The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Genetic lineage tracing defines myofibroblast origin and function in the injured heart
Open accessAbstract
Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. Myofibroblasts remain a poorly defined cell type in terms of their origins and functional effects in vivo . Here we generate Postn (periostin) gene-targeted mice containing a tamoxifen-inducible Cre for cellular lineage-tracing analysis. This Postn allele identifies essentially all myofibroblasts within the heart and multiple other tissues. Lineage tracing with four additional Cre-expressing mouse lines shows that periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage, but not endothelial, immune/myeloid or smooth muscle cells. Deletion of periostin + myofibroblasts reduces collagen production and scar formation after MI. Periostin-traced myofibroblasts also revert back to a less-activated state upon injury resolution. Our results define the myofibroblast as a periostin-expressing cell type necessary for adaptive healing and fibrosis in the heart, which arises from Tcf21 + tissue-resident fibroblasts.
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Cites
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Self-citationTargeting cardiac fibrosis with engineered T cells
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Spatial multi-omic map of human myocardial infarction
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Metadata
- Authors
- Kanisicak, O., Khalil, H., Ivey, M. J., Karch, J., Maliken, B. D., Correll, R. N., Brody, M. J., J. Lin, S.-C., Aronow, B. J., Tallquist, M. D., & Molkentin, J. D.
- Venue
- Nature Communications
- Published
- 2016-07-22
- Volume
- 7
- Issue
- 1
- Pages
- 12260-12260
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2482213414
- Cited by
- 892
- References
- 57
- FWCI
- 51.05
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
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- Kanisicak, O., Khalil, H., Ivey, M. J., Karch, J., Maliken, B. D., Correll, R. N., Brody, M. J., J. Lin, S.-C., Aronow, B. J., Tallquist, M. D., & Molkentin, J. D. (2016). Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature Communications. https://doi.org/10.1038/ncomms12260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
