling lipid control of biological barriers

Rosen, H. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a93-d

Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P

Fujii, Y., Ohtake, H., Ono, N., Hara, T., Sakurai, T., Takahashi, S., Takayama, T., Fukasawa, Y., Shiozawa, F., Tsukahara, N., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.12.006 · Cited by 13 · see citing works

Tipping the gatekeeper: S1P regulation of endothelial barrier function

Rosen, H., Sanna, M., Cahalan, S. M., & Gonzalez‐Cabrera, P. J. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.007 · Cited by 152 · see citing works

Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function

Weigel, C., Bellaci, J., & Spiegel, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104775 · Cited by 81 · see citing works