BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes

Qi, Zhen, Li, Yehua, Zhao, Bing, Xu, Chi, Liu, Yuan, Li, Haonan, Zhang, Bingjie, Wang, Xinquan, Yang, Xiao, Xie, Wei, Li, Baojie, Han, Jing-Dong Jackie, Chen, Ye-Guang·2017·Nature Communications

DOI 10.1038/ncomms13824

Cited by (320)

Items 101–200 of 320

Pathways regulating intestinal stem cells and potential therapeutic targets for radiation enteropathy
Si-Min Chen, Bing-Jie Guo, An-Qiang Feng, Xuelian Wang, Sai-Long Zhang, Chao‐Yu Miao · 2024 · Molecular Biomedicine
Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis
Maria‐Theodora Melissari, Ana Raquel Henriques, Christos Tzaferis, Alejandro Prados, Michalis E. Sarris, Niki Chalkidi, Dimitra Mavroeidi, Panagiotis Chouvardas, Sofia Grammenoudi, George A. Kollias et al. · 2021 · Cellular and Molecular Life Sciences
Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAome
Andrea Angius, Antonio Mario Scanu, Caterina Arru, Maria R. Muroni, Vincenzo Rallo, Giulia Deiana, Chiara Ninniri, Ciriaco Carru, Alberto Porcu, Giovanna Pira et al. · 2021 · International Journal of Molecular Sciences
Microbial recognition regulates intestinal epithelial growth in homeostasis and disease
Meghan Ferguson, Edan Foley · 2021 · FEBS Journal
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease
Suze A. Jansen, Edward E. S. Nieuwenhuis, Alan M. Hanash, Caroline A. Lindemans · 2022 · Mucosal Immunology
Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
Lie Zheng, Sheng-Lei Duan · 2023 · World Journal of Gastroenterology
The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory Lineages
Anna Baulies, Nikolaos Angelis, Valentina Foglizzo, Erik Thomas Danielsen, Harshil Patel, Laura Novellasdemunt, Anna Kucharska, Joana Carvalho, Emma L. Nye, Paolo De Coppi et al. · 2020 · Gastroenterology
Cellular mechanisms of epithelial stem cell self‐renewal and differentiation during homeostasis and repair
Diya Das, Russell B. Fletcher, John Ngai · 2019 · Wiley Interdisciplinary Reviews Developmental Biology
Establishment of bovine 3D enteroid-derived 2D monolayers
Kate Sutton, Brigid Orr, Jayne C. Hope, Stina Rikke Jensen, Lonneke Vervelde · 2022 · Veterinary Research
Regulation of homeostasis and regeneration in the adult intestinal epithelium by the TGF ‐β superfamily
Mardi Fink, Jeffrey L. Wrana · 2022 · Developmental Dynamics
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members
2023
RANK drives structured intestinal epithelial expansion during pregnancy
Masahiro Onji, Verena Sigl, Thomas Lendl, Maria Novatchkova, Asier Ullate‐Agote, Amanda Andersson-Rolf, I. Kozieradzki, Rubina Koglgruber, Tsung‐Pin Pai, Dominic Lichtscheidl et al. · 2024 · Nature
Epigenetic regulation of intestinal stem cell differentiation
Michael Paul Verzi, Ramesh A. Shivdasani · 2020 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Recent developments on BMPs and their antagonists in inflammatory bowel diseases
Zhuo Xie, Gaoshi Zhou, Mudan Zhang, Jing Han, Ying Wang, Xiaoling Li, Qirui Wu, Manying Li, Shenghong Zhang · 2023 · Cell Death Discovery
Recent advances in understanding contextual TGFβ signaling
Arshad Ayyaz, Liliana Attisano, Jeffrey L. Wrana · 2017 · F1000Research
Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling
Dong‐Seok Park, Gang‐Ho Yoon, Eun‐Young Kim, Taehyeong Lee, Kyuhee Kim, Peter CW Lee, Eun‐Ju Chang, Sun‐Cheol Choi · 2020 · EMBO Reports
Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer
Roelof A. Wester, Lisa van Voorthuijsen, Hannah K. Neikes, Jelmer J. Dijkstra, Lieke A. Lamers, Siebren Frölich, Maarten van der Sande, Colin Logie, Rik G.H. Lindeboom, Michiel Vermeulen · 2021 · iScience
Re-evaluation of the myoepithelial cells roles in the breast cancer progression
Anwar M. Shams · 2022 · Cancer Cell International
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms
Sigita Malijauskaite, Sinéad A. Connolly, David T. Newport, Kieran McGourty · 2021 · Cytokine & Growth Factor Reviews
Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3
Lei Hu, Junji Xu, Xue Wang, Liang Feng, Chunmei Zhang, Jinsong Wang, Songlin Wang · 2021 · Frontiers in Cell and Developmental Biology
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Sarika Heino, Shentong Fang, Marianne Lähde, Jenny M. Hogstrom, Sina Nassiri, Andrew D. Campbell, Dustin James Flanagan, Alexander Raven, Michael C. Hodder, Nadia Nasreddin et al. · 2021 · Science Advances
Intestinal stem cells and intestinal organoids
Qian Zhao, Jiawei Guan, Xia Wang · 2020 · Journal of genetics and genomics/Journal of Genetics and Genomics
Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase
Sara Dionisi, Karol Piera, Armin Baumschlager, Mustafa Khammash · 2022 · ACS Synthetic Biology
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration
Brisa Palikuqi, Jérémie Rispal, Ophir D. Klein · 2021 · Cold Spring Harbor Perspectives in Biology
The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
Douja Chamseddine, Siraje Arif Mahmud, Aundrea K. Westfall, Todd A. Castoe, Rance E. Berg, Mark W. Pellegrino · 2022 · Cell Reports
1α,25-Dihydroxyvitamin D3 Improves Follicular Development and Steroid Hormone Biosynthesis by Regulating Vitamin D Receptor in the Layers Model
Manman Cheng, Zhenquan Song, Yan Guo, Xuliang Luo, Xue‐Lian Li, Xiaohui Wu, Yanzhang Gong · 2023 · Current Issues in Molecular Biology
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease
Takahiko Toyonaga, Erin C. Steinbach, Benjamin P. Keith, Jasmine Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jennifer C. Huling, Yuli Wang, Nancy L. Allbritton et al. · 2020 · Cellular and Molecular Gastroenterology and Hepatology
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
Zhang, Yuetong, Chen, Jiaying, She, Yong, Fang, Zhaoyuan, Zhang, Yaxin, Ruan, Danyun, Guo, Wenjun, Liao, Jianping, Zhou, Weiping, Lao, Jianpei et al. · 2026 · Cancer Cell
Regulation of intestinal epithelial homeostasis by mesenchymal cells
Hisako Kayama, Kiyoshi Takeda · 2024 · Inflammation and Regeneration
Extracellular Microenvironmental Control for Organoid Assembly
Kathryn M. Sullivan, Eunkyung Clare Ko, Eun Mi Kim, William C. Ballance, John D. Ito, Madeleine Chalifoux, Young Jun Kim, Rashid Bashir, Hyunjoon Kong · 2022 · Tissue Engineering Part B Reviews
Human 2D Crypt Model for Assaying Intestinal Stem Cell Proliferation and Differentiation
Yuli Wang, Christopher E. Sims, Nancy L. Allbritton · 2022 · Analytical Chemistry
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17
Yalong Wang, Ruoyu Lou, Zhe Zhang, Chuyu Xiao, Shicheng Yu, Siting Wei, Yuan Liu, Wei Fu, Baojie Li, Ye‐Guang Chen · 2023 · Science Advances
Astragalus polysaccharide promotes the regeneration of intestinal stem cells through HIF‐1 signalling pathway
