BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes
Qi, Zhen, Li, Yehua, Zhao, Bing, Xu, Chi, Liu, Yuan, Li, Haonan, Zhang, Bingjie, Wang, Xinquan, Yang, Xiao, Xie, Wei, Li, Baojie, Han, Jing-Dong Jackie, Chen, Ye-Guang·2017·Nature Communications
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- Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradientJoep Beumer, Benedetta Artegiani, Yorick Post, Frank M. Reimann, Fiona Mary Gribble, Thuc Nghi Nguyen, Hongkui Zeng, den Born Maaike Van, Es Johan H Van, Hans C. Clevers · 2019 · Yearbook of pediatric endocrinology
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- Organoid Technology and Clinical Applications in Digestive System CancerXiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu · 2021 · Engineering
- Digestive Tract and Salivary GlandsChristy A. McKnight, Lauri J. Diehl, Ingrid L. Bergin · 2024 · Elsevier eBooks
- New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseasesShuchen Gu, Rik Derynck, Ye‐Guang Chen, Xin‐Hua Feng · 2024 · Cell Regeneration
- The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseasesPanida Sittipo, Yun Kyung Lee · 2022 · Organoid
- Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization studyZhen-Kun Pan, Meng-Hua Wu, Shi H, Yong-Jian Ni, Quan-Li Geng, Jinsheng Ye · 2025 · Clinical Proteomics
- Construction of a Duck Intestinal Organoid Culture System: From Crypt Isolation to Medium OptimizationRui Tang, Xiang Luo, Li Zhang, Zhenhua Liang, Yan Wu, Jingbo Liu, Jinsong Pi, Hao Zhang · 2025 · Animals
- Bioengineered intestinal models: structural precision drives functional and microbial fidelityZiqi Gao, Huilong Du, Shuyuan Yu, Qi Li, Yang Li, Jun Yin, Huayong Yang, Yue Wang, Hongzhao Zhou, Luqi Shen · 2025 · Bio-Design and Manufacturing
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- Effect of genetic variants in the SMAD1 and SMAD5 genes promoter on growth and beef quality traits in cattleYue Ning, Le Zhang, Wenbo Wang, Sen Wu · 2022 · Gene
- REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cellsXiao Chan Gao, Qingwei Wang, Lei Yuan, Chan Jiao, Ying Yu, Xiaoshuang Wang, Peng Xu, Yining Ma, Yelin Wu, Zhipeng Wu et al. · 2021 · Journal of Dermatological Science
- Delineation and Birth of a Layered Intestinal Stem Cell NicheNeil McCarthy, Guodong Tie, Shariq Madha, Judith Kraiczy, Adrianna Maglieri, Ramesh A. Shivdasani · 2022 · SSRN Electronic Journal
- Mapping and tracing Grem1+ stromal cells in an ApcMin/+ mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll techniqueYouheng Jiang, Zhang Fu, Yanfang Chen, Qunlong Jin, Yuan‐Han Yang, Zerong Lin, Changxue Li, Yunfei Gao, Zepeng Dong, He Bei Yang et al. · 2024 · iScience
- Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injuryXiang-Yi Bu, Haoyuan Tan, An Min Wang, Ming-Tong Wei, Sophie Pan, Juan-Zi Gao, Yonghai Li, Guixiang Qian, Zihan Chen, Chao Ye et al. · 2025 · World Journal of Gastroenterology
- Transcriptional and Epigenetic Mechanisms Controlling Intestinal Cell FateFulvio Chiacchiera · 2019 · Elsevier eBooks
- Alternative splicing variant of NRP/B promotes tumorigenesis of gastric cancerAram Kim, Bo Ram Mok, Soojung Hahn, Jongman Yoo, Dong Hyun Kim, Tae‐Aug Kim · 2022 · BMB Reports
- In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer InvasionKevin Tong, Manisha Bandari, Jillian N. Carrick, Anastasia Zenkevich, Om A. Kothari, Eman Shamshad, Katarina Stefanik, Katherine S. Haro, Ansu O. Perekatt, Michael Paul Verzi · 2023 · Cancers
- Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestineMichael Momoh, Francisca Adeniran, Cynthia Ramos, Kathleen E. DelGiorno, Hiroshi Seno, Joseph T. Roland, Izumi Kaji · 2025 · Physiological Reports
- Intestinal epithelial cells in health and diseaseChenchen An, Chonggui Jiang, Wangxiang Pei, Ao Li, Minghui Wang, Yufei Wang, Hua Wang, Li Zuo · 2025 · Tissue Barriers
