The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
Open accessAbstract
Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses.
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RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179
Comparative functional genomics of the fission yeasts
Rhind, N., Chen, Z., Yassour, M., Thompson, D. A., Haas, B. J., Habib, N., Wapinski, I., Roy, S., Lin, M. F., Heiman, D. I., et al. (2011) · Science · doi:10.1126/science.1203357 · Cited by 484
Self-citationHistoplasma capsulatum α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor
Rappleye, C. A., Eissenberg, L. G., & Goldman, W. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609848104 · Cited by 419
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival
Lionakis, M. S., Swamydas, M., Fischer, B. G., Plantinga, T. S., Johnson, M. D., Jaeger, M., Green, N. M., Masedunskas, A., Weigert, R., Mikelis, C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71307 · Cited by 230
Self-citationKuznets, G., Vigonsky, E., Weissman, Z., Lalli, D., Gildor, T., Kauffman, S. J., Turano, P., Becker, J., Lewinson, O., & Kornitzer, D. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004407 · Cited by 118
Cited by
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
Interactions of fungal pathogens with phagocytes
Erwig, L. P., & Gow, N. A. R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.21 · Cited by 626
Architecture of the dynamic fungal cell wall
Gow, N. A. R., & Lenardon, M. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00796-9 · Cited by 447
Fishman, J. A., Gans, H., & Practice, T. A. I. D. C. O. (2019) · Clinical Transplantation · doi:10.1111/ctr.13587 · Cited by 293
Inferring synteny between genome assemblies: a systematic evaluation
Liu, D., Hunt, M., & Tsai, I. J. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2026-4 · Cited by 147
Metadata
- Authors
- Ma, L., Chen, Z., Huang, D. W., Kutty, G., Ishihara, M., Wang, H., Abouelleil, A., Bishop, L., Davey, E., Deng, R., Deng, X., Fan, L., Fantoni, G., Fitzgerald, M., Gogineni, E., Goldberg, J. M., Handley, G., Hu, X., Huber, C., Jiao, X., Jones, K., Levin, J. Z., Liu, Y., Macdonald, P., Melnikov, A., Raley, C., Sassi, M., Sherman, B. T., Song, X., Sykes, S., Tran, B., Walsh, L., Xia, Y., Yang, J., Young, S., Zeng, Q., Zheng, X., Stephens, R., Nusbaum, C., Birren, B. W., Azadi, P., Lempicki, R. A., Cuomo, C. A., & Kovacs, J. A.
- Venue
- Nature Communications
- Published
- 2016-02-22
- Volume
- 7
- Issue
- 1
- Pages
- 10740-10740
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2288062690
- Cited by
- 190
- References
- 6
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Ma, L., Chen, Z., Huang, D. W., Kutty, G., Ishihara, M., Wang, H., Abouelleil, A., Bishop, L., Davey, E., Deng, R., Deng, X., Fan, L., Fantoni, G., Fitzgerald, M., Gogineni, E., Goldberg, J. M., Handley, G., Hu, X., Huber, C., . . . Kovacs, J. A. (2016). Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nature Communications. https://doi.org/10.1038/ncomms10740
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
