The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
Open accessAbstract
Throughout vertebrates, cerebrospinal fluid-contacting neurons (CSF-cNs) are ciliated cells surrounding the central canal in the ventral spinal cord. Their contribution to modulate locomotion remains undetermined. Recently, we have shown CSF-cNs modulate locomotion by directly projecting onto the locomotor central pattern generators (CPGs), but the sensory modality these cells convey to spinal circuits and their relevance to innate locomotion remain elusive. Here, we demonstrate in vivo that CSF-cNs form an intraspinal mechanosensory organ that detects spinal bending. By performing calcium imaging in moving animals, we show that CSF-cNs respond to both passive and active bending of the spinal cord. In mutants for the channel Pkd2l1, CSF-cNs lose their response to bending and animals show a selective reduction of tail beat frequency, confirming the central role of this feedback loop for optimizing locomotion. Altogether, our study reveals that CSF-cNs constitute a mechanosensory organ operating during locomotion to modulate spinal CPGs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Optogenetic dissection of a behavioural module in the vertebrate spinal cord
Wyart, C., Bene, F. D., Warp, E., Scott, E. K., Trauner, D., Baier, H., & Isacoff, E. Y. (2009) · Nature · doi:10.1038/nature08323 · Cited by 409
Self-citation
Cited by
Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo
Verweij, F. J., Revenu, C., Arras, G., Dingli, F., Loew, D., Pegtel, D. M., Follain, G., Allio, G., Goetz, J. G., Zimmermann, P., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.004 · Cited by 346
Self-citationDjenoune, L., Desban, L., Gomez, J., Sternberg, J. R., Prendergast, A., Langui, D., Quan, F. B., Marnas, H., Auer, T. O., Rio, J.-P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00350-1 · Cited by 65
Self-citationA spinal organ of proprioception for integrated motor action feedback
Picton, L. D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E. R., Iacoviello, F., Shearing, P. R., & El Manira, A. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.018 · Cited by 59
Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control
Callahan, R. A., Roberts, R., Sengupta, M., Kimura, Y., Higashijima, S.-I., & Bagnall, M. W. (2019) · eLife · doi:10.7554/elife.47837 · Cited by 57
Modeling spinal locomotor circuits for movements in developing zebrafish
Roussel, Y., Gaudreau, S. F., Kacer, E. R., Sengupta, M., & Bui, T. V. (2021) · eLife · doi:10.7554/elife.67453 · Cited by 39
“…(5-HT) has been found to either increase motor output by decreasing inter-episode intervals in intact larval zebrafish (Brustein and Drapeau, 2005; Brustein et al., 2003) or decrease swimming frequency or burst firing in spinalized larvae and adult zebrafish (Gabriel et al., 2009; Montgomery et…”
Background
Metadata
- Authors
- Böhm, U. L., Prendergast, A., Djenoune, L., Nunes Figueiredo, S., Gomez, J., Stokes, C., Kaiser, S., Suster, M., Kawakami, K., Charpentier, M., Concordet, J.-P., Rio, J.-P., Del Bene, F., & Wyart, C.
- Venue
- Nature Communications
- Published
- 2016-03-07
- Volume
- 7
- Issue
- 1
- Pages
- 10866-10866
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2293074947
- Cited by
- 174
- References
- 3
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. https://app.cochat.ai/papers/10.1038/ncomms10866
- The paper
- Böhm, U. L., Prendergast, A., Djenoune, L., Nunes Figueiredo, S., Gomez, J., Stokes, C., Kaiser, S., Suster, M., Kawakami, K., Charpentier, M., Concordet, J.-P., Rio, J.-P., Del Bene, F., & Wyart, C. (2016). CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications. https://doi.org/10.1038/ncomms10866
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
