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Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
Open accessAbstract
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes—including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH—in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.
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Cites
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Cited by
Expanding applications of SERS through versatile nanomaterials engineering
Cardinal, M. F., Vander Ende, E., Hackler, R. A., McAnally, M. O., Stair, P. C., Schatz, G. C., & Van Duyne, R. P. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00207f · Cited by 431
Surface-Enhanced Raman Spectroscopy: Current Understanding, Challenges, and Opportunities
Ma, H., Pan, S.-Q., Wang, W.-L., Yue, X., Xi, X.-H., Yan, S., Wu, D.-Y., Wang, X., Liu, G., & Ren, B. (2024) · ACS Nano · doi:10.1021/acsnano.4c02670 · Cited by 346
Zhang, D., Chen, Q., Shi, C., Chen, M., Ma, K., Wan, J., & Liu, R. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202007226 · Cited by 303
Metadata
- Authors
- Sun, F., Hung, H.-C., Sinclair, A., Zhang, P., Bai, T., Galvan, D. D., Jain, P., Li, B., Jiang, S., & Yu, Q.
- Venue
- Nature Communications
- Published
- 2016-11-11
- Volume
- 7
- Issue
- 1
- Pages
- 13437-13437
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2553373516
- Cited by
- 239
- References
- 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, F., Hung, H.-C., Sinclair, A., Zhang, P., Bai, T., Galvan, D. D., Jain, P., Li, B., Jiang, S., & Yu, Q. (2016). Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma. Nature Communications. https://doi.org/10.1038/ncomms13437
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