Qianqian Ding, Xianpeng Zu, Wei Chen, Jiayun Xin, Xi‐Ke Xu, Yanhui Lv, Xin‐Tong Wei, Jie Wang, Yanping Wei, Zhanhong Li et al. · 2023 · Journal of Cellular and Molecular Medicine
Mesenchymal Niches for Digestive Organ Development, Homeostasis, and Disease
Adrian Kwan Ho Loe, Abilasha Rao‐Bhatia, Ji‐Eun Kim, Tae-Hee Kim · 2020 · Trends in Cell Biology
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential
Ariana A. Entezari, Adam Eugene Snook, Scott Arthur Waldman · 2021 · Expert Opinion on Therapeutic Targets
Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling
Min Kyoung Jo, Chang Mo Moon, Hyeon-Jeong Jeon, Yerim Han, Eun Sook Lee, Ji-Hee Kwon, Kyung‐Min Yang, Young‐Ho Ahn, Seong‐Eun Kim, Sung-Ae Jung et al. · 2023 · Inflammation and Regeneration
Nutrient metabolism in regulating intestinal stem cell homeostasis
Ruicheng Shi, Bo Wang · 2024 · Cell Proliferation
Linking stemness with colorectal cancer initiation, progression, and therapy
Deepak Narayanan Iyer, Wai-Yan Sin, Lui Ng · 2019 · World Journal of Stem Cells
Loss of Apc Rapidly Impairs DNA Methylation Programs and Cell Fate Decisions in Lgr5+ Intestinal Stem Cells
Marco Bruschi, Laure Garnier, Elouan Cleroux, Alicia Giordano, Michaël Dumas, Anaïs F. Bardet, Thomas Kergrohen, Stanislas Quesada, Pierre Cesses, Michaël Weber et al. · 2020 · Cancer Research
LGR5 constitutively activates NF‐κB signaling to regulate the growth of intestinal crypts
Shanshan Lai, Ran Cheng, Dan Gao, Ye‐Guang Chen, Cheng Deng · 2020 · The FASEB Journal
Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract
Wyatt E. Lanik, Madison Mara, Belgacem Mihi, Carolyn B. Coyne, Misty L. Good · 2018 · Viruses
Gut homeostasis at a glance
Jieun Choo, Neda Glisovic, Danijela Matic Vignjevic · 2022 · Journal of Cell Science
Segregation of the stemness program from the proliferation program in intestinal stem cells
Yuan Liu, Meimei Huang, Xiaodan Wang, Zinan Liu, Siqi Li, Ye‐Guang Chen · 2023 · Stem Cell Reports
Recent advances in understanding intestinal stem cell regulation
Deqing Hu, Han Yan, Xi He, Linheng Li · 2019 · F1000Research
Tissue Niches Formed by Intestinal Mesenchymal Stromal Cells in Mucosal Homeostasis and Immunity
Mária Pásztói, Caspar Ohnmacht · 2022 · International Journal of Molecular Sciences
Helicobacter pylori–activated fibroblasts as a silent partner in gastric cancer development
Gracjana Krzysiek-Mączka, Tomasz Brzozowski, Agata Ptak‐Belowska · 2023 · Cancer and Metastasis Reviews
Roles of fibroblasts in the pathogenesis of inflammatory bowel diseases and IBD-associated fibrosis
Takayoshi Ito, Hisako Kayama · 2025 · International Immunology
CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis
Yanmei Cui, Haiyong Wu, Zhihang Liu, Tenghui Ma, Wenfeng Liang, Qingzhi Zeng, Daici Chen, Qiyuan Qin, Binjie Huang, Michael Hu Wang et al. · 2022 · The Journal of Pathology
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells
Junlong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono et al. · 2024 · Stem Cell Research & Therapy
The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models
Meera Krishnan, Sahil Kumar, Luis Johnson Kangale, Éric Ghigo, Prasad Abnave · 2021 · Biomolecules
Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure
Simon Coyle Rowan, Hanne Jahns, Liberty Mthunzi, Lucie Piouceau, Joanna Cornwell, Róisín Doody, Stephen Fröhlich, John J. Callanan, Paul McLoughlin · 2020 · The Journal of Pathology
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell
Swarnabh Bhattacharya, Guodong Tie, Pratik Narendra Pratap Singh, Ermanno Malagola, Onur Eskiocak, Ruiyang He, Judith Kraiczy, Wei Gu, Yakov Perlov, Aybuke Alici-Garipcan et al. · 2025 · Cell stem cell
Radiation-induced intestinal injury: from molecular mechanisms to clinical translation
Wenjie Wu, Yubo Cai, Zhi Yang, Mengshuang Chen, Jing Hu, Kunlong Qu, Jian Yang · 2025 · Oncology Reviews
Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer
Alexandru Filippi, Teodora Deculescu-Ioniță, Ariana Hudiță, Oana Baldasici, Bianca Gălățeanu, Maria‐Magdalena Mocanu · 2025 · International Journal of Molecular Sciences
Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation
Shan Hua, Ze Zhang, Zhe Zhang, Liansheng Liu, Shicheng Yu, Yanhui Xiao, Yuan Liu, Siting Wei, Ying Xu, Ye‐Guang Chen · 2025 · EMBO Reports
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis
Xiaole Sheng, Lanfei Jin, Zhengrong Yao, Jiaji Gu, Longtao Zhu, Andi Huang, Junxuan Peng, Xin Juan Xu, Xiaolong Ge, Wei Zhou et al. · 2025 · Cell Discovery
Oncogenic signaling is coupled to colorectal cancer cell differentiation state
Thomas Sell, Christian Klotz, Matthias M. Fischer, Rosario Astaburuaga-García, Susanne M. Krug, Jarno Drost, Hans C. Clevers, Christine Sers, Markus Morkel, Nils Blüthgen · 2023 · The Journal of Cell Biology
Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer
Gareth Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika‐Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna M. West et al. · 2023 · mAbs
Extracellular Matrix Remodeling in Intestinal Homeostasis and Disease
Sang-Eun Lee, Isobel Massie, Laween Meran, Vivian Sze Wing Li · 2018 · Advances in stem cells and their niches
Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
Brian G. Jorgensen, Seungil Ro · 2019 · Journal of Neurogastroenterology and Motility
Mechanisms of epithelial growth and development in the zebrafish intestine
Reegan J. Willms, Edan Foley · 2023 · Biochemical Society Transactions
Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
Pilar Bustamante‐Madrid, Antonio Barbáchano, David Albandea‐Rodríguez, Javier Rodríguez‐Cobos, Nuria Rodrı́guez-Salas, Isabel Prieto, Aurora Burgos, Jaime Martínez de Villarreal, Francisco X. Real, José Manuel González‐Sancho et al. · 2024 · Cell Death and Disease
Activin A-mediated epithelial de-differentiation contributes to injury repair in an in vitro gastrointestinal reflux model
Cedric Roudebush, Alma Catala-Valentin, Thomas Andl, Grégoire F. Le Bras, Claudia D. Andl · 2019 · Cytokine
The Colonic Crypt: Cellular Dynamics and Signaling Pathways in Homeostasis and Cancer
Anh L. Nguyen, Molly A. Lausten, Bruce M. Boman · 2025 · Cells
Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis
Jianbo Liu, Kaixuan Liu, Ying Wang, Ziru Shi, Runze Xu, Yundi Zhang, Jingxin Li, Chuanyong Liu, Bing Xue · 2024 · Cell Death and Disease
Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics
Ran Ran, Javier Muñoz Briones, Smrutiti Jena, Nicole L. Anderson, Matthew Richard Olson, Leopold N. Green, Douglas K. Brubaker · 2024 · iScience
Intestinal stem cells and gut microbiota therapeutics: hype or hope?
