The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Open accessAbstract
Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.
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The adult cell types of Ia inhibitory neurons and CSF-contacting neurons each have dual origins.
“It is already known that the adult cell types of Ia inhibitory neurons and CSF-contacting neurons each have dual origins43,45,121, suggesting that this could be a common occurrence.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [45]
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A harmonized atlas of mouse spinal cord cell types and their spatial organization
Russ, D. E., Cross, R. B. P., Li, L., Koch, S. C., Matson, K. J. E., Yadav, A., Alkaslasi, M. R., Lee, D. I., Le Pichon, C. E., Menon, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25125-1 · Cited by 255 · see citing works
- Authors
- Djenoune, L., Desban, L., Gomez, J., Sternberg, J. R., Prendergast, A., Langui, D., Quan, F. B., Marnas, H., Auer, T. O., Rio, J.-P., Del Bene, F., Bardet, P.-L., & Wyart, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut Curie (FR)
- Corresponding author
- Bardet, Pierre-Luc
- Wyart, Claire
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-04-07
- Volume
- 7
- Issue
- 1
- Pages
- 719-719
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5428266
- OpenAlex
- W2604646408
- Cited by
- 65
- References
- 89
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 18 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-IAHU-0006)
- Universität zu Köln
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- cerebrospinal fluid-contacting neurons, spinal cord, developmental origins, GABAergic neurons, sensory neurons, axonal projections, zebrafish, mice, transcription factor cascade, locomotion, posture
- MeSH terms
- Animals, Axons, Carrier Proteins, Cell Differentiation, Cerebrospinal Fluid, Fluorescent Antibody Technique, Ganglia, Spinal, Homozygote, Mutation, Neurons, Sensory Receptor Cells, Spinal Cord, Spinal Nerve Roots, Zebrafish, Signal Transduction, Biomarkers, Zebrafish Proteins, Animals, Genetically Modified, TRPP Cation Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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