- Notch Pathway Regulation of Intestinal Cell FatePeter J. Dempsey, Natacha Bohin, Linda C. Samuelson · 2018 · Elsevier eBooks
- Intestinal Stem Cells and Their Defining NicheCoralie Trentesaux, Béatrice Romagnolo · 2018 · Advances in stem cells and their niches
- Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell NicheRobert C. Mines, Kai‐Yuan Chen, Xiling Shen · 2019 · Methods in molecular biology
- Grading TESI: Crypt and villus formation in tissue-engineered small intestine alters with stem/progenitor cell sourceElizabeth A. Gilliam, Christopher R. Schlieve, Kathryn L. Fowler, Jessica N. Rea, Kathy A. Schall, Sha Huang, Jason R. Spence, Tracy Cannon Grikscheit · 2020 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- DDB1 maintains intestinal homeostasis by preventing cell cycle arrestLianzheng Zhao, Hongwei Liao, Xiaodan Wang, Ye‐Guang Chen · 2022 · Cell Regeneration
- The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1 + mesothelial cellsSimone Isling Pærregaard, Sophie Schussek, Line Wulff, Kristoffer Niss, Urs Mörbe, Johan Jendholm, Kerstin Wendland, Anna T. Andrusaite, Kevin Brulois, Robert J. B. Nibbs et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell GrowthShinya Kato, Norikatsu Miyoshi, Shiki Fujino, Masafumi Horie, Shinichi Yachida, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino et al. · 2025 · Annals of Surgical Oncology
- Age-Related Transcriptomic Changes in the Vermiform AppendixDamir Quien, Jelena Korać-Prlić, Katarina Vilović, Zenon Pogorelić, Matija Borić, Ognjen Barčot, Marina Degoricija · 2025 · International Journal of Molecular Sciences
- Matrix metalloproteinases in intestinal fibrosis and fibrostenosing Crohn’s disease: Current evidence, mechanistic hypotheses, and translational challengesTHIERRY KOCHKARIAN, Kevin M. Lopez, Rongliwen Ou, Don W. Powell, Qingjie Li · 2026 · Inflammatory Bowel Diseases
- Histone acetyltransferase HAT1 regulates intestinal stem cell proliferation and differentiationPrabakaran Nagarajan, Caden J. Martin, Andrea R. Keller, Kubra B. Akkaya-Colak, Maria H. Festing, Maria M. Mihaylova, Mark R. Parthun · 2026 · Journal of Biological Chemistry
- Bone Morphogenetic Protein Signaling Restricts Proximodistal Extension of the Ventral Fin FoldJun Ka, Jun‐Dae Kim, Boryeong Pak, Orjin Han, Woosoung Choi, Il Hwan Kim, Suk‐Won Jin · 2020 · Frontiers in Cell and Developmental Biology
- Gut stem cells: Interplay with immune system, microbiota, and agingFrancesco Marotta, Baskar Balakrishnan, Azam Yazdani, Antonio Ayala, Fang He, Roberto Catanzaro · 2021 · Elsevier eBooks
- Single cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblastsYaqing Huang, N.-K. Wang, Hao Xing, Daqian Gao, Henry C. Hsia, Micha Sam Brickman Raredon, Themis R. Kyriakides · 2025 · Scientific Reports
- P149 DECREASED COLONIC ACTIVIN RECEPTOR-LIKE KINASE 1 DISRUPTS EPITHELIAL BARRIER INTEGRITY AND IS ASSOCIATED WITH A POOR CLINICAL OUTCOME IN CROHN’S DISEASETakahiko Toyonaga, Benjamin P. Keith, Jasmine Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jeniffer Huling, Yuli Wang, Nancy L. Allbritton, Nicole Chaumont et al. · 2020 · Gastroenterology
- IPSC-derived intestinal organoids and current 3D intestinal scaffoldsSigita Malijauskaite, John Joseph Mulvihill, Andreas Martin Grabrucker, Kieran McGourty · 2021 · Elsevier eBooks
- Organoid systems for recapitulating the intestinal stem cell niche and modeling disease in vitroHui Yi Grace Lim, Lana Kostic, Nick Barker · 2022 · Advances in stem cells and their niches
- Isolation, culture and maintenance of rabbit intestinal organoids, and organoid-derived cell monolayersEgi Kardia, Michael Frese, Tanja Strive, Xi‐Lei Zeng, Mary Kolb Estes, Robyn N. Hall · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- ARID3A coordinates the proliferation-differentiation switch of transit-amplifying cells in the intestineNikolaos Angelis, Anna Baulies, Anna Kucharska, Gavin P. Kelly, Miriam Llorián Sopeña, Stefan Boeing, Vivian Sze Wing Li · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell propertiesJae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K. Dinesh, Stephen E. Maher, Jeonghyun Kim, So Yeon Park, Jun Young Hong, John J. Wysolmerski et al. · 2024 · eLife
- Tet1 safeguards lineage allocation in intestinal stem cellsAntoine R. Gleizes, Nicolas V. Janto, Sergei Bombin, Vivek Rao, Gürel Arı, Siyang Sun, Maria Fonseca, Adam D. Gracz · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivoLucas Unger, Ulrik Larsen, T. A. Legøy, Md Kaykobad Hossain, J.H. Gudmestad, Amanda Friestad, Shayla Sharmine, P. Njølstad, H. Ræder, P. Herrera et al. · 2026 · Genes & Development
- Transcriptional Regulation of the Intestinal Cancer Stem Cell PhenotypeAntoine R. Gleizes, Vincent Cavaillès, Marion Lapierre · 2018 · InTech eBooks
- Intestinal stem cells: current understanding of functions andregulationYeHua LI, Ye‐Guang Chen · 2018 · Scientia Sinica Vitae
- Constructing roadmaps towards functional cell types using organoidsJoep Beumer · 2020 · Utrecht University Repository (Utrecht University)
- Utilizing organoids to study general and tissue-specific adult stem cell profilesKim E. Boonekamp · 2020 · Utrecht University Repository (Utrecht University)
- Col6a1 + /CD201 + mesenchymal cells regulate intestinal morphogenesis and homeostasisMaria‐Theodora Melissari, Ana Raquel Henriques, Christos Tzaferis, Alejandro Prados, Michalis E. Sarris, Panagiotis Chouvardas, Sofia Grammenoudi, George A. Kollias, Vasiliki Koliaraki · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cellsWouter L. Smit, Jarom Heijmans · 2021 · Molecular & Cellular Oncology
- Faculty Opinions recommendation of Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.Rongwen Xi · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.Leigh A. Knodler · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.Malcolm Ronald Alison · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancerShota Shimizu, Jumpei Kondo, Kunishige Onuma, Kasumi Ota, Mayumi Kamada, Yohei Harada, Yoshihisa Tanaka, Mai Adachi Nakazawa, Yoshinori Tamada, Yasushi Okuno et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Exploring Epithelial Communication to the Mesenchyme and Its Impact on the Expression of Genes Related to TumorigenesisJay Patel, Michael Paul Verzi · 2022 · Aresty Rutgers Undergraduate Research Journal
- Data from Lineage Reversion Drives WNT Independence in Intestinal CancerTeng Han, Sukanya Goswami, Yang Hu, Fanying Tang, María Paz Zafra, Charles Murphy, Zhen Cao, John Thomas Poirier, Ekta Khurana, Olivier Elemento et al. · 2023
- The Role of Lrig1 in the Development of the Colonic EpitheliumRachel E. Hopton, Nicholas J. Jahahn, Anne E. Zemper · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancerYonghyo Kim, Myoung Hee Kang, Geon‐Woo Kim, Yong‐Hee Cho · 2023 · Organoid
- In Vitro and in Vivo Assays for Testing Retinoids Effect on Intestinal Progenitors’ Lineage CommitmentsKrishna R. Gajera, Kathryn L. Fair, Gordon William Moran, Nicholas R. F. Hannan, Joerg Huelsken, Paloma Ordóñez‐Morán · 2023 · Methods in molecular biology
- Human intestinal organoid-derived PDGFRα+ mesenchymal stroma empowers LGR4+ epithelial stem cellsChen JunLong, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 2 of Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signalingMin Kyoung Jo, Chang Mo Moon, Hyeon-Jeong Jeon, Yerim Han, Eun Sook Lee, Ji-Hee Kwon, Kyung‐Min Yang, Young‐Ho Ahn, Seong‐Eun Kim, Sung-Ae Jung et al. · 2023 · Figshare
- Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell propertiesJae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K. Dinesh, Stephen E. Maher, Jeonghyun Kim, So Yeon Park, Jun Young Hong, John J. Wysolmerski et al. · 2024 · eLife
- Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell propertiesJae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K. Dinesh, Stephen E. Maher, Jun Young Hong, John J. Wysolmerski, Jungmin Choi, Alfred L.M. Bothwell · 2024 · eLife
- Acute tuft cell ablation induces malabsorption and alterations in secretory and immune cell lineages in small intestineMichael Momoh, Francisca Adeniran, Cynthia Ramos, Kathleen E. DelGiorno, Hiroshi Seno, Joseph T. Roland, Izumi Kaji · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Pancreastatin Inhibition Alters the Colonic Epithelial Cells Profile in a Sex-Dependent MannerDiane M. Tshikudi, Hannah Hutchison, Jean‐Eric Ghia · 2024 · International Journal of Molecular Sciences
- Tracing Early Molecular Drivers of Gastrinoma in MEN1: A Systematic Review for Precision Surveillance and Improved Patient OutcomesOvais Shafi, Aakash Aakash, Luqman Naseer Virk, Mustafa Ali Hamid, Sohaib Khalid, Deepak Kumar, Raveena, Deepika Kumari Kataria, Muhammad Danial Yaqub, Rahimeen Rajpar et al. · 2025 · medRxiv
- Recent Research Trends in Modeling Digestive Cancer using Stem Cell OrganoidsHan-Soo Kim, Jeonghoon Heo · 2025 · Journal of Digestive Cancer Research
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- Transcriptome of the Murine Duodenum during Recovery after a Lethal Dose of Total Body IrradiationLing He, Kruttika Bhat, Frank Pajonk · 2025 · Journal of Radiation Protection and Research
- Transcriptome profiles of telocytes along the intestinal crypt-villus axisAmal Gharbi, Noa Corem, Sharona Elgavish, Inbar Plachkes, Abrar Jamous, Marco Canella, Moriya Shmuel, Hadar Horowitz, Jianmei Tan, Hongqian Chen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 4 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 6 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Kimura, Tohru, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 7 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 5 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 1 of Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signalingJo, Min Kyoung, Chang Mo Moon, Jeon, Hyeon-Jeong, Han, Yerim, Lee, Eun Sook, Kwon, Ji-Hee, Yang, Kyung-Min, Ahn, Young-Ho, Kim, Seong-Eun, Jung, Sung-Ae et al. · 2023 · Figshare
- Additional file 3 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Additional file 2 of Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsChen, JunLong, Horiuchi, Shinichiro, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Arai, Tomoki, Morinaga, Kenichi, Tohru Kimura, Tohru Kiyono et al. · 2024 · Figshare
- Polyphenols as Modulators of the BMP Signaling Pathway to Counter Phenotypic Transformation of ColonocytesEmma Cogo, Edwin Fouché, Jacques Dupuy, Fabrice H.F. Pierre, Françoise Guéraud, Pascale Plaisancié · 2026 · Molecular Nutrition & Food Research
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- Lgr5 positive stem cells sustain homeostasis and drive regeneration of the nasal septum olfactory epitheliumSuyeon Lee, Hyun‐Yi Kim, Jonghoon H. Choi, Seung‐Jun Yoo, J. Lee, Han-Sung Jung · 2026 · Cell and Tissue Research
- NOL7 Inhibits Ovarian Cancer Progression and Suppresses Angiogenesis by Stabilizing GADD45A to Deactivate STAT3Xinyu Xu, Jiayuan Wang, Meng Jiang, Ling Ouyang · 2026 · Cancer Science
- HAT1 Regulates Intestinal Stem Cell Proliferation and DifferentiationPrabakaran Nagarajan, Caden J. Martin, Andrea R. Keller, Kubra B. Akkaya-Colak, Maria H. Festing, Maria M. Mihaylova, Mark R. Parthun · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Unmasking prostate cancer risk factors leveraging organoid technologyMarta Cantarelli, Elisa Marmocchi, Andrea Lunardi, Rubens Begaj · 2026 · Gene
- Étude du rôle de la Nétrine-1 dans l'ontogénèse et le maintien de l'homéostasie de l'épithélium intestinal murinPauline Vieugué · 2017
- Rôles de l’autophagie dans l'homéostasie des cellules souches intestinalesCoralie Trentesaux · 2018 · theses.fr (ABES)