Ahmad Naqiuddin Ahmad Sophien, Amirah Syamimi Jusop, Gee Jun Tye, Yuen-Fen Tan, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin · 2023 · Frontiers in Medicine
Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death
Pan Ye, Y. Jeffrey Chiang, Zhen Qi, Yehua Li, Shan Wang, Yuan Liu, Xintong Li, Ye‐Guang Chen · 2018 · PLoS Genetics
Positional BMP signaling orchestrates villus length in the small intestine
Xu Wang, Siqi Li, Yuan Liu, Xiangyu Kuang, Jianxin Chen, Pei Yu, Lianzheng Zhao, Ze Zhang, Meimei Huang, Liansheng Liu et al. · 2025 · Nature Communications
Current Trends and Research Topics Regarding Intestinal Organoids: An Overview Based on Bibliometrics
Mengmeng Zhang, Ke-Lu Yang, Yancheng Cui, Yushi Zhou, Haoran Zhang, Quan Wang, Yingjiang Ye, Shan Wang, Kewei Jiang · 2021 · Frontiers in Cell and Developmental Biology
Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK / ERK ‐dependent colorectal cancer
Shota Shimizu, Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Kasumi Ota, Mayumi Kamada, Yohei Harada, Yoshihisa Tanaka, Mai Adachi Nakazawa, Yoshinori Tamada et al. · 2023 · Cancer Science
Gli1 labels progenitors during chondrogenesis in postnatal mice
Boer Li, Puying Yang, Fangyuan Shen, Chengjia You, Fanzi Wu, Yu Shi, Ling Ye · 2024 · EMBO Reports
Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt
Louis Gall, Carrie A. Duckworth, Ferran Jardí, Lieve Lammens, Aimée Parker, Ambra Bianco, Holly H. C. Kimko, David Mark Pritchard, Carmen Pin · 2023 · eLife
BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells
Yehua Li, Xiaodan Wang, Meimei Huang, Xu Wang, Chunlin Li, Siqi Li, Yuhui Tang, Shicheng Yu, Yalong Wang, Wanlu Song et al. · 2024 · The EMBO Journal
HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?
Carl Herdenberg, Håkan Hedman · 2022 · Stem Cell Reviews and Reports
Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
Jicong Du, Fang Lan, Jianpeng Zhao, Yike Yu, Zhenlan Feng, Yuedong Wang, Ying Hua Cheng, Bailong Li, Fu Gao, Cong Liu · 2022 · Cell Death and Disease
Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation
Yanhui Xiao, Shicheng Yu, Mengxian Zhang, Nanshan Zhong, Shan Hua, Zhi Hong Fang, Zhe Zhang, Huidong Liu, Ronghui Tan, Yuan Liu et al. · 2025 · Nature Communications
METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium
Meimei Huang, Xiaodan Wang, Mengxian Zhang, Yuan Liu, Ye‐Guang Chen · 2024 · Cell Regeneration
Origin, development and therapy of colorectal cancer from the perspective of a biologist and an oncologist
Jiří Švec, Jakub Onhajzer, Vladimír Kořínek · 2024 · Critical Reviews in Oncology/Hematology
Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning
Enara Larrañaga, Miquel Marín-Riera, Aina Abad‐Lázaro, David Bartolomé-Català, Aitor Otero-Tarrazón, Vanesa Fernández‐Majada, Eduard Batlle, James A. Sharpe, Samuel Ojosnegros, Jordi Comelles et al. · 2025 · Nature Communications
Innate immunity of the gut epithelium: Blowing in the WNT?
