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Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Abstract
Conditional mutagenesis in mice has recently been made possible through the combination of gene targeting techniques and site-directed mutagenesis, using the bacteriophage P1-derived Cre/loxP recombination system. The versatility of this approach depends on the availability of mouse mutants in which the recombinase Cre is expressed in the appropriate cell lineages or tissues. Here we report the generation of mice that express Cre in myeloid cells due to targeted insertion of the cre cDNA into their endogenous M lysozyme locus. In double mutant mice harboring both the LysMcre allele and one of two different loxP-flanked target genes tested, a deletion efficiency of 83-98% was determined in mature macrophages and near 100% in granulocytes. Partial deletion (16%) could be detected in CD11c+ splenic dendritic cells which are closely related to the monocyte/macrophage lineage. In contrast, no significant deletion was observed in tail DNA or purified T and B cells. Taken together, LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells.
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The knockout efficiency of myeloid-specific Insig1 deletion with the LysM-Cre system is highest in mature macrophages.
“Although the knockout efficiency of myeloid-specific Insig1 deletion with the LysM-Cre system is highest in mature macrophage44”
From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [44]
The efficiency of loxP-mediated gene recombination driven by LysM-Cre varies markedly among myeloid cell types, with the highest efficiency in mature macrophages (approximately 83-98%) and much lower efficiency in splenic DCs (about 16%).
“It is important to note that the efficiency of loxP-mediated gene recombination driven by LysM-Cre varies markedly among myeloid cell types63–65. with the highest efficiency observed in mature macrophages (approximately 83–98%) and much lower efficiency in splenic DCs (about 16%)44.”
From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [44]
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Metadata
- Authors
- Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I.
- Venue
- Transgenic Research
- Published
- 1999-08
- Volume
- 8
- Issue
- 4
- Pages
- 265-277
- ISSN
- 0962-8819
- 1573-9368
- Cited by
- 2,098
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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