VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
Guo, Xing, Sun, XiaoYan, Hu, Di, Wang, Ya-Juan, Fujioka, Hisashi, Vyas, Rajan, Chakrapani, Sudha, Joshi, Amit Umesh, Luo, Yu, Mochly-Rosen, Daria, Qi, Xin·2016·Nature Communications
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Items 101–200 of 200
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- Mitochondrial biogenesis in organismal senescence and neurodegenerationIoanna Daskalaki, Nektarios Tavernarakis · 2020 · Mechanisms of Ageing and Development
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- Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complexXiaojing Li, Yuanyuan Zhang, Yuhua Fu, Hao Zhang, He-xuan Li, Quanfu Li, Hailing Li, Renke Tan, Chen-xiao Jiang, Wei Jiang et al. · 2021 · Acta Pharmacologica Sinica
- Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseasesMegan M. Braun, Luigi Puglielli · 2022 · Frontiers in Cellular Neuroscience
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- Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilationHaikel Dridi, Mohamad Yehya, Robert Barsotti, Yang Liu, Steven R. Reiken, Lan Azria, Qi Yuan, Laith Bahlouli, Rajesh Kumar Soni, Andrew R. Marks et al. · 2023 · PNAS Nexus
- Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease modelsDi Hu, Xiaoyan Sun, Xin Qi · 2025 · Molecular Neurodegeneration
- BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's diseaseYingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron D. Johnstone, Linda Zhixia Shi, Xu‐Qiao Chen, Sarai A. Santos, Claire Cecile Bacon-Brenes, Thomas A. Shoff et al. · 2024 · Neurobiology of Disease
- Proteomimetic polymer blocks mitochondrial damage, rescues Huntington’s neurons, and slows onset of neuropathology in vivoWonmin Choi, Mara A. Fattah, Yutong Shang, Matthew P. Thompson, Kendal Paige Carrow, Di Hu, Zunren Liu, Michael J. Avram, Keith L. Bailey, Or Berger et al. · 2024 · Science Advances
- Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic ProtocolsJenny Sassone, Elsa Papadimitriou, Dimitra Thomaidou · 2018 · Frontiers in Neuroscience
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- Methods to detect mitophagy in neurons during diseaseFaith E Carter, M. Elyse Moore, Alicia M. Pickrell · 2019 · Journal of Neuroscience Methods
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- Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerizationZhilong Zheng, Lu Han, Yuanbo Li, Zhen Chen, Wangju Yang, Chunyue Liu, Mengdan Tao, Yueqing Jiang, Xiaoyan Ke, Yan Liu et al. · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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