Maaike Hillegonda de Vries, Ewart Kuijk, Edward E. S. Nieuwenhuis · 2025 · Mucosal Immunology
Decoding adenomyosis pathogenesis using an assembloid model
Yiliang Xu, Tao Cheng, Jianzhang Wang, Zhiruo Qiu, Xiaohong Guan, Yayuan Yu, Jiacheng Shen, Fangfang Xu, Xiaohong Jiang, Dandan Bai et al. · 2025 · Science China Life Sciences
The role of the tuft cell–interleukin-25 axis in the pathogenesis of inflammatory bowel disease
Zishao Tao, Li Li, Ying Zhang, Yufang Tang, Simeng Zhang, Heying Yang, Guorong Jiang, Rui Zhang, Zhiwei Wu, Miao He · 2025 · Frontiers in Immunology
IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion
Alberto Dinarello, Makenna May, Jesús Amo‐Aparicio, Tania Azam, Joseph M. Gaballa, Carlo Marchetti, Annachiara Tesoriere, Rachele Ghirardo, Jasmina S. Redzic, William S. Webber et al. · 2023 · Proceedings of the National Academy of Sciences
RETRACTED: SHP2 regulates the development of intestinal epithelium by modifying OSTERIX + crypt stem cell self‐renewal and proliferation
Lijun Wang, Douglas C. Moore, Jiahui Huang, Yuhong Wang, Hu Zhao, Jerry D‐H Yue, Cynthia L. Jackson, Peter J. Quesenberry, Weibiao Cao, Wentian Yang · 2020 · The FASEB Journal · Retracted
Cathelicidin-WA Protects Against LPS-Induced Gut Damage Through Enhancing Survival and Function of Intestinal Stem Cells
Sisi Wang, Lixia Kai, Luoyi Zhu, Bocheng Xu, Nana Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan · 2021 · Frontiers in Cell and Developmental Biology
Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture
Pascale Plaisancié, Charline Buisson, Edwin Fouché, Pierre Martin, Céline Noirot, Claire Maslo, Jacques Dupuy, Françoise Guéraud, Fabrice H.F. Pierre · 2022 · PLoS ONE
Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy
Chuanjing Dai, Yuting Cao, Fang Huang, Yigang Wang · 2022 · World Journal of Stem Cells
Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development
Sarah Ouahoud, B. Florien Westendorp, Philip W. Voorneveld, Subinuer Abudukelimu, Pim J. Koelink, Elena Pascual Garcia, Jessica Flora Isabella Buuren, Tom J. Harryvan, Kristiaan Lenos, Tom van Wezel et al. · 2022 · Journal of Gastroenterology
The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling
Siting Wei, Meng Li, Wanlu Song, Jiaye Liu, Shicheng Yu, Yalong Wang, Mengxian Zhang, Huijun Du, Yuan Liu, Huidong Liu et al. · 2023 · Cell Regeneration
Gastric Stem Cell Biology and Helicobacter pylori Infection
Jonas Wizenty, Michael J. Sigal · 2023 · Current topics in microbiology and immunology
Engineering Cell Instructive Microenvironments for In Vitro Replication of Functional Barrier Organs
Francesco Urciuolo, Giorgia Imparato, Paolo Antonio Netti · 2024 · Advanced Healthcare Materials
Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp.
Olatz Crende, Patricia García-Gallastegui, J. Luzuriaga, I. Badiola, C. de la Hoz, F. Unda, Gaskon Ibarretxe, J. R. Pineda · 2020 · Biology
Building bridges between fields: bringing together development and homeostasis
Sonja D. C. Weterings, Marek J. van Oostrom, Katharina F. Sonnen · 2021 · Development
Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland
Chunlei Shao, Pengbo Lou, Ruiqi Liu, Xueyun Bi, Guilin Li, Yang Xu, Xiaole Sheng, Jiuzhi Xu, Cong Lv, Zhengquan Yu · 2021 · Frontiers in Cell and Developmental Biology
Intestinal Wnt in the transition from physiology to oncology
Julia Swoboda, Patrick Mittelsdorf, Yuan Chen, Ralf Weiskirchen, Johannes Stallhofer, Silke Schüle, Nikolaus Gaßler · 2022 · World Journal of Clinical Oncology
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling
Yingzi Cui, Qiaoni Shi, Pu Song, Jianyu Tong, Zhimin Cheng, Hangchuan Zhang, Xiaodan Wang, Yuxuan Zheng, Yao Wu, Meng Wan et al. · 2024 · The Journal of Experimental Medicine
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration
Nikolaos Angelis, Anna Baulies, Florian Hubl, Anna Kucharska, Gavin P. Kelly, Miriam Llorian, Stefan Boeing, Vivian Sze Wing Li · 2024 · The Journal of Experimental Medicine
Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K. Dinesh, Stephen E. Maher, Jeonghyun Kim, So Yeon Park, Jun Young Hong, John J. Wysolmerski et al. · 2024 · eLife
The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective
Sudhir Verma, Xiao Lin, Vivien Jane Coulson‐Thomas · 2024 